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| 1 | Dynamic Prediction Method of Production Logistics Bottleneck Based on Bottleneck Index显示文摘In modern manufacturing pattern,there are many uncertain factors in the modern manufacturing process,such as changes of product attribute,changes of manufacturing resources' state,and so on,which cause production logistics bottleneck frequently shift,and make decisions of production planning and control based on formed bottleneck deviated from practical production process.Considering these factors,present researches mainly apply afterwards control to optimize production process to passively adapt to bottleneck changes.If the direction of bottleneck shifting can be accurately forecasted,the transition from afterwards control of chasing bottleneck to beforehand control can be realized.Therefore,aiming at the phenomenon of production logistics bottleneck shifting under uncertain manufacturing circumstances,this paper starts off with dynamic property of capability and requirement and then builds the concepts of bottleneck degree and bottleneck index to describe dynamic bottleneck characteristic of production unit;taken production capability,production load and quality assurance capability into consideration,mathematical model of bottleneck index is established to measure bottleneck degree accurately,consequently,quantitative research on mechanism of production logistics shifting is achieved.Based on bottleneck index,the prediction model of production logistics bottleneck is founded to predict dynamic change of bottleneck accurately.Finally,an example of forecasting and monitoring the production logistics bottleneck in one manufacturing shop is given to testify the validation and practicability of the prediction method. | LIU Mingzhou TANG Juan GE Maogen JIANG Zengqiang HU Jing LING Lin | 2009 | Chinese Journal of Mechanical Engineering2009，22，5： | 22 |
| 2 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 3 | Liuwei Dihuang Pill(六味地黄丸)Treats Postmenopausal Osteoporosis with Shen(Kidney) Yin Deficiency via Janus Kinase/Signal Transducer and Activator of Transcription Signal Pathway by Up-regulating Cardiotrophin-Like Cytokine Factor 1 Expression显示文摘Objectives: To investigate the mechanism of Liuwei Dihuang Pill(六味地黄丸, LDP) in treating postmenopausal osteoporosis(PMOP) with Shen(Kidney) yin deficiency. Methods: In this study, 205 cases of PMOP were divided into the PMOP Shen-yin deficiency group(Group A), PMOP Shen-yang deficiency group(Group B), PMOP without Shen deficiency group(Group C), and control group(Group N). Real-time polymerase chain reaction(RT-PCR) and Western blot techniques were used to observe the effects of LDP treatment on the cardiotrophin-like cytokine factor 1(CLCF1), ankyrin repeat and SOCS box containing 1(ASB1), and prokineticin 2(PROK2) genes and the Janus kinase/signal transducer and activator of transcription(JAK/STAT) signaling pathway. Results: The m RNA(P<0.05) and protein(P<0.01) expression levels of the CLCF1 gene in Group A were significantly lower than the corresponding levels in Group N. After LDP treatment for 3 months, the m RNA expression levels of the CLCF1 gene were obviously up-regulated(P<0.01). After 6-month treatment, the expression levels of CLCF1 m RNA and protein were significantly up-regulated(both P<0.01), and the average bone density of the top femur had significantly increased(P<0.05). In vitro, CLCF1 overexpression resulted in a significant increase in the total protein and phosphorylated protein levels of JAK2 and STAT3. Conclusions: The CLCF1 gene is an important gene associated with PMOP Shen-yin deficiency and the therapeutic effects of LDP may be mediated by up-regulation of CLCF1 gene expression and activation of the JAK/STAT signaling pathway. | GE Ji-rong XIE Li-hua CHEN Juan LI Sheng-qiang XU Hui-juan LAI Yu-lian QIU Long-long NI Chen-bo | 2018 | Chinese Journal of Integrative Medicine2018，24，6： | 17 |
