|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 3 | Extensive translation of circular RNAs driven by N6-methyladenosine显示文摘广泛的 pre-mRNA 拼接背在人的 transcriptome 产生众多的圆形的 RNA (circRNAs ) 。然而,这些 circRNAs 的生物功能仍然保持大部分不清楚。这里,我们报导那 N 6-methyladenosine (m 6 一) , RNA 的最丰富的基础修正,在人的房间从 circRNAs 支持蛋白质翻译的有效开始。我们发现那一致 m 6 A 主题在 circRNAs 和单个 m 6 一个地点是足够的驾驶翻译开始。这 m 6A 驱动的翻译要求开始因素 eIF4G2 和 m 6 读者 YTHDF3,并且被 methyltransferase METTL3/14 提高,在热吃惊之上由 demethylase FTO,和 upregulated 禁止了。通过介绍的 polysome 的进一步的分析,计算预言和集体 spectrometry 揭示那 m 6 circRNAs 的 A 驱动的翻译是普遍的,与有翻译潜力的几百内长的 circRNAs。我们的学习扩展人的 transcriptome 的编码风景,并且在对环境应力的细胞的回答建议导出 circRNA 的蛋白质的一个角色。 | Yun Yang Xiaojuan Fan Miaowei Mao Xiaowei Song Ping Wu6,7 Yang Zhang Yongfeng Jin Yi Yang Ling-Ling Chen Yang Wang Catherine CL Wong Xinshu Xiao Zefeng Wang | 2017 | Cell Research2017，27，5： | 246 |
| 4 | Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study显示文摘Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern globally.Here,we report a novel batorigin CoV causing severe and fatal pneumonia in humans.Methods:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,China.Nucleic acids of the BAL were extracted and subjected to next-generation sequencing.Virus isolation was carried out,and maximum-likelihood phylogenetic trees were constructed.Results:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress syndrome.Chest radiography revealed diffuse opacities and consolidation.One of these patients died.Sequence results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the isolates.These isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate clade.Moreover,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin CoVs.However,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same receptor.Conclusion:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans. | Li-Li Ren Ye-Ming Wang Zhi-Qiang Wu Zi-Chun Xiang Li Guo Teng Xu Yong-Zhong Jiang Yan Xiong Yong-Jun Li Xing-Wang Li Hui Li Guo-Hui Fan Xiao-Ying Gu Yan Xiao Hong Gao Jiu-Yang Xu Fan Yang Xin-Ming Wang Chao Wu Lan Chen Yi-Wei Liu Bo Liu Jian Yang Xiao-Rui Wang Jie Dong Li Li Chao-Lin Huang Jian-Ping Zhao Yi Hu Zhen-Shun Cheng Un-Lin Liu Zhao-Hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei Wang | 2020 | Chinese Medical Journal2020，，9： | 99 |
| 5 | Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China显示文摘Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person transmission.Limited data are available for asymptomatic infections.This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers.Epidemiological investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in community.Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples.Their clinical records,laboratory assessments,and chest CT scans were reviewed.As a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening.Five cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during hospitalization.Twelve(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the lungs.The remaining 7(29.2%)cases showed normal CT image and had no symptoms during hospitalization.These 7 cases were younger(median age:14.0 years;P=0.012)than the rest.None of the 24 cases developed severe COVID-19 pneumonia or died.The median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 pneumonia.Overall,the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization.However,the communicable period could be up to three weeks and the communicated patients could develop severe illness.These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests.Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged. | Zhiliang Hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen Yuan Lin Yishan Zheng Jianming Wang Zhibin Hu Yongxiang Yi Hongbing Shen | 2020 | Science China(Life Sciences)2020，63，5： | 77 |
