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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Optimization of the dispersion of gold and platinum nanoparticles on indium tin oxide for the electrocatalytic oxidation of cysteine and arsenite显示文摘 | Diep Vu Ca Sun Laisheng James A Cox | 2006 | Electrochim Acta2006，51，11： | 1 |
| 3 | Differential regulation of secretory compartments containingthe insulin -responsive glucose transporter 4 in 3T3 -LIadipocytes显示文摘 | Millar CA Shewan A Hickson GR James DE Gould GW | 1999 | Mol Biol Cell1999，10，11： | 1 |
| 4 | Early diagnosis of right ventrieular or posterior infarction associated with anterior wall left ventricular acute myocardial infarction显示文摘 | Lan BAM James A John Mc CA | 2000 | Am J Cardiol2000，85，8： | 1 |
| 5 | Alterations in gene regulation following inhibition of the striatum-enriehed phosphodiesterase, PDE10A显示文摘 | Strick CA James LC Fox CB | 2010 | Neuropharmaeology2010，58，2： | 1 |
| 6 | Congenital nonprogressive hemang ioma:a distinct clinicopathoiogic entity unlike infantile hemangioma显示文摘 | North PE Waner M James CA | 2001 | Arch Dermatol2001，137，： | 1 |
| 7 | Bronchial artery embolization experience with 54 patients显示文摘 | Karen LS Udaya BP James CA | | 0，，： | 1 |
| 8 | Thromboembolism in pregnancy:recurrence and its prevention显示文摘 | James AH Grotegut CA Brancazio LR | | 0，，03： | 1 |
| 9 | Procedural elements involved in maintaining bioanalytical data integrity for good laboratory practices studies and regulated clinical studies显示文摘 | JAMES CA HILL HM | 2007 | AAPS J2007，9，2： | 1 |
| 10 | Diagnosis and management of pediatric cervicofacial venous malformations: retrospective review from a vascular anomalies center 显示文摘 | Glade RS Richter GT James CA | 2010 | Laryngoscope2010，120，2： | 1 |
| 11 | Social anxiety and HIV transmission risk among HIV-seropositive male patients显示文摘 | Hart TA James CA Purcell DW | 2008 | AIDS Patient Care STDS2008，22，11： | 1 |
| 12 | Reconversion of bone marrow in Gaucher disease treated with enzyme therapy documented by MR显示文摘 | Allison JW James CA Amold GL | 1998 | Pediatr Radiol1998，28，4： | 1 |
| 13 | The N-terminal pro-BNP investi- gation of dyspnea in the emergency department(PRIDE) study 显示文摘 | James L Januzzi Jr Camargo CA | 2005 | AM J Cardiol2005，95，： | 1 |
| 14 | Ophthalmologic disease in children显示文摘 | Adler IN James CA Glasier CM | 2001 | Magn Reson Imaging Clin N Am2001，9，1： | 1 |
| 15 | Diagnosis and management of pediatric cervicofacial venous malformations: retrospective review from a vascular anomalies center 显示文摘 | Glade RS Richter GT James CA | 2010 | Laryngoscope2010，120，2： | 1 |
| 16 | Thromboembolism in pregnancy: recurrence and its prevention显示文摘 | James AH Grotegut CA Brancazio LR | 2007 | Semin Perinatol2007，31，： | 1 |
| 17 | Congenital nonprogressive hemangioma: a distinct clinicopathologic entity unlike infantile hemangioma显示文摘 | North PE Waner M James CA | 2001 | Arch Dermato12001，137，12： | 1 |
| 18 | Congenital heart defects and genetic variants in the methylenetetrahydroflate reductase gene显示文摘 | Hobbs CA James SJ Parsian A | 2006 | J Med Genet2006，43，： | 1 |
| 19 | Popliteal artery disease:diagnosis and treatment显示文摘 | Wright LB Matchett WJ Crtz CP James CA Culp WC Eidt JF | | 0，，： | 1 |
| 20 | Cell-matrix ad hesions differentially regulate fascin phosphorylation 显示文摘 | James DC G eorgina DM | 1999 | Mol Biol Cell1999，10，： | 1 |
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