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| 1 | Statins Decrease Adverse Outcomes in Coronary Artery Bypass for Extensive Coronary Artery Disease as well as Left Main Coronary Stenosis显示文摘 | Hui‐LiGan Jian‐QunZhang PingBo Sheng‐XunWang Chun‐ShangLu | 2010 | Cardiovascular Therapeutics2010，，2： | 1 |
| 2 | Ecological risk assessment of parent and halogenated polycyclic aromatic hydrocarbons in surface sediments from an urban river in south China显示文摘 | Jian‐Lin Sun Hong‐Gang Ni Hui Zeng | 2012 | Environmental Toxicology and Chemistry2012，，8： | 1 |
| 3 | Catalytic Asymmetric Hydrogenation of δ‐Ketoesters: Highly Efficient Approach to Chiral 1,5‐Diols显示文摘 | Xiao‐Hui Yang Jian‐Hua Xie Wei‐Peng Liu Qi‐Lin Zhou | 2013 | Angew Chem Int Ed2013，，30： | 1 |
| 4 | Scale adaptive fitness evaluation‐based particle swarm optimisation for hyperparameter and architecture optimisation in neural networks and deep learning显示文摘Research into automatically searching for an optimal neural network(NN)by optimi-sation algorithms is a significant research topic in deep learning and artificial intelligence.However,this is still challenging due to two issues:Both the hyperparameter and ar-chitecture should be optimised and the optimisation process is computationally expen-sive.To tackle these two issues,this paper focusses on solving the hyperparameter and architecture optimization problem for the NN and proposes a novel light‐weight scale‐adaptive fitness evaluation‐based particle swarm optimisation(SAFE‐PSO)approach.Firstly,the SAFE‐PSO algorithm considers the hyperparameters and architectures together in the optimisation problem and therefore can find their optimal combination for the globally best NN.Secondly,the computational cost can be reduced by using multi‐scale accuracy evaluation methods to evaluate candidates.Thirdly,a stagnation‐based switch strategy is proposed to adaptively switch different evaluation methods to better balance the search performance and computational cost.The SAFE‐PSO algorithm is tested on two widely used datasets:The 10‐category(i.e.,CIFAR10)and the 100−cate-gory(i.e.,CIFAR100).The experimental results show that SAFE‐PSO is very effective and efficient,which can not only find a promising NN automatically but also find a better NN than compared algorithms at the same computational cost. | Ye‐Qun Wang Jian‐Yu Li Chun‐Hua Chen Jun Zhang Zhi‐Hui Zhan | 2023 | CAAI Transactions on Intelligence Technology2023，8，3： | 0 |
| 5 | Epidemiological survey and risk factor analysis of fatty liver disease of adult residents, B eijing, C hina显示文摘 | Jie Yan Wen Xie Wei‐ni Ou Hong Zhao Su‐yun Wang Jian‐hui Wang Qi Wang Yu‐ying Yang Xin Feng Jun Cheng | 2013 | J Gastroenterol Hepatol2013，，10： | 3 |
| 6 | Surgery Upregulates High Mobility Group Box‐1 and Disrupts the Blood–Brain Barrier causing Cognitive Dysfunction in Aged Rats显示文摘 | Hui‐Juan He Yi Wang Yuan Le Kai‐Ming Duan Xue‐Bin Yan Qin Liao Yan Liao Jian‐Bin Tong Niccolò Terrando Wen Ouyang | 2012 | CNS Neurosci Ther2012，，： | 2 |
| 7 | Giant Electrocaloric Response Over A Broad Temperature Range in Modified BaTiO<sub>3</sub> Ceramics显示文摘 | Xiao‐Shi Qian Hui‐Jian Ye Ying‐Tang Zhang Haiming Gu Xinyu Li C. A. Randall Q. M. Zhang | 2014 | Adv Funct Mater2014，，9： | 1 |
| 8 | Staging, prognostic factors and adjuvant therapy of intrahepatic cholangiocarcinoma after curative resection显示文摘 | Tao Li Lun‐Xiu Qin Jian Zhou Hui‐Chuan Sun Shuang‐Jian Qiu Qing‐Hai Ye Lu Wang Zhao‐You Tang Jia Fan | 2014 | Liver Int2014，，6： | 1 |
| 9 | Tumor‐associated macrophages promote angiogenesis and lymphangiogenesis of gastric cancer显示文摘 | Hui Wu Jian‐Bo Xu Yu‐Long He Jian‐Jun Peng Xin‐Hua Zhang Chuang‐Qi CHEN Wen Li Shi‐Rong Cai | 2012 | J. Surg. Oncol2012，，4： | 1 |
| 10 | Interleukin‐12 and interleukin‐2 alone or in combination against the infection in invasive pulmonary aspergillosis mouse model显示文摘 | Chang‐Ran Zhang Jian‐Cong Lin Wen‐Ming Xu Ming Li Hui‐Shao Ye Wei‐Ling Cui Qing Lin | 2012 | Mycoses2012，，2： | 1 |
| 11 | TNF ‐α Upregulates Fgl2 Expression in Rat Myocardial Ischemia/Reperfusion Injury显示文摘 | Peng Jia Jue Wang Li Wang Xin Chen Yu Chen Wen‐Zhu Li Rui Long Jian Chen Yan‐Wen Shu Kun Liu Zhao‐Hui Wang | 2013 | Microcirculation2013，，6： | 1 |