| 6 | Factors related to lymph node metastasis and surgical strategy used to treat early gastric carcinoma显示文摘AIM:The prognosis of early gastric carcinoma (EGC) is generally excellent after surgery. The presence or absence of lymph node metastasis in EGC is an important prognostic factor. The survival and recurrence rates of node-negative EGC are much better than those of node-positive EGC. This study examined the factors related to lymph node metastasis in EGC to determine the appropriate treatment for EGC.METHODS: We investigated 748 patients with EGC who underwent surgery between January 1985 and December 1999 at the Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Hospital. Several clinicopathologic factors were investigated to analyze their relationship to lymph node metastasis: age, sex, tumor location, tumor size, gross type, histologic type, depth of invasion, extent of lymph node dissection, type of operation,and DNA ploidy.RESULTS:Lymph node metastases were found in 75 patients (10.0%). Univariate analysis showed that male sex, tumor size larger than 2.0cm, submucosal invasion of tumor, histologic differentiation, and DNA ploidy pattern were risk factors for regional lymph node metastasis in EGC patients. However, a multivariate analysis showed that three risk factors were associated with lymph node metastasis:large tumor size, undifferentiated histologic type and submucosal invasion. No statistical relationship was found for age, sex, tumor location, gross type, or DNA ploidy in multivariate analysis. The 5-year survival rate was 94.2% for those without lymph node metastasis and 87.3% for those with lymph node metastasis, and the difference was significant (P<0.05).CONCLUSION: In patients with EGC, the survival rate of patients with positive lymph nodes is significantly worse than that of patients with no lymph node metastasis. Therefore,a standard D2 lymphadenectomy should be performed in patients at high risk of lymph node metastasis: large tumor size, undifferentiated histologic type and submucosal invasion. | Dong Yi Kim Jae Kyoon Joo Seong Yeob Ryu Young Jin Kim Shin Kon Kim | 2004 | World Journal of Gastroenterology2004，10，5： | 68 |
| 7 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 8 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 9 | Decrease-radix design principle for carrying/borrowing free multi-valued and application in ternary optical computer显示文摘In this paper a new theory referred to as the decrease-radix design (DRD) is pro-posed,which is found in the research of logic units of ternary (tri-valued) optical computer. Based on the theory proposed,the principles and the regulations of the DRD for making operation units of multi-valued operation with carrying/borrowing free are also presented. The research work has come to the following important conclusion: let D be a special state contained in n physical informative states,then one may figure out any multi-valued processors within n(n×n) carrying/borrowing free n-valued units by the composition some of n×n×(n-1) simplest basic operating units according to the regulations of DRD proposed in this paper. The detailed systematic way of our design regulations is highlighted step by step in the paper with an example of design of a tri-valued logic optical operating unit. The real ar-chitecture,the procedure,and the experimental results of our sample in tri-valued logic operating unit are given. Finally,a re-constructible model of ternary logical optical processor is introduced. The theory proposed in the paper has laid down a solid foundation for the design of re-constructible carrying/borrowing free operat-ing units in ternary optical computers and can be widely used as the designing reference in a variety of multi-valued logic operating units. | YAN JunYong JIN Yi ZUO KaiZhong | 2008 | Science in China(Series F)2008，51，10： | 41 |
| 10 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 11 | Spatial coupling analysis of regional economic development and environmental pollution in China显示文摘给集中于在经济、环境的分系统之间的时间的相互作用的研究的大数字,执行对这些分系统的一个量的空间评价是有用的。在这份报纸,为地区性的经济开发和环境污染分系统的全面评价指示物被构造。然后,联合和地区性的经济环境系统的协作的度在中国为 350 个县的单位被计算。以很县的单位的经济发展和环境污染仍然在联合和协作的底层,这被发现。根据联合和协作价值,中国领土能被划分成区域的四种类型:经济环境和谐区域,经济环境传动区域,经济环境匹敌区域和经济环境的低联合度区域。在区域的四种类型基于工业部门的结构的分析,在地区性的工业部门结构和夫妇协作水平之间有一种空间关系。在经济环境,和谐区域,高科技生产的扇区和高增值产品例如通讯,计算机和电子设备,搬运设备和电的机械,为本地工业输出的值的一个大比例的报道。传动区域的经济环境的工业价值被专注于生产机械和设备,并且包含象铁、非铁的冶金学,化学生产和电产生那样的一些弄脏的部门。匹敌区域的经济环境是弄脏的部门专注的区域的类型,例如铁和钢,僵化,煤采矿,大楼材料和电产生。在经济环境区域的低联合度,它的工业被专注于生产并且主要产品处理。 | MALi | 2013 | Journal of Geographical Sciences2013，23，3： | 36 |
