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| 1 | SNARE-RNAi Results in Higher Terpene Emission from Ectopically Expressed Caryophyllene Synthase in Nicotiana benthamiana显示文摘植物生产众多的萜烯和许多努力被奉献了给萜烯 biosynthetic 基因的鉴定和描述。然而,很少萜烯怎么在房间以内并且从房间被搬运进 apoplast 被知道。为了在这调查泡熔化的一个通常认为的角色,处理,我们使用了 Agrobacterium 在 Nicotiana benthamiana 的调停 tumefaciens 的短暂 coexpression ? 有也的 MtVAMP721e-RNAi 构造(Vi ) caryophyllene synthase 或沉香醇 synthase 分别地。叶子的 Headspace 分析证明那 caryophyllene 或沉香醇排出物增加了关于五倍什么时候 N.? benthamiana VAMP72 功能被堵住。RNA 定序和 agroinfiltrated N. 的蛋白质 ubiquitination 分析 ? benthamiana 叶摘录建议增加的萜烯排出物可以被归因于 proteasome 基于三观察失灵:离开 DsRed 标记蛋白质的高水平, TPS+Vi (1 ) 出现了,(2 ) ubiquitinated 蛋白质的高水平,并且(3 ) 多重 proteasome 基因的协调导致的表示,大概由调停 proteasome 的反馈规定的缺乏引起了。然而, caryophyllene 或沉香醇没禁止 proteasome 相关的朊酶活动在在里面 ? vitro 试金。当结果不为在萜烯运输的泡熔化的一个角色是最后的时,他们确实显示出在泡熔化和某些萜烯的宫外的表示的抑制之间的一个强壮的相互作用。结果在新陈代谢的工程有潜在的应用。 | Hieng-Ming Ting Thierry L. Delatte Pim Kolkman Johana C. Misas-Villamil Renier A.L. van der Hoom Harro J. Bouwmeester Alexander R. van der Krol | 2015 | Molecular Plant2015，8，3： | 2 |
| 2 | 基于企业战略的社会责任财务评价体系研究显示文摘全球竞争环境的变更导致企业社会责任约束力越来越大。企业在承受外部企业社会责任评价体系带来的压力的同时,更希望提高自身的企业社会责任内部管理能力。将企业社会责任与经济绩效联系在一起,从财务评价体系的角度融入社会责任元素,是提高企业社会责任内部管理能力的关键途径。为此,企业可以借助日常财务嵌入、信息披露和财务数据挖掘等三种途径,并将其与企业社会责任战略链接在一起,从财务数据中和战略方向上体现社会责任绩效。 | 帅萍 Johana Sosa Copa | 2010 | 生态经济(学术版)2010，，2： | 2 |
| 3 | The HTR3A Polymorphism c. -42C>T Is Associated With Amygdala Responsiveness in Patients With Irritable Bowel Syndrome显示文摘 | Lisa A. Kilpatrick Jennifer S. Labus Kristen Coveleskie Christian Hammer Gudrun Rappold Kirsten Tillisch Joshua A. Bueller Brandall Suyenobu Johana M. Jarcho Jim A. McRoberts Beate Niesler Emeran A. Mayer | 2011 | Gastroenterology2011，，7： | 2 |
| 4 | Urinary excretion of TGF- β1,PDGF-BB and fibronectin in insulin-dependent diabetes mellitus patients 显示文摘 | JOHANA FAGERUDD PER-HENRIK GROOP EERO HONKANEN | 1997 | Kidney Int1997，，： | 1 |
| 5 | Prevalence ,morphology,and topography of blood vessels in herniated disc tissue 显示文摘 | Johana S Tone P | 1996 | Spine1996，21，： | 1 |
| 6 | Chromatographic study of adsorption of n-alkanes on zeolites at high temperatures显示文摘 | Denayer J F Baron G V JohanA M | 1998 | J Phys Chem B1998，102，17： | 1 |
| 7 | On strong ground motion synthesis with k ?2 slip distributions显示文摘 | Franti?ek Gallovi? Johana Broke?ová | 2004 | Journal of Seismology2004，，2： | 1 |
| 8 | Interactional group discussion: Results of a controlled trial using a behavioral intervention to reduce the use of injections in public health facilities显示文摘 | Johana E.Prawitasari Hadiyono Sri Suryawati Sulanto S. Danu Sunartono Budiono Santoso | 1996 | Social Science & Medicine1996，，8： | 1 |
| 9 | Implications of Uncertainty and Scale in Carbon Emission Estimates on Locally Appropriate Designs to Reduce Emissions from Deforestation and Degradation( REDD + ) 显示文摘 | Lusiana B van Noordwijk M Johana F Galudra G Suyanto S Cadisch G | 2014 | Mitigation and Adaptation Strategies for Global Change2014，19，6： | 1 |
| 10 | Neurogenic differentiation of human adipose-derived stem cells: Relevance of different signaling molecules, transcription factors, and key marker genes显示文摘 | Alejandra Johana Cardozo Daniel Eduardo Gómez Pablo Francisco Argibay | 2012 | Gene2012，，2： | 1 |
| 11 | Implications of uncertainty and scale in carbon emission estimates on locally appropriate designs to reduce emissions from deforestation and degradation(REDD+)显示文摘 | LUSIANA B VAN NOORDWIJK M JOHANA F | 2014 | Mitigation and adaptation strategies for global change2014，19，6： | 1 |
| 12 | On strong ground motion synthesis with k ?2 slip distributions显示文摘 | Franti?ek Gallovi? Johana Broke?ová | 2004 | Journal of Seismology2004，，2： | 1 |
| 13 | Endo-scopic nasobiliary drainage is the most suitable preoperativebiliary drainage method in the management of patients withhilar cholangiocarcinoma 显示文摘 | Johana AMGTOL Oliver RC Busch Niels A | 2011 | Journal of gastroenterology2011，46，2： | 1 |
