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| 1 | Fermented liquid feed for pigs: an ancient technique for the future显示文摘Fermented liquid feed is feed that has been mixed with water at a ratio ranging from 1:1.5 to 1:4.By mixing with water,lactic acid bacteria and yeasts naturally occurring in the feed proliferate and produce lactic acid,acetic acid and ethanol which reduces the pH of the mixture.This reduction in pH inhibits pathogenic organisms from developing in the feed.In addition,when this low pH mixture is fed,it reduces the pH in the stomach of pigs and prevents the proliferation of pathogens such as coliforms and Salmonella in the gastrointestinal tract.For piglets,the use of fermented liquid feed offers the possibility of simultaneously providing feed and water,which may facilitate an easier transition from sow's milk to solid feed.Secondly,offering properly produced fermented liquid feed may strengthen the role of the stomach as the first line of defense against possible pathogenic infections by lowering the pH in the gastrointestinal tract thereby helping to exclude enteropathogens.Finally,feeding fermented liquid feed to pigs has been shown to improve the performance of suckling pigs,weaner pigs and growing-finishing pigs.In this review,current knowledge about the use of fermented liquid feed in pig diets will be discussed.This will include a discussion of the desirable properties of fermented liquid feed and factors affecting fermentation.In addition,advantages and disadvantages of fermented liquid feed will be discussed including its effects on gastrointestinal health,intestinal pH and the types of bacteria found in the gastrointestinal tract as well as the effects of fermented liquid feeds on pig performance. | Joris AM Missotten Joris Michiels Jeroen Degroote Stefaan De Smet | 2016 | Journal of Animal Science and Biotechnology2016，7，1： | 67 |
| 2 | Association between heat stress and oxidative stress in poultry;mitochondrial dysfunction and dietary interventions with phytochemicals显示文摘Heat as a stressor of poultry has been studied extensively for many decades; it affects poultry production on a worldwide basis and has significant impact on well-being and production. More recently, the involvement of heat stress in inducing oxidative stress has received much interest. Oxidative stress is defined as the presence of reactive species in excess of the available antioxidant capacity of animal cells. Reactive species can modify several biologically cellular macromolecules and can interfere with cell signaling pathways. Furthermore, during the last decade, there has been an ever-increasing interest in the use of a wide array of natural feed-delivered phytochemicals that have potential antioxidant properties for poultry. In light of this, the current review aims to(1) summarize the mechanisms through which heat stress triggers excessive superoxide radical production in the mitochondrion and progresses into oxidative stress,(2) illustrate that this pathophysiology is dependent on the intensity and duration of heat stress,(3) present different nutritional strategies for mitigation of mitochondrial dysfunction, with particular focus on antioxidant phytochemicals.Oxidative stress that occurs with heat exposure can be manifest in all parts of the body; however, mitochondrial dysfunction underlies oxidative stress. In the initial phase of acute heat stress, mitochondrial substrate oxidation and electron transport chain activity are increased resulting in excessive superoxide production. During the later stage of acute heat stress, down-regulation of avian uncoupling protein worsens the oxidative stress situation causing mitochondrial dysfunction and tissue damage. Typically, antioxidant enzyme activities are upregulated. Chronic heat stress, however, leads to