| 4 | Sea surface temperature and terrestrial biomarker records of the last 260 ka of core MD05-2904 from the northern South China Sea显示文摘This paper reports high-resolution biomarker records of the last 260 ka for core MD05-2904 from the northern South China Sea (SCS). The sea surface temperature (SST) record using the U k3’7 index re-veals a minimum of 21.5℃ (MIS 2) and a maximum of 28.3℃ (MIS 5.5), for a temperature difference of almost 7℃, and provides the longest high-resolution U k3’7 SST record in northern SCS. The content of odd-number long chain n-alkanes and several n-alkanes indexes such as the CPI, ACL and the C31/C27 ratio, all reveal generally higher values during the glacials and lower values during the interglacials. Terrestrial input as indicated by n-alkane content was mostly controlled by sea-level changes: During the glacials, lower sea-level exposed the continental shelf to enable rivers to transport more terrestrial materials to the slope; and the situation reverses during the interglacials. The n-alkane indexes changes reveal more n-alkanes from contemporary vegetation during glacials as a result of the prox-imity of the core site to the source region, while the increases in ACL and C31/C27 ratio during glacials indicate a change to more grassy vegetation. However, the highest values for CPI, ACL and the C31/C27 ratio all occurred during late MIS 3, and it was suggested that this period was characterized by a strong summer monsoon-dominated humid climate which resulted in a denser vegetation for the exposed continental shelf region. | HE Juan ZHAO MeiXun LI Li WANG PinXian GE HuangMin | 2008 | Chinese Science Bulletin2008，53，15： | 17 |
| 5 | Design of the Full-disk Magneto Graph (FMG) onboard the ASO-S显示文摘The Full-disk Magneto Graph(FMG),a payload onboard the Advanced Space Solar Observatory(ASO-S),will measure the vector magnetic field in the photosphere.The instrument consists of a frontwindow filter,a telescope,an LCVR polarimeter,an image-stabilization system,a seven-stage tunable Lyot filter,a CMOS camera with 4096×4096 pixels and a pair of calibration/focus wheels.In this paper,we describe the design of the FMG instrument and provide a summary of test observations carried out with the FMG prototype. | Yuan-Yong Deng Hai-Ying Zhang Jian-Feng Yang Fu Li Jia-Ben Lin Jun-Feng Hou Zhen Wu Qian Song Wei Duan Xian-Yong Bai Dong-Guang Wang Juan Lv Wei Ge Jia-Ning Wang Zhao-Ying Zheng Chen-Jie Wang Nan-Ge Wang Hou-Kun Ni Yi-Zhong Zeng Yang Zhang Xiao Yang Ying-Zi Sun Zhi-Yong Zhang Xiao-Fan Wang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 14 |
| 6 | Quantitative analysis of diffusion-weighted magnetic resonance images:differentiation between prostate cancer and normal tissue based on a computer-aided diagnosis system显示文摘Diffusion-weighted imaging(DWI) is considered to be one of the dominant modalities used in prostate cancer(PCa) detection and the assessment of lesion aggressiveness,especially for peripheral zone(PZ) PCa.Computer-aided diagnosis(CAD),which is capable of automatically extracting and evaluating image features,can integrate multiple parameters and improve the detection of PCa.In this study,13 quantitative image features were extracted from DWI by CAD,and diagnostic efficacy was analyzed in both the PZ and transition zone(TZ).The results demonstrated that there was a significant difference(P<0.05) between PCa and non-PCa for nine of the 13 features in the PZ and five of the 13 features in the TZ.Besides,the prediction outcome of CAD had a strong correlation with the DWI scores that were graded by experienced radiologists according to the Prostate Imaging-Reporting and Data System Version 2(PI-RADS v2). | Ge Gao Chengyan Wang Xiaodong Zhang Juan Hu Xuedong Yang He Wang Jue Zhang Xiaoying Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 7 | m^6A-dependent biogenesis of circular RNAs in male germ cells显示文摘The majority of circular RNAs(circRNAs)spliced from coding genes contain open reading frames(ORFs)and thus,have protein coding potential.However,it remains unknown what regulates the biogenesis of these ORF-containing circRNAs,whether they are actually translated into proteins and what functions they play in specific physiological contexts.Here,we report that a large number of circRNAs are synthesized with