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| 1 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway显示文摘当严重急性呼吸症候群日冕病毒(SARS-CoV ) 开始被认为与质膜通过直接熔化进入房间时,更最近的证据建议那个病毒条目可以也包含 endocytosis。我们发现了那 SARS-CoV 进入房间经由 pH 依赖并且受体依赖者 endocytosis。有任何一个 SARS-CoV 尖铁蛋白质或忍受尖铁的假病毒的房间的治疗导致了变换血管收缩素的酶的 translocation 2 (ACE2 ) , SARS-CoV 的功能的受体,从房间表面到内涵体。另外,忍受尖铁的假病毒和 1 在内涵体被发现到 colocalize 的早内涵体抗原。用象 caveolin-1 colocalization 学习一样的特定的 endocytic 小径禁止者和主导否定的 Eps15 的进一步的分析建议那个病毒条目被 clathrin 独立、 caveolae 独立的机制调停。而且,在质膜的微域,它被显示出到为许多生理的发信号小径作为平台扮演的充满胆固醇、 sphingolipid 富有的类脂化合物木排,被显示涉及病毒入口。SARS-CoV 的 Endocytic 入口可以扩展这里的 SARS-CoV 感染,和我们的调查结果的细胞的范围贡献 SARS-CoV 致病的理解,为抗病毒的药研究提供新信息。 | Wang,H Yang,P Liu,K Guo,F Zhang,Y Zhang,G Jiang,C | 2008 | Cell Research2008，18，2： | 50 |
| 2 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 3 | Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid显示文摘 | Shi Y Hou L Tang F Jiang W Wang P Ding M Deng H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 4 | Influence of Fe Addition on Products of Self-Propagating High-Temperature Synthesis Reaction in 3Ti-Si-2C System显示文摘Influence of Fe addition on products of self-propagating high-temperature synthesis (SHS) reaction in 3Ti-Si-2C system was investigated in the present study. Without Fe addition, Ti5Si3 and TiC are the dominant phases along with a small amount of Ti3SiC2 phase and unreacted C left in the final products. As Fe content ranges from 10% to 30%, the products consist of TiC, Ti5Si3, Fe2Ti and unreacted C, but no trace of Ti3SiC2 phase is detected. Furthermore, the amounts of both Fe2Ti and C phases increase with Fe content increasing. Addition of Fe has a great effect on the reaction route and significantly restrains the formation of Ti3SiC2 during the combustion synthesis process, and therefore, the SHS is not an effective fabrication technique to synthesize the ternary Ti3SiC2 ceramic in either 3Ti-Si-2C or Fe-3Ti-Si-2C system. Besides, without Fe addition, Ti5Si3 presents as the coarse irregular appearance with an obviously sintered morphology. In contrast, the shape of Ti5Si3 exhibits more and more spherical (cobblestone-like) and the surface becomes increasingly smooth, because the amount of liquids formed during the SHS reaction increases with the increase of Fe content. On the other hand, with Fe content increasing from 0 to 30 wt.%, the particulate size of TiC decreases from more than 5 μm to 1 μm or less, mainly due to the fact that the combustion temperature decreases with the increase of Fe content in the preforms. | Guan Q L Wang H Y Li S L Si W P Jiang Q C | 2009 | 稀有金属材料与工程2009，38，A03： | 2 |
| 5 | Quality control measures for lowering the seroconversion rate of hemodialysis patients with hepatitis B or C virus显示文摘BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the prevention of transmission of blood-borne viruses. METHODS: A total of 6182 adult maintenance HD patients from all HD units in Zhejiang Province were recruited on January 1, 2007. The baseline demographic and clinical characteristics were recorded and all patients were followed up until death or survival at 4 years later. The Quality Control Standards of Hemodialysis were gradually implemented in HD units. The HBV or HCV seroconversion rates of the recruited patients were calculated and compared every year during the observation period. RESULTS: The prevalence of HBV was 8.3% at the beginning of the study, and 6.6% for HCV. With the implementation of the HD quality control measures, the HBV seroconversion rate tended to decrease year by year (χ 2 =6.620, P=0.085), and the HCV seroconversion rate decreased significantly (χ 2 =10.41, P=0.015). Compared with the data in 2007, the