downsizing of mitochondrial metabolic oxidative capacity, up-regulation of avian uncoupling protein, a clear alteration in the pattern of antioxidant enzyme activities, and depletion of antioxidant reserves.Some phytochemicals, such as various types of flavonoids and related compounds, were shown to be beneficial in chronic heat-stressed poultry, but were less or not effective in non-heat-stressed counterparts. This supports the contention that antioxidant phytochemicals have potential under challenging conditions. Though substantial progress has been made in our understanding of the association between heat stress and oxidative stress, the means by which phytochemicals can alleviate oxidative stress have been sparsely explored. | Abdollah Akbarian Joris Michiels Jeroen Degroote Maryam Majdeddin Abolghasem Golian Stefaan De Smet | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 21 |
| 3 | 岩石裂隙决定喀斯特关键带地表木本与草本植物覆盖显示文摘地球关键带研究将地表植被组成和功能与岩石层的特性联系起来,为研究喀斯特地区特殊的岩石和土壤条件如何影响地表植被提供了新的思路.文章基于贵州中部喀斯特关键带白云岩和石灰岩分布区岩石、土壤和植被调查结果,发现木本植物覆盖度随宽度1mm以上的裂隙数目增多而线性增加,而草本植物覆盖度则呈相反的趋势(p<0.01).白云岩分布区由于岩性致密、裂隙不发育、土层厚度一般在20cm以内,适合浅根系的草本植物分布.石灰岩分布区由于裂隙发育、土壤分布深、树木的深根系分布在裂隙中,植被组成和结构复杂.基于2001~2010年MODIS遥感数据获取的每16天一个时相的归一化植被指数(NDVI)和年净第一性生产力(NPP)结果进一步表明,石灰岩分布区各时相NDVI总体显著高于白云岩分布区,但多年平均NPP则相反.本文结果表明,在喀斯特关键带,岩性决定土壤的结构和分布,进而决定地上植被木本植物和草本植物的覆盖.尽管石灰岩地区土壤量可能比白云岩地区偏低,但发达的裂隙结构更适合深根系的树木生长,植被活动强.当前喀斯特地区石漠化治理需要充分考虑地球关键带岩石-土壤-植被-大气相互作用,提出适合不同岩性的植被恢复措施. | 刘鸿雁 蒋子涵 戴景钰 吴秀臣 彭建 王红亚 Jeroen MEERSMANS Sophie MGREEN Timothy AQUINE | 2019 | 中国科学:地球科学2019，49，12： | 16 |
| 4 | Is there a role for surgery in stage ⅢA-N2 non-small cell lung cancer?显示文摘The role of surgery in stage ⅢA-N2 non-small cell lung cancer(NSCLC) remains controversial.Most important prognostic factors are mediastinal downstaging and complete surgical resection.Different restaging techniques exist to evaluate response after induction therapy and these are subdivided into non-invasive,invasive and alternative or minimally invasive techniques.In contrast to imaging or functional studies,remediastinoscopy provides pathological evidence of response after induction therapy.Although techn... | Paul E.VAN SCHIL Michèle DE WAELE Jeroen M.HENDRIKS Patrick R.LAUWERS | 2008 | 中国肺癌杂志2008，11，5： | 14 |
| 5 | Improving the outcomes in oncological colorectal surgery显示文摘During the last several decades,colorectal cancer surgery has experienced some major perioperative improvements.Preoperative risk-assessment of nutrition,frailty,and sarcopenia followed by interventions for patient optimization or an adapted surgical strategy,contributed to improved postoperative outcomes.Enhanced recovery programs or fast-track surgery also resulted in reduced length of hospital stay and overall complications without affecting patient safety.After an initially indecisive start due to uncertainty about oncological safety,the most significant improvement in intraoperative care was the introduction of laparoscopy.Laparoscopic surgery for colon and rectal cancer is associated with better short-term outcomes,whereas long-term outcomes regarding survival and recurrence rates are comparable.Nevertheless,long-term results in rectal surgery remain to be seen.Early recognition of anastomotic leakage remains a challenge,though multiple improvements have allowed better management of this complication. | Jeroen LA van Vugt Kostan W Reisinger Joep PM Derikx Djamila Boerma Jan HMB Stoot | 2014 | World Journal of Gastroenterology2014，20，35： | 13 |
| 6 | 四成分教学设计模型--面向复杂学习环境的多媒体原理显示文摘四成分教学设计模型认为要实现复杂学习需要借助学习任务、支持性信息、程序性信息和子任务练习等因素。本文探讨运用这一模型设计多媒体学习环境及相关的14条多媒体原理。学习者可以在一个模拟的环境下完成学习任务,利用相关的多媒体原理有利于促进归纳学习过程;学习者还可以在超媒体系统中掌握支持性信息,相关的多媒体原理有利于促进信息的提取和精细加工过程;学习者也可以通过电子绩效支持系统来获取程序性信息,相关的多媒体原理有利于知识处理;最后,学习者能通过基于计算机练习程序来进行子任务的练习与训练,相关的多媒体原理有利于促进知识技能的巩固。本文还讨论了四成分模型框架的启示和不足。 | Jeroen J. G. van Merrienboer Liesbeth Kester 盛群力(译) 徐瑞(译) | 2008 | 远程教育杂志2008，26，2： | 13 |