increasing abundance when late pachytene spermatocytes develop into round and then elongating spermatids during murine spermatogenesis.For a subset of circRNAs,the back splicing appears to occur mostly at m^6A-enriched sites,which are usually located around the start and stop codons in linear mRNAs.Consequently,approximately a half of these male germ cell circRNAs contain large ORFs with m^6A-modified start codons in their junctions,features that have been recently shown to be associated with protein-coding potential.Hundreds of peptides encoded by the junction sequences of these circRNAs were detected using liquid chromatography coupled with mass spectrometry,suggesting that these circRNAs can indeed be translated into proteins in both developing(spermatocytes and spermatids)and mature(spermatozoa)male germ cells.The present study discovered not only a novel role of m^6A in the biogenesis of coding circRNAs,but also a potential mechanism to ensure stable and long-lasting protein production in the absence of linear mRNAs,i.e.,through production of circRNAs containing large ORFs and m^6A-modified start codons in junction sequences. | Chong Tang Yeming Xie Tian Yu Na Liu Zhuqing Wang Rebekah J.Woolsey Yunge Tang Xinzong Zhang Weibing Qin Ying Zhang Ge Song Weiwei Zheng Juan Wang Weitian Chen Xiongyi Wei Zhe Xie Rachel Klukovich Huili Zheng David R.Quilici Wei Yan | 2020 | Cell Research2020，30，3： | 12 |
| 8 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 9 | Bioactive biodegradable polycitrate nanoclusters enhances the myoblast differentiation and in vivo skeletal muscle regeneration via p38 MAPK signaling pathway显示文摘Complete skeletal muscle repair and regeneration due to severe large injury or disease is still a challenge.Biochemical cues are critical to control myoblast cell function and can be utilized to develop smart biomaterials for skeletal muscle engineering.Citric acid-based biodegradable polymers have received much attention on tissue engineering,however,their regulation on myoblast cell differentiation and mechanism was few investigated.Here,we find that citrate-based polycitrate-polyethylene glycol-polyethylenimine(POCG-PEI600)nanoclusters can significantly enhance the in vitro myoblast proliferation by probably reinforcing the mitochondrial number,promote the myotube formation and full-thickness skeletal muscle regeneration in vivo by activating the myogenic biomarker genes expression of Myod and Mhc.POCG-PEI600 nanoclusters could also promote the phosphorylation of p38 in MAP kinases(MAPK)signaling pathway,which led to the promotion of the myoblast differentiation.The in vivo skeletal muscle loss rat model also confirmed that POCG-PEI600 nanoclusters could significantly improve the angiogenesis,myofibers formation and complete skeletal muscle regeneration.POCG-PEI600 nanocluster could be also biodegraded into small molecules and eliminated in vivo,suggesting their high biocompatibility and biosafety.This study could provide a bioactive biomaterial-based strategy to repair and regenerate skeletal muscle tissue. | Yi Guo Min Wang Juan Ge Wen Niu Mi Chen Wei Cheng Bo Lei | 2020 | Bioactive Materials2020，5，3： | 12 |
| 10 | Synthesis,Crystal Structure and Fluorescence Property of the Ag(Ⅰ) Coordination Polymer Constructed by 2D[Ag(1,3-BIP)(PMA)_(0.5)]_n^(n-)Layers and 1D[Ag(1,3-BIP)(H_2O)]_n^(n+) Chains显示文摘A new Ag(I) coordination polymer,{[Ag(l,3-BIP)(H_2O)][Ag(l,3- BIP)(PMA)_(0.5)·-4H_2O}_n(PMA = 1,2,4,5-benzenetricarboxylic acid,1,3-BIP = l,3-bis(imidazole)propane),have been synthesized and characterized by single-crystal X-ray diffraction,powder XRD,FTIR,TGA and elemental analysis techniques.The single-crystal X-ray diffraction reveals that the title complex is formed by 1D polymeric cationic chains of[Ag(l,3-BIP)(H_2O)]_n^(n+) and 2D polymetric anionic layer of[Ag(l,3-BIP)(PMA)_(0.5]_n^(n-),which are further linked by intermolecular H-bonding to form a3 D supramolecular framework.In addition,the photoluminescence property of the title complex in the solid state at room temperature was also investigated. | LU Jiu-Fu GE Hong-Guang SHI Juan | 2015 | Chinese Journal of Structural Chemistry2015，34，8： | 11 |
