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| 1 | Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors显示文摘The International Committee of Medical Journal Editors (ICMJE) believes that there is an ethical obligation to responsibly share data generated by interventional clinical trials because participants have put themselves at risk.In a growing consensus,many funders around the world-foundations,government agencies,and industry-now mandate data sharing.Here,we outline ICMJE's proposed requirements to help meet this obligation.We encourage feedback on the proposed requirements.Anyone can provide feedback at www.icmje.org by April 18,2016. | Darren B Taichman Joyce Backus Christopher Baethge Howard Bauchner Peter W de Leeuw Jeffrey M Drazen John Fletcher Frank Frizelle Irish Groves Abraham Haileamlak Astrid James Christine Laine Larry Peiperl Anja Pinborg Peush Sahni Si-Nan Wu | 2016 | Chinese Medical Journal2016，，2： | 20 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | 临床试验数据共享声明国际医学期刊编辑委员会统一要求显示文摘国际医学期刊编辑委员会(ICMJE)认为,由于临床试验参与者处于研究风险之中,我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月,ICMJE发表了1项关于临床试验数据共享的提案,旨在帮助创造共享去标识个体患者数据的常态化环境。迄今,应我们的反馈要求,ICMJE收到了很多来自个人和团体的意见。 | Darren B Taichman Peush Sahni Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Deutsches Arzteblatt Joyce Backus 季媛媛 | 2017 | 英国医学杂志中文版2017，20，7： | 2 |
| 4 | 临床试验数据共享声明显示文摘国际医学期刊编辑委员会(ICMJE)认为,由于临床试验参与者处于研究风险之中,我们有伦理义务来负责任地共享干预性临床试验产生的原始数据。2016年1月,ICMJE发表了一项关于临床试验数据共享的提案,旨在帮助创造共享去标识个体患者数据的常态化环境。 | Darren B Taichman Peush Sahni Anja Pinborg Larry Peiperl Christine Laine Astrid James Sung-Tae Hong Abraham Haileamlak Laragh Gollogly Fiona Godlee Frank A Frizelle Fernando Florenzano Jeffrey M Drazen Howard Bauchner Christopher Baethge Joyce Backus 季媛媛 | 2017 | 中国医院院长2017，13，16： | 2 |
| 5 | Portable ultrasonography in mass casualty incidents:The CAVEAT examination显示文摘Ultrasonography used by practicing clinicians has been shown to be of utility in the evaluation of time-sensitive and critical illnesses in a range of environments,including pre-hospital triage,emergency department,and critical care settings.The increasing availability of lightweight,robust,user-friendly,and low-cost portable ultrasound equipment is particularly suited for use in the physically and temporally challenging environment of a multiple casualty incident(MCI).Currently established ultrasound applications used to identify potentially lethal thoracic or abdominal conditions offer a base upon which rapid,focused protocols using hand-carried emergency ultrasonography could be developed.Following a detailed review of the current use of portable ultrasonography in military and civilian MCI settings,we propose a protocol for sonographic evaluation of the chest,abdomen,vena cava,and extremities for acute triage.The protocol is two-tiered,based on the urgency and technical difficulty of the sonographic examination.In addition to utilization of well-established bedside abdominal and thoracic sonography applications,this protocol incorporates extremity assessment for long-bone fractures.Studies of the proposed protocol will need to be conducted to determine its utility in simulated and actual MCI settings. | Stanislaw Peter Stawicki James M Howard John P Pryor David P Bahner Melissa L Whitmill Anthony J Dean | 2010 | World Journal of Orthopedics2010，1，1： | 1 |
| 6 | Nutrient recovery from swine lagoon water by Spirodela punctata显示文摘 | Jiayang Cheng Ben A Bergmann John J Classen Anne M Stomp James W Howard | 2001 | Bioresource Technology2001，，1： | 1 |
| 7 | Study of strap-down navigation attitude algorithms 显示文摘 | Howard M James H M | 1995 | Journal of Guidance Control and Dynamics1995，18，2： | 1 |
| 8 | The cortical ischemic core and not the consistently present penumbra is a determinant of clinical outcome in acute middle cerebral artery occlusion显示文摘 | Tudor G Howard Y James M | 2003 | Stroke2003，34，： | 1 |
| 9 | Advances in monolithic ferroelectric uncooled IRFPA technology显示文摘 | Charles M Hanson Howard R Beratan James F Belcher | 1998 | SPIE1998，3379，： | 1 |
| 10 | Uncooled m-onolithic ferroelectric IRFPA tectmology显示文摘 | James F Beicher Charles M Hanson Howard R Beratan | 1998 | SPIE1998，3436，： | 1 |
| 11 | The cortical ischemic core and not the consistently present penumbra is a determinant of clinical outcome in acute middle cerebral artery occlusion显示文摘 | Tudor G Howard Y James M | 2003 | Stroke2003，34，10： | 1 |
| 12 | Vitamintherapy in IgA Nephropathy:A double-blind,placebo-study显示文摘 | James C M Chan John D Mahan Howard Trachoma | 2003 | Pediatr Nephrol2003，18，： | 1 |
| 13 | Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer显示文摘 | Atnit MAlgotar M Suzanne Stmtton Frederick R Ahmann James Ranger- Moore iqaytltond B Nagle Patrieia A Thompson Elizabeth Slate Chiu i4 Hsu Be L Dalkin Puneet Sindhwani Michael A Holmes John A Tuckey lt/td L Graham Howard L Parnes Lawrence C Clark Steven P Stratton | 2013 | The Prostate2013，73，3： | 1 |
| 14 | Sim- ple and rapid docetaxel assay in plasma by protein pre- cipitation and high-performance liquid chromatography- tandem mass spectrometry显示文摘 | HOU Wei-ying JAMES W W HOWARD L M | 2004 | J Chromatogr B2004，804，2： | 1 |
| 15 | Zebrafish as a cancer model system Cancer Cell显示文摘 | James F Amatruda Jennifer L Shepard Howard M Stern | | 0，，： | 1 |
| 16 | 1,3-二氧环辛烷-2-羧酸类三环化合物的合成及其除草活性显示文摘12H-Dibenzo d,g 1,3 dioxocin-6-carboxylic acid is a patented herbicide (US4976770)With good pre-and post-emergence activity on dicot weeds and sedges. Structure activity studies were initiated with the goal of discovering more synthetically accessible analogs with improved unit activity and crop-weed selectivity.An improved procedure to prepare the lead compound was developed.Analogs were prepared in which both the tricyclic core and the carboxylic acid function were varied.The synthesis and screening results of these analogs will be presented. | 李斌 满瀛 张宗俭 Colin M Tice Lori A.Spangler James Gallagher Lois M. Bryman Howard C. Smith Manuel V. Nunez | 2000 | 浙江化工2000，31，C00： | 1 |
| 17 | From Bars to Valleys:The Sedimen-tology and Seismic Geomorphology of Fluvial to Estuarine Incised-Valley Fills of the Grand Rapids Formation (Lower Cretaceous),Iron River Field,Alberta,Canada显示文摘 | James R M Howard R F Robert A | 2010 | Journal of Sedimentary Research2010，80，7： | 1 |
| 18 | Demand uncertainty and returns policies 显示文摘 | Howard P M James P | 1995 | International Economic Review1995，36，3： | 1 |
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