| 14 | Development of a sandwich enzyme linked immunosorbent assay (ELISA) for the quantification of iduronate-2-sulfate sulfatase显示文摘 | Angela Catalina Sosa Angela Johana Espejo Edwin Alexander Rodriguez Lina Maria Lizaraso Andrea Rojas Johana Guevara Olga Yaneth Echeverri Luis Alejandro Barrera | 2011 | Journal of Immunological Methods2011，，1： | 1 |
| 15 | The Immunome of Colon Cancer: Functional In Silico Analysis of Antigenic Proteins Deduced from IgG Microarray Pro?ling显示文摘Characterization of the colon cancer immunome and its autoantibody signature from differentially-reactive antigens(DIRAGs)could provide insights into aberrant cellular mechanisms or enriched networks associated with diseases.The purpose of this study was to characterize the antibody pro?le of plasma samples from 32 colorectal cancer(CRC)patients and 32 controls using proteins isolated from 15,417 human c DNA expression clones on microarrays.671 unique DIRAGs were identi?ed and 632 were more highly reactive in CRC samples.Bioinformatics analyses reveal that compared to control samples,the immunoproteomic IgG pro?ling of CRC samples is mainly associated with cell death,survival,and proliferation pathways,especially proteins involved in EIF2 and m TOR signaling.Ribosomal proteins(e.g.,RPL7,RPL22,and RPL27A)and CRC-related genes such as APC,AXIN1,E2F4,MSH2,PMS2,and TP53 were highly enriched.In addition,differential pathways were observed between the CRC and control samples.Furthermore,103 DIR-AGs were reported in the SEREX antigen database,demonstrating our ability to identify known and new reactive antigens.We also found an overlap of 7 antigens with 48‘‘CRC genes.'These data indicate that immunomics pro?ling on protein microarrays is able to reveal the complexity of immune responses in cancerous diseases and faithfully re?ects the underlying pathology. | Johana A. Luna Coronell Khulan Sergelen Philipp Hofe Istvan Gyurjan Stefanie Brezina Peter Hettegger Gernot Leeb Karl Mach Andrea Gsur Andreas Weinhausel | 2018 | Genomics, Proteomics & Bioinformatics2018，16，1： | 1 |
| 16 | Escitalopram-induced hepatitis:A case report显示文摘BACKGROUND The antidepressant escitalopram is widely prescribed for the treatment of depression.It is generally well-tolerated,and cholestasis is not mentioned in its summary of product characteristics(Sm PC).We present a case of cholestatic and cytolysis liver injury due to escitalopram and a Vigi Base?study.CASE SUMMARY A 68-year-old man was admitted to our emergency unit due to clinical jaundice associated with hepatitis,pruritus and dark urine.We tested the patient for the most common etiologies of jaundice,including hemolysis,viral hepatitis,cirrhosis,carcinoma,cholangitis,cholelithiasis and intrahepatic or extrahepatic obstruction.The etiological study was negative,and an adverse drug reaction was the sole possible explanation.The patient was receiving treatment with escitalopram.Two days after its withdrawal,pruritus was resolved.Ten days after withdrawal,clinical jaundice disappeared.It took a month and three weeks after withdrawal for the patient to have normalized liver function tests.To our knowledge,this is the first reported case of cholestasis where treatment with escitalopram was the only possible cause,with a highly probable causality.In addition,we determined whether escitalopram is associated with hepatotoxicity and cholestasis by performing a disproportionality analysis.All cases of hepatobiliary disorders induced by escitalopram and reported in the World Health Organization pharmacovigilance database(Vigi Base?)were analyzed to characterize this toxicity.We found that patients treated with escitalopram had an increased risk of hepatitis[odds ratio(OR)=1.938(1.186-3.166)]and cholestasis[OR=1.866(1.279-2.724)][OR(95%confidence interval)].The median duration between the introduction of escitalopram and the occurrence of acute hepatitis and/or cholestasis was ten days+/-seven days.CONCLUSION Although extremely rare,this case report,the review of the