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| 1 | 人类世:人类将压倒大自然的威力吗?显示文摘我们探讨人类世的发展。人类世是当前世,在此期间人类及人类社会成为全球性的地球物理作用力。人类世开始于1800年左右,工业化开始之际,重要特征是矿物燃料极其广泛的使用。我们用大气CO_2浓度作为唯一的、简单的指标来追溯人类世的行进过程。前工业化时代的大气CO_2浓度为270~275 ppm,到1950年上升至大约310ppm。从此,人类事业经历了一个显著的爆发——大加速时期,对地球系统功能带来了明显的后果。自1950年以来,大气CO_2浓度从310ppm升至380ppm,自前工业化时代以来总上升值的大约一半发生在最后区区30年间。大加速即将达到临界状态。无论将来呈现的是何等景象,未来几十年肯定是人类世演进过程中的一个转折点。 | Will Steffen Paul J. Crutzen John R. McNeill 寒江(译) | 2007 | AMBIO-人类环境杂志2007,36,B12: | 8 |
| 2 | Parallel effects of β-adrenoceptor blockade on cardiac function and fatty acid oxidation in the diabetic heart: Confronting the maze显示文摘Diabetic cardiomyopathy is a disease process in which diabetes produces a direct and continuous myocardial insult even in the absence of ischemic, hypertensive or valvular disease. The β-blocking agents bisoprolol, carvedilol and metoprolol have been shown in large-scale randomized controlled trials to reduce heart failure mortality. In this review, we summarize the results of our studies investigating the effects of β-blocking agents on cardiac function and metabolism in diabetic heart failure, and the complex inter-related mechanisms involved. Metoprolol inhibits fatty acid oxidation at the mitochondrial level but does not prevent lipotoxicity; its benefi cial effects are more likely to be due to prosurvival effects of chronic treatment. These studies have expanded our understanding of the range of effects produced by β-adrenergic blockade and showhow interconnected the signaling pathways of function and metabolism are in the heart. Although our initial hypothesis that inhibition of fatty acid oxidation would be a key mechanism of action was disproved, unexpected results led us to some intriguing regulatory mechanisms of cardiac metabolism. The fi rst was upstream stimulatory factor-2-mediated repression of transcriptional master regulator PGC-1α, most likely occurring as a consequence of the improved function; it is unclear whether this effect is unique to β-blockers, although repression of carnitine palmitoyltransferase (CPT)-1 has not been reported with other drugs which improve function. The second was the identif ication of a range of covalent modifications which can regulate CPT-1 directly, mediated by a signalome at the level of the mitochondria. We also identif ied an important interaction between β-adrenergic signaling and caveolins, which may be a key mechanism of action of β-adrenergic blockade. Our experience with this labyrinthine signaling web illustrates that initial hypotheses and anticipat-ed directions do not have to be right in order to open up meaningful directions or reveal new information. | Vijay Sharma John H McNeill | 2011 | World Journal of Cardiology2011,3,9: | 8 |
