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| 1 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 2 | Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUS-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUS-FNA materials DNA, mRNA and miRNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. Similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion(S100P, S100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUS-FNA materials. | Barbara Bournet Marion Gayral Jérme Torrisani Janick Selves Pierre Cordelier Louis Buscail | 2014 | World Journal of Gastroenterology2014，20，31： | 3 |
| 3 | Fruit breeding in the 21st century显示文摘 | JANICK J | 1978 | Acta Hort1978，490，： | 2 |
| 4 | Breeding apples for scab resistance显示文摘 | Crosby J A Janick J Pecknold P C | 1992 | FruitVar1992，46，3： | 1 |
| 5 | Assessment of axilary lymph node involvement in breast cancer patients with postron emission tomography using radiolabeled 2-(Fluorine-18) -fluoro -2 -deoxy-D-glucose显示文摘 | AVRIL N DOSE J JANICKe F | 1996 | J Natl Cancer Inst1996，88，： | 1 |
| 6 | 'Velvet Rose' Pelargonium, ascented geranium 显示文摘 | SKIRVIN R M JANICK J | 1976 | Hort Science1976，，11： | 1 |
| 7 | Computer traeing of Pedigrees显示文摘 | Bell R L Janick J | 1980 | Hort Science1980，15，3： | 1 |
| 8 | The role of cell wall hydrolases in fruit softening显示文摘 | Janick J Huber D J | 1983 | Horticultural Reviews1983，5，： | 1 |
| 9 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 10 | Production and detection of artemisinin form Artemisia annua显示文摘 | Ferreira J F S Janick J | 1995 | Acta Hort1995，390，： | 1 |
| 11 | The apple in Java显示文摘 | Janick J | 1974 | Hortscience1974，，1： | 1 |
| 12 | Experimental Modification of Plant Senescence 显示文摘 | Leopold A C Niedergang-Kamien E Janick J | 1959 | Plant Physiology1959，34，5： | 1 |
| 13 | Loquat: botany and horticulture显示文摘 | LIN S SHARPER H JANICK J | 1999 | Hort Rev1999，23，： | 1 |
| 14 | ABA and polyox-encapsulation or high humidity increases survial of desictated somatic embryos of celery显示文摘 | Janick J | 1989 | Hort Science1989，24，4： | 1 |
| 15 | Tissue culture-induced variation in scented pelargonium SPP显示文摘 | Skirvin R M Janick J | 1976 | Journal of American Society for Horticultural Science1976，101，： | 1 |
| 16 | Regulation of apple shoot proliferation on and growth in vitro显示文摘 | LUNDERGAN C A JANICK J | 1980 | HorticRes1980，20，1： | 1 |
| 17 | Metabolic characterization of breast tumors with positron emission tomography using F-18 fluorodexyglucose显示文摘 | Avril N Dose J Janicke F | 1996 | J Clin Oncol1996，14，6： | 1 |
| 18 | Relationship of artemisinin content of tissue-cultured, greenhouse-grown and field-grown plants of Artemisia annua显示文摘 | Ferreira J F Simon J E Janick J | 1995 | Planta Med1995，61，： | 1 |
| 19 | Developmental studies of Artemisia annual, flowering and artemisinin production under green house and field condition 显示文摘 | Ferreira J F S Simon J E Janick J | 1995 | Planta Med1995，61，： | 1 |
| 20 | Somatic embryogenesis in carnation显示文摘 | Frey L Saranga Y Janick J | 1992 | Hort Sci1992，27，： | 1 |
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