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| 1 | Management of hepatocellular carcinoma: The role of contrast-enhanced ultrasound显示文摘Hepatocellular carcinoma(HCC)is the sixth most common neoplasm and the third cause of cancer death worldwide.Contrast enhanced ultrasound(CEUS)has been applied for more than ten years and plays increasingly important roles in the management of HCC.On the basis of the Guideline and Good Clinical Practice Recommendations for CEUS in the liver-update 2012and related literature about the management of HCC,we summarize the main roles and applications of CEUS in the management of HCC,including HCC surveillance,diagnosis,CEUS-guided treatment,treatment response evaluation and follow-up.The diagnostic algorithm for HCC is also suggested.Meanwhile,the comparisons between CEUS and contrast enhanced computed tomography/magnetic resonance imaging(CECT/CEMRI)in these areas are made.Although CEUS is subject to the same limitation as ordinary US and is inferior to CECT/CEMRI in some aspects,CEUS has proved to be of great value in the management of HCC with inher-ent advantages,such as sufficient high safety profile making it suitable for patients with renal failure or allergic to iodine,absence of radiation,easy reproducibility and high temporal resolution.The tremendous application of CEUS to the diagnosis and treatment of HCC provides more opportunities for patients with HCC diagnosed at different stages. | Shu-Guang Zheng Hui-Xiong Xu Lin-Na Liu | 2014 | World Journal of Radiology2014，6，1： | 20 |
| 2 | 超声造影对子宫内膜病变良恶性的诊断价值显示文摘目的探讨超声造影在子宫内膜良恶性病变中的诊断价值。方法对68例诊断为子宫内膜病变的患者行经阴道超声造影检查,观察良恶性病变与正常肌层灌注时间差值,分析其临床应用价值。结果经手术病理证实68例中子宫内膜良性病变42例,恶性26例,两者在时间-强度曲线参数中的始增时间、峰值强度、病变与正常肌层始增时间差值、达峰时间差值、始消时间差值差异有统计学意义(.P<0.05)。通过ROC曲线得出以上五个参数的曲线下面积分别为0.303、0.875、0.904、0.878、0.889,以病变与正常肌层始增时间差-840 ms为诊断界点时,曲线下面积最大,其灵敏度(99.1%)和特异度(88.9%)最大,说明始增时间差值对子宫内膜病变良恶性诊断价值较好。结论子宫内膜病变与正常肌层始增时间差值可作为诊断子宫内膜良恶性病变的新指标。 | 李向红 刘慧 向红 | 2014 | 中国超声医学杂志2014，30，11： | 7 |
| 3 | Nano/microparticles and ultrasound contrast agents显示文摘Microbubbles have been used for many years now in clinical practice as contrast agents in ultrasound imaging.Recently,their therapeutic applications have also attracted more attention.However,the short circulation time(minutes)and relatively large size(two to ten micrometers)of currently used commercial microbubbles do not allow effective extravasation into tumor tissue,preventing efficient tumor targeting.Fortunately,more multifunctional and theranostic nanoparticles with some special advantages over the traditional microbubbles have been widely investigated and explored for biomedical applications.The way to synthesize an ideal ultrasound contrast agent based on nanoparticles in order to achieve an expected effect on contrast imaging is a key technique.Currently a number of nanomaterials,including liposomes,polymers,micelles,dendrimers,emulsions,quantum dots,solid nanoparticles etc.,have already been applied to pre or clinical trials.Multifunctional and theranostic nanoparticles with some special advantages,such as the tumor-targeted(passive or active),multi-mode contrast agents(magnetic resonance imaging,ultrasonography or fluorescence),carrier or enhancer of drug delivery,and combined chemo or thermal therapy etc.,are rapidly gaining popularity and have shown a promising application in the field of cancer treatment.In this mini review,the trends and the advances of multifunctional and theranostic nanoparticles are briefly discussed. | Shu-Guang Zheng Hui-Xiong Xu Hang-Rong Chen | 2013 | World Journal of Radiology2013，5，12： | 5 |
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