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| 1 | Nutritional risk index as a predictor of postoperative wound complications after gastrectomy显示文摘AIM:To investigate the correlation between the nutritional risk index (NRI) and postoperative wound complications.METHODS:From January 2008 through June 2008,669 patients who underwent curative gastrectomy for gastric cancer were included in a retrospective study.Medical records of consecutive patients were collected and analyzed to determine postoperative wound complication rates.The NRI was assessed on the fifth postoperative day and other possible risk factors for the incidence of wound complications were analyzed to identify the factors affecting postoperative wound complications.Patients with other postoperative complications were excluded from the study.RESULTS:On the 5th postoperative day,the NRI showed a malnutrition rate of 84.6% among postoperative patients.However,postoperative wound complications occurred in only 66/669 (9.86%) patients.Of the patients with wound complications,62/66 (94%) belonged to the malnourished group (NRI < 97.5),and 4/66 (6%) patients to the non-malnourished group (NRI ≥ 97.5).The only factor correlated with wound complications was the NRI on the 5th postoperative day (odds ratio of NRI ≥ 97.5 vs NRI < 97.5:0.653;95% confidence interval:0.326-0.974;P=0.014) according to univariate analysis as well as multivariate analysis.CONCLUSION:This study suggests that malnutrition immediately after surgery may play a significant role in the development of wound complications. | Cheong Ah Oh Dae Hoon Kim Seung Jong Oh Min Gew Choi Jae Hyung Noh Tae Sung Sohn Jae Moon Bae Sung Kim | 2012 | World Journal of Gastroenterology2012，18，7： | 25 |
| 2 | Analysis on sports and recreation activity-related eye injuries presenting to the Emergency Department显示文摘AIM:To investigate the incidence and general characteristics of sports-related eye injuries in patients visiting the Emergency Department. METHODS: A cross-sectional,multi-center,observational study.Patients with an injured eye who visited the Emergency Department at one of nine hospitals in Korea were enrolled.All data were prospectively collected between March and September 2010 using a questionnaire.Eye injuries that occurred during risky sports were examined by gender and age.Additionally,the rate of open globe injuries that occurred with and without protective eyewear was examined for each activity.Continuous variables were compared using Student's t-test and categorical variables were compared using Chi-square test.RESULTS: A total of 446 patients had sports-related eye injuries.Teenagers(10-19 years old) and young adults(20-29 years old) had the most eye injuries.Eye injuries accounted for 0.2% of Emergency Department patients.Baseball was the most common cause of sports-related eye injuries,followed by soccer and hiking.Protective gear was worn by 9.4% of all patients.Patients that were 30-39 years of age had the highest rate of protective gear use,followed by patients that were 40-49 years of age.The proportion of sports-related eye injuries that were open-globe injuries was highest for soccer and hiking.CONCLUSION: Although injuries were most common in patients below the age of 10 years,these patients had the lowest rate of protective eyewear use.Injuries in adults over 40 years of age most commonly occurred during hiking,but the rate of protective eyewear use was low.Young athletes should be educated on and provided with protective eyewear and policies protective gear use should be established.For older adults,eye protection should be encouraged,especially during hiking. | Sungbae Moon Hyun Wook Ryoo Jae Yun Ahn Jung Bae Park Kang Suk Seo Sang Do Shin Kyoung Jun Song Kang Hyun Lee In Sool Yoo Jin Seong Cho Hyun Ho Ryu Tae Oh Jeong Seok Ran Yeom Young Taek Kim Sung Ok Hong | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 3 |
