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| 1 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 2 | Impacts of controlled irrigation and drainage on the yield and physiological attributes of rice显示文摘 | Guangcheng Shao Jintao Cui Shuangen Yu | 2015 | Agricultural War er Management2015，149，： | 1 |
| 3 | Diatom-inspired multiscale mineralization of patterned protein-polysaccharide complex structures显示文摘Marine diatoms construct their hierarchically ordered,three-dimensional(3D)external structures called frustules through precise biomineralization processes.Recapitulating the remarkable architectures and functions of diatom frustules in artificial materials is a major challenge that has important technological implications for hierarchically ordered composites.Here,we report the construction of highly ordered,mineralized composites based on fabrication of complex self-supporting porous structures—made of genetically engineered amyloid fusion proteins and the natural polysaccharide chitin—and performing in situ multiscale protein-mediated mineralization with diverse inorganic materials,including SiO_(2),TiO_(2)and Ga_(2)O_(3).Subsequently,using sugar cubes as templates,we demonstrate that 3D fabricated porous structures can become colonized by engineered bacteria and can be functionalized with highly photoreactive minerals,thereby enabling co-localization of the photocatalytic units with a bacteria-based hydrogenase reaction for a successful semi-solid artificial photosynthesis system for hydrogen evolution.Our study thus highlights the power of coupling genetically engineered proteins and polysaccharides with biofabrication techniques to generate hierarchically organized mineralized porous structures inspired by nature. | Ke Li Yingfeng Li Xinyu Wang Mengkui Cui Bolin An Jiahua Pu Jintao Liu Boyang Zhang Guijun Ma Chao Zhong | 2021 | National Science Review2021，8，8： | 1 |
| 4 | Empirical modeling of normal/cyclo-alkanes pyrolysis to produce light olefins显示文摘Due to the complexity of feedstock,it is challenging to build a general model for light olefins production.This work was intended to simulate the formation of ethylene,propene and 1,3-butadiene in alkanes pyrolysis by referring the effects of normal/cyclo-structures.First,the pyrolysis of n-pentane,n-hexane,n-heptane,n-octane,n-nonane,n-decane,cyclohexane,methylcyclohexane,n-hexane and cyclohexane mixtures,and n-heptane and methylcyclohexane mixtures were carried out at 650–800℃,and a particular attention was paid to the measurement of ethylene,propene and 1,3-butadiene.Then,pseudo-first order kinetics was taken to characterize the pyrolysis process,and the effects of feedstock composition were studied.It was found that chain length and cyclo-alkane content can be qualitatively and quantitively represented by carbon atom number and pseudo-cyclohexane content,which made a significant difference on light olefins formation.Furthermore,the inverse proportional/quadratic function,linear function and exponential function were proposed to simulate the effects of chain length,cycloalkane content and reaction temperature on light olefins formation,respectively.Although the obtained empirical model well reproduced feedstock conversion,ethylene yield and propene yield in normal/cycloalkanes pyrolysis,it exhibited limitations in simulating 1,3-butadiene formation.Finally,the accuracy and flexibility of the present model was validated by predicting light olefins formation in the pyrolysis of multiple hydrocarbon mixtures.The prediction data well agreed with the experiment data for feedstock conversion,ethylene yield and propene yield,and overall characterized the changing trend of 1,3-butadiene yield along with reaction temperature,indicating that the present model could basically reflect light olefins production in the pyrolysis process even for complex feedstock. | Xu Hou Bochong Chen Zhenzhou Ma Jintao Zhang Yuanhang Ning Donghe Zhang Liu Zhao Enxian Yuan Tingting Cui | 2022 | Chinese Journal of Chemical Engineering2022，35，2： | 1 |
| 5 | Evolution of Desertification Types on the North Shore of Qinghai Lake显示文摘Land desertification is a widely concerned ecological environment problem.Studying the evolution trend of desertification types is of great significance to prevent and control land desertification.In this study,we applied the decision tree classification method,to study the land area and temporal and spatial change law of different types of desertification in the North Bank of Qinghai Lake area from 1987 to 2014,based on the current land use situation and TM remote sensing image data of Haiyan County,Qinghai Province,The results show that the area of mild desertification land and moderate desertification land in the study area has decreased,while the area of severe desertification land and extreme desertification land has increased significantly in the past 30 years.The area of desertification land decreased by 4.02 km2,of which the area of mild and moderate desertification land decreased by 39.73 km2 and 36.8 km2 respectively,and the area of severe and extreme desertification land increased by 32.78 km2 and 39.73 km2 respectively.As for the mutual transformation relationship,the transformation from severe desertification land to extreme desertification land is the main,and the junction of severe desertification land and extreme desertification land is the sensitive area of transformation.In the north shore of Qinghai Lake,the sandy land tends to expand eastward.The research provides reference basis for local land desertification monitoring,and has a great guidance for local effective land desertification and soil and water conservation. | Wenzheng Yu Jintao Cui Yang Gao Mingxuan Zhu Li Shao Yanbo Shen Xiaozhao Zhang Chen Guo Hanxiaoya Zhang | 2022 | Computers, Materials & Continua2022，，5： | 0 |
