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55篇 您的检索式:作者名="Janni M"
    题名 作者 年代 出处 被引量
1Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang 2014Cell Research2014,24,2:244
2FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang 2014Cell Research2014,24,12:109
3Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination显示文摘DNA 双海滨裂缝(DSB ) 是高度细胞毒素的损害并且如果,形成主要威胁到染色体稳定性不适当地修理了。我们和其它以前证明了导致 DSB 的小 RNA (diRNAs ) 的一个班在 DSB 地点附近从序列被生产。DiRNAs 与 Argonaute 被联系(以前) 蛋白质和戏在 DSB 修理的一个重要角色,不过,他们通过行动的机制仍然保持不清楚。这里,我们报导在 DSB 修理的 diRNAs 的角色被限制由相应再结合(HR ) 修理并且它明确地在哺乳动物的房间依靠受动器蛋白质 Ago2。有趣地,我们证明 Ago2 与 Rad51 形成建筑群并且相互作用在与电离对待的房间被提高放射。我们证明在 DSB 地点和 HR 修理的 Rad51 累积取决于催化活动和 Ago2 的小 RNA 有约束力的能力。相反,象装载的 RPA 和 Mre11 一样的 DSB 切除术由 Ago2 或 Dicer 弄空是未受影响的,建议 Ago2 很多半在调停直接工作在 DSB 的 Rad51 累积。一起拿,我们的调查结果建议由 diRNAs 指导了那, Ago2 能在 DSB 支持 Rad51 招募或保留由 HR 便于修理。Min Gao Wei Wei Ming-Ming Li Yong-Sheng Wu Zhaoqing Ba Kang-Xuan Jin Miao-Miao Li You-Qi Liao Samir Adhikari Zechen Chong Ting Zhang Cai-Xia Guo Tie-shah Tang Bing-Tao Zhu Xing-Zhi Xu Niels Mailand Yun-Gui Yang Yijun Qi Jannie M Rendtlew Danielsen 2014Cell Research2014,24,5:3
4Antiemetic effect of subhypnotic doses of propofol after thyroidectomy 显示文摘Ewalenko P Janny S Dejonckheere M 1996Br J Anaesth1996,77,4:1
5Environmental characteristics and bacterial counts in bedding and milk bulk tank of low-profile cross-ventilated, naturally ventilated, and compost bedded pack dairy barns显示文摘Lobeck K M Endres M I Janni K A 2011Applied Engineering in Agriculture2011,28,1:1
6Hepsin promotes pros-tate cancer progression andmetastasis显示文摘Olga K John C Janni M 0,,15:1
7Low grade supratentorial astrocytomas: Management and prognostic factors 显示文摘 Cure H Mohr M 1994Cancer1994,73,7:1
8Environmental characteristics and bacterial counts in bedding and milk bulk tank of lowprofile cross-ventilated,naturally ventilated,and compost bedded pack dairy barns显示文摘Lobeck K M Endres M I Janni K A 2012Applied Engineering in Agriculture2012,28,1:1
9Cytotoxic T Lymphocyte Antigen–4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis显示文摘Nicole M. F. Gerven Ynto S. Boer Antonie Zwiers Bart Hoek Karel J. Erpecum Ulrich Beuers Henk R. Buuren Joost P. H. Drenth Jannie W. den Ouden Robert C. Verdonk Ger H. Koek Johannes T. Brouwer Maureen M. J. Guichelaar Jan M. Vrolijk G. Kraal Chris J. J. M 2013Liver Int2013,,7:1
10Appliaction of an electron-ic nose system for prediction of sensory quality changes of a meat product during storage显示文摘Jannie S Martens M Turkki P 0,,:1
11Increasing the amylose content of durum wheat through silencing of the SBEIIa genes显示文摘Sestili F Janni M Doherty A E 0,,01:1
12Increasing the amylose content of durum wheat through silencing of the SBEIIa genes 显示文摘Sestili F Janni M Doherty A 2010BMC Plant Biology2010,10,:1
13Muhicentric and mu|tifocal versus unifocal breast cancer: is the tumor-node-metasta- sis classification justified 显示文摘Weissenbacher TM Zschage M Janni W 2010Breast Cancer Res Treat2010,122,1:1
14Airborne transmission of Actinobacillus pleuropneumoniae and porcine reproductive and respiratory syndrome virus in nursery pigs 显示文摘TORREMORELL M PIJOAN C JANNI K 1997Am J Vet Res1997,58,:1
15Circular dichroism a powerful tool for the assessment of absolute configuration of flavonoids 显示文摘DESMOND S DANEEL F JANNIE P J M 2005Phytochenistry2005,66,:1
16Inventory lot sizing with supplier selection 显示文摘Chuda Basnet Janny M Y Leung 2005computers & operations research2005,32,:1
17Low grade supratentorial strocytomas 显示文摘Janny R Cure H Mohr M 1994Cancer1994,73,1:1
18Inventory lot-sizing with supplier selection显示文摘Chuda B Janny M Y L 2005Computers & Operations Research2005,,32:1
19Antiemetic effect of subhypnotic doses of propofol after thy- roidectomy显示文摘EWALENKO P JANNY S DEJONCKHEERE M 1996Br J Anesth1996,77,4:1
20The utility of polyglactin-910 mesh in the plastic reconstruction of the chest wall after en-bloc resection显示文摘Janni A Lucchi M Melfi F 1996Eur J Surg Oncol1996,22,:1
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