| 12 | Long-term changes in the fishery ecosystem structure of Laizhou Bay,China显示文摘Laizhou Bay provides a critical spawning and nursery habitat for many fishery species,including commercially important species,such as Fenneropenaeus chinensis and Larimichthys polyactis.The bay is severely stressed due to high fishing pressure and environmental changes.Based on the long-term ecosystem surveys in Laizhou Bay during the main spawning period(May) of most fishery species from 1959 to 2008,the responses of the Laizhou Bay fishery ecosystem were analyzed here,including regime shifts in species composition,biomass,species diversity,zooplankton,phytoplankton,and environmental variables.The dominant species of large-size and high economic value(e.g.Trichiurus haumela,L.polyactis) have been replaced by the short-lived,low-trophic-level planktivorous pelagic species(e.g.Setipinna taty,Engraulis japonicus) since the 1980s,and it is probable that the small-sized pelagic fishes have been recently replaced by invertebrates(e.g.Oratosquilla oratoria,Crangon affinis).The biomass of fishery resources declined continuously from 423.6 kg haul?1 h?1 in 1959 to 164.6 kg haul?1 h?1 in 1982,37.7 kg haul?1 h?1 in 1993,and less than 8 kg haul?1 h?1 in 1998-2008.Moreover,the biomass of zooplankton showed an increasing trend during 1959-2006,but showed a slight decline in 2008.The abundance of phytoplankton increased from 1959 through 1982,decreased substantially in 1993,and increased again until 2004.More recently,however,the phytoplankton abundance was very low.The sea surface temperature(SST) and sea bottom temperature(SBT) in May increased by 0.23°C a?1 and 0.16°C a?1,respectively,during 1982-2008.The salinity in May showed large fluctuations and reached its lowest values in 2004 and 2006.The ratio of dissolved inorganic nitrogen(DIN) to dissolved inorganic phosphate(DIP) increased.However,the dissolved silicon(DSi):DIP and DSi:DIN ratios decreased to a low level during 1959-2008.These changes seriously impacted primary production,and cascade effects then changed the structure and function of the fishery ecosystem.Further analysis indicated that multiple stresses caused the alterations in the structure of the Laizhou Bay fishery ecosystem.The top-down effect was identified as the main influence on the fishery species(at the top of the food chain) over the past five decades due to the increasing fishing pressure,whereas the bottom-up effect increased over the past three decades due to the strong variations in the environment. | JIN XianShi SHAN XiuJuan LI XianSen WANG Jun CUI Yi ZUO Tao | 2013 | Science China Earth Sciences2013，56，3： | 31 |
| 13 | SEMI-GLOBAL C^1 SOLUTION TO THE MIXED INITIAL-BOUNDARY VALUE PROBLEM FOR QUASILINEAR HYPERBOLIC SYSTEMS显示文摘By means of an equivalent invariant form of boundary conditions, the authors get the exis- tence and uniqueness of semi-global C1 solution to the mixed initial-boundary value problem for quasilinear hyperbolic systems with general nonlinear boundary conditions. | LI TA-TSIEN (LI DAQIAN), JIN YI Department of Mathematics, Fudan University, Shanghai 200433, China. | 2001 | Chinese Annals of Mathematics,Series B2001，22，3： | 30 |
| 14 | Principles and construction of MSD adder in ternary optical computer显示文摘The two remarkable features of ternary values and a massive unit with thousands bits of parallel computation will make the ternary optical computer (TOC) with modified signed-digit (MSD) adder more powerful and e?cient than ever before for numerical calculations. Based on the decrease-radix design presented previously, a TOC can satisfy either a user requiring huge capacity for data calculations or one with a moderate amount of data, if it is equipped with a prepared adder. Furthermore, with the application of pipelined operations and the proposed data editing technique, the e?ciency of the prepared adder can be greatly improved, so that each calculated result can be obtained almost within one clock cycle. It is hopeful that by employing a MSD adder, users will be able to enter a new dimension with the creation of a new multiplier, new divider, as well as new matrix operator in a TOC in the near future. | JIN Yi SHEN YunFu PENG JunJie XU ShiYi DING GuangTai YUE DongJian YOU HaiHang | 2010 | Science China(Information Sciences)2010，53，11： | 26 |
