|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Six-year outcomes in neovascular age-related macular degeneration with ranibizumab显示文摘● AIM: To evaluate the outcomes of ≥6y ranibizumab therapy in neovascular age-related macular degeneration(AMD).● METHODS: HELIX was a retrospective, observational effeciveness study using medical records of patients treated in three clinics in Belgium. Patients had neovascular AMD and were initially treated with intravitreal ranibizumab(0.5 mg) between November 1, 2007 and October 31, 2008, had ≥6y of data available, and were treated on an ongoing, as-needed basis. Outcomes included best-corrected visual acuity(BCVA) and central retinal thickness(CRT).● RESULTS: The sample consisted of 88 eyes from 69 patients. Mean age was 76.4±6.5y, most patients were female(62.3%). Most eyes(62.5%) were treatment-naive, 33 previously treated eyes had received predominantly other anti-vascular endothelial growth factor agents and verteporfin. Mean baseline BCVA was 57.4±12.7 ETDRS letters and CRT was 292±86 μm. On average, patients received 20.6±11.9 ranibizumab injections over the ≥6y. Intervals between injections were on average 12.7±16.1wk. Mean change in BCVA from baseline to last observation for the sample was less than one letter(-0.9±17.3 letters), with an average loss of-3.2±15.6 letters in previously treated eyes versus a gain of 0.6±18.4 letters in treatment-na?ve eyes. When considering a loss of <15 letters over 6y as stabilization of disease, 75.9% of all eyes showed a positive(improvement or stabilization) outcome. Mean change in CRT from baseline to last observation for the sample was-26.9±148.4 μm with the greatest reduction observed in treatment-naive eyes.● CONCLUSION: This retrospective study of 69 neovascular AMD patients treated for ≥6y with ranibizumab demonstrates long-term visual stabilization. In light of the natural evolution of the disease, these data confirm that ranibizumab is effective long-term under real-world conditions of heterogeneity of patients, clinicians, and centers. | Julie Jacob Heidi Brié Anita Leys Laurent Levecq Filip Mevgaerts Kris Denhaerynck Stefaan Vancayzeele Eline Van Craeyveld Ivo Abraham Karen MacDonald | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 5 |
| 2 | Aging and menopause reprogram osteoclast precursors for aggressive bone resorption显示文摘Women gradually lose bone from the age of〜35 years,but around menopause,the rate of bone loss escalates due to increasing bone resorption and decreasing bone formation levels,rendering these individuals more prone to developing osteoporosis.The increased osteoclast activity has been linked to a reduced estrogen level and other hormonal changes.However,it is unclear whether intrinsic changes in osteoclast precursors around menopause can also explain the increased osteoclast activity.Therefore,we set up a protocol in which CD14f blood monocytes were isolated from 49 female donors(40-66 years old).Cells were differentiated into osteoclasts,and data on differentiation and resorption activity were collected.Using multiple linear regression analyses combining in vitro and in vivo data,we found the following:(1)age and menopausal status correlate with aggressive osteoclastic bone resorption in vitro;(2)the type I procollagen N-terminal propeptide level in vivo inversely correlates with osteoclast resorption activity in vitro;(3)the protein level of mature cathepsin K in osteoclasts in vitro increases with age and menopause;and(4)the promoter of the gene encoding the dendritic cell-specific transmembrane protein is less methylated with age.We conclude that monocytes are'reprogrammed'in vivo,allowing them to'remember'age,the menopausal status,and the bone formation status in vitro,resulting in more aggressive osteoclasts.Our discovery suggests that this may be mediated through DNA methylation.We suggest that this may have clinical implications and could contribute to understanding individual differences in age-and menopause-induced bone loss. | Anais Marie Julie Moller Jean-Marie Delaisse Jacob Bastholm Olesen Jonna Skov Madsen Luisa Matos Canto Troels Bechmann Silvia Regina Rogatto Kent Soe | 2020 | Bone Research2020，8，3： | 4 |
| 3 | Evaluation of technique to overcome small dataset problems during neural-network based contamination classification of packaged beef using integrated olfactory sensor system显示文摘 | Lav R. Khot Suranjan Panigrahi Curt Doetkott Young Chang Jacob Glower Jayendra Amamcharla Catherine Logue Julie Sherwood | 2011 | LWT - Food Science and Technology2011，，2： | 1 |