| 7 | Evidence for the involvement of infectious agents in the pathogenesis of Crohn's disease显示文摘Many advances have been made in the understanding of Crohn’s disease (CD) pathogenesis during the last decade. CD is currently seen as a predominantly T-lym-phocyte-driven disease characterized by the presence of a complex cocktail of interacting cytokines, chemokines and other mediators produced by a variety of cell types. Prevailing theories of CD pathogenesis suggest that patients’ T-lymphocytes are inappropriately activated in the setting of an immune imbalance, which is itself caused by an unfortunate confluence of genetic and en- vironmental factors. The T-cell response then leads to the chronic inflammation characteristic for the disease. Various environmental factors may play a role in the development of CD, but microbes are most consistently implied. This theory is based on epidemiological, clinico- pathological, genetic and experimental evidence. Despite the abundance of arguments for the implication of bac-teria in the aetiopathogenesis of CD, the precise role of bacteria in this disease still remains elusive. Three not necessarily mutually exclusive theories have been pro- posed: (1) an unidentified persistent pathogen; (2) an abnormally permeable mucosal barrier leading to exces-sive bacterial translocation; and (3) a breakdown in the balance between putative 'protective' versus 'harmful' intestinal bacteria ('dysbiosis'). At present, one cannot exclude with certainty any of these three proposed hy-potheses; they may all apply to CD to a certain extent. | Gert De Hertogh Jeroen Aerssens Karen P Geboes Karel Geboes | 2008 | World Journal of Gastroenterology2008，14，6： | 11 |
| 8 | A great thermal divergence in the mantle beginning 2.5 Ga:Geochemical constraints from greenstone basalts and komatiites显示文摘Greenstone basalts and komatiites provide a means to track both mantle composition and magma generation temperature with time.Four types of mantle are characterized from incompatible element distributions in basalts and komatiites:depleted,hydrated,enriched and mantle from which komatiites are derived.Our most important observation is the recognition for the first time of what we refer to as a Great Thermal Divergence within the mantle beginning near the end of the Archean,which we ascribe to thermal and convective evolution.Prior to 2.5 Ga,depleted and enriched mantle have indistinguishable thermal histories,whereas at 2.5-2.0 Ga a divergence in mantle magma generation temperature begins between these two types of mantle.Major and incompatible element distributions and calculated magma generation temperatures suggest that Archean enriched mantle did not come from mantle plumes,but was part of an undifferentiated or well-mixed mantle similar in composition to calculated primitive mantle.During this time,however,high-temperature mantle plumes from dominantly depleted sources gave rise to komatiites and associated basalts.Recycling of oceanic crust into the deep mantle after the Archean may have contributed to enrichment of Ti,Al,Ca and Na in basalts derived from enriched mantle sources.After 2.5 Ga,increases in Mg~# in basalts from depleted mantle and decreases in Fe and Mn reflect some combination of growing depletion and cooling of depleted mantle with time.A delay in cooling of depleted mantle until after the Archean probably reflects a combination of greater radiogenic heat sources in the Archean mantle and the propagation of plate tectonics after 3 Ga. | Kent C.Condie Richard C.Aster Jeroen van Hunen | 2016 | Geoscience Frontiers2016，7，4： | 11 |
