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| 1 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 23 |
| 2 | Controlling cyanobacterial blooms by managing nutrient ratio and limitation in a large hypereutrophic lake: Lake Taihu, China显示文摘Excessive nitrogen(N) and phosphorus(P) loading of aquatic ecosystems is a leading cause of eutrophication and harmful algal blooms worldwide, and reducing nutrient levels in water has been a primary management objective. To provide a rational protection strategy and predict future trends of eutrophication in eutrophic lakes, we need to understand the relationships between nutrient ratios and nutrient limitations. We conducted a set of outdoor bioassays at the shore of Lake Taihu. It showed that N only additions induced phytoplankton growth but adding only P did not. Combined N plus P additions promoted higher phytoplankton biomass than N only additions, which suggested that both N and P were deficient for maximum phytoplankton growth in this lake(TN:TP = 18.9). When nutrients are present at less than 7.75–13.95 mg/L TN and 0.41–0.74 mg/L TP, the deficiency of either N or P or both limits the growth of phytoplankton. N limitation then takes place when the TN:TP ratio is less than 21.5–24.7(TDN:TDP was 34.2–44.3), and P limitation occurs above this. Therefore, according to this ratio, controlling N when N limitation exists and controlling P when P deficiency is present will prevent algal blooms effectively in the short term. But for the long term, a persistent dual nutrient(N and P) management strategy is necessary. | Jianrong Ma Boqiang Qin Pan Wu Jian Zhou Cheng Niu Jianming Deng Hailin Niu | 2015 | Journal of Environmental Sciences2015，27，1： | 20 |
| 3 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 4 | Synthesis,characterization,and adsorption performance of Pb(Ⅱ)-imprinted polymer in nano-TiO_2 matrix显示文摘Surface ion-imprinted in combination with sol-gel process was applied to synthesis a new Pb(Ⅱ)-imprinted polymer for selective separation and enrichment of trace Pb(II) from aqueous solution. The prepared material was characterized by using the infrared spectra, X-ray diffractometer, and scanning electron microscopy. The batch experiments were conducted to study the optimal adsorption condition of adsorption trace Pb(Ⅱ) from aqueous solutions on Pb(Ⅱ)-imprinted polymer. The equilibrium was achieved in approximately 4.0 h, and the experimental kinetic data were fitted the pseudo second-order model better. The maximum adsorption capacity was 22.7 mg/g, and the Langmuir equation fitted the adsorption isotherm data. The results of selectivity experiment showed that selectively adsorbed rate of Pb(Ⅱ) on Pb(Ⅱ)-imprinted polymer was higher than all other studied ions. Desorption conditions of the adsorbed Pb(Ⅱ) from the Pb(Ⅱ)-imprinted polymer were also studied in batch experiments. The prepared Pb(Ⅱ)-imprinted polymer was shown to be promising for the separation and enrichment of trace Pb(Ⅱ) from water samples. The adsorption and desorption mechanisms were proposed. | LI Chunxiang GAO Jie PAN Jianming ZHANG Zulei YAN Yongsheng | 2009 | Journal of Environmental Sciences2009，21，12： | 12 |
| 5 | Static Extracting Method of Software Intended Behavior Based on API Functions Invoking显示文摘The method of extracting and describing the intended behavior of software precisely has become one of the key points in the fields of software behavior's dynamic and trusted authentica-tion. In this paper,the author proposes a specified measure of ex-tracting SIBDS (software intended behaviors describing sets) statically from the binary executable using the software's API functions invoking,and also introduces the definition of the struc-ture used to store the SIBDS in detail. Experimental results dem-onstrate that the extracting method and the storage structure defi-nition offers three strong properties: (i) it can describe the soft-ware's intended behavior accurately; (ii) it demands a small stor-age expense; (iii) it provides strong capability to defend against mimicry attack. | PENG Guojun PAN Xuanchen FU Jianming ZHANG Huanguo | 2008 | Wuhan University Journal of Natural Sciences2008，13，5： | 11 |
| 6 | The partial pressure of carbon dioxide and air-sea fluxes in the Changjiang River Estuary and adjacent Hangzhou Bay显示文摘The distributions of partial pressure of carbon dioxide (p CO2 ) in the surface waters of the Changjiang River Estuary and adjacent Hangzhou Bay were examined in the summer of 2010. Surface water p CO2 ranged from 751-2 095 μatm (1 atm=101 325 Pa) in the inner estuary, 177-1 036 μatm in the outer estuary, and 498-1 166 μatm in Hangzhou Bay. Overall, surface p CO2 behaved conservatively during the estuary mixing. In the inner estuary, surface p CO2 was relatively high due to urbanized pollution and a high respiration rate. The lowest p CO2 was observed in the outer estuary, which was apparently induced by a phytoplankton bloom because the dissolved oxygen and chlorophyll a were very high. The Changjiang River Estuary was a significant source of atmospheric CO2 and the degassing fluxes were estimated as 0-230 mmol/(m2 d) [61 mmol/(m2 d) on average] in the inner estuary. In contrast, the outer estuary acted as a CO2 sink. | YU Peisong ZHANG Haisheng ZHENG Minhui PAN Jianming BAI Yan | 2013 | Acta Oceanologica Sinica2013，32，6： | 8 |