| 3 | Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib显示文摘Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of chemo-resistance.This study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to TKIs.We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms.The associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression analysis.Results:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI resistance.SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo.CAF-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI treatment.Conclusions:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion.Its inhibition represents a promising therapeutic strategy against TKI resistance inHCC.Moreover,plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction. | JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong | 2023 | Cancer Communications2023，43，4： | 2 |
| 4 | Changes in Postoperative Recurrence and Prognostic Risk Factors for Patients with Gastric Cancer who Underwent Curative Gastric Resection during Different Time Periods显示文摘 | Dae Hoon Kim Su Mi Kim Jung Kuk Hyun Min Gew Choi Jae Hyung Noh Tae Sung Sohn Jae Moon Bae Sung Kim | 2013 | Annals of Surgical Oncology2013，，7： | 2 |
| 5 | Pseudomyxoma Peritonei: Extraperitoneal Spread to the Pleural Cavity and Lung显示文摘 | Bae Young Lee Hyeon Sook Kim Sang Haak Lee Hwa Sik Moon Song Mee Cho Kang Hoon Lee Kyung Sub Song Ki Ouk Min Eun Joo Seo Jae Moon Lee | 2004 | Journal of Thoracic Imaging2004，，2： | 1 |
| 6 | Clinical Significance of Splenic Hilar Lymph Node Metastasis in Proximal Gastric Cancer显示文摘 | Suk Hee Shin MD Hun Jung MD Seong Hee Choi MD Ji Yeong An MD Min Gew Choi MD Jae Hyung Noh MD Tae Sung Sohn MD Jae Moon Bae MD Sung Kim MD | 2009 | Annals of Surgical Oncology2009，，5： | 1 |
| 7 | Changes of Quality of Life in Gastric Cancer Patients After Curative Resection: A Longitudinal Cohort Study in Korea显示文摘 | Ae Ran Kim Juhee Cho Yea-Jen Hsu Min Gew Choi Jae Hyung Noh Tae Sung Sohn Jae Moon Bae Young Ho Yun Sung Kim | 2012 | Annals of Surgery2012，，： | 1 |
| 8 | Sexual function and psychological characteristics ofpenile paraffinoma显示文摘Aim:To identify the sexual, emotional and psychological status of men who augmented their penis with mineral oil injection for their small penis. Methods: Men who had penile paraffin were asked to answer the semi-structured questionnaire. The questionnaire was designed to assess the motivation, method of penile injection, changes in erectile function and satisfaction after penile injection. SCL (Symptom checklist)-90-R, STAI (State and Trait Anxiety Inventory) and Zung SDS (Self-rating depression scale) were also included in the questionnaire for psycho-logical evaluation. Results: A total of 357 men completed the questionnaire. The first-ranked motivation of the injection was recommendation by their acquaintances (48.9 %). The majority of the respondents had the procedure by non-medical person (78.0 %). Before injection, 17.2 % had a sense of inferiority in their penis and 32 % worried about their weak erectile function. After injection, 33.0 % have found relief from their sense of inferiority and 17.8 % wish to feel improvement in their cr^tile function. Most of the respondents (91%) were not satisfied with their penis and 74 % of them replied that they want to remove the injected material. Only 15.6 % did not experience side effects.Most of the subjects have suffered from various side effects such as inflammation, skin necrosis, pain, etc. No evidence of psychiatric pathology was found in psychological evaluation. Conclusion: The motivations of mineral oil injection were recommendation by their acquaintances or desire to be more mannish. Most of them had suffered from various side effects and only a small number of them felt improvement in their sense of inferiority, in their penis and erectile function. Increased public awareness is needed for the prevention of this physically and psychologically debilitating problem. (Asian J Andro12003 Sep; 5:191-194 ) | Du Geon Moon Jeong Woo Yoo Jae Hyun Bae Chang Su Han Yong Ku Kim Je Jong Kim | 2003 | Asian Journal of Andrology2003，5，3： | 1 |