| 3 | 新版国际植物命名法规(维也纳法规)中的主要变化显示文摘出版于2006年9月的最新版的《国际植物命名法规》,即维也纳法规(Vienna Code),取代了圣路易斯法规(Saint Louis Code)而成为管理植物学(包括藻类学和真菌学)科学命名的唯一有效法规。本文报道了维也纳法规和圣路易斯法规之间的主要区别。这些区别包括两版法规在起始日期、有效发表、合格发表、化石植物、多型真菌、拼写和附录诸方面的不同。 | 张丽兵 杨亲二 Nicholas J.TURLAND John MCNEILL | 2007 | 植物分类学报2007,45,2: | 6 |
| 4 | N-乙酰半胱氨酸对糖尿病大鼠肾脏NADPH氧化酶表达的影响显示文摘目的探讨N-乙酰半胱氨酸(NAC)对糖尿病大鼠肾脏尼克酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶表达的影响。方法大鼠随机分为正常对照(NC)组、正常对照NAC治疗组(CT组)、糖尿病组(DM组)和糖尿病NAC治疗组(DT组)。8周后测定血糖、胰岛素、肌酐、游离15-F2t-异前列烷和总抗氧化物水平、24小时尿蛋白排泄量(UPro/24h)、肾系膜基质增宽指数、肾皮质p22phox、p67phox、铜-锌-超氧化物歧化酶(Cu-Zn-SOD)和结缔组织生长因子(CTGF)蛋白表达。结果糖尿病大鼠UPro/24h、血浆游离15-F2t-异前列烷水平、系膜基质增宽指数、肾脏p22phox、p67phox和CTGF蛋白表达显著增高,血浆总抗氧化物浓度和肾脏Cu-Zn-SOD蛋白表达显著降低。NAC治疗能显著逆转糖尿病大鼠上述各项指标的变化。结论NAC显著降低糖尿病大鼠肾脏氧化应激水平,减轻氧化应激对肾组织的损伤,产生肾脏保护作用。 | 郭志新 John H McNeill | 2008 | 中国糖尿病杂志2008,16,9: | 5 |
| 5 | 国际植物命名法规中的术语介绍显示文摘现今,国际上已普遍接受国际植物命名法规(Internationalcodeofbotanicalnomenclature)作为管理植物学(包括藻类学和真菌学)科学命名的规则。该规则由历届国际植物学大会的命名法分会会议修订,因而每六年出版一次修订版。最新版的维也纳法规(ViennaCode;McNeilleta1.,2006;中文版:张丽兵译,2007)取代了前一版的圣路易斯法规(SaintLouisCode,Greutereta1.,2000;中文版:朱光华译,2001)。 | 张丽兵 Paul C.SILVA John MCNEILL Nicholas J.TURLAND | 2007 | 植物分类学报2007,45,4: | 4 |
| 6 | 在墨尔本召开的第18届国际植物学大会做出的有关名称发表要求的变化——电子出版物对你意味着什么?显示文摘《国际植物命名法规》的修订由每六年一次的国际植物学大会(IBC)命名分会来决定。第18届国际植物学大会在澳大利亚墨尔本举行;命名分会于2011年7月18日至22日召开,其决议获得7月30日的全体会议通过。'墨尔本法规'有几个重要的变化,将影响新名称的发表。这些变化中的两个将在'墨尔本法规'出版前的几个月,即于2012年1月1日起生效。通过以移动文档格式(Portable Document Format;pdf)在线发表的具有国际标准连续出版物号(ISSN)或国际标准图书编号(ISBN)的电子出版物,将构成有效发表。新分类群名称的合格发表所必须的拉丁文描述或特征集要将更改为拉丁文或英文描述或特征集要。此外,自2013年1月1日起,被处理为真菌的生物的新名称必须在原始资料(某一名称合格发表时与之有关的所有资料)中引证一个由一家公认的存储库(例如MycoBank)签发的标识码,才构成合格发表。本文提供了有关电子出版物的新规则的草案文本,并概述了相应的最佳做法。 | Sandra Knapp John McNeill Nicholas J.Turland 张丽兵 | 2011 | 植物分类与资源学报2011,33,5: | 2 |
| 7 | Stimulation of MAP kinase and S6 kinase by vanadium and selenium in rat adipocytes显示文摘 | Yong-jiang Hei Sepehr Farahbakhshian Xunsheng Chen Mary L. Battell John H. McNeill | 1998 | Molecular and Cellular Biochemistry (-)1998,,1: | 1 |
| 8 | Sympathectomy prevents fructose-induced hyperinsulinemia and hypertension显示文摘 | Subodh Verma Sanjay Bhanot John H McNeill | 1999 | European Journal of Pharmacology1999,,2: | 1 |
| 9 | The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension显示文摘 | Linda T. Tran Violet G. Yuen John H. McNeill | 2009 | Molecular and Cellular Biochemistry (-)2009,,1: | 1 |
| 10 | Fructose-induced hypertension in rats is concentration-and duration-dependent显示文摘 | Soter D John H McNeill | 1995 | Journal of Pharmacological and Toxicological Methods1995,33,: | 1 |
