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| 1 | Upper tract urothelial carcinoma: Paradigm shift towards nephron sparing management显示文摘Upper tract urothelial carcinoma(UTUC) is relatively rare compared to urothelial carcinoma of the lower tract, comprising only 5%-10% of all urothelial cancers. Although both entities share histologic properties, UTUC tends to be more invasive at diagnosis and portend a worse prognosis, with a 5 year overall mortality of 23%. To date, the gold standard management of UTUC has been radical nephroureterectomy(RNU), with nephron sparing techniques reserved for solitary kidneys or cases where the patient could not tolerate radical surgery. Limited data from these series, as well as select series where nephron-sparing endoscopic management has been offered to a broader patient base, suggest that minimally invasive, nephron sparing techniques can offer comparable oncologic and survival outcomes to RNU in appropriately selected patients. We review the current literature on the topic and discuss long term outcomes and sequelae of the gold standard treatment, RNU. We also discuss the oncologic outcomes of minimally invasive, endoscopic management of UTUC. Our goal is to provide the reader a comprehensive overview of the current state of the field in order to inform and guide their treatment decisions. | Julia V Fiuk Brad F Schwartz | 2016 | World Journal of Nephrology2016，5，2： | 3 |
| 2 | Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia显示文摘AIM: To explore methylation of DAPK, THBS1, CDH-1, and p14 genes, and Helicobacter pylori(H. pylori) status in individuals harboring esophageal columnar metaplasia.METHODS: Distal esophageal mucosal samples obtained by endoscopy and histologically diagnosed as gastric-type(non-specialized) columnar metaplasia, were studied thoroughly. DNA was extracted from paraffin blocks, and methylation status of deathassociated protein kinase(DAPK), thrombospondin-1(THBS1), cadherin-1(CDH1), and p14 genes, was examined using a methyl-sensitive polymerase chain reaction(MS-PCR) and sodium bisulfite modification protocol. H. pylori cag A status was determined by PCR.RESULTS: In total, 68 subjects(33 females and 35 males), with a mean age of 52 years, were included. H. pylori cag A positive was present in the esophageal gastric-type metaplastic mucosa of 18 individuals. DAPK, THSB1, CDH1, and p14 gene promoters were methylated by MS-PCR in 40(58.8%), 33(48.5%), 46(67.6%), and 23(33.8%) cases of the 68 esophageal samples. H. pyloristatus was associated with methylation of DAPK(P = 0.003) and THBS1(P = 0.019).CONCLUSION: DNA methylation occurs in cases of gastric-type(non-specialized) columnar metaplasia of the esophagus, and this modification is associated with H. pylori cag A positive infection. | Roberto Herrera-Goepfert Luis F Onate-Ocana José Luis Mosqueda-Vargas Luis A Herrera Clementina Castro Julia Mendoza Rodrigo González-Barrios | 2016 | World Journal of Gastroenterology2016，22，18： | 3 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Analysis of feline calicivirus capsid protein genes:identification of varia ble antigenic determinant regions of the protein显示文摘 | Bruce S S Julia F R William L M | 1993 | J Gen Virol1993，74，： | 1 |
| 5 | The use of internal stents in chronicureteral obstruction 显示文摘 | Julia F Yige B John GC | 2015 | The Journal of Urology2015，193，5： | 1 |
| 6 | Natural fractures in the Barnett shale and their importance for hydraulic fracture treatments显示文摘 | Julia F W G Reed R M Holder Jon | 2007 | AAPG2007，91，4： | 1 |
| 7 | The collection of NFATcl-dependent transcripts in the osteoclast includes nuerous genes non -essential to physiologic bone resorption 显示文摘 | Julia F Fabienner Coury Rosalyn S | 2012 | Bone2012，51，： | 1 |
| 8 | Blastic plasmacytoid dendritic cell neoplasms: clinico cal correlations in a series of 91 patients显示文摘 | Julia F Dalle S Duru G | 2014 | Am J Surg Pathol2014，38，5： | 1 |
| 9 | Reflex cardiac activity in ischemia and reperfusion heart rate turbulence in patients undergoing direct percutaneous coronary intervention for myocardial infarction显示文摘 | Hendrik B Uwe KH Julia F | 2003 | Circulation2003，108，： | 1 |
| 10 | Natural fractures in the Barnett Shale and their importance for hydraulic fracture treatments显示文摘 | Julia F W Robert M R Holder J | 2007 | AAPG Bulletin2007，91，4： | 1 |
| 11 | Natural fractures in the Barnett shale and their importance for hydraulic fracture treatments显示文摘 | Julia F W G Robert M R Holder J | 2007 | AAPG Bulletin2007，91，4： | 1 |
| 12 | Clinical and epidemiologic observations ofbovine viral diarrhea virus in the northwestern United States 显示文摘 | James F Evermann Julia F | 2002 | Vet Microbiol2002，89，： | 1 |
| 13 | A posteriori error estimates for fully discrete nonlinear parabolic problems显示文摘 | Javier F Bosco G A Julia N | 2007 | Comput Methods Appl Mech Engrg2007，196，： | 1 |
| 14 | Linkage analysis of high myopia susceptibility locus in 25 fami- lies显示文摘 | Paget S Julia S Vitezica ZG Soler V Malecaze F Calvas P | 2008 | Mol Vis2008，14，： | 1 |
| 15 | Recombineering mycobacteria and their phages显示文摘 | Julia C V K Laura J M Graham F H | 2008 | Nat Rev Microbiol2008，6，11： | 1 |
| 16 | Anaerobic biodegradation of aromatic hydrocarbons: pathway and prospect显示文摘 | JULIA F | 2008 | Journal of Molecular Microbiology and Biotechnology2008，15，23： | 1 |
| 17 | Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4显示文摘 | Miriam E. Jaax Krystin Krauel Thomas Marschall Sven Brandt Julia Gansler Birgitt Fürll Bettina Appel Silvia Fischer Stephan Block Christiane A. Helm Sabine Müller Klaus T. Preissner Andreas Greinacher | 2013 | Blood2013，，： | 1 |
| 18 | Aquatic birds as bioindicators of trophic changes and ecosystem deterioration in the Mar Menor Lagoon (SE Spain)显示文摘 | Julia M F Miguel A E S Francisco RA | 2005 | Hydrobiologia2005，550，： | 1 |
| 19 | Swalpamycin,a new macrolide antibiotic显示文摘 | CHRISTOPHER M M F JULIA N G SUGATA C | 1987 | The Jour-nal of Aantibiotics1987，11，10： | 1 |
| 20 | Root hairs as a model system for studing plant cell growth显示文摘 | Julia F Liam D | 2001 | Annals of Botany2001，88，： | 1 |
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