| 15 | Principles,structures,and implementation of reconfigurable ternary optical processors显示文摘This paper discusses the principles,structures,and implementation procedures for reconfiguring a ternary optical processor (TOP).Typical structures,classifications,and naming of the TOP and basic operation units (BOUs) are described in this paper.The circuit implementations,commands,and processes for the reconfiguration are also discussed in detail.A simple analysis of the high performance and low power consumption of ternary optical computers is presented.Finally,an experiment is performed on reconfiguring a 1-bit BOU,which shows that the principles of reconfigurable TOPs are valid,and that the implementations and commands for the reconfiguration are effective. | JIN Yi WANG HongJian OUYANG shan ZHOU Yu SHEN YunPu PENG JunJie LIU XueMin | 2011 | Science China(Information Sciences)2011，54，11： | 23 |
| 16 | Outcome and risk factors of early onset severe preeclampsia显示文摘 | GONG Yun-hui JIA Jin LU Dong-hao DAI Li BAI Yi ZHOU Rong | 2012 | Chinese Medical Journal2012，，14： | 23 |
| 17 | Combination of percutaneous radiofrequency ablation with transarterial chemoembolization for hepatocellular carcinoma: observation of clinical effects显示文摘Objective: To observe the clinical effect of radiofrequency ablation(RFA) combined with transcatheter arterial chemoembolization(TACE) for advanced hepatocellular carcinoma(HCC).Methods: A total of 92 cases of advanced primary liver cancer underwent TACE and RFA treatment from June 2005 to 2011 at the Department of Hepatobiliary Surgery, the First Affiliated Hospital of Bengbu Medical College. A total of 88 cases with complete clinical treatment and follow-up data were divided into two groups: 43 patients treated with TACE(TACE group) and 45 patients that received TACE combined with RFA treatment(TACE + RFA group). After clinical data assessment, tumor size and survival status were not significantly different between the groups as determined by stratified analysis.Results: Before and after surgery, spiral CT radiography and color comparison observed ablation conditions. The tumor necrosis rates after treatment(CR + PR) were 67.4%(29/43) and 91.1%(41/45) for the TACE and combined treatment groups, respectively, and the difference was statistically significant(P<0.05). The quality of life was significantly improved for patients undergoing TACE + RFA compared with the control group. Survival duration was not significantly different in patients undergoing TACE + RFA compared with the control group.Conclusions: In this study, the effect of RFA combined with TACE treatment was better than TACE alone in treating advanced HCC. | Hui-Chun Liu Er-Bo Shan Lei Zhou Hao Jin Pei-Yuan Cui Yi Tan Yi-Min Lu | 2014 | Chinese Journal of Cancer Research2014，26，4： | 22 |
| 18 | Intracoronary arterial retrograde thrombolysis with percutaneous coronary intervention: a novel use of thrombolytic to treat acute ST-segment elevation myocardial infarction显示文摘Background Clearance of coronary arterial thrombosis is necessary in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing urgent percutaneous coronary intervention (PCI). There is currently no highly-recommended method of thrombus removal during interventional procedures. We describe a new method for opening culprit vessels to treat STEMI: intracoronary arterial retrograde thrombolysis (ICART) with PCI. Methods & Results Eight patients underwent ICART. The guidewire was advanced to the distal coronary artery through the occlusion lesion. Then, we inserted a microcatheter into the distal end of the occluded coronary artery over