| 9 | 系统综述与网状Meta分析的PRISMA扩展声明显示文摘PRISMA声明旨在提高系统综述和META分析报告的完整性,该声明已经广泛用于指导系统综述和META分析的报告和发表。原始的PRISMA声明是针对两种干预措施比较的传统的系统综述与META分析而制定的,然而,随着多种干预措施比较的系统综述的发展,实施和报告这一类系统综述面临较大挑战。此时,针对网状META分析的PRISMA扩展声明应运而生,旨在提高网状META分析系统综述的报告质量。PRISMA扩展声明是由专家们通过DELPHI调查、面对面讨论和共识大会而最终确立的。PRISMA扩展声明是在原始PRISMA声明的报告清单的基础上经过修改,最终确定了32个条目,每个条目均与网状META分析报告的内容直接相关。本文对网状META分析的PRISMA扩展声明进行了阐述,对报告清单各条目进行了举例说明,并详细说明了在原始PRISMA声明的基础上新增和修改各条目的理由。此外,PRISMA扩展声明强调了在网状META分析的实际操作中需要重点关注的信息。本文的目标读者包括网状META分析的作者与读者,以及期刊杂志的编辑与同行评审。 | 李志霞 杨俊 叶欣 周凌波 杨智荣 孙凤 詹思延 Brian Hutton Georgia Salanti Deborah M.Caldwell Anna Chaimani Christopher H.Schmid Chris Cameron John P.A.Ioannidis Sharon Straus Kristian Thorlund Jeroen P.Jansen Cynthia Mulrow Ferrán Catalá-López Peter C.Gozsche Kay Dickersin Isabelle Boutron Douglas G.Altman David Moher | 2016 | 中国循证心血管医学杂志2016，8，6： | 11 |
| 10 | 基于业绩表现:系统设计复杂学习的十大步骤显示文摘复杂学习任务理论把人的业绩表现置于中心位置。这些理论首先对预期业绩表现加以分析,强调整体性业绩表现目标的重要性。具体来说,复杂技能要求把重复性技能(又称“常规性”技能,即不随情况而变化的技能)与非重复性技能(如以知识为基础的问题解决与推理,即是随情形而变化的技能)加以协调组合。因此,没有必要严格区分陈述性知识学习与程序性知识学习,因为两者都是复杂学习任务的有效组成部分。复杂学习任务理论明确以改进业绩表现为宗旨,对单纯的记忆和知识构建不感兴趣。相反,它们注重的是如何应用这些知识解决实际生活中所遇到问题的能力。 | Jeroen J.G.van Merriěnboer Marcel B.M.de Crook 程景利 | 2003 | 远程教育杂志2003，21，6： | 10 |
| 11 | 纳米药物的风险及控制显示文摘纳米技术在药学领域的应用表现为药物的靶向传递和纳米级粒子药物。纳米药物的风险表现为对人健康的风险和对环境损害的风险。应对纳米药物带来的风险和伦理问题,需要创建风险评估标准;维护人的知情权和自主权;遵守自然规律,严格规范生产设计;强化政策导向、监督管理和法律保障。 | 赵迎欢 Jeroen Vanden Hoven | 2010 | 医学与哲学(A)2010，31，7： | 10 |
| 12 | Connect & Drive:design and evaluation of cooperative adaptive cruise control for congestion reduction显示文摘Road throughput can be increased by driving at small inter-vehicle time gaps.The amplification of velocity disturbances in upstream direction,however,poses limitations to the minimum feasible time gap.This effect is covered by the notion of string stability.String-stable behavior is thus considered an essential requirement for the design of automatic distance control systems,which are needed to allow for safe driving at time gaps well below 1 s.Using wireless inter-vehicle communications to provide real-time information of the preceding vehicle,in addition to the information obtained by common Adaptive Cruise Control(ACC) sensors,appears to significantly decrease the feasible time gap,which is shown by practical experiments with a test fleet consisting of six passenger vehicles.The large-scale deployment of this system,known as Cooperative ACC(CACC),however,poses challenges with respect to the reliability of the wireless communication system.A solution for this scalability problem can be found in decreasing the transmission power and/or beaconing rate,or adapting the communications protocol.Although the main CACC objective is to increase road throughput,the first commercial application of CACC is foreseen to be in truck platooning,since short distance following is expected to yield significant fuel savings in this case. | Jeroen PLOEG Alex F.A.SERRARENS Geert J.HEIJENK | 2011 | Journal of Modern Transportation2011，19，3： | 9 |
| 13 | Acute necrotizing pancreatitis as fi rst manifestation of primary hyperparathyroidism显示文摘We report the case of a female patient with severe acute necrotizing pancreatitis associated with hypercalcemia as first manifestation of primary hyperparathyroidism caused by a benign parathyroid adenoma.Initially the acute pancreatitis was treated conservatively.The patient subsequently underwent surgical resection of the parathyroid adenoma and surgical clearance of a large infected pancreatic pseudocyst.Although the association of parathyroid adenoma-induced hypercalcemia and acute pancreatitis is a known medical entity,it is very uncommon.The pathophysiology of hypercalcemia-induced acute pancreatitis is therefore not well known,although some mechanisms have been proposed.It is important to treat the provoking factor.Therefore,the cause of hypercalcemia should be identif ied early.Surgical resection of the parathyroid adenoma is the ultimate therapy. | Jeroen I Lenz Jimmy M Jacobs Bart Op de Beeck Ivan A Huyghe Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，23： | 9 |
