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| 1 | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus显示文摘AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.METHODS High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro RNAs.RESULTS Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher levels in postablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These mi RNAs were expressed at similar levels in preablation Barrett's esophagus mucosa, matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in regulating the expression of proteins that contribute to barrier function.CONCLUSION Neosquamous mucosa arising after ablation of Barrett's esophagus expresses micro RNAs that may contribute to decreased barrier function and micro RNAs that may be involved in the regulation of survival signaling pathways. | Loveena Sreedharan George C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang Jakob Kist David StJ Astill Damian J Hussey | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 2 | Detection of fecal shed- ding of rotavirus vaccine in infants following their first dose of pentavalent rotavirus vaccine 显示文摘 | YEN C JAKOB K ESONA MD | 2011 | Vaccine2011，29，24： | 1 |
| 3 | Proteasome:an emerging target for cancer therapy显示文摘 | Zavrski I Jakob C Schmid P | 2005 | Anticancer Drugs2005，16，5： | 1 |
| 4 | Loss of angiomiR - 126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: role for impaired in vivo neovascularization and cardiac repair capacity 显示文摘 | Jakob P Doerries C Briand S | 2012 | Circulation2012，126，25： | 1 |
| 5 | Alpha-aminoadipic semialdehyde is the biomarker for pyridoxine dependent epilepsy caused by alpha-aminoadipic semialdehyde dehydrogenase deficiency显示文摘 | Struys EA Jakobs C | | 0，，04： | 1 |
| 6 | Conditional disorder in chaperone action 显示文摘 | Bardwell J C Jakob U | 2012 | TrendsBiochem Sci2012，37，12： | 1 |
| 7 | Inherited disorders of GABA metabolism显示文摘 | Jakobs C Jaeken J Gibson K M | 1993 | Journal of inherited metabolic disease1993，16，4： | 1 |
| 8 | Mutations in antiquitin in individuals with pyridoxine-dependent seizures显示文摘 | Mills PB Struys E Jakobs C | | 0，，03： | 1 |
| 9 | Hyperhomocysteinemia increases risk of death,especially in type 2 diabete:5-year follow-up of the Hoorn Study显示文摘 | Hoogeveen EK Kostense PJ Jakobs C | 2000 | Circulation2000，101，13： | 1 |
| 10 | Serum levels of the angiogenic cytokines basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in multiple myeloma显示文摘 | Jakob C Eucker J | 2001 | Eur J Haematol2001，66，2： | 1 |
| 11 | 显示文摘 | Erler F Jakob C Romanus H | 2003 | Electrochimica Acta2003，48，： | 1 |
| 12 | Comparison of problem-and lecture-based pharmacology teaching显示文摘 | MICHEL M C BISCHOFF A JAKOBS K H | 2002 | Trends Pharmacol Sci2002，23，4： | 1 |
| 13 | Pancreatic endoscopic sphincteroyomy in patients with chronic pancreatitis: a single -center experience in 171 consecutive patients 显示文摘 | Jakobs R Benz C Leonhardt A | 2002 | Endoscopy2002，34，7： | 1 |
| 14 | Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure显示文摘 | Jakob P Doerries C Briand S | 2012 | Circulation2012，126，25： | 1 |
| 15 | Radiofrequency ablationin combination with osteoplastyin the treatment of painful metastaticbone disease 显示文摘 | Hoffmann RT Jakobs TF Trumm C | 2008 | J Vase Interv Radiol2008，19，3： | 1 |
| 16 | Fracture incidence and changes in quality of life in women with an inadequate clinical outcome from osteoporosis therapy : the observational study of severe osteoporosis 显示文摘 | Cooper C Jakob F Chinn C | 2008 | Osteoporos Int2008，19，4： | 1 |
| 17 | Immunocytochemistry reveals RANKL expression of myeloma cells 显示文摘 | Sezer O Heider U Jakob C | 2002 | Blood2002，99，12： | 1 |
| 18 | The threedimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism 显示文摘 | Kauppi B Jakob C Farnegardh M | 2003 | J Biol Chem2003，278，22： | 1 |
| 19 | No net renal extraction of homocysteine in fasting humans显示文摘 | van Guldener C Donker AJ Jakobs C | 1998 | Kidney Int1998，54，： | 1 |
| 20 | Morphology of the rat peritoneum after carbon dioxide and helium pneumoperitoneum: a scanning electron microscopic study 显示文摘 | Ordemann J Jakob J Braumann C | 2004 | Surg Endosc2004，18，9： | 1 |
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