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| 1 | Chemotherapy plus percutaneous radiofrequency ablation in patients with inoperable colorectal liver metastases显示文摘AIM:To access the efficacy of chemotherapy plus radiofrequency ablation(RFA)as one line of treatment in inoperable colorectal liver metastases.METHODS:Eligible patients were included in three PhaseⅡstudies.In the first study percutaneous RFA was used first followed by 6 cycles of 5-fluorouracil,leucovorin and irinotecan combination(FOLFIRI)(adjunctive chemotherapy trial).In the other two,chemotherapy(FOLFIRI or 5-fluorouracil,leucovorin and oxaliplatin combination)up to 12 cycles was used first with percutaneous RFA offered to responding patients (primary chemotherapy trials).RESULTS:Thirteen patients were included in the adjunctive chemotherapy trial and 17 in the other two.At inclusion they had 1-4 liver metastases(up to 6.5 cm in size).Two patients died during chemotherapy.All patients in the adjunctive chemotherapy trial and 44%in the primary chemotherapy studies had their metastases ablated.Median PFS and overall survival in the adjunctive study were 13 and 24 mo respectively while in the primary chemotherapy studies they were 10 and 21 mo respectively.Eighty one percent of the patients had tumour relapse in at least one previously ablated lesion.CONCLUSION:Chemotherapy plus RFA in patients with low volume inoperable colorectal liver metastases seems safe and relatively effective.The high local recurrence rate is of concern. | Joseph Sgouros James Cast Krishna K Garadi Maria Belechri David J Breen John RT Monson Anthony Maraveyas | 2011 | World Journal of Gastrointestinal Oncology2011，3，4： | 4 |
| 2 | Design of slender concrete columns显示文摘 | JAMES G MAC GREGOR JOHN E BREEN | 1970 | ACI Journal1970，，2： | 1 |
| 3 | Endocrine disrupting chemicals in fish: Developing exposure indicators and predictive models of effects based on mechanism of action显示文摘 | Gerald T. Ankley David C. Bencic Michael S. Breen Timothy W. Collette Rory B. Conolly Nancy D. Denslow Stephen W. Edwards Drew R. Ekman Natalia Garcia-Reyero Kathleen M. Jensen James M. Lazorchak Dalma Martinovi? David H. Miller Edward J. Perkins Edward F | 2009 | Aquatic Toxicology2009，，3： | 1 |
| 4 | Management of Renal Tumors by Image-Guided Radiofrequency Ablation: Experience in 105 Tumors显示文摘 | David J. Breen Elizabeth E. Rutherford Brian Stedman Shuvro H. Roy-Choudhury James E. I. Cast Matthew C. Hayes Christopher J. Smart | 2007 | CardioVascular and Interventional Radiology2007，，5： | 1 |
| 5 | MR imaging findings in 76 consecutive surgically proven cases of pericardial disease with CT and pathologic correlation显示文摘 | PhillipM Young James F Glockner Eric E Williamson Michael F Morris Philip A Araoz Paul R Julsrud Hartzell V SchafiF William D Edwards Jae K Oh Jerome F Breen | 2012 | The international journal of cardiovascular imaging2012，28，5： | 1 |
| 6 | Apical ballooning syndrome or aborted acute myocardial infarction? Insights from cardiovascular magnetic resonance imaging显示文摘 | Imran S. Syed Abhiram Prasad Jae K. Oh Matthew W. Martinez DaLi Feng Arashk Motiei James D. Glockner Jerome F. Breen Paul R. Julsrud | 2008 | The International Journal of Cardiovascular Imaging2008，，8： | 1 |
| 7 | Tissue and regional expression patterns of dicistronic tRNA–mRNA transcripts in grapevine (Vitis vinifera) and their evolutionary co-appearance with vasculature in land plants显示文摘Transfer RNAs(tRNA)are crucial adaptor molecules between messenger RNA(mRNA)and amino acids.Recent evidence in plants suggests that dicistronic tRNA-like structures also act as mobile signals for mRNA transcripts to move between distant tissues.Co-transcription is not a common feature in the plant nuclear genome and,in the few cases where polycistronic transcripts have been found,they include non-coding RNA species,such as small nucleolar RNAs and microRNAs.It is not known,however,the extent to which dicistronic transcripts of tRNA and mRNAs are expressed in field-grown plants,or the factors contributing to their expression.We analysed tRNA–mRNA dicistronic transcripts in the major horticultural crop grapevine(Vitis vinifera)using a novel pipeline developed to identify dicistronic transcripts from high-throughput RNA-sequencing data.We identified dicistronic tRNA–mRNA in leaf and berry samples from 22 commercial vineyards.Of the 124 tRNA genes that were expressed in both tissues,18 tRNA were expressed forming part of 19 dicistronic tRNA–mRNAs.The presence and abundance of dicistronic molecules was tissue and geographic sub-region specific.In leaves,the expression patterns of dicistronic tRNA–mRNAs significantly correlated with tRNA expression,suggesting that their transcriptional regulation might be linked.We also found evidence of syntenic genomic arrangements of tRNAs and protein-coding genes between grapevine and Arabidopsis thaliana,and widespread prevalence of dicistronic tRNA–mRNA transcripts among vascular land plants but no evidence of these transcripts in non-vascular lineages.This suggests that the appearance of plant vasculature and tRNA–mRNA occurred concurrently during the evolution of land plants. | Pastor Jullian Fabres Lakshay Anand Na Sai Stephen Pederson Fei Zheng Alexander A.Stewart Benjamin Clements Edwin R.Lampugnani James Breen Matthew Gilliham Penny Tricker Carlos M.Rodriguez Lopez Rakesh David | 2021 | Horticulture Research2021，8，1： | 0 |
| 8 | The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin显示文摘Overnutrition causes hyperactivation of mTORC1-dependent negative feedback loops leading to the downregulation of insulin signaling and development of insulin resistance.In osteoblasts(OBs),insulin signaling plays a crucial role in the control of systemic glucose homeostasis.We utilized mice with conditional deletion of Rptor to investigate how the loss of mTORC1 function in OB affects glucose metabolism under normal and overnutrition dietary states.Compared to the controls,chow-fed Rptorob−/−mice had substantially less fat mass and exhibited adipocyte hyperplasia.Remarkably,upon feeding with high-fat diet,mice with pre-and post-natal deletion of Rptor in OBs were protected from diet-induced obesity and exhibited improved glucose metabolism with lower fasting glucose and insulin levels,increased glucose tolerance and insulin sensitivity.This leanness and resistance to weight gain was not attributable to changes in food intake,physical activity or lipid absorption but instead was due to increased energy expenditure and greater whole-body substrate flexibility.RNA-seq revealed an increase in glycolysis and skeletal insulin signaling pathways,which correlated with the potentiation of insulin signaling and increased insulin-dependent glucose uptake in Rptorknockout osteoblasts.Collectively,these findings point to a critical role for the mTORC1 complex in the skeletal regulation of wholebody glucose metabolism and the skeletal development of insulin resistance. | Pawanrat Tangseefa Sally K.Martin Peck Yin Chin James Breen Chui Yan Mah Paul A.Baldock Gary A.Wittert Amanda J.Page Christopher G.Proud Stephen Fitter Andrew C.W.Zannettino | 2021 | Bone Research2021，9，1： | 0 |
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