| 6 | Dynamic Biaxial Compression of CFRP Laminates Using Electromagnetic Loading显示文摘The dynamic biaxial compression test for carbon-fiber-reinforced polymer(CFRP)laminates was carried out via synchronous electromagnetic loading in this study.During the experiments,four stress pulses transmitted along four incident bars,loading the square specimen simultaneously from four directions to keep the center of the specimen still.The dynamic mechanical behavior of CFRP was obtained employing the one-dimensional wave propagation theory,and the deformation and failure processes of the specimens were recorded by a high-speed camera.The effects of various biaxial stresses on the compressive strength were investigated in three biaxial and one uniaxial loading cases.For the CFRP laminates,the dynamic transverse compressive stress showed little effect on the longitudinal ultimate compressive strength.Numerical simulations were performed to understand the dynamic stress wave propagation.It showed that the employed loading device could guarantee good biaxial loading conditions until the ultimate failure of the specimens.This approach allows for the dynamic biaxial compression testing of various materials,which is of great significance in evaluating the dynamic impact performance of aeronautical composites. | Huaipu Kang Jintao Liang Yi Li Hao Cui Yulong Li | 2022 | Acta Mechanica Solida Sinica2022，35，5： | 0 |
| 7 | Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer’s disease:a phaseⅠ/Ⅱclinical trial显示文摘Background There have been no effective treatments for slowing or reversing Alzheimer’s disease(AD)until now.Growing preclinical evidence,including this study,suggests that mesenchymal stem cells-secreted exosomes(MSCs-Exos)have the potential to cure AD.Aims The first three-arm,drug-intervention,phase I/II clinical trial was conducted to explore the safety and efficacy of allogenic human adipose MSCs-Exos(ahaMSCs-Exos)in patients with mild to moderate AD.Methods The eligible subjects were assigned to one of three dosage groups,intranasally administrated with ahaMSCs-Exos two times per week for 12 weeks,and underwent follow-up visits at weeks 16,24,36 and 48.Results No adverse events were reported.In the medium-dose arm,Alzheimer’s Disease Assessment Scale–Cognitive section(ADAS-cog)scores decreased by 2.33(1.19)and the basic version of Montreal Cognitive Assessment scores increased by 2.38(0.58)at week 12 compared with baseline levels,indicating improved cognitive function.Moreover,the ADAS-cog scores in the medium-dose arm decreased continuously by 3.98 points until week 36.There were no significant differences in altered amyloid or tau deposition among the three arms,but hippocampal volume shrank less in the medium-dose arm to some extent.Conclusions Intranasal administration of ahaMSCs-Exos was safe and well tolerated,and a dose of at least 4×10^(8)particles could be selected for further clinical trials. | Xinyi Xie Qingxiang Song Chengxiang Dai Shishuang Cui Ran Tang Suke Li Jing Chang Ping Li Jintao Wang Jianping Li Chao Gao Hongzhuan Chen Shengdi Chen Rujing Ren Xiaoling Gao Gang Wang | 2023 | General Psychiatry2023，36，5： | 0 |
| 8 | Wheat Breeding Strategies under Climate Change based on CERES-Wheat Model显示文摘Climate change has inevitably had a negative impact on agricultural production and food security.Crop breeding improvement is an efficient option to adapt to future climate and increase grain production.To study the potential to provide valuable advice for breeding under climate change condition,the crop growth model was used as basis to investigate,the effects of the cultivar genotype parameters of the crop estimation through resource and environment synthesis-wheat(CERES-Wheat)model on yield under different climate scenarios.In this study,solar radiation had a positive effect on the yield of winter wheat,while the effects of daily temperature change conditions on yield were vague,particularly under a change in daily maximum temperature.For the seven cultivar genotype parameters in the CERES-Wheat model,the yield had an approximately linear increasing relationship with kernel number(G1)and kernel size(G2).Vernalization days(P1V)had a fluctuating effect on winter yield without an evident unidirectional tendency.The yield of winter wheat increased with an increase in photoperiodic response(P1D)when P1D values varied from 64.81 to 79.81.Phyllochron interval(PHINT)had a positive impact on the yield of winter wheat.This study presented the potential benefits of the crop growth model to provide directional suggestions for crop breeding. | Jintao Cui Jihui Ding Sheng Deng Guangcheng Shao Weiguang Wang Xiaojun Wang Yesilekin Nebi | 2022 | Computers, Materials & Continua2022，，9： | 0 |
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