| 11 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 12 | Synthesis, Crystal Structure and Luminescent Property of a Ag(Ⅰ) Coordination Polymer with a 3D Sandwich-like Framework显示文摘A new coordination polymer,{[Ag_2(bpp)_2(H_2O)_2]·bpdc·3H_2O}_n,derived from the ligand biphenyl-4,4'-dicarboxylic acid(H_2bpdc),has been obtained through a hydrothermal technique(bpp = l,3-bis(4-pyridyl)propane).Its single-crystal structure has been characterized by single-crystal X-ray diffraction,powder XRD,FT-IR,TGA and elemental analysis techniques.The single-crystal X-ray diffraction reveals that complex 1 consists of 1D infinite[Ag(bpp)(H_2O)]_n^(n+)cationic chains,2D anionic layer constructed by bpdc anions and free water which provide charge compensation in the crystal structure.The 1D infinite[Ag(bpp)(H_2O)]_n^(n+) cationic chains and 2D anionic layer are further stacked in-ABAB- fashion through intermolecular H-bonding to form a 3D sandwich-like framework.In addition,the luminescent property of complex 1 in the solid state at room temperature was investigated. | LU Jiu-Fu SHI Juan ZHENG Nan GUO Xiao-Hua GE Hong-Guang | 2016 | Chinese Journal of Structural Chemistry2016，35，2： | 10 |
| 13 | Bartonella Species Detected in the Plateau Pikas(Ochotona curzoiae) from Qinghai Plateau in China显示文摘Bartonella 种类能感染许多哺乳动物的主人并且在人引起许多疾病,但是在那里有不是在 Ochotonidae 的 Bartonella 感染的报告。这是第一研究在 Qinghai 高原在高原一种短耳野兔检测 Bartonella,提供为对在这个区域的人的 Bartonella 感染的风险评价的基线数据。我们与 18.99% 的积极的率在 Qinghai 的 Binggou 和 Maixiu 区域从 79 只一种短耳野兔获得了 15 Bartonella 紧张。基于基因定序的 Bartonella 柠檬酸盐 synthase (gltA ) 的种系发生的分析,大多数紧张是仔细与 B 有关。taylorii (3/15 ) 和 B。grahamii (12/15 ) 。后者是在人的病原的紧张。我们的结果建议相应预防和控制策略应该在 Qinghai 省被考虑。 | RAO Hua Xiang YU Juan GUO Peng MA Yong Cheng LIU Qi Yong JIAO Ming MA Zhong Wen GE Hua WANG Chun Xiang SONG Xiu Ping SHI Yan LI Dong Mei | 2015 | Biomedical and Environmental Sciences2015，28，9： | 8 |
| 14 | Effects of lifestyle interventions on rural patients with type 2 diabetes mellitus显示文摘BACKGROUND The prevalence of type 2 diabetes mellitus(T2DM)is rising rapidly in rural areas,and lifestyle interventions can effectively reduce the blood glucose levels of patients with T2DM.However,current dietary and exercise guidelines are still at experimental stages and are difficult for subjects to understand and implement.The Human Metabolism Analyzer provides real life interventions for the prevention and treatment of T2DM,and our pilot research has demonstrated its effectiveness and good compliance.AIM To investigate the effect of and compliance with lifestyle interventions in rural patients with T2DM.METHODS A total of ten rural villages were randomly selected in Chaoshui Township,Penglai City,Shandong Province,China,to conduct health screening among residents aged 50 years or older.Each rural village represented a group,and 12 patients with T2DM were randomly selected from each group(total:120)to participate in this study and receive real life lifestyle interventions and medication guidance.Lifestyle interventions included changing the meal order(A),postprandial activities(B),resistance exercise(C),and reverse abdominal breathing(D).Diabetes education was conducted at least once a month with a weekly phone follow-up to monitor exercise and diet.Waist circumference,blood pressure,body mass index(BMI),motor function,body composition,fasting blood glucose,and glycated hemoglobin(HbA1c)were analyzed before and 3 mo after the intervention.Moreover,patient compliance and adjustments of hypoglycemic drugs were evaluated.RESULTS A total of 109 subjects completed the study.The compliance rates for lifestyle interventions A,B,C,and D were 57.79%,60.55%,64.22%,and 75.23%,respectively.Among the subjects who received hypoglycemic drugs,the dose was reduced 2 to 3 times based on blood glucose in 54(67.50%)subjects and was tapered and discontinued in 5(6.25%)subjects within 3 mo,with no significant fluctuations in blood glucose after dose reduction and withdrawal.After lifestyle interventions,waist circumference,BMI,fasting blood glucose,and HbA1c significantly decreased(P<0.001);motor function and body composition also significantly improved(P<0.001).CONCLUSION For patients with T2DM,compliance to real-life lifestyle interventions is good,and the interventions significantly improve metabolic indicators such as waist circumference,BMI,blood pressure,HbA1c,body composition,and motor function.Some patients are able to taper or discontinue hypoglycemic drugs. | Bo Wang Xiao-Li Mu Juan Zhao Hai-Ping Jiang Shan-Shan Li Ge Yan Ying-Ying Hua Xue-Yi Ren Li-Xia Xing Yan Liang Shu-Dong Zhang Yu-Chi Zhao | 2020 | World Journal of Diabetes2020，11，6： | 5 |
