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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | Can activity within the external abdominal oblique be measured using real-time ultrasound imaging?显示文摘 | John EK Beith ID | 2007 | CLINICAL BIOMECHANICS2007，，22： | 1 |
| 3 | Changes in bank lending standards and the macroeconomy显示文摘 | William F. Bassett Mary Beth Chosak John C. Driscoll Egon Zakraj?ek | 2013 | Journal of Monetary Economics2013，，： | 1 |
| 4 | Atypical atrial flutter originating in the right atrial free wall显示文摘 | John GK Donald SR Douglas EK | 2000 | Circulation2000，101，： | 1 |
| 5 | Red blood cell dis- tribution width is a significant prognostic marker in ad- vanced heart failure,independent of hemoglobin Levels显示文摘 | Eleni T John VT Elisabeth EK | 2014 | Hellenic J Cardiol2014，55，6： | 1 |
| 6 | Parosteal lipoma associated with an underlying osteochondroma arising from the hallux显示文摘 | Eugene T. H. Ek John L. Slavin Mark C. Blackney Gerard J. Powell | 2007 | Skeletal Radiology2007，，7： | 1 |
| 7 | Bone mineral density and its correlation with clinical and laboratory factors in chronic peritoneal dialysis patients显示文摘 | Fettah Fevzi Ersoy Stauros Ploumis Passadakis Paul Tam Evaggelos Dimitros Memmos Pericles Konstantinos Katopodis ?etin ?zener Fehmi Ak?i?ek Taner ?amsar? Kenan Ate? Rezzan Ataman John George Vlachojannis Athanasios Nicholas Dombros Cengiz Uta? Tekin Akpol | 2006 | Journal of Bone and Mineral Metabolism2006，，1： | 1 |
| 8 | Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol 显示文摘 | Elhahib B John IB Daniel EK | 2004 | J Med Food2004，7，18： | 1 |
| 9 | Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in rats receiving free access to water and alcohol 显示文摘 | Elhabtb B John IB Daniel EK | 2004 | J Med Food2004，7，2： | 1 |
| 10 | Effects of purified purearin on wotuntawy alcohol intake and alcohol,withdrawal symptoms in ratsweleiwing free access to water and alcohol显示文摘 | Elhabtb B John IB Daniel EK | 2004 | Jmed Food2004，7，2： | 1 |
| 11 | Starvation alters the activity and m level of glutaminase and glutamine synthetase in the rat intestine显示文摘 | SUNG EK JOHN C HALLA DC | 2000 | J Nut Biochem2000，11，78： | 1 |
| 12 | Gender and tachycardia: independent modulation of platelet reactivity in patients with atrial fibrillation显示文摘有纤维性颤动(AF ) 经验增加了的 atrial 的 BackgroundFemale 病人与男性相比 thromboembolism 冒险,被它的包括在 CHA 2 DS 2 VASc 分数。新发作 AF (经常与心悸亢进联系了) 也讨论病人增加的 thromboembolic 风险。位于这风险下面的机制不明确,却新发作 AF 与血小板的深刻缺陷被联系氮的氧化物(没有) 发信号。给对 catecholamines 的心血管的回答是性依赖者,并且在新发作 AF 的心悸亢进的存在可以代表回答到 catecholaminergic 刺激,我们在血小板聚集上探索了性和心悸亢进的潜在的影响,没有 signalling.MethodsInteractions 在在导致的腺苷 diphosphate (自动数据处理)的程度之间的 87 个 AF 病人被寻求血小板聚集, anti-aggregatory NO 完成施主,钠 nitroprusside ,性,和承认 h 交往 thioredoxin 蛋白质(Txnip ) 的血小板表示的潜在的影响也是证实的协变性的 evaluated.ResultsAnalysis 在血小板自动数据处理和没有回答之间的生理的对抗的存在[F (1, 74 )= 12.212, P <0.01 ] 当女性相关与时没损害血小板 aggregability 的回答独立人士[F (2, 74 )= 8.313, P <0.01 ] 。承认心率与血小板聚集直接相关(r = 0.235, P <0.05 ) ,并且相反地没有反应(r =− 0.331, P <0.01 ) 。既不与性也不与心 rate.ConclusionsThese 改变的 Txnip 表示结果显示那性和心率是血小板功能的独立决定因素。正常血小板功能的恢复上的心悸亢进的颠倒的通常认为的利益的未来的研究因此是优先级。 | Nathan EK Procter Jocasta Ball Doan TM Ngo Jeffrey S Isenberg Elaine M Hylek Yuliy Y Chirkov Simon Stewart John D Horowitz | 2016 | Journal of Geriatric Cardiology2016，13，3： | 1 |
| 13 | Emulsifying properties to proteins: evaluation of a turbidimetric technique 显示文摘 | Kevin NP John EK | 1978 | J Agric Food Chem1978，26，3： | 1 |
| 14 | Mapping soil nutrients via different covariates combinations:theory and an example from Morocco显示文摘Background:Mapping of soil nutrients using different covariates was carried out in northern Morocco.This study was undertaken in response to the region’s urgent requirement for an updated soil map.It aimed to test various covariates combinations for predicting the variability in soil properties using ordinary kriging and kriging with external drift.Methods:A total of 1819 soil samples were collected at a depth of 0–40 cm using the 1-km grid sampling method.Samples were screened for their pH,soil organic matter(SOM),potassium(K_(2)O),and phosphorus(P_(2)O_(5))using standard laboratory protocols.Terrain attributes(T)computed using a 30-m resolution digital elevation model,bioclimatic data(C),and vegetation indices(V)were used as covariates in the study.Each targeted soil property was modeled using covariates separately and then combined(e.g.,pH~T,pH~C,pH~V,and pH~T+C+V).k=tenfold cross-validation was applied to examine the performance of each employed model.The statistical parameter RMSE was used to determine the accuracy of different models.Results:The pH of the area is slightly above the neutral level with a corresponding 7.82%of SOM,290.34 ppm of K_(2)O,and 100.86 ppm of P_(2)O_(5).This was used for all the selected targeted soil properties.As a result,the studied soil properties showed a linear relationship with the selected covariates.pH,SOM,and K 2O presented a moderate spatial autocorrelation,while P2O5 revealed a strong autocorrelation.The cross-validation result revealed that soil pH(RMSE=0.281)and SOM(RMSE=9.505%)were best predicted by climatic variables.P_(2)O_(5)(RMSE=106.511 ppm)produced the best maps with climate,while K_(2)O(RMSE=209.764 ppm)yielded the best map with terrain attributes.Conclusions:The findings suggest that a combination of too many environmental covariates might not provide the actual variability of a targeted soil property.This demonstrates that specific covariates with close relationships with certain soil properties might perform better than the compilation of different environmental covariates,introducing errors due to randomness.In brief,the approach of the present study is new and can be inspiring to decision-makers in the region and other world areas as well. | Kingsley John Yassine Bouslihim Isong Abraham Isong Lahcen Hssaini Rachid Razouk Ndiye M.Kebonye Prince C.Agyeman Vit Penížek Tereza Zádorová | 2022 | Ecological Processes2022，11，1： | 0 |
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