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| 1 | Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis显示文摘AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma(HCC) in patients with known liver cirrhosis.METHODS: A literature search of MEDLINE, EMBASE, and Cochrane databases was conducted. The search terms used included(laparoscopic OR laparoscopy) AND(hepatic or liver) AND(surgery or resection) AND 'hepatocellular carcinoma' AND(cirrhosis or cirrhotic). Furthermore, to widen the search, we also used the 'related articles' section. Studies reporting a comparison of outcomes and methods of open vs laparoscopic hepatic resection for HCC in patients with liver cirrhosis were included. Meta-analysis of results was performed using a random effects model to compute relative risk(RR) and for dichotomous variablesand standard mean differences(SMD) for continuous variables.RESULTS: A total of 420 patients from 4 cohort studies were included in final analysis. Patients undergoing laparoscopic procedures had statistically less blood loss compared to the open cohort, SMD of-1.01(95%CI:-1.23-0.79), P < 0.001, with a reduced risk of transfusion, RR = 0.19(95%CI: 0.09-0.38), P < 0.001. A wider clearance at tumour resection margins was achieved following a laparoscopic approach, SMD of 0.34(95%CI: 0.08-0.60), P = 0.011. No significant difference was noted between laparoscopic and open resection operative times, SMD of-0.15(95%CI: 0.35-0.05), P = 0.142. The overall RR of suffering from postoperative morbidity is 0.25 in favour of the open surgery cohort(95%CI: 0.17-0.37), P < 0.001. Patients under-going laparoscopic surgery had significantly shorter length of stays in hospital compared to the open cohort, SMD of-0.53(95%CI:-0.73 to-0.32), P < 0.001.CONCLUSION: This review suggests that laparoscopic resection of hepatocellular carcinoma in patients with cirrhosis is safe and may provide improved patient outcomes when compared to the open technique. | Ahmed Twaij Philip H Pucher Mikael H Sodergren Tamara Gall Ara Darzi Long R Jiao | 2014 | World Journal of Gastroenterology2014，20，25： | 16 |
| 2 | Surgical treatment for liver cancer显示文摘Primary liver cancer is amongst the commonest tumors worldwide,particularly in parts of the developing world,and is increasing in incidence. Over the past three decades,surgical hepatic resection has evolved from a high risk,resource intensive procedure with limited application,to a safe and commonly performed operation with a range of indications. This article reviews the approach to surgical resection for malignancies such as hepatocellular cancer,metastatic liver de-posits and neuroendocrine tumors. Survival data after resection is also reviewed,as well as indications for curative resection. | Nicole C Tsim Adam E Frampton Nagy A Habib Long R Jiao | 2010 | World Journal of Gastroenterology2010，16，8： | 12 |
| 3 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 4 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 5 | A Coupled Variable Coefficient Modified KdV Equation Arising from a Two-Layer Fluid System显示文摘A quite general coupled variable coefficient modified KdV (VCmKdV) equation in a two-layer fluid systemis derived by means of the reductive perturbation method.Making use of the CK's direct method,some similarityreductions of the coupled VCmKdV equation are obtained and their corresponding group explanations are discussed.Some exact solutions of the coupled equations are also presented. | GAO Yuan~1 and TANG Xiao-Yan~(1,2)~1 Department of Physics,Shanghai Jiao Tong University,Shanghai 200240,China~2 Institut Für Theoretische Physik IV,Fakultt für Physik und Astronomie,Ruhr-Universitt Bochum,D-44870 Bochum,Germany | 2007 | Communications in Theoretical Physics2007，，12： | 3 |
| 6 | Breeding for Parents of Hybrid Rice with Maize pepc Gene显示文摘The results of the investigation on transgenic rice with maize C4-specific phosphoenolpyruvate carboxylase (pepc) gene showed that the transgenic rice plants with the maize pepc gene expressed at high level and the maize PEPC expression was inherited in the progenies in a Mendelian manner. The transgenic plants had PEPC activity of more than 10-fold higher than untransformed plants. As compared with untransformed plants, the panicle per plant, spikelet per panicle, 1000-grain weight and grain-weight per plant for transgenic plants increased by 14.9 %, 5.7%, 1.3 % and 13.9 %, respectively. By crossing the maize pepc gene was incorporated into the parents of hybrid rice, which were the photo-sensitive genic male sterile (PGMS)lines of two-line hybrid rice such as Peiai64s, 7001s, 2302s, 2304s and 2306s-1, and the BT type of cytoplasmic male sterile (CMS) line of three-line hybrid rice such as Shuangjiu A, and restorer lines 5129, Wanjing97 in the spring of 1998. The following progresses were made: (1) The inheritance of the high-level expression of the maize PEPC was stable in different genetic background of rice; (2) PEPC activity of F1 hybrid was the mean of the two parents. Its saturated photosynthetic rate (Pn) rose to 50 % higher than that of the receptor parent. These results demonstrated that it is possible to increase the vigor of the rice plant by transgenic approach with maize pepc gene; (3) The activity of PEPC in leaf could be considered as the major physiological index because the correlation coefficient between PEPC activity and Pn was 0.6470 * *; (4) We have developed three rice lines with maize pepc gene; (5) The selection method of high photosynthetic efficiency rice has been established, which includes soaking seeds into solution of hygromycin phosphotransferase to germinate, tracing the pepc gene by PCR analysis, evaluating the performance of the rice plants in the field and examining PEPC activities and Pn of rice plants with maize pepc gene. | WANG De-zheng, JIAO De-mao, WU Shuang, LI Xia, LI Li, CHI Wei, WANG Shou-hai, LI Cheng-quan, LUO Yan-chang and WANG Xiu-feng(Rice Research Institute , Anhui Academy of Agricultural Sciences , Hefei 230031 , P. R . China Institute of Agrobiological Genetics and Physiology, Jiangsu Academy of Agricultural Sciences , Nanjing 210014 , P. R . China) | 2002 | Agricultural Sciences in China2002，1，10： | 2 |