the guidewire. Urokinase (5–10 wu) mixed with contrast agents was slowly injected into the occluded section of the coronary artery through the microcatheter. The intracoronary thrombus gradually dissolved in 3–17 min, and the effect of thrombolysis was visible in real time. Stents were then implanted according to the characteristics of the recanalized culprit lesion to achieve full revascularization. One patient experienced premature ventricular contraction during vascular revascularization, and no malignant arrhythmias were seen in any patient. No reflow or slow flow was not observed post PCI. Thrombolysis in myocardial infarction flow grade and myocardial blush grade post-primary PCI was 3 in all eight patients. No patients experienced bleeding or stroke. Conclusions ICART was accurate and effective for treating intracoronary thrombi in patients with STEMI in this preliminary study. ICART was an effective, feasible, and simple approach to the management of STEMI, and no intraprocedural complications occurred in any of the patients. ICART may be a breakthrough in the treatment of acute STEMI. | Jin-Wen TIAN Mei ZHU Feng-Qi WANG Ke LI Chao-Fei ZHOU Bo LI Min WANG Jue-Lin DENG Bo JIANG Jing BAI Yi GUO Rong-Jie JIN Zhao ZHANG Ying LIN Ji-Hang WANG Shi-Hao ZHAO Ming-Zhi SHEN | 2019 | Journal of Geriatric Cardiology2019，16，6： | 22 |
| 19 | The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North Africa.To develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the guidelines.Based on the findings of evidencebased medicine in China and abroad,domestic experts have iteratively developed these guidelines to provide proper management of NPC.Overall,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC. | Ling-Long Tang Yu-Pei Chen Chuan-Ben Chen Ming-Yuan Chen Nian-Yong Chen Xiao-Zhong Chen Xiao-Jing Du Wen-Feng Fang Mei Feng Jin Gao Fei Han Xia He Chao-Su Hu De-sheng Hu Guang-Yuan Hu Hao Jiang Wei Jiang Feng Jin Jin-Yi Lang Jin-Gao Li Shao-Jun Lin Xu Liu Qiu-Fang Liu Lin Ma Hai-Qiang Mai Ji-Yong Qin Liang-Fang Shen Ying Sun Pei-Guo Wang Ren-Sheng Wang Ruo-Zheng Wang Xiao-Shen Wang Ying Wang Hui Wu Yun-Fei Xia Shao-Wen Xiao Kun-Yu Yang Jun-Lin Yi Xiao-Dong Zhu Jun Ma | 2021 | Cancer Communications2021，41，11： | 22 |
| 20 | An updated megaphylogeny of plants,a tool for generating plant phylogenies and an analysis of phylogenetic community structure显示文摘Aims The aim of this article is 3-fold.First,we present an updated version of a published megaphylogeny of vascular plants that can be used in studies of plant ecology and biogeography.second,we develop a tool that can be used by botanists and plant ecologists to generate phylogenetic hypotheses in three scenarios.Third,we use a set of regional assemblages of angiosperm trees in North america as a model system to evaluate the effect of differences in phylogenies generated using the three scenarios on the quantification of phylogenetic properties and the relationship between measures of phylogenetic properties and environment.Methods The taxonomy and nomenclature of plant species in the megaphy-logeny were standardized according to The Plant list(version 1.1).a tool for generating phylogenies was created using the r language.The robustness of derived phylogenies was evaluated using correlation and regression analyses.Important Findingsan updated megaphylogeny of vascular plants(PhytoPhylo)and a tool for reconstructing phylogenies of seed plants(s.Phylomaker)were generated.our study shows that phylogenies generated by s.Phylomaker using the PhytoPhylo megaphylogeny as a backbone are nearly as good as phylogeny resolved at the species level when using derived phylogenies to quantify phylogenetic properties(e.g.phylogenetic diversity and phylogenetic relatedness)of biological assemblages,and that s.Phylomaker-generated phylogenies are robust for studies of community ecology and biogeography,par-ticularly those seeking for patterns of phylogenetic properties along environmental gradients. | Hong Qian Yi Jin | 2016 | Journal of Plant Ecology2016，9，2： | 23 |
您所在的机构暂未开通此部分的功能，请联系管理员