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| 1 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 2 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis: Special situations显示文摘 | Gert Van Assche Axel Dignass Bernd Bokemeyer Silvio Danese Paolo Gionchetti Gabriele Moser Laurent Beaugerie Fernando Gomollón Winfried H?user Klaus Herrlinger Bas Oldenburg Julian Panes Francisco Portela Gerhard Rogler Jürgen Stein Herbert Tilg Simon Tra | 2012 | Journal of Crohn’s and Colitis2012，，： | 4 |
| 3 | Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials显示文摘 | Guglielmo Ronco Joakim Dillner K Miriam Elfstr?m Sara Tunesi Peter J F Snijders Marc Arbyn Henry Kitchener Nereo Segnan Clare Gilham Paolo Giorgi-Rossi Johannes Berkhof Julian Peto Chris J L M Meijer | 2013 | The Lancet2013，，： | 3 |
| 4 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 5 | Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial显示文摘 | Wendy Atkin Edward Dadswell Kate Wooldrage Ines Kralj-Hans Christian von Wagner Rob Edwards Guiqing Yao Clive Kay David Burling Omar Faiz Julian Teare Richard J Lilford Dion Morton Jane Wardle Steve Halligan | 2013 | The Lancet2013，，： | 3 |
| 6 | Computed tomographic colonography versus barium enema for diagnosis of colorectal cancer or large polyps in symptomatic patients (SIGGAR): a multicentre randomised trial显示文摘 | Steve Halligan Kate Wooldrage Edward Dadswell Ines Kralj-Hans Christian von Wagner Rob Edwards Guiqing Yao Clive Kay David Burling Omar Faiz Julian Teare Richard J Lilford Dion Morton Jane Wardle Wendy Atkin | 2013 | The Lancet2013，，： | 2 |
| 7 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 8 | The effects of dietary flax oil and antioxidants on ascites and pulmonary hypertension in broilers using a low temperature model 显示文摘 | Walton J P Julian R J Squires E J | 2001 | Br Poult Sci2001，42，1： | 1 |
| 9 | Aberrant gly- cosylation of IgA1 and anti-glyean antibodies in IgA nephropathy: role of mucosal immune system显示文摘 | Novak J Moldoveanu Z Julian BA | 2011 | Adv Otorhinolaryngol2011，72，： | 1 |
| 10 | Earthquake-induced landslides in Central America显示文摘 | Julian J B Carlos E Rodriguez | 2002 | Engineering Geology2002，63，： | 1 |
| 11 | Randomized trial of breast irradiation schedules after lumpectomy for wom- en with lymph node-negative breast cancer 显示文摘 | Whelan T MacKenzie R Julian J | 2002 | J J Natt Cancer Inst2002，94，15： | 1 |
| 12 | Prevention and treatment of postphlebitic syndrome:results of a 3-part study显示文摘 | Ginsberg JS Hirsh J Julian J | 2001 | Arch Intern Med2001，161，17： | 1 |
| 13 | Glycosylation of IgA1 and pathogenesis of IgA nephropathy显示文摘 | Novak J Julian B A Mestecky J | 2012 | Semin Immunopathol2012，34，3： | 1 |
| 14 | Enterococcus spp on fomi- tes and hands indicate increased risk of respiratory illness in child care centers 显示文摘 | Julian TR Picketing A J Leckie JO | 2013 | Am J Infect Control2013，41，8： | 1 |
| 15 | Sentinel - lymph - node resection compared with conventional axillary -lymph - node dissection in clinically node - negative patients with breast cancer: overall survival findings from the NSABP B -32 ran- domised phase 3 trial显示文摘 | KRAG D N ANDERSON S J JULIAN T B | 2010 | Lancet Oncol2010，11，10： | 1 |
| 16 | The effect of cold and dietary energy on right ventricle hypertrophy, right ventricle failure and ascites in meat-type chickens 显示文摘 | Julian R J McMillan I Quinton M | 1989 | Avian Pathology1989，18，： | 1 |
| 17 | Impact of fluorodeoxyglucose positron emission tomography response evaluationin patients with high-tumor burden follicular lymphoma treated withimmunochemotherapy : a prospective study from the Groupe d' Etudesdes Lymphomes de 1'Adulte and GOELAMS显示文摘 | Dupuis J Berriolo-Riedinger A Julian A | 2012 | J Clin Oncol2012，30，43： | 1 |
| 18 | Carbon losses from soil and its consequences for land-use management显示文摘 | Julian J C Dawson Pete Smith | 2007 | Science of the Total Environment2007，382，2： | 1 |
| 19 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase Ⅲ trial显示文摘 | Krag DN Anderson S J Julian TB | 2007 | Lancet Oncol2007，8，10： | 1 |
| 20 | Abnormal permeability of inner and outer mitochondrial membranes contributes independently to mitochondrial dysfunction in the liver during acute endotoxemia 显示文摘 | Crouser E D Julian M W Huff J E | 2004 | Crit Care Med2004，32，2： | 1 |
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