| 7 | Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)显示文摘 | Lin Shen Jin Li Jianming Xu Hongming Pan Guanghai Dai Shukui Qin Liwei Wang Jinwan Wang Zhenzhou Yang Yongqian Shu Ruihua Xu Lei Chen Yunpeng Liu Shiying Yu Lilian Bu Yongzhe Piao | 2015 | Gastric Cancer2015，，1： | 7 |
| 8 | Study on chemical forms of fluorine enrichment of Antarctic krill显示文摘The different forms fluoine in different parts of molting process of krill was analyzed by culture of Antarctic krill (Euphausia superba). The results shaw that fluorine amount in cuticle is up to 90% of total in the krill. During the krill molting process, the fluorine content in cuticle and muscle varies alternatively. This is to say, the fluorine content in new cuticle and muscle is much lower after molted, the fluorine in krill comes from seawater by biological absorption of the krill, and the fluorine absorbed by krill lost with the old cuticle at the end stage of molting process. Meanwhile, the new molting process starts again. The evidence is proved by the change of different forms fluorine content in cuticle and muscle during krill’s molting process. At last the author proposes the fluorine enriching process model of Antarctic krill. | Pan Jianming, Zhang Haisheng, Liu Xiaoya (Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012, China) | 2000 | Acta Oceanologica Sinica2000，19，4： | 5 |
| 9 | Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial显示文摘 | Ann-Lii Cheng Zhongzhen Guan Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Tsai-Sheng Yang Won Young Tak Hongming Pan Shiying Yu Jianming Xu Fang Fang Jessie Zou Giuseppe Lentini Dimitris Voliotis Yoon-Koo Kang | 2011 | European Journal of Cancer2011，，10： | 4 |
| 10 | Distribution and sources of heavy metals in the sediment of Xiangshan Bay显示文摘Heavy metals in the surface sediments and sediment core from the Xiangshan Bay, a mariculture base on the coast of the East China Sea, were determined by inductively coupled plasma mass spectrometry(ICP–MS) in order to evaluate their levels and sources. The results showed that the levels of Cu, Pb, Zn, and Cr in the sediments of the bay have been generally influenced by anthropogenic inputs since the founding of the People's Republic of China. In particular, Cu and Zn were polluted to some extent, as evidenced by high enrichment factors. Organic matter, grain size, wastewater discharge, and low energy hydrodynamic environment played dominant roles in the heavy metal enrichment in the sediments. The ratio of terrigenous source to marine biogenic deposit of trace metals in the sediments was calculated, revealing that terrigenous inputs were the main source of Cu, Pb, and Zn, while biological pellets contributed much more to the enrichment of Cr and Cd. Considering the influence of biological sources on the enrichment of Cd and Cr, and the fact that the sediment has been polluted by Cu and Zn, the development of mariculture and discharge of wastewater into the Bay should be restricted. | SUN Weiping YU Jianjun XU Xiaoqun ZHANG Weiyan LIU Ruijuan PAN Jianming | 2014 | Acta Oceanologica Sinica2014，33，4： | 4 |
| 11 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 3 |
| 12 | PREPARATION OF SURFACE ION-IMPRINTED ATTAPULGITE-SUPPORTED POLYMER AND ITS ADSORPTION BEHAVIORS OF Sr(II)显示文摘The surface ion-imprinting concept and chitosan incorporated sol-gel process were applied to the preparation of a new attapulgite-supported organic-inorganic hybrid polymer for selective separation of Sr(II) from aqueous solution. The prepared polymer was characterized with SEM, IR and XRD. The results showed that as a sorbent, it had good configuration and binding sites. Its adsorption behaviors for Sr(II) was investigated by FAAS and ICP-AES. The effects on adsorption capacities, including pH, quiescent time, and adsorbent amount were discussed, and the adsorption isothermal curve was obtained. Then the Kd a parameter estimating relative adsorbability, was conducted to study the selectivity towards Sr(II) of the prepared polymer. Under the optimum conditions, the ion-imprinted polymer offered a fast kinetics for the adsorption of Sr(II) and the maximum capacity was 12.9mg/g. The Kd and K parameters estimating relative adsorbability towards target ion, suggested that selective recognition of the ion-imprinted polymer towards Sr(II) was much higher than that of the non-imprinted polymer and attapulgite. Furthermore, the ion-imprinted polymer is of great regeneration capacity. The prepared functional polymer was shown to be promising for selective preseparation and enrichment of trace Sr(II) in environmental samples. | PAN Jianming YAN Yongsheng LI Chunxiang | 2008 | Chinese Journal of Reactive Polymers2008，17，1： | 3 |
