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您的检索式：作者名="Jittima Amie Luckanagul"
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| 1 | Hyaluronic acid-based hydrogels with tobacco mosaic virus containing cell adhesive peptide induce bone repair in normal and osteoporotic rats显示文摘Tobacco mosaic virus(TMV)has been studied as a multi-functional agent for bone tissue engineering.An osteo-inductive effect of wild-type TMV has been reported,as it can significantly enhance the bone differentiation potential of bone marrow stromal cells both on a two-dimensional substrate and in a three-dimensional(3D)hydrogel system.A TMV mutant(TMV-RGD1)was created which featured the adhesion peptide arginyl-glycyl-aspartic acid(RGD),the most common peptide motif responsible for cell adhesion to the extracellular matrix,on the surface of the virus particle to enhance the bio-functionality of the scaffold material.We hypothesised that the incorporation of either wild-type TMV or TMV-RGD1 in the 3D hydrogel scaffold would induce bone healing in critical size defects of the cranial segmental bone.We have previously tested the virus-functionalised scaffolds,in vitro,with a hyaluronic acid-based system as an in-situ hydrogel platform for 3D cell encapsulation,culture,and differentiation.The results of these experiments suggested the potential of the virus-functionalised hydrogel to promote in vitro stem cell differentiation.The hydrogel-forming system we employed was shown to be safe and biocompatible in vivo.Here,we further explored the physiological responses regarding bone regeneration of a calvarial defect in both normal and osteoporotic ovariectomized rat models.Our results,based on histological analysis in both animal models,suggested that both wild-type TMV and TMV-RGD1 functionalised hydrogels could accelerate bone regeneration,without systemic toxicity,evaluated by blood counts.New bone formation was intensified by the incorporation of the RGD-mutant viral particles.This finding increased the potential for use of the rodshaped plant virus as a platform for the addition of powerful biofunctionality for tissue engineering applications.This study was approved by the Ethics Committee on Animal Use of the Zhenjiang Affiliated First People’s Hospital affiliated to Jiangsu University. | Jishan Yuan Panita Maturavongsadit Zhihui Zhou Bin Lv Yuan Lin Jia Yang Jittima Amie Luckanagul | 2020 | Biomaterials Translational2020，1，1： | 2 |
| 2 | Development of personal protective equipment for the COVID-19 pandemic in Thailand and technical aspects of testing gown materials显示文摘During the coronavirus disease 2019(COVID-19)pandemic in early 2020,Thailand,like many other countries around the world,experienced a lack of personal protective equipment(PPE)for frontline medical staff.This was not only due to the scarcity of PPE,but also because some of the available PPE did not meet the standard to properly protect frontline medical staff from the virus.During that time,the industrial sector worked closely with academic and governmental sectors to develop and produce appropriate isolation gowns,coveralls and masks. | Visarut Buranasudja Anongnat Somwangthanaroj Suched Likitlersuang Tirawat Boonyatee Chartchalerm Isarankura-Na-Ayudhya Jittima Amie Luckanagul | 2021 | Biomaterials Translational2021，2，1： | 1 |
| 3 | Osteogenic differentiation of encapsulated cells in dexamethasone-loaded phospholipid-induced silk fibroin hydrogels显示文摘The tissue engineering triad comprises the combination of cells,scaffolds and biological factors.Therefore,we prepared cell-and drug-loaded hydrogels using in situ silk fibroin(SF)hydrogels induced by dimyristoyl glycerophosphoglycerol(DMPG).DMPG is reported to induce rapid hydrogel formation by SF,facilitating cell encapsulation in the hydrogel matrix while maintaining high cell viability and proliferative capacity.In addition,DMPG can be used for liposome formulations in entrapping drug molecules.Dexamethasone(Dex)was loaded into the DMPG-induced SF hydrogels together with human osteoblast-like SaOS-2 cells,then the osteogenic differentiation of the entrapped cells was evaluated in vitro and compared to cells cultured under standard conditions.Calcium production by cells cultured in DMPG/Dex-SF hydrogels with Dex-depleted osteogenic medium was equivalent to that of cells cultured in conventional osteogenic medium containing Dex.The extended-release of the entrapped Dex by the hydrogels was able to provide a sufficient drug amount for osteogenic induction.The controlled release of Dex was also advantageous for cell viability even though its dose in the hydrogels was far higher than that in osteogenic medium.The results confirmed the possibility of using DMPG-induced SF hydrogels to enable dual cell and drug encapsulation to fulfil the practical applications of tissue-engineered constructs. | Chavee Laomeephol Helena Ferreira Sorada Kanokpanont Jittima Amie Luckanagul Nuno M Neves Siriporn Damrongsakkul | 2022 | Biomaterials Translational2022，3，3： | 1 |
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