| 12 | A novel role for cyanide in the control of cucumber ( Cucumis sativus L.) seedlings response to environmental stress显示文摘 | FEI XU DA‐WEI ZHANG FENG ZHU HE TANG XIN LV JIAN CHENG HUANG‐FAN XIE HONG‐HUI LIN | 2012 | Plant, Cell & Environment2012，，11： | 1 |
| 13 | Molecular and structural characterization of a promiscuous chalcone synthase from the fern species Stenoloma chusanum显示文摘The key enzymes involved in the flavonoid biosynthesis pathway have been extensively studied in seed plants,but relatively less in ferns.In this study,two 4-Coumarate:coenzyme A ligases(Sc4CL1 and Sc4CL2)and one novel chalcone synthase(ScCHS1)were functionally characterized by mining the Stenoloma chusanum transcriptome database.Recombinant Sc4CLs were able to esterify various hydroxycinnamic acids to corresponding acyl-coenzyme A(CoA).ScCHS1could catalyze p-coumaroyl-CoA,cinnamoyl-CoA,caffeoyl-CoA,and feruloyl-CoA to form naringenin,pinocembrin,eriodictyol,and homoeriodictyol,respectively.Moreover,enzymatic kinetics studies revealed that the optimal substrates of ScCHS1were feruloyl-CoA and caffeoyl-CoA,rather than p-coumaroyl-CoA,which was substantially different from the common CHSs.Crystallographic and sitedirected mutagenesis experiments indicated that the amino acid residues,Leu87,Leu97,Met165,and Ile200,located in the substrate-binding pocket near the B-ring of products,could exert a significant impact on the unique catalytic activity of ScCHS1.Furthermore,overexpression of ScCHS1 in tt4 mutants could partially rescue the mutant phenotypes.Finally,ScCHS1 and Sc4CL1 were used to synthesize flavanones and flavones with multi-substituted hydroxyl and methoxyl B-ring in Escherichia coli,which can effectively eliminate the need for the cytochrome P450 hydroxylation/O-methyltransferase from simple phenylpropanoid acids.In summary,the identification of these important Stenoloma enzymes provides a springboard for the future production of various flavonoids in E.coli. | Rong Ni Meng Niu Jie Fu Hui Tan Ting‐Ting Zhu Jing Zhang Hong‐Xiang Lou Peng Zhang Jian‐Xu Li Ai‐Xia Cheng | 2022 | Journal of Integrative Plant Biology2022，64，10： | 1 |
| 14 | Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma显示文摘 | Bo Hui Ying‐Hong Shi Zhen‐Bin Ding Jian Zhou Cheng‐Yu Gu Yuan‐Fei Peng Hua Yang Wei‐Ren Liu Guo‐Ming Shi Jia Fan | 2012 | Cancer2012，，22： | 1 |
| 15 | Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK ‐dependent autophagy显示文摘 | Teng Jiang Jin‐Tai Yu Xi‐Chen Zhu Hui‐Fu Wang Meng‐Shan Tan Lei Cao Qiao‐Quan Zhang Li Gao Jian‐Quan Shi Ying‐Dong Zhang Lan Tan | 2014 | Br J Pharmacol2014，，13： | 1 |
| 16 | Positive effects of treatment of donor cells with aphidicolin on the preimplantation development of somatic cell nuclear transfer embryos in Chinese Bama mini‐pig (Sus Scrofa)显示文摘 | Ting‐YuZHANG Jian‐JunDAI Cai‐FengWU Xiao‐LongGU LiangLIU Zhi‐QiangWU Yi‐ NiXIE BinWU Hui‐LanCHEN YaoLI Xue‐JinCHEN De‐FuZHANG | 2012 | Animal Science Journal2012，，2： | 1 |
| 17 | Pooled analysis of the performance of liquid‐based cytology in population‐based cervical cancer screening studies in China显示文摘 | Qin‐Jing Pan Shang‐ying Hu Xun Zhang Pu‐wa Ci Wen‐hua Zhang Hui‐qin Guo Jian Cao Fang‐hui Zhao Alice Lytwyn You‐lin Qiao | 2013 | Cancer Cytopathology2013，，9： | 1 |
| 18 | An updated classification for the hyper-diverse genus Corydalis(Papaveraceae: Fumarioideae)based on phylogenomic and morphological evidence显示文摘The genus Corydalis, with ca. 530 species, has long been considered taxonomically challenging because of its great variability. Previous molecular analyses,based on a few molecular markers and incomplete taxonomic sampling, were clearly inadequate to delimit sections and subgenera. We have performed phylogenetic analyses of Corydalis and related taxa,using 65 shared protein-coding plastid genes from313 accessions(including 280 samples of ca. 226species of Corydalis) and 152 universal low-copy nuclear genes from 296 accessions(including 271samples of Corydalis) covering all 42 previously recognized sections and