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| 1 | 成人型梭行细胞横纹肌肉瘤高频发生MYOD1基因反式激活突变显示文摘习惯上将横纹肌肉瘤(RMS)分为以下3型,即腺泡状横纹肌肉瘤(ARMS)、胚胎型横纹肌肉瘤(ERMS)及多形性横纹肌肉瘤(PRMS),而ERMS中包括了梭形细胞RMS。在2013版的WHO软组织及骨肿瘤分类中,梭形细胞RMS已从ERMS中分离出来,其梭形细胞/硬化性RMS被列为一种独立的类型。迄今为止,成人梭形细胞RMS并未被检测到高频发生的基因突变。 | Szuhai K de Jong D Leung A Y 杨文婷(摘译) 余英豪(审校) | 2014 | 临床与实验病理学杂志2014，30，5： | 6 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 4 |
| 4 | Leitlinien für den Gebrauch von Ultraschallkontrastmitteln - Januar 2004显示文摘 | T Albrecht M Blomley L Bolondi M Claudon J.-M Correas D Cosgrove L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani L Solbiati L Thorelius F Tranquart H Weskott T Whittingham | 2004 | Ultraschall in Med2004，，04： | 3 |
| 5 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D'Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 3 |
| 6 | Consensus on the definition of colorectal anastomotic leakage: A modified Delphi study显示文摘BACKGROUND Despite the emerging knowledge about colorectal anastomotic leakage(CAL)through the increasing number of clinical and experimental studies, there is no generally accepted definition of CAL. Because of the wide variety of definitions used in literature, comparison of study outcomes and quality of care is complicated.AIM To reach consensus on the definition of CAL using a modified Delphi method.METHODS The RAND/UCLA appropriateness method was used. The expert panel consisted of international colorectal surgeons and researchers who had published three or more articles about CAL. The consensus process consisted of two online distributed questionnaires and a third round with a recommendation. In the questionnaires participants were asked to rate the appropriateness of statements using a 1-9 Likert scale. Consensus was defined as a panel median between 1-3 or 7-9 without disagreement. In the final round a recommendation was formed regarding the definition of CAL and the expert panel was asked if they agreed or disagreed.RESULTSTwenty-three authors participated in the first round and twenty-one finished the second round. After two rounds consensus was reached on 37 items(80%) in nine different categories. The International Study Group of Rectal Cancer definition is the most frequently advised general definition by our panel. Consensus was reached regarding the clinical symptoms of CAL, which serum markers contributes to the suspicion of CAL, which radiological and perioperative findings should be considered as CAL, which grading system is appropriate and if there should be a range of postoperative days in the definition. Eventually, 19 experts completed all three rounds of which 16(84%) agreed with our final recommendations for the definition of CAL.CONCLUSION A consensus-based recommendation for the definition of CAL was formed using our modified Delphi method that can be widely incorporated in the field. | Claire PM van Helsdingen Audrey CHM Jongen Wouter J de Jonge Nicole D Bouvy Joep PM Derikx | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 7 | 气道管理对通气机相关性肺炎的影响显示文摘 | Cook,D Jong,BD | 1998 | 美国医学会杂志(中文版)1998，17，5： | 2 |
| 8 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 9 | Receptor-ligand binding assays: technologies and applications 显示文摘 | JONG L A UGES D R FRANKE J P BISCHOFFR | 2005 | JChromatogr: B2005，829，12： | 1 |
| 10 | Controlled release of platelet-derived growth factor using ethylene vinyl acetate copolymer(EVAc)coated on stainless-steel wires显示文摘 | Walsh W R Kim H D Jong Y S | 1995 | Biomaterials1995，16，17： | 1 |
| 11 | Biological nitrogen removal with enhanced phosphate uptake in a sequencing bath reac- tor using single sludge system显示文摘 | Lee D S Jeon C O Jong M P | 2001 | Water Research2001，35，16： | 1 |
| 12 | Human infection with highly pathogenic H5N1 influenza virus显示文摘 | GAMBOTTO A BARRATT-BOYES S M DE JONG M D | 2008 | Lancet2008，371，9622： | 1 |
| 13 | Modelling and simulation of genetic regulatory systems: aliterature review显示文摘 | Jong H D | 2002 | Journal of Computational Biology2002，9，： | 1 |
| 14 | Spatial distribution of nerve sprouting after myocardial infarction in mice显示文摘 | Oh Y S Jong A Y Kim D T | 2006 | Heart Rhythm2006，3，6： | 1 |
| 15 | Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial显示文摘 | de Jonge E D Schultz M J Spanjaard L | 2003 | Lancet2003，362，9389： | 1 |
| 16 | Using genetic algorithms for concept learning显示文摘 | DE JONG K A SPEARS W M GORDON F D | 1993 | Machine Learning1993，13，： | 1 |
| 17 | Endocrine profilesafter triggering of final oocyte maturation with GnRH agonistafter cotreatment with the GnRH antagonist ganirelix duringovarian hyperstimulation for in vitro fertilization 显示文摘 | Fauser BC de Jong D Olivennes F | 2002 | J ClinEndocrinol Metab2002，87，2： | 1 |
| 18 | Endocrine profile after triggering of final oocytes maturation with Gn RH agonist after cotreatment with Gn RH antagonist ganirelix ovarian hyperstimulation for IVF显示文摘 | Fauser B Jong D Olivennes F et a1 | 2002 | Clin Endocrinol Metab2002，87，2： | 1 |
| 19 | Enhancement of optical re- mote sensing images by subband-decomposed multi- scale Retinex with hybrid intensity transfer Function 显示文摘 | Jae H J Sung D K Jong B | 2011 | IEEE Geoscience and Remote Sensing Letters2011，8，5： | 1 |
| 20 | Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma显示文摘 | Kluiver J van den Berg A de Jong D | 2007 | Oncogene2007，26，26： | 1 |
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