| 13 | Variations of nutrient elements and its effect on ecological environment off the Changjiang estuarine waters显示文摘On the basis of the date obtained in two cruises during October 1997 and May 1998, the concentration distribution and the variation of present species of nutrient elements in the water masses are described. The transform mechanism of present species of nutrients and the of differrnt water masses, frontal area and thermohaline transition layer on convergence or divergence and the biogeochemical cycle of nutrient elements off the Changjiang Estuary are studied. Meanwhile, the environmental capaci- ty of nutrients is primarily estimated: they are 1.803 x 104t DIN and 6.18 x 102t PO43- -P in autumn, and 4.20x 102t PO43- -P in spring. | Lin Yi’ an, Tang Renyou, Pan Jianming, Jin Mingming ( Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012, China) | 2001 | Acta Oceanologica Sinica2001，20，2： | 2 |
| 14 | Sugar transfer of nanomaterials and flexible electrodes显示文摘Nanomaterials with various dimensionalities(e.g.,nanowires,nanofilms,two-dimensional materials,and three-dimensional nanostructures)have shown great potential in the recent development of flexible electronics.Conventionally,organic solvents are inevitable while integrating nanomaterials onto flexible substrates,where polymer mediator-assisted transfer techniques are involved.This often damages the flexible substrate and thus hamper the large-scale application of nanomaterials.Here we report a method using watersoluble sugar as a mediator to facilely transfer nanomaterials onto rigid or flexible substrates.This method requires no organic solvent during transfer.More importantly,the morphology and properties of transferred nanomaterials,such as shape,microstructure,resistivity,and transmittance are well preserved on the target substrate.We believe that this universal and rapid transfer method can greatly advance the applications of nanomaterials in the field of flexible devices and beyond. | Tianzeng Hong Tianze Shen Junlong Yang Yichen Sun Jianming Zhang Haiyang Pan Ying Hong Yan Wang Shuo Chen Yue Zhao Chuan Fei Guo | 2020 | International Journal of Smart and Nano Materials2020，11，1： | 1 |
| 15 | Physical characteristics,electrochemical behavior,and stability of BaFeO4显示文摘 | Yang Weihua Wang Jianming Pan Tao | 2004 | Electrochimica Acta2004，49，21： | 1 |
| 16 | Effect of TiO_2 nanoparticle aggregation on marine microalgae Isochrysis galbana显示文摘TiO_2 nanoparticles(NPs) could adversely impact aquatic ecosystems. However, the aggregation of these NPs could attenuate this effect. In this work, the biological effects of TiO_2 NPs on a marine microalgae Isochrysis galbana were investigated. The aggregation kinetics of TiO_2 NPs under different conditions was also investigated to determine and understand these effects. Results showed that, though TiO_2 NPs had no obvious impact on the size and reproducibility of algal cells under testing conditions, they caused a negative effect on algal chlorophyll, which led to a reduction in photosynthesis. Furthermore, fast aggregation of TiO_2 NPs occurred under all conditions, especially at the pH close to the p Hzpc. Increasing ionic strength and NP concentration also enhanced the aggregation rate.The aggregation and the following sedimentation of TiO_2 NPs reduced their adverse effects on I. galbana. | Ji Hu Jianmin Wang Shuxia Liu Zhechao Zhang Haifeng Zhang Xiaoxia Cai Jianming Pan Jingjing Liu | 2018 | Journal of Environmental Sciences2018，30，4： | 1 |
| 17 | Surface molecular imprinting onto magnetic yeast composites via atom transfer radical polymerization for selective recognition of cefalexin显示文摘 | LI Xiuxiu PAN Jianming DAI Jiandong | 2012 | Chem Eng J2012，，： | 1 |
| 18 | Distribution, source and enrichment of some chemical elements in sediments of the Pearl River Estuary, China 显示文摘 | Zhou Huaiyang Peng Xiaotong Pan Jianming | 2004 | Continental Shelf Research2004，，： | 1 |
| 19 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 1 |
| 20 | In vivo pharmacokinetic comparisons of ferulic acid and puerarin after oral administration of monomer, medicinal substance aqueous extract and Nao-De-Sheng to rats显示文摘 | Zhen Ouyang Ming Zhao Jianming Tang Lulin Pan | 2012 | Pharmacognosy Magazine2012，，32： | 1 |
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