five independent “series”.Phylogenetic trees were inferred using Bayesian Inference and Maximum Likelihood. Eight selected morphological characters were estimated using ancestral state reconstructions. Results include:(i) of the three subgenera of Corydalis, two are fully supported by both the plastid and nuclear data;the third,subg. Cremnocapnos, is weakly supported by plastid DNA only, whereas in the nuclear data the two included sections form successive outgroups to the rest of the genus;(ii) among all 42 sections and five“series”, 25 sections and one “series” are resolved as monophyletic in both data sets;(iii) the common ancestor of Corydalis is likely to be a perennial plant with a taproot, yellow flowers with a short saccate spur, linear fruits with recurved fruiting pedicels, and seeds with elaiosomes;(iv) we provide a new classification of Corydalis with four subgenera(of which subg. Bipapillatae is here newly described), 39 sections, 16 of which are consistent with the previous classification, 16 sections have been recircumscribed, one section has been reinstated and six new sections are established. Characters associated with lifespan, underground structures, floral spur, fruit and elaiosomes are important for the recognition of subgenera and sections. These new phylogenetic analyses combined with ancestral character reconstructions uncovered previously unrecognized relationships, and greatly improved our understanding of the evolution of the genus. | Jun‐Tong Chen Magnus Lidén Xian‐Han Huang Liang Zhang Xin‐Jian Zhang Tian‐Hui Kuang Jacob BLandis Dong Wang Tao Deng Hang Sun | 2023 | Journal of Integrative Plant Biology2023，65，9： | 0 |
| 19 | Genetic variants in XPD gene and glioma susceptibility in Chinese children:A multicenter case–control study显示文摘Background:Glioma is one of the central nervous system(CNS)tumors in children,accounting for 80%of malignant brain tumors.Nucleotide excision repair(NER)is a vital pathway during DNA damage repair progression.Xeroderma pigmentosum group D(XPD)or excision repair cross‐complementing group 2(ERCC2)is a critical factor in the NER pathway,playing an indispensable role in the DNA repair process.Therefore,the genetic variants in XPD may be associated with carcinogenesis induced by defects in DNA repair.Methods:We are the first to conduct a multi‐center case‐control study to investigate the correlation between XPD gene polymorphisms and pediatric glioma risk.We chose three single nucleotide polymorphisms and genotyped them using the TaqMan assay.Results:Although there is no significant association of these genetic variations with glioma susceptibility,the stratified analysis revealed that in the subtype of astrocytic tumors,the rs13181 TG/GG genotype enhanced glioma risk than the TT genotype,and carriers with two to three genotypes also elevated the tumor risk than 0‐1 genotypes.Conclusion:In conclusion,our findings provided an insight into the impact of XPD genetic variants on glioma risk. | Yong‐Ping Chen Yuxiang Liao Li Yuan Xiao‐Kai Huang Ji‐Chen Ruan Hui‐Ran Lin Lei Miao Zhen‐Jian Zhuo | 2022 | Cancer Innovation2022，1，1： | 0 |
| 20 | Cas12a-based on-site, rapid detection of genetically modified crops显示文摘Genetically modified(GM)crops that impart herbicide resistance,improved tolerance to biotic and abiotic stresses,and enhanced yield or nutritional quality have been developed and grown worldwide(ISAAA Brief 55-2019:International Servicefor theAcquisition ofAgri-biotech Applications(ISAAA),2019).In response topublic concern on genetically modified organisms(GMOs),DNA-based and protein-based methods have been developed to detect GMOs infood/feed samples(Fraitureetal.,2015).These methods,however,require expensive equipment and technical expertise and are unsuitable for field diagnosis(DNA-based methods)or cannot detect non-coding sequences such as promoters or terminators(protein-based methods). | Zhiqiang Duan Xiaoliang Yang Xingkun Ji Ying Chen Xiaomu Niu Anping Guo Jian‐Kang Zhu Feng Li Zhaobo Lang Hui Zhao | 2022 | Journal of Integrative Plant Biology2022，64，10： | 0 |
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