| 7 | Deoxynivalenol accumulation and detoxification in cereals and its potential role in wheat-Fusarium graminearum interactions显示文摘Deoxynivalenol(DON)is a prominent mycotoxin showing significant accumulation in cereal plants during infection by the phytopathogen Fusarium graminearum.It is a virulence factor that is important in the spread of F.graminearum within cereal heads,and it causes serious yield losses and significant contamination of cereal grains.In recent decades,genetic and genomic studies have facilitated the characterization of the molecular pathways of DON biosynthesis in F.graminearum and the environmental factors that influence DON accumulation.In addition,diverse scab resistance traits related to the repression of DON accumulation in plants have been identified,and experimental studies of wheat–pathogen interactions have contributed to understanding detoxification mechanisms in host plants.The present review illustrates and summarizes the molecular networks of DON mycotoxin production in F.graminearum and the methods of DON detoxification in plants based on the current literature,which provides molecular targets for crop improvement programs.This review also comprehensively discusses recent advances and challenges related to genetic engineering-mediated cultivar improvements to strengthen scab resistance.Furthermore,ongoing advancements in genetic engineering will enable the application of these molecular targets to develop more scab-resistant wheat cultivars with DON detoxification traits. | Kun Luo Jiao Guo Dejia He Guangwei Li Thérèse Ouellet | 2023 | aBIOTECH2023，4，2： | 2 |
| 8 | Influence of Coal Nature and Structure on Ash Size Formation Characteristic and Related Pollutant Emissions During CFB Combustion显示文摘The size distribution of coal particles in a Circulating Fluidized Bed (CFB) boiler plays a crucial role in the complicated combustion, heat exchange and pollutant emissions in such a plat. Therefore, it is fundamental to study the different factors having influence on the size distribution of coal particles. Above all, the coal itself and in particular, the coal combination phenomenon is a very influent factor. In the frame of this work, the coal nature (elementary composition) and coal internal structure (mineral components) are studied in detail. At this intermediary stage, experiments on three typical Chinese coals on a l.5 MWt CFBC pilot plant have been made. Some primary fragmentation tests have also been made in a small lab scale fluidized bed reactor. The results from the hot pilot test show i) the variation of coal ash distributions and other CFB performance data due to the cyclone and the coal characteristics and ii) the variation of desulfurization efficiency with limestone. Whereas the bench scale primary fragmentation test, likely linked to the caking propriety of a coal, does not seem to change considerably the char size distribution. | Min QIAN Arnaud BOELLE Philippe JAUD ( Electricite de France Division R&D, 6 quai Watier B.P.49 78401 Chatou, France ) Yongjie NA Qinggang LU Shaolin BAO ding CUI Weihong JIAO Huanming ZHAO (Institute of Engineering Thermophysics, Chinese Academ | 2000 | Journal of Thermal Science2000，9，3： | 2 |
| 9 | A Kansei mining system for affective design显示文摘 | JIAO R ZHANG Y MARTIN H | 2006 | Expert Systems with Applications2006，，30： | 1 |
| 10 | Redox reactions involving hydrocarbons and mineral oxidants: a mechanism for significant porosity enhancement in sandstones 显示文摘 | Surdam R C Jiao Z S MacGowan D B | 1993 | AAPG Bull1993，77，9： | 1 |
| 11 | Induction of muhispecific Th-1 type immune response against HCV in mice by protein immunization using CpG and montanide ISA 720 as adjuvants 显示文摘 | Qiu Q Wang R Y Jiao X | 2008 | Vaccine2008，26，43： | 1 |
| 12 | Cholesterol-lowering nutraceuticals and functional foods 显示文摘 | Chen ZY Jiao R Ma KY | 2008 | J Agric Food Chem2008，56，： | 1 |
| 13 | 2013, Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011显示文摘 | Qi x Cui L Jiao Y Pan Y Li X Zu R Huo X Wu B Tang F Song Y Zhou M Wang H Cardona C J Xing Z | 2013 | Archives of Virology2013，158，1： | 1 |
| 14 | Isolation and characterization of a genetically tractable photo autotrophic Fe(Ⅱ)-oxidizing bacterium, Rhodopseudomonaspalustris strain TIE-1显示文摘 | Jiao Y Q Kappler A Croal L R | 2005 | Applied and Environmental Microbiology2005，71，8： | 1 |
| 15 | Clinical short-term results of radiofrequency ablation in primary and secondary liver tumors 显示文摘 | Jiao LR Hansen PD Havlik R | 1999 | Am J Surg1999，177，4： | 1 |
| 16 | Community detection based on modularity and an improved genetic algorithm 显示文摘 | SHANG R H BAI J JIAO L C | 2013 | Physica A: Statistical Mechanics and its Applications2013，392，5： | 1 |
| 17 | Pediatric tuberculosis at Beijing Children's Hospital:2002-2010显示文摘 | WU X R YIN Q Q JIAO A X | | 0，，06： | 1 |
| 18 | Electrode influence on effective electromechanical coupling coefficient of thin film bulk acoustic resonators显示文摘 | ZHANG R JIAO X Q YANG J | 2014 | Mater Res Innov2014，18，4： | 1 |
| 19 | Anomalously pressured gas accumulations in the Laramide basins, North America 显示文摘 | Jiao Z S Surdam R C | 1996 | AAPG Bulletin1996，5，： | 1 |
| 20 | What is aromaticity显示文摘 | Schleyer P v R Jiao H J | 1996 | Pure Appl Chem1996，68，： | 1 |
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