| 4 | The history of awake craniotomy for brain tumor and its spread into Asia显示文摘 | Julius July Pirjo Manninen Jacob Lai Zhenhai Yao Mark Bernstein | 2009 | Surgical Neu- rology2009，71，5： | 1 |
| 5 | Cognitive Transformation as a Marker of Resilience显示文摘 | Jacob Kraemer Tebes Julie T. Irish Mary Jo Puglisi Vasquez David V. Perkins | 2004 | Substance Use & Misuse2004，，5： | 1 |
| 6 | Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan)显示文摘 | Dominique S. Michaud Alina Vrieling Li Jiao Julie B. Mendelsohn Emily Steplowski Shannon M. Lynch Jean Wactawski-Wende Alan A. Arslan H. Bas Bueno-de-Mesquita Charles S. Fuchs Myron Gross Kathy Helzlsouer Eric J. Jacobs Andrea LaCroix Gloria Petersen Wei | 2010 | Cancer Causes & Control2010，，8： | 1 |
| 7 | The future of whole grains in whole grain & health显示文摘 | Len M Julie M Jacobs DR | 2007 | Blackwell publishing2007，，： | 1 |
| 8 | Docetaxel chemotherapy for metastatic hormone refractory prostate canceras first-line palliative chemotherapy and subsequent re-treatment: Birminghamexperience显示文摘 | Jawaher Ansari Syed Hussain Anjali Zarkar Jacob Tanguay Julie Bliss John Glaholm | 2008 | Oncology Reports2008，，4： | 1 |
| 9 | Contemporary Fontan Operation: Association Between Early Outcome and Type of Cavopulmonary Connection显示文摘 | Robert D. Stewart Sara K. Pasquali Jeffrey P. Jacobs Daniel K. Benjamin James Jaggers Julie Cheng Constantine Mavroudis Marshall L. Jacobs | 2012 | The Annals of Thoracic Surgery2012，，4： | 1 |
| 10 | Attenuated Pik3r1 Expression Prevents Insulin Resistance and Adipose Tissue Macrophage Accumulation in Diet-Induced Obese Mice显示文摘 | Carrie E. McCurdy Simon Schenk Michael J. Holliday Andrew Philp Julie A. Houck David Patsouris Paul S. MacLean Susan M. Majka Dwight J. Klemm Jacob E. Friedman | 2012 | Diabetes2012，，10： | 1 |
| 11 | Mitogen-inducible gene-6 expression correlates with survival and is an independent predictor of recurrence in BRAF V600E positive papillary thyroid cancers显示文摘 | Daniel T. Ruan Robert S. Warren Jacob Moalem Ki-Wook Chung Ann C. Griffin Wen Shen Quan-Yang Duh Eric Nakakura David B. Donner Elham Khanafshar Julie Weng Orlo H. Clark Electron Kebebew | 2008 | Surgery2008，，： | 1 |
| 12 | Sequential Expression of Type IV Collagen Networks: Testis as a Model and Relevance to Spermatogenesis显示文摘 | Scott J. Harvey Julie Perry Keqin Zheng Dilys Chen Yoshikazu Sado Barbara Jefferson Yoshifumi Ninomiya Robert Jacobs Billy G. Hudson Paul S. Thorner | 2006 | The American Journal of Pathology2006，，5： | 1 |
| 13 | Cannabinoids function in defense against chewing herbivores in Cannabis sativa L.显示文摘In the decades since the first cannabinoids were identified by scientists,research has focused almost exclusively on the function and capacity of cannabinoids asmedicines and intoxicants for humans and other vertebrates.Very little is knownabout the adaptive value of cannabinoid production,though several hypotheses have been proposed including protection from ultraviolet radiation,pathogens,and herbivores.To test the prediction that genotypeswith greater concentrations of cannabinoidswill have reduced herbivory,a segregating F2 population of Cannabis sativa was leveraged to conduct lab-and field-based bioassays investigating the function of cannabinoids in mediating interactions with chewing herbivores.In the field,foliar cannabinoid concentration was inversely correlated with chewing herbivore damage.On detached leaves,Trichoplusia ni larvae consumed less leaf area and grew less when feeding on leaves with greater concentrations of cannabinoids.Scanning electron and light microscopy were used to characterize variation in glandular trichome morphology.Cannabinoid-free genotypes had trichomes that appeared collapsed.To isolate cannabinoids from confounding factors,artificial insect diet was amended with cannabinoids in a range of physiologically relevant concentrations.Larvae grew less and had lower rates of survival as cannabinoid concentration increased.These results support the hypothesis that cannabinoids function in defense against chewing herbivores. | George M.Stack Stephen I.Snyder Jacob A.Toth Michael A.Quade Jamie L.Crawford John K.McKay John Nicholas Jackowetz Ping Wang Glenn Philippe Julie L.Hansen Virginia M.Moore Jocelyn K.C.Rose Lawrence B.Smart | 2023 | Horticulture Research2023，10，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员