5篇
您的检索式：作者名="Jenny Zhan"
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| 1 | An in-vitro cocktail assay for assessing compound-mediated inhibition of six major cytochrome P450 enzymes显示文摘An efficient screening assay was developed and validated for simultaneous assessment of compound-mediated inhibition of six major human cytochrome P450(CYP) enzymes.This method employed a cocktail of six probe substrates(i.e.,phenacetin.amodiaquine.diclofenac,S-mephenytoin,dextromethorphan and midazolam for CYP1A2,2C8.2C9,2C19,2D6 and 3A4.respectively) as well as individual prototypical inhibitors of the six CYP enzymes in human liver microsomes under optimized incubation conditions.The corresponding marker metabolites(i.e.,acetaminophen,N-deselhylamodiaquine,4-OH-diclofenac.4-OH-Smephenytoin,dextrorphan and 1-OH-midazolam) in the incubates were quantified using LC-MS/MS methods either by an internal standaid(IS) calibration curve or a simplified analyte-to-IS peak area ratio approach.The results showed that the IC_(50) values determined by the cocktail approach were in good agreement with those obtained by the individual substrate approach as well as those reported in the literature.Besides,no remarkable difference was observed between the two quantification approaches.In conclusion,this new cocktail assay can be used for reliable screening of compound-mediated CYP inhibition. | Jing-Jing Wang Jian-Jun Guo Jenny Zhan Hai-Zhi Bu Jiunn H.Lin | 2014 | Journal of Pharmaceutical Analysis2014，4，4： | 6 |
| 2 | Willingness and availability: Explaining new attitudes toward institutional elder care among Chinese elderly parents and their adult children显示文摘 | Heying Jenny Zhan Guangya Liu Xinping Guan | 2006 | Journal of Aging Studies2006，，3： | 1 |
| 3 | Willingness and availability Explaining new attitudes toward institutional elder care among Chinese elderly parents and their adult children显示文摘 | Heying Jenny Zhan Guangya Liu Xinping Guan | 2006 | Journal of Aging Studies2006，，20： | 1 |
| 4 | Willingness and availability: Explaining new attitudes toward institutional elder care among Chinese elderly parents and their adult children显示文摘 | Heying Jenny Zhan Guangya Liu Xinping Guan | 2006 | Journal of Aging Studies2006，，3： | 1 |
| 5 | 品牌老化得掉渣,你以为做个H5就能捕获年轻人了?显示文摘1.品牌知名度高。人家连听都没听说过这个品牌,何谈老化?因此那些年代久远、但只在少数区域有认知的品牌不在讨论的范围内。2.销量多年停滞不前。这会是品牌老化最明显的表现。3.新的主力消费人群对该品牌缺乏认识。当年的可口可乐,NewBalance等国际品牌都经历过这个阶段。 | Jenny Zhan | 2017 | 销售与市场2017，0，6： | 0 |
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