| 14 | Sensory innervation around immediately vs. delayed loaded implants: a pilot study显示文摘Although neurophysiological and psychophysical proof of osseoperception is accumulating, histomorphometric evidence for the neural mechanisms of functional compensation following immediate and delayed implant loading is still lacking. For this randomized split-mouth study, six mongrel dogs randomly received one of four treatment protocols at 36 implant-recipient sites over 16 weeks(third maxillary incisor, third and fourth mandibular premolar): immediate implant placement and immediate loading(IIP1IL);delayed implant placement and delayed loading(DIP1DL); delayed implant placement and immediate loading(DIP1IL); and natural extraction socket healing(control). Histomorphometry was performed in the peri-implant bone and soft tissues within 300 mm around the implants. Immunocytochemistry and transmission electron microscopy were used to confirm the presence of neural structures and to reveal their ultrastructural characteristics, respectively. Myelinated nerve fibres densely populated the peri-implant crestal gingival and apical regions, although they were also identified in the woven bone and in the osteons near the implant threads. Compared with the control group in the mandible, the group that received IIP1 IL showed a higher innervation(in Nmm22, 5.9461.12 vs. 3.1560.63,P,0.001) and smaller fibre diameter(in mm, 1.3760.05 vs. 1.6460.13, P50.016), smaller axon diameter(in mm, 0.8960.05 vs.1.2460.10, P50.009) and g-ratio(0.6460.04 vs. 0.7660.05, P,0.001) in the middle region around the implants. Compared with DIP1 IL in the mandible, IIP1 IL had a higher nerve density(in Nmm22, 13.2362.54 vs. 9.6461.86, P50.027), greater fibre diameter(in mm, 1.3260.02 vs. 1.2060.04, P50.021), greater axon diameter(in mm, 0.9260.01 vs. 0.8960.03, P50.035) and lower g-ratio(0.6960.01 vs. 0.7460.01, P50.033) in the apical region around the implants. It may be assumed that the treatment protocol with IIP1 IL is the preferred method to allow optimized peri-implant re-innervation, but further functional measurements are still required. | Yan Huang Jeroen van Dessel Wendy Martens Ivo Lambrichts Wei-Jian Zhong Guo-Wu Ma Dan Lin Xin Liang Reinhilde Jacobs | 2015 | International Journal of Oral Science2015，7，1： | 7 |
| 15 | Validation of a novel imaging approach using multi-slice CT and cone-beam CT to follow-up on condylar remodeling after bimaxillary surgery显示文摘The main goal of this study was to introduce a novel three-dimensional procedure to objectively quantify both inner and outer condylar remodelling on preoperative multi-slice computed tomography(MSCT) and postoperative cone-beam computed tomography(CBCT) images. Second, the reliability and accuracy of this condylar volume quantification method was assessed. The mandibles of 20 patients(11 female and 9 male) who underwent bimaxillary surgery were semi-automatically extracted from MSCT/CBCT scans and rendered in 3D. The resulting condyles were spatially matched by using an anatomical landmark-based registration procedure.A standardized sphere was created around each condyle, and the condylar bone volume within this selected region of interest was automatically calculated. To investigate the reproducibility of the method, inter-and intra-observer reliability was calculated for assessments made by two experienced radiologists twice five months apart in a set of ten randomly selected patients. To test the accuracy of the bone segmentation, the inner and outer bone structures of one dry mandible, scanned according to the clinical set-up, were compared with the gold standard, micro-CT. Thirty-eight condyles showed a significant(P<0.05) mean bone volume decrease of 26.4% ± 11.4%(502.9 mm^3± 268.1 mm^3). No