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| 1 | Early surgery in Crohn's disease a benefit in selected cases显示文摘AIM: To compare the outcomes of a cohort of Crohn's disease(CD) patients undergoing early surgery(ES) to those undergoing initial medical therapy(IMT).METHODS: We performed a review of a prospective database CD patients managed at a single tertiary institution. Inclusion criteria were all patients with ileal or ileocolonic CD between 1995-2014. Patients with incomplete data, isolated colonic or perianal CD were excluded. Primary endpoints included the need for, and time to subsequent surgery. Secondary endpoints included the number and duration of hospital admissions, and medical therapy. RESULTS: Forty-two patients underwent ES and 115 underwent IMT. The operative intervention rate at 5 years in the ES group was 14.2% vs IMT 31.3%(HR = 0.41, 95%CI: 0.23-0.72, P = 0.041). The ES group had fewer hospital admissions per patient [median 1 vs 3(P = 0.012)] and fewer patients required anti-TNF therapy than IMT(33.3% vs 57%, P = 0.003). A subgroup analysis of 62 IMT patients who had undergone surgery were compared to ES patients, and showed similar 5 year(from index surgery) re-operation rates 16.1% vs 14.3%. In this subset, a significant difference was still found in median number of hospital admissions favouring ES, 1 vs 2(P = 0.002).CONCLUSION: Our data supports other recent studies suggesting that patients with ileocolonic CD may have a more benign disease course if undergoing early surgical intervention, with fewer admissions to hospital and atrend to reduced overall operation rates. | Vinna An Lauren Cohen Matthew Lawrence Michelle Thomas Jane Andrews James Moore | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 3 |
| 2 | A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance显示文摘 | Christopher B. Newgard Jie An James R. Bain Michael J. Muehlbauer Robert D. Stevens Lillian F. Lien Andrea M. Haqq Svati H. Shah Michelle Arlotto Cris A. Slentz James Rochon Dianne Gallup Olga Ilkayeva Brett R. Wenner William S. Yancy Howard Eisenson Gera | 2009 | Cell Metabolism2009，，4： | 2 |
| 3 | Cutting edge: novel RNA ligands able to bind CD4 antigen and inhibit CD4+ T Lymphocyte function显示文摘 | Kraus E James W Barclay AN | 1998 | J Immunol1998，160，： | 1 |
| 4 | Magneticresonance imaging of the femoral head after acute intracap-sular fracture of the femoral neck 显示文摘 | Speer KP Spritzer CE Harrelson JM James AN | 1990 | J Bone Joint SurgAm1990，72，： | 1 |
| 5 | Effect of indomethacin on gallblad- derinflammation and contractility during acute cholecysitis显示文摘 | Parkman HP James AN | 2011 | J Surg Res2011，96，： | 1 |
| 6 | Developmental and environmental regulation of two ribosomal protein genes in tobacco显示文摘 | Jianwei Gao Seong-Ryong Kim Yong-Yoon Chung James M. Lee Gynheung An | 1994 | Plant Molecular Biology1994，，5： | 1 |
| 7 | 显示文摘 | Papademetriou Vasilios Hainer James W Sugg Jennifer Factorial antihypertensive study of an extended-release metoprolol and hydrochlorothiazide combination | 2006 | American Journal of Hypertension2006，19，12： | 1 |
| 8 | Inhibitory effects of botulinum toxin on pyloric and antral smooth muscle 显示文摘 | James AN Ryan JP Parkman HP | 2003 | Am J Physiol Gastrointest Liver Physiol2003，285，2： | 1 |
| 9 | Does Multilevel Lumbar Stenosis Lead to Poorer Outcomes?: A Subanalysis of the Spine Patient Outcomes Research Trial (SPORT) Lumbar Stenosis Study显示文摘 | Daniel K. Park Howard S. An Jon D. Lurie Wenyan Zhao Anna Tosteson Tor D. Tosteson Harry Herkowitz Thomas Errico James N. Weinstein | 2010 | Spine2010，，4： | 1 |
| 10 | Kinetics and mechanism of the degradation and mineralization of acetone in dilute aqueous solution sensitize by the UV photolysis of hydrogen peroxide显示文摘 | Mihaela I Ste{an James Bolton | 1996 | Environment Science Technology1996，30，7： | 1 |
| 11 | Cutting edge:novel RNA ligands able to bind CD4 antigen and inhibit CD4+ Tlym-phocyte function显示文摘 | Kraus E James W Barclay AN | 1998 | J Imm unol1998，160，： | 1 |
| 12 | Regional gastric contractility alterations in a diabetic gastroparesis mouse modeleffects of eholinergic and serotoninergic stimulation显示文摘 | James AN Ryan JP Crowell MD | 2004 | Am J Physiol Gastrointest Liver Physiol2004，287，3： | 1 |
| 13 | Large T Antigens of Polyomaviruses: Amazing Molecular Machines显示文摘 | Ping An Maria Teresa Sáenz Robles James M. Pipas | 2012 | Annual Review of Microbiology2012，，： | 1 |
| 14 | A Randomized Controlled Trial of Follow-up of Patients Discharged From the Hospital Following Acute Asthma Best Performed by Specialist Nurse or Doctor显示文摘 | James AN Linda P Carol F | 2006 | Chest2006，130，： | 1 |
| 15 | Cutting edge:novel RNA ligands able to bind CD4 antigen and inhibit CD4^+ T lymphocyte function显示文摘 | Kraus E James W Barclay AN | 1998 | J Immunol1998，160，11： | 1 |
| 16 | Inhibitory effects of botuli-num toxin on pyloric and antral smooth muscle显示文摘 | James AN Ryan JP Parkman HP | 2003 | Am JPhysiol Gastrointest Liver Physiol2003，285，2： | 1 |
| 17 | Cloned transgenic offspring resulting from somatic cell nuclear transfer in the goat:oocytes derived from both follicle-stimulating hormonestimulated and nonstimulated abattoir-derived ovaries显示文摘 | Reggio BC James AN Green HL | 2001 | Biol Reprod2001，65，5： | 1 |
| 18 | Cercarial dermatitis transmit- ted by exotic marine snail 显示文摘 | Brant SV Cohen AN James D | 2010 | Emerg Infect Dis2010，16，9： | 1 |
| 19 | Biomechanical analysis of an interbody cage with three integrated cancellous lag screws in a two-level cervical spine fusion construct: an in vitro study 显示文摘 | Nayak AN Stein MI James CR | 2014 | Spine J2014，14，12： | 1 |
| 20 | Renal failure does not preclude cure in children receiving chemotherapy for wilms tumor: a report from the National Wilms Tumor Study Group 显示文摘 | James HF Michael LR Pat AN | 2008 | Pediatr Blood Cancer2008，50，： | 1 |
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