| 15 | Phenotypic and molecular characteristics of androgen insensitivity syndrome patients显示文摘 | Shi-Min Yuan Ya-Nan Zhang Juan Du Wen Li Chao-Feng Tu Lan-Lan Meng Ge Lin Guang-Xiu Lu Yue-Qiu Tan | 2018 | Asian Journal of Andrology2018，20，5： | 5 |
| 16 | New progress of research on water cycle in atmosphere in China显示文摘New progresses are introduced briefly about the water cycle study on atmosphere of China made in recent years. The introduction includes eight aspects as follows: 1) precipitation characteristics, 2) stability of climatic system, 3) precipitation sensitive region, 4) regional evaporation and evapotranspiration, 5) water surface evaporation, 6) vegetation transpiration, 7) cloud physics, and 8) vapor source. | Wang Guo Jia Shao-feng Yu Gui-rui Xu Juan Wang Jin-xia Wang Qiu-feng Ge Quan-sheng Huang Ji-kun Xia Jun Li Li-fnjuan et al. | 2001 | Journal of Geographical Sciences2001，11，4： | 4 |
| 17 | Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates显示文摘The ongoing coronavirus disease 2019(COVID-19)pandemic caused more than 96 million infections and over 2 million deaths worldwide so far.However,there is no approved vaccine available for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the disease causative agent.Vaccine is the most effective approach to eradicate a pathogen.The tests of safety and efficacy in animals are pivotal for developing a vaccine and before the vaccine is applied to human populations.Here we evaluated the safety,immunogenicity,and efficacy of an inactivated vaccine based on the whole viral particles in human ACE2 transgenic mouse and in non-human primates.Our data showed that the inactivated vaccine successfully induced SARS-CoV-2-specific neutralizing antibodies in mice and non-human primates,and subsequently provided partial(in low dose)or full(in high dose)protection of challenge in the tested animals.In addition,passive serum transferred from vaccine-immunized mice could also provide full protection from SARS-CoV-2 infection in mice.These results warranted positive outcomes in future clinical trials in humans. | Yan-Feng Yao Ze-Jun Wang Ren-Di Jiang Xue Hu Hua-Jun Zhang Yi-Wu Zhou Ge Gao Ying Chen Yun Peng Mei-Qin Liu Ya-Nan Zhang Juan Min Jia Lu Xiao-Xiao Gao Jing Guo Cheng Peng Xu-Rui Shen Qian Li Kai Zhao Lian Yang Xin Wan Bo Zhang Wen-Hui Wang Jia Wu Peng Zhou Xing-Lou Yang Shuo Shen Chao Shan Zhi-Ming Yuan Zheng-Li Shi | 2021 | Virologica Sinica2021，36，5： | 4 |
| 18 | Association of traditional Chinese exercises with glycemic responses in people with type 2 diabetes:A systematic review and meta-analysis of randomized controlled trials显示文摘Background: There is increasing evidence showing the health benefits of various forms of traditional Chinese exercises(TCEs) on the glycemic profile in people with type 2 diabetes. However, relatively little is known about the combined clinical effectiveness of these traditional exercises.This study was designed to perform a systematic review and meta-analysis of the overall effect of 3 common TCEs(Tai Ji Quan, Qigong, Ba Duan Jin) on glycemic control in adults with type 2 diabetes.Methods: We conducted an extensive database search in Cochrane Library, EMBASE, Pub Med, Web of Science, EBSCO, and China National Knowledge Infrastructure on randomized controlled trials published between April 1967 and September 2017 that compared any of the 3 TCEs with a control or comparison group on glycemic control. Data extraction was performed by 2 independent reviewers. Study quality was evaluated using the Cochrane Handbook for Systematic Reviews of Interventions, which