HBV seroconversion rate (χ 2 =4.204, P=0.040, relative risk ratio 0.393, 95% CI 0.156-0.991) and the HCV seroconversion rate (χ 2 =7.373, P=0.007, relative risk ratio 0.386, 95% CI 0.189-0.787) decreased significantly in 2010. CONCLUSION: Quality control measures for HD decreased the seroconversion rates of HBV or HCV in HD patients, showing that updated quality control measures reduce the risk for transmission of blood-borne viruses in the HD population. | Jing Yuan,Yi Yang, Fei Han, Ping Zhang, Xiao-Ying Du, Hua Jiang and Jiang-Hua Chen The Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine (Yuan J, Yang Y, Han F, Zhang P, Du XY, Jiang H and Chen JH) and Hemodialysis Quality Control Center of Zhejiang Province (Yuan J, Zhang P, Du XY and Chen JH), Hangzhou 310003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 2 |
| 6 | Design and fabrication of a micro wankel engine using MEMS technology 显示文摘 | Lee C H Jiang K C Jin P | 2004 | Microelectronic Engineering2004，，： | 1 |
| 7 | Treatment of organic pollutants in coke plant wastewater by the method of ultrasonic irradiation, catalytic oxidation and activated sludge显示文摘 | NING P BART H J JIANG Y J | 2005 | Separation and Purification Technology2005，41，2： | 1 |
| 8 | Immobilization of oligonucleotides onto a glass support via disulfide bonds: A method for preparation of DNA microarrays 显示文摘 | Rogers Y H Jiang - Baucom P Huang Z J | 1999 | Anal Biochem1999，266，： | 1 |
| 9 | A New Redundant Variable Pruning Approach-Minor Latent Variable Perturbation-PLS Used for QSAR Studies on Anti-HIV Drugs显示文摘 | Xie H P Jiang J H Cui H | 2002 | Computes & Chemistry2002，59，： | 1 |
| 10 | Microstructural evolution, microhardness and thermal stability of HPT-processed Cu 显示文摘 | Jiang H Zhu Y T Butt D P | 2000 | Materials Science and Engineering2000，290，12： | 1 |
| 11 | Sequence diversity of small, round-structured viruses in the Norwalk virus group 显示文摘 | Wang J X Jiang Madore H P | 1994 | J Virol1994，68，9： | 1 |
| 12 | Synthesis of a novel hybrid synergistic flame retardant and its application in PP/IFR 显示文摘 | Qian Y’Wei P Jiang P K Zhao X M Yu H Z | 2011 | Polymer Degradation and Stability2011，96，6： | 1 |
| 13 | Effects of ultrasonic vibration treatment on microstructure of heat-resistant A1-Si alloy显示文摘 | ZHONG G WU S S JIANG H W SHA M AN P | | 0，，： | 1 |
| 14 | Purification and characterization of antioxidative peptides from round scad ( Decapterus maruadsi) muscle protein hydrolysate 显示文摘 | Jiang H P Tong T Z Sun J H Xu Y J Zhao Z X Liao D K | 2014 | Food Chemistry2014，154，： | 1 |
| 15 | Phase-separated DC- SK: A simple delay-component-free solution for chaotic communications 显示文摘 | YANG H JIANG G P DUAN J Y | 2014 | IEEE Transactions on Circuits and Systems II: Express Briefs2014，61，12： | 1 |
| 16 | A Container Yard Storage Strategy for Improving Land Utilization And Opera- tion Efficiency in a Transshipment Hub Port显示文摘 | Jiang X Lee L H Chew E P | 2012 | European Journal of Operational Research2012，221，1： | 1 |
| 17 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 18 | Dissection of genetic o- verlap of drought and low-temperature tolerance QTLs at the germi- nation stage using backcross introgression lines in soybean 显示文摘 | Zhang W B Qiu P C Jiang H W | 2012 | Molecular Biology Reports2012，39，5： | 1 |
| 19 | A novel hybrid carbon material 显示文摘 | Nasibulin A G Pikhitsa P V Jiang H et aI | 2007 | Nat Nanotechnol2007，2，： | 1 |
| 20 | Effects of initial low oxygen and perforated film package on quality of fresh-cut cabbages显示文摘 | HU W Z JIANG A L QI H P | 2007 | Journal of the Science of Food and Agriculture2007，87，： | 1 |
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