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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Increase in quinolone resistance in a Haemophilus influenzae strain isolate from a patient with recurrent respiratory infections treated with ofloxacin显示文摘 | JORDI V RUIZ J SANCHEZ F | 1999 | Antimicrob Agents Chemother1999，43，： | 1 |
| 3 | 显示文摘 | Merceds R Jose M Jordi F | 2000 | Thromb Haemost2000，84，2： | 1 |
| 4 | Crystal structure and DNA interaction of the facial-type rac-tris[2-(aminomethyl) benzimidazole] cobalt(Ⅲ) complex显示文摘 | JORDI G S MARíA J P MERCèF B | | 0，，25： | 1 |
| 5 | The synthesis of an N-lobe noncircular gear using Bezier and B-spline nonparametric curve on the design of its displacement law显示文摘 | Quintero Riaza H F Cardona Foix S Jordi Nebot L | | 0，，09： | 1 |
| 6 | The Barcelona approach: Diagno sis, staging, and treatment of hepatocellular carcinoma显示文摘 | Josep M L Josep F Jordi B | 2004 | Liver Transpl2004，10，21： | 1 |
| 7 | Effects ofnitrogensource and empty bed residence time on the removal of styrene gas-eous emissions by biotricklinR filtration显示文摘 | Vicente F S Jordi M S Josep-manuel P | 2011 | Biolarocess BiosystEng2011，34，7： | 1 |
| 8 | 显示文摘 | JORDI G S MARIA J P MERCE F B | 2006 | Inorg Chem2006，45，10： | 1 |
| 9 | Nurses' accu- racy and self-perceived ability using the? Emergency severity index triage tool: a cross-sectional study in four Swiss hospitals 显示文摘 | Jordi K Grossmann F Gaddis GM | 2015 | Scand J Trauma Resusc Emerg Med2015，，23： | 1 |
| 10 | Effect of UV irradiation on enzymatic activities and physicochemical properties of apple juices from different varieties显示文摘 | Victor F Jordi P Albert I | 2011 | LWT-Food Science and Technology2011，44，： | 1 |
| 11 | X-ray diffraction analysis ofinternal wool lipids 显示文摘 | Jordi F Lourdes C Meritxell M | 2004 | Chem Phys Lipids2004，130，2： | 1 |
| 12 | Azetidinylquinolones as antibacterial agents 显示文摘 | Jordi F Antoni T Jose A C | 1994 | Journal of Medicinal Chemistry1994，37，24： | 1 |
| 13 | The interaction of gibberellins and photoperiod in the control of potato tuberization显示文摘 | Jaime F M Jose L G Jordi B | 2002 | Journal of Plant Growth Regulation2002，20，： | 1 |
| 14 | Serial NT proBNP monitoring and outcomes in outpa tients with decompensation of heart failure显示文摘 | ANTONI B G DOMINGO P F JORDI F | 2007 | Int J Cardiol2007，120，： | 1 |
| 15 | Microbleed Burden and Hematoma Expansion in Acute Intracerebral Hemorrhage显示文摘 | Martí-fàbregas Joan Delgado-mederos Raquel Granell Esther Morenas Rodríguez Estrella Marín Lahoz Juan Dinia Lavinia Carrera David Pérez De La Ossa Natalia Sanahuja Jordi Sobrino Tomás De Arce Ana María Alonso De Leci?ana María | 2013 | European Neurology . 2013 (3-4)2013，，3： | 1 |
| 16 | Effects of nitrogen source and empty bed residence time on the re- moval of styrene gaseous emissions by biotfickling filtra- tion 显示文摘 | Vicente F S Jordi M S Josep-manuel P | 2011 | Bioprocess Biosyst Eng2011，34，7： | 1 |
| 17 | Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities显示文摘 | Anna Hernández-Aguilera Anna Rull Esther Rodríguez-Gallego Marta Riera-Borrull Fedra Luciano-Mateo Jordi Camps Javier A. Menéndez Jorge Joven Fábio Santos Lira | 2013 | Mediators of Inflammation2013，，： | 1 |
| 18 | Synthesis and biological activity of 7-(2,3-disubstituted-l-azetidinyl)-4-oxoquinolainnde-1,8-naphthyridine-3-carboxylic acids显示文摘 | Jordi F Antoni T Jose A C | 1994 | J Med Chem1994，37，： | 1 |
| 19 | Mystery shopping and alcohol sales: Do supermarkets and liquor stores sell alcohol to underage customers? 显示文摘 | Jordy F Gosselt M S Joris J van H | 2007 | Journal of Adolescent Health2007，，41： | 1 |
| 20 | Determination of mycotoxins in bee pollen by gas chromatography-tandem mass spectrometry显示文摘 | YELKOR C GUILLERMINA F JORDI M | 2013 | Journal of Agricultural and Food Chemistry2013，61，8： | 1 |
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