| 9 | Genome-Wide Analysis of DNA Methylation and the Gene Expression Change in Lung Cancer显示文摘 | Yong-Jae Kwon Seog Joo Lee Jae Soo Koh Sung Han Kim Hae Won Lee Moon Chul Kang Jae Bum Bae Young-Joon Kim Jong Ho Park | 2012 | Journal of Thoracic Oncology2012，，1： | 1 |
| 10 | Clinical Significance of Splenic Hilar Lymph Node Metastasis in Proximal Gastric Cancer显示文摘 | Suk Hee Shin MD Hun Jung MD Seong Hee Choi MD Ji Yeong An MD Min Gew Choi MD Jae Hyung Noh MD Tae Sung Sohn MD Jae Moon Bae MD Sung Kim MD | 2009 | Annals of Surgical Oncology2009，，5： | 1 |
| 11 | Clinical Significance of Splenic Hilar Lymph Node Metastasis in Proximal Gastric Cancer显示文摘 | Suk Hee Shin Hun Jung Seong Hee Choi Ji Yeong An Min Gew Choi Jae Hyung Noh Tae Sung Sohn Jae Moon Bae Sung Kim | 2009 | Annals of Surgical Oncology2009，，5： | 1 |
| 12 | CD151 Overexpression is Associated with Poor Prognosis in Patients with pT3 Gastric Cancer显示文摘 | Sang Yun Ha In-Gu Do Jeeyun Lee Se Hoon Park Joon Oh Park Won Ki Kang Min-Gew Choi Jun Ho Lee Jae Moon Bae Sung Kim Kyoung-Mee Kim Tae Sung Sohn | 2014 | Annals of Surgical Oncology2014，，4： | 1 |
| 13 | Differential expression of CD133 based on microsatellite instability status in human colorectal cancer显示文摘 | Jae Jun Park Ji‐hee Kwon Sun‐Hee Oh Junjeong Choi Chang Mo Moon Joong Bae Ahn Sung Pil Hong Jae Hee Cheon Tae Il Kim Hoguen Kim Won Ho Kim | 2014 | Carcinog2014，，1： | 1 |
| 14 | Clinical significance of gastritis cystica profunda and its association with Epstein‐Barr virus in gastric cancer显示文摘 | Min‐Gew Choi Ji Yun Jeong Kyoung‐Mee Kim Jae Moon Bae Jae Hyung Noh Tae Sung Sohn Sung Kim | 2012 | Cancer2012，，21： | 1 |
| 15 | A comparison of short-term postoperative outcomes including nutritional status between gastrectomy with simultaneous cholecystectomy and gastrectomy only in patients with gastric cancer显示文摘Objective: We aimed to evaluate the effect of simultaneous cholecystectomy on the short-term postoperative outcomes and nutritional status in patients with gastric cancer.Methods: We retrospectively reviewed data from 4,820 patients with gastric cancer who underwent gastrectomy from January 2011 to December 2016. Patients who underwent only gastrectomy(N=4,578) were matched to those who underwent simultaneous cholecystectomy during gastrectomy(N=242) at a 1:1 ratio using propensity score matching analysis. The nutritional status and inflammatory responses preoperatively and postoperatively and postoperative outcomes were compared between the groups.Results: The simultaneous cholecystectomy group showed more intraoperative blood loss and a longer operative time than the gastrectomy only group [150.0(100.0, 200.0) m L vs. 100.0(100.0, 200.0) m L, P=0.006;176.0(150.0,210.0) min vs. 155.0(128.0, 188.0) min, P<0.001, respectively]. Intraoperative event rate, postoperative complication rate, and postoperative recovery did not differ between the groups. All parameters including body weight, the hemoglobin level, absolute lymphocyte count, total protein level, albumin level, fasting glucose level,and prognostic nutritional index excluding the cholesterol level were not significantly different between the groups,and their changing patterns were similar. Although the cholesterol level was significantly lower in the simultaneous cholecystectomy group than in the gastrectomy only group at all follow-up points, the mean value of the decreased cholesterol level was within normal range.Conclusions: In gastric cancer patients with gallbladder disease, simultaneous cholecystectomy is safe and not associated with additional nutritional loss. | You Na Kim Ji Yeong An Min-Gew Choi Jun Ho Lee Tae Sung Sohn Jae Moon Bae Sung Kim | 2019 | Chinese Journal of Cancer Research2019，31，3： | 0 |
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