| 11 | Chronic etanercept treatment prevents the development of hypertension in fructose-fed rats显示文摘 | Linda T. Tran Kathleen M. MacLeod John H. McNeill | 2009 | Molecular and Cellular Biochemistry (-)2009,,1: | 1 |
| 12 | Functional effects of protein kinases and peroxynitrite on cardiac carnitine palmitoyltransferase-1 in isolated mitochondria显示文摘 | Vijay Sharma Thomas Abraham Amie So Michael F. Allard John H. McNeill | 2010 | Molecular and Cellular Biochemistry (-)2010,,1: | 1 |
| 13 | Vanadyl sulfate prevents fructose induced hyperinsulinemia and hypertensionin rats 显示文摘 | Saniay Bhanot John H McNeill Michael Bryer-Ash | 1994 | Hypertension1994,123,3: | 1 |
| 14 | Metabolic disturbances in diabetic cardiomyopathy显示文摘 | Brian Rodrigues Margaret C. Cam John H. McNeill | 1998 | Molecular and Cellular Biochemistry (-)1998,,1: | 1 |
| 15 | Vanady 1Sulfate prevents fructose induced hyperinsulinemia and hypertension inr ats 显示文摘 | Anjay Bhanot John H McNeill Michael Bryer-Ash | 1994 | Hypertension1994,123,3: | 1 |
| 16 | Potential of squalene as a functional lipid in foods and conmetics显示文摘 | Laurence Eyres John Croft Angus McNeill | 2002 | Lipid Technology2002,,12: | 1 |
| 17 | Potential of squalene as a functional lipid in foods and conmetics 显示文摘 | Laurence Eyres John Croft Angus McNeill | 2002 | Lipid Technology2002,12,: | 1 |
| 18 | Potential of squalene as a functional lipid in foods and conmeties 显示文摘 | Laurence Eyres John Croft Angus McNeill | 2002 | Lipid Technology2002,12,: | 1 |
| 19 | Vanadium increases GLUT4 in diabetic rat skeletal muscle显示文摘 | Askar Mohammad Vijay Sharma John H. McNeill | 2002 | Molecular and Cellular Biochemistry (-)2002,,1: | 1 |
| 20 | 知识转化和可持续性背景下的社会运动概念和行为:概念分析显示文摘目的 进行社会运动的概念分析,促进其应用于健康领域的知识转化和可持续性。 方法 应用Avant和Walker的方法阐明知识转化和可持续性背景下社会运动的概念。系统检索了同行评审和灰色文献数据库中描述社会运动行为如何促成健康照护和社区环境中循证实践变革的文章,2名研究者对标题、摘要和全文进行了独立审查,对结果协商一致。最终共纳入38篇文章。 结果 促进知识转化和可持续性的社会运动可以被定义为:个人、团体或组织作为自愿和具有内在动机的变革推动者,围绕一个共同目标动员起来,通过知识转化和可持续性的努力改善结局。通过概念分析,共确定了10个概念属性、3个前置因素和3个结局指标。它们是动态的、相互关联的,往往相互促进以强化社会运动的各个方面。重要的概念属性包括行动的迫切性、集体行动和集体认同等。基于概念分析结果建立社会运动行为框架。 结论 社会运动行为可以提供看待实施科学的新视角。集体行动和集体认同--在实施科学文献中不太常见的概念--有助于深入了解基层方式对知识转化和可持续性的作用。研究结果可以指导健康照护者和变革领导者利用社会运动的视角实现现实中的变革项目。通过社会运动方式动员个人、团体或组织,使之作为强有力的变革推动者和团队参与变革,影响个人、组织和卫生系统,促进知识转化和可持续性。 | Doris Grinspun Katherine Wallace Shelly-Anne Li Susan McNeill Janet Elaine Squires Jesús Bujalance Maryanne D’Arpino Gina De Souza Nataly Farshait John Gabbay Ian D.Graham Alison Hutchinson Kim Kinder Celia Laur Tina Mah Julia E.Moore Jennifer Plant Jodi Ploquin P.Jim A.Ruiter Daphney St-Germain Margie Sills-Maerov May Tao Marita Titler Junqiang Zhao | 2022 | International Journal of Nursing Sciences2022,9,4: | 0 |