assessed the risk of bias, including sequence generation, allocation concealment, blinding, completeness of outcome data, and selective outcome reporting. The resulting quality of the reviewed studies was characterized in 3 grades representing the level of bias: low, unclear, and high. All analyses were performed using random effects models and heterogeneity was quantified. We a priori specified changes in biomarkers of hemoglobin A1 c(in percentage) and fasting blood glucose(mmol/L) as the main outcomes and triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein-cholesterol, 2-h plasma glucose, and fasting plasma glucose as secondary outcomes.Results: A total of 39 randomized, controlled trials(Tai Ji Quan = 11; Qigong = 6; Ba Duan Jin = 22) with 2917 type 2 diabetic patients(aged41à80 years) were identified. Compared with a control or comparison group, pooled meta-analyses of TCEs showed a significant decrease in hemoglobin A1 c(mean difference(MD) = ?0.67%; 95% confidence interval(CI): ?0.86% to ?0.48%; p < 0.00001) and fasting blood glucose(MD = ?0.66 mmol/L; 95%CI: ?0.95 to ?0.37 mmol/L; p < 0.0001). The observed effect was more pronounced for interventions that were medium range in duration(i.e., >3à<12 months). TCE interventions also showed improvements in the secondary outcome measures. A high risk of bias was observed in the areas of blinding(i.e., study participants and personnel, and outcome assessment).Conclusion: Among patients with type 2 diabetes, TCEs were associated with significantly lower hemoglobin A1 c and fasting blood glucose.Further studies to better understand the dose and duration of exposure to TCEs are warranted. | ge song changcheng chen juan zhang lin chang dong zhu xueqiang wang | 2018 | Journal of Sport and Health Science2018，7，4： | 3 |
| 19 | Anti-cancer Effect of 20(S)-Ginsenoside-Rh2 on Oral Squamous Cell Carcinoma Cells via the Decrease in ROS and Downregulation of MMP-2 and VEGF显示文摘Squamous cell carcinoma(SCC) is the most common in oral and maxillofacial regions and occupy more than 90% of the malignant lesions in the oral cavity[1]. The complex anatomy of the head and neck region gives rise to intricate patterns of local invasion and regional spread, which makes primary tumors more difficult to eradicate. | ZHANG Bao Ping LI Bo CHENG Jing Yang CAO Rui GAO Shu Ting HUANG Chun Juan LI Rui Ping NING Jing LIU Bin LI Zhi Ge | 2020 | Biomedical and Environmental Sciences2020，33，9： | 3 |
| 20 | Bioinspired hybrid patches with self-adhesive hydrogel and piezoelectric nanogenerator for promoting skin wound healing显示文摘Wound management is a crucial measure for skin wound healing and is significantly important to maintaining the integrity of skins and their functions.Electrical stimulation at the wound site is a compelling strategy for skin wound repair.However,there has been an urgent need for wearable and point-of-care electrical stimulation devices that have self-adhesive and mechanical properties comparable to wound tissue.Herein,we develop a bioinspired hybrid patch with self-adhesive and piezoelectric nanogenerator(HPSP)for promoting skin wound healing,which is composed of a mussel-inspired hydrogel matrix and a piezoelectric nanogenerator based on aligned electrospun poly(vinylidene fluoride)nanofibers.The device with optimized modulus and permeability for skin wear can self-adhere to the wound site and locally produce a dynamic voltage caused by motion.We show that the HPSP not only promotes fibroblast proliferation and migration in vitro,but also effectively facilitates the collagen deposition,angiogenesis,and re-epithelialization in vivo with the increased expressions of crucial growth factors.The HPSP reduces the wound closure time of full-thickness skin defects by about 1/3,greatly accelerating the healing process.This patch can serve as wearable and real-time electrical stimulation devices,potentially useful in clinical applications of skin wound healing. | Shuo Du Nuoya Zhou Yujie Gao Ge Xie Hongyao Du Hao Jiang Uanbin Zhang Juan Tao Jintao Zhu | 2020 | Nano Research2020，13，9： | 3 |
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