significant effects of side, sex or age were found. Good to excellent(ICC>0.6) intra-and inter-observer reliability was observed for both MSCT and CBCT. Moreover, the bone segmentation accuracy was less than one voxel(0.4 mm) for MSCT(0.3 mm ± 0.2 mm) and CBCT(0.4 mm ± 0.3 mm), thus indicating the clinical potential of this method for objective follow-up in pathological condylar resorption. | laura ferreira pinheiro nicolielo jeroen van dessel eman shaheen carolina letelier marina codari constantinus politis ivo lambrichts reinhilde jacobs | 2017 | International Journal of Oral Science2017，9，3： | 7 |
| 16 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 17 | Spectral-Element andAdjointMethods in Seismology显示文摘We provide an introduction to the use of the spectral-elementmethod (SEM)in seismology. Following a brief review of the basic equations that govern seismicwave propagation, we discuss in some detail how these equations may be solved numericallybased upon the SEM to address the forward problem in seismology. Examplesof synthetic seismograms calculated based upon the SEM are compared to datarecorded by the Global Seismographic Network. Finally, we discuss the challenge ofusing the remaining differences between the data and the synthetic seismograms toconstrain better Earth models and source descriptions. This leads naturally to adjointmethods, which provide a practical approach to this formidable computational challengeand enables seismologists to tackle the inverse problem. | Jeroen Tromp Dimitri Komatitsch Qinya Liu | 2008 | Communications in Computational Physics2008，3，1： | 5 |
| 18 | 迈向完整、准确的诊断准确性研究报告:STARD计划显示文摘背景要理解诊断准确性研究的结果,读者必须了解其设计、实施、分析及结果。这只能通过作者完全公开研究资料才能实现。目的提高诊断准确性研究报告的准确性和完整性,以便读者评估研究的偏倚可能性及推广性。方法诊断准确性研究报告标准(STARD)指导委员会通过文献检索,找出正确实施和报告的诊断性试验,并提取可能有用的条目形成一份泛表。再由研究人员、编辑及相关专业组织成员在为期两天的共识会议中对这份泛表进行缩减,以制定出一份诊断准确性研究的清单和通用流程图。结果检索已发表的诊断性研究指南,共找到33份清单,从中提取出75项可能有用的条目。根据当前可得的所有提示偏倚的证据,将之缩减至25项条目。制定出的典型流程图提供了招募患者的方法、执行“诊断措施”的顺序及接受试验诊断措施或/和金标准诊断措施的患者人数等信息。结论判断研究的价值有赖于完整、准确的报告。若医学期刊采用此清单和流程图,诊断准确性研究报告的质量将会有所提高,更好地服务于临床医生、研究人员、评价者、期刊及公众。 | Patrick M.Bossuyt Johannes B.Reitsma David E.Bruns Constantine A.Gatsonis Paul P.Glasziou Les M.Irwig Jeroen G.Lijmer David Moher Drummond Rennie Henrica C.W.de Vet the STARD Group 刁骧 秦莉 姚巡 | 2006 | 中国循证医学杂志2006，6，7： | 5 |
| 19 | Numerical study of hydrodynamic mechanism of dynamic tidal power显示文摘Dynamic tidal power is a new way of capturing tidal energy by building a water head using a dike perpendicular to the coast. This study explored the hydrodynamic mechanism of the water head across an intended dynamic tidal power dike system using the Delft3 D-FLOW software module. The propagating wave was simulated in a rectangular domain with a horizontal sea bottom at a 30-m depth. A significant water head was created across the dike by blocking the water. The water head increased with increasing dike length and increasing undisturbed tidal current acceleration. The maximum water head for the dike with a length of 50 km, located 900 km from the western boundary, was 2.15 m,which exceeded the undisturbed tidal range. The time series of the water head behaved in a manner identical to the undisturbed tidal current acceleration. The distribution of the water head over the dike assumed an elliptical shape. A parasitic wave was generated at the attachment and scattered outward. The phase lag across the dike did not behave as a linear function of the detour distance. | Peng Dai Ji-sheng Zhang Jin-hai Zheng Kees Hulsbergen Gijs van Banning Jeroen Adema Zi-xuan Tang | 2018 | Water Science and Engineering2018，11，3： | 5 |
| 20 | Cognitive Architecture and Instructional Design显示文摘 | John Sweller Jeroen J. G. van Merrienboer Fred G. W. C. Paas | 1998 | Educational Psychology Review1998，，3： | 4 |
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