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| 1 | Progress in the mechanism and targeted drug therapy for COPD显示文摘Chronic obstructive pulmonary disease(COPD)is emphysema and/or chronic bronchitis characterised by long-term breathing problems and poor airflow.The prevalence of COPD has increased over the last decade and the drugs most commonly used to treat it,such as glucocorticoids and bronchodilators,have significant therapeutic effects;however,they also cause side effects,including infection and immunosuppression.Here we reviewed the pathogenesis and progression of COPD and elaborated on the effects and mechanisms of newly developed molecular targeted COPD therapeutic drugs.Among these new drugs,we focussed on thioredoxin(Trx).Trx effectively prevents the progression of COPD by regulating redox status and protease/anti-protease balance,blocking the NF-κB and MAPK signalling pathways,suppressing the activation and migration of inflammatory cells and the production of cytokines,inhibiting the synthesis and the activation of adhesion factors and growth factors,and controlling the cAMP-PKA and PI3K/Akt signalling pathways.The mechanism by which Trx affects COPD is different from glucocorticoid-based mechanisms which regulate the inflammatory reaction in association with suppressing immune responses.In addition,Trx also improves the insensitivity of COPD to steroids by inhibiting the production and internalisation of macrophage migration inhibitory factor(MIF).Taken together,these findings suggest that Trx may be the ideal drug for treating COPD. | Cuixue Wang Jiedong Zhou Jinquan Wang Shujing Li Atsushi Fukunaga Junji Yodoi Hai Tian | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 2 | Treatment of nonalcoholic steatohepatitis with vitamins E and C: a pilot study显示文摘 | Miwa Kawanaka Mitsuhiko Suehiro Gotaro Yamada Jun Nakamura Keisuke Hino Ken Nishino Junji Yodoi Hajime Nakamura Hirofumi Kawamoto Takahito Oka Noriyo Urata Daisuke Goto | 2013 | 2013 (defa)2013，，： | 2 |
| 3 | Persistent oxidative stress in cancer显示文摘 | Shinya Toyokuni Keisei Okamoto Junji Yodoi Hiroshi Hiai | 1995 | FEBS Letters1995，，1： | 1 |
| 4 | Overexpression of thioredoxin prevents thioacetamide-induced hepatic fibrosis in mice显示文摘 | Hiroaki Okuyama Hajime Nakamura Yasuyuki Shimahara Naoki Uyama Yong-Won Kwon Norifumi Kawada Yoshio Yamaoka Junji Yodoi | 2004 | Journal of Hepatology2004，，1： | 1 |
| 5 | Effect of Vitamin E on Serum Aminotransferase and Thioredoxin Levels in Patients with Viral Hepatitis C显示文摘 | Sabina Mahmood Gotaro Yamada Gouichi Niiyama Miwa Kawanaka Kazumi Togawa Miho Sho Toshio Ito Takayo Sasagawa Misako Okita Hajime Nakamura Junji Yodoi | 2003 | Free Radical Research2003，，7： | 1 |
| 6 | Molecular cloning and chromosomal assignment of a human perforin (PFP) gene显示文摘 | Yoichi Shinkai Michihiro C. Yoshida Keiko Maeda Tetsuji Kobata Kazuo Maruyama Junji Yodoi Hideo Yagita Ko Okumura | 1989 | Immunogenetics1989，，6： | 1 |
| 7 | Baicalin induces apoptosis via mitochondrial pathway as prooxidant显示文摘 | Shugo Ueda Hajime Nakamura Hiroshi Masutani Tetsuro Sasada Arimichi Takabayashi Yoshio Yamaoka Junji Yodoi | 2002 | Molecular Immunology2002，，10： | 1 |
| 8 | Extracellular thioredoxin: A therapeutic tool to combat inflammation显示文摘 | Yoshiyuki Matsuo Junji Yodoi | 2013 | Cytokine and Growth Factor Reviews2013，，： | 1 |
| 9 | Attenuation of neuronal degeneration in thioredoxin-1 overexpressing mice after mild focal ischemia显示文摘 | Feng Zhou Masanori Gomi Motoaki Fujimoto Makoto Hayase Takeshi Marumo Hiroshi Masutani Junji Yodoi Nobuo Hashimoto Kazuhiko Nozaki Yasushi Takagi | 2009 | Brain Research2009，，： | 1 |
| 10 | Redox regulation of mast cell histamine release in thioredoxin-1 (TRX) transgenic mice显示文摘Thioredoxin-1 (TRX ) 是有抗氧化、反煽动性的效果的压力可诱导的氧化还原作用规章的蛋白质。这里,我们证明从高亲密关系的受体的 cross-linking 为 IgE (FcepsilonRI ) 得到的桅杆房间的组织安的版本显著地在 TRX 被压制转基因(TRX-tg ) 与野类型(WT ) 相比的老鼠老鼠。IgE 和抗原刺激的桅杆房间的细胞内部的反应的氧种类(ROS ) 也与 WT 老鼠相比在 TRX-tg 老鼠被减少。而从响应 2,4-dinitrophenylated 的桅杆房间在 cytokines (IL-6 和 TNF-alpha ) 的生产没有差别在 TRX-tg 和 WT 老鼠的牛的浆液白朊(DNP-BSA ) 刺激。TRX-tg 老鼠的免疫学的地位倾向了 T 助手(Th ) 2 在主要有免疫力的反应主导,尽管在树枝状的房间(DC ) 和规章的 T 房间的人口没有差别。我们断定从在 TRX-tg 老鼠的桅杆房间的组织安版本被 ROS 产生的抑制压制。当 ROS 涉及桅杆房间激活并且便于调停人版本, TRX 可以是在在桅杆房间和过敏发炎发信号的 IgE 调整早事件的一个关键发信号分子。 | Aoi Son Hajime Nakamura Norihiko Kondo Yoshiyuki Matsuo Wenrui Liu Shin-ichi Oka Yasuyuki lshii Junji Yodoi | 2006 | Cell Research2006，16，2： | 1 |
| 11 | Localization of Glutaredoxin (Thioltransferase) in the Rat Brain and Possible Functional Implications during Focal Ischemia显示文摘 | Yasushi Takagi Takayuki Nakamura Akira Nishiyama Kazuhiko Nozaki Toru Tanaka Nobuo Hashimoto Junji Yodoi | 1999 | Biochemical and Biophysical Research Communications1999，，2： | 1 |
| 12 | Persistent oxidative stress in cancer显示文摘 | Shinya Toyokuni Keisei Okamoto Junji Yodoi Hiroshi Hiai | 1995 | FEBS Letters1995，，1： | 1 |
| 13 | Immunohistochemical localization of adult T-cell leukaemia-derived factor, a human thioredoxin homologue, in human fetal tissues显示文摘 | Shingo Fujii Yoshihiko Nanbu Ikuo Konishi Takahide Mori Hiroshi Masutani Junji Yodoi | 1991 | Virchows Archiv A Pathological Anatomy and Histopathology1991，，4： | 1 |
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