literature and the pharmacovigilance update confirm that escitalopram can cause drug-induced hepatotoxicity and cholestasis,generally within a week after initiation.Thus,escitalopram should be withdrawn immediately if an iatrogenic cause cannot be excluded.If its responsibility is ascertained,escitalopram should be consequently contraindicated.In addition,serotoninergic antidepressants in patients with nonsevere depression are ineffective and harmful.Finally,the Sm PC of escitalopram should be updated to alert for this risk and give clear clinical guidelines. | Guillaume Wabont Laurie Ferret Nicolas Houdre Antoine Lepied Johana Bene Etienne Cousein | 2022 | World Journal of Clinical Cases2022，10，8： | 0 |
| 17 | Development of heartwood,sapwood,bark,pith and specific gravity of teak(Tectona grandis)in fast-growing plantations in Costa Rica显示文摘To elucidate the development of heartwood,bark,sapwood,pith and specific gravity of wood in fastgrowing teak(Tectona grandis)plantations in Costa Rica,we sampled three trees in each of 55 plantations and modelled each variable with age,site and different tree heights.Age and stand density of plantations were significant correlated with stem diameter at breast height and total height of the tree.Formation of heartwood was initiated at the age of 4-year-old and increased in direct proportion with age.The age of plantation had a significant relationship with stem diameter at breast height,heartwood percentage,sapwood thickness,sapwood percentage,percentage of bark,pith diameter and percentage,and specify gravity.The model for these tree parameters was model with these parameters as dependent variable and in relation to age as independent variable. | Alexander Berrocal Johana Gaitan-Alvarez Roger Moya David Fernandez-Solis Edgar Ortiz-Malavassi | 2020 | Journal of Forestry Research2020，31，2： | 0 |
| 18 | Numerical investigation of tunneling induced surface movement:A case study of MRT line 1,Dhaka显示文摘The proposed underground tunnel for Mass Rapid Transit Line 1,Dhaka brings immense attention to the engineers and experts not only because of its construction challenges through a densely-built city,but also for the potential tunneling-induced ground settlements.This very preliminary study investigates the ground surface movement due to the progression of the tunnel boring machine(TBM)using numerical analysis.A series of finite element(FE)models have been developed using PLAXIS 3D,in which Mohr–Coulomb(MC),modified Cam-Clay(MCC),and hardening soil(HS)have been considered.The in-field data of Mashhad Metro Line-2 have been compared to verify PLAXIS 3D’s efficacy in tunnel modeling.Subsequently,the outcomes of the FE analyses are compared with the existing empirical formulas.The PLAXIS 3D analysis considering the MCC soil model exhibits strong agreement with the real monitored data,with a variance of only 3.85%.After simulating different stages of the tunnel construction,results are reported in terms of the distance of the inflexion point from the center,the settlement trough pattern,the maximum transverse settlements,and the vertical settlements.They are also compared with the established empirical formula.In order to comprehend the surface settlement with various tunnel depths and diameters,a parameter dependency study has been carried out.The analysis findings showed that increasing the TBM’s depth and radius causes the inflexion point’s distance from the center of the tunnel to increase by 4%and decrease by 5%,respectively.It is also observed that as tunnel depth increases,the overall settlement of the tunnel lowers by 11%for every additional 5 meters of depth.The MCC model,out of the three,exhibits the most accurate value of the settlement compared to that obtained from the empirical solutions,and also the best-fit form to the Gaussian curve. | Khondaker Sakil Ahmed Johana Sharmin Mehedi Ahmed Ansary | 2023 | Underground Space2023，，5： | 0 |
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