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| 1 | MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes显示文摘 | Li Y Guessous F Zhang Y Dipierro C Kefas B Johnson E Marcinkiewicz L Jiang J Yang Y Schmittgen TD Lopes B Schiff D Purow B Abounader R | 2009 | 中国神经肿瘤杂志2009，7，4： | 56 |
| 2 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 3 | Upregulation of vimentin and aberrant expression of E-cadherin /beta-catenin complex in oral squamous cell carcinomas:correlation with the clinicopathological features and patient outcome显示文摘Oral squamous cell carcinoma is a challenging oncology problem.A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined.Using quantitative immunohistochemistry,we examined the expression of vimentin,E-cadherin,and beta-catenin in 83 oral squamous cell carcinoma patients,and the relationships between the expression of these markers and specific clinicopathological features were analysed.The high expression of vimentin was observed in 23 of 43(53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death(P < 0.001 and < 0.001,respectively).The decreased expression of E-cadherin was observed in 36 of 43(84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death(P < 0.001 and < 0.001,respectively).Although no correlation between beta-catenin expression in whole-tumour sections and clinicopathological features was observed,decreased beta-catenin expression at the tumour invasive front was closely associated with recurrence and death(P=0.002 and 0.002,respectively).The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses.Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients.The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. | Liu,LK Jiang,XY Zhou,XX Wang,DM Song,XL Jiang,HB Nanjing Med Univ,Coll Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Inst Stomatol,Dept Oral Pathol,Nanjing 210029,Jiangsu,Peoples R China Nanjing Med Univ,Coll Stomatol,Dept Oral & Maxillofacial Surg,Nanjing 210029,Jiangsu,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 25 |
| 4 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 5 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 6 | Lithological Discrimination of the Mafic-Ultramafic Complex, Huitongshan, Beishan, China: Using ASTER Data显示文摘The Beishan area has more than seventy mafic-ultramafic complexes sparsely distributed in the area and is of a big potential in mineral resources related to mafic-ultramafic intrusions. Many mafic-ultramafic intrusions which are mostly in small sizes have been omitted by previous works. This research takes Huitongshan as the study area, which is a major district for mafic-ultramafic occurrences in Beishan. Advanced spaceborne thermal emission and reflection radiometer(ASTER) data have been processed and interpreted for mapping the mafic-ultramafic complex. ASTER data were processed by different techniques that were selected based on image reflectance and laboratory emissivity spectra. The visible near-infrared(VNIR) and short wave infrared(SWIR) data were transformed using band ratios and minimum noise fraction(MNF), while the thermal infrared(TIR) data were processed using mafic index(MI) and principal components analysis(PCA). ASTER band ratios(6/8, 5/4, 2/1) in RGB image and MNF(1, 2, 4) in RGB image were powerful in distinguishing the subtle differences between the various rock units. PCA applied to all five bands of ASTER TIR imagery highlighted marked differences among the mafic rock units and was more effective than the MI in differentiating mafic-ultramafic rocks. Our results were consistent with information derived from local geological maps. Based on the remote sensing results and field inspection, eleven gabbroic intrusions and a pyroxenite occurrence were recognized for the first time. A new geologic map of the Huitongshan area was created by integrating the results of remote sensing, previous geological maps and field inspection. It is concluded that the workflow of ASTER image processing, interpretation and ground inspection has great potential for mafic-ultramafic rocks identifying and relevant mineral targeting in the sparsely vegetated arid region of northwestern China. | Lei Liu Jun Zhou Dong Jiang Dafang Zhuang Lamin R Mansaray | 2014 | Journal of Earth Science2014，25，3： | 8 |
| 7 | Structure and Property of Bamboo Fiber显示文摘The chemical composition, fiber characteristics, crystalline structure, mechanical properties and thermal behavior of the five species of bamboo (Phyllostachys edulis cv.Pachyloe, Bambusa tootisk, Arundinaia amabilis, B.vulgaris cv. Vittata, and Dendrocalamus affinis) were studied with IR, X-ray, DSC and chemical analyses. The results indicated that the benzene-ethanol extractive content of bamboo was higher than that of wood, the content of lignin and the content of pentosan were 19.1% - 25.3% and 14.9% - 22.6%, respectively. Except for Ph. edulis cv. Pachyloe, the cellulose content in the other 4 species was over 50%. The average length of fiber of D. affinis was the longest (1.861 mm). The length/ width ratio of bamboo fiber was also higher than that of wood, and it was the highest for B.tootisk, which reached 142. The results of IR and X-ray confirmed that crystalline structure of bamboo fibers was cellulose, and A. amabilis had the highest crystallinity index. The differential thermal analysis (DSC) can be one of the methods to identify various fiber materials. After steam explosive pretreatment, cellulose content of D. affinis had increased from 50.5% to 69.2%, the crystallinity index had increased and the breaking tenacity of bamboo fibers was suitable for producing textile products, indicating that steam explosion is an useful pretreatment for bamboo fibers made into composite materials and textiles. | JIANG Jianxin1 YANG Zhongkai2 ZHU Liwei1 SHI Limin2 YAN Lijie1 1. College of Materials Science and Technology, Beijing Forestry University, Beijing100083, P. R. China 2 .Beijing Municipal Key Laboratory of Clothing Materials R & D and Assessment, Beijing Institute of Clothing Technology, Beijing 100029, P. R. China. | 2008 | Chinese Forestry Science and Technology2008，7，2： | 8 |
| 8 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 9 | Targeted conditional gene knockout in human embryonic stem cells显示文摘 | Lei Bu Xiaolin Gao Xin Jiang Kenneth R Chien Zhong Wang | 2010 | Cell Research2010，20，3： | 6 |
| 10 | A Dynamic Knowledge Model for Design of Suitable Sowing Date and Sowing Rate in Winter Wheat显示文摘Based on research concerning dynamic relationships of winter wheat growth to environments and production conditions, a winter wheat model for selecting suitable sowing date, population density and sowing rate under different varieties, spatial and temporal environments was developed. Case studies on sowing date with the data sets of five different eco-sites, three climatic years and soil fertility levels, and on population density and sowing rate with the data sets of two different variety types, three different soil types, soil fertility levels, sowing dates and grain yield levels indicate a good model performance for decision-making. | ZHU Yan, CAO Wei-xing, JIANG Dong and DAI Ting-bo(Key Laboratory of Crop Growth Regulation , Ministry of Agriculture /Nanjing Agricultural University,Nanjing 210095 , P. R . China) | 2002 | Agricultural Sciences in China2002，1，10： | 4 |
| 11 | 术中神经电生理监测在单椎板入路选择性神经后根离断术中的作用显示文摘目的单椎板入路选择性神经后根离断术(SL-SDR)治疗痉挛性脑瘫完全依赖术中神经电生理监测结果。本研究旨在讨论SL-SDR术中肌电图判读对神经根选择和离断的影响及作用。方法回顾分析2016年5月至2019年3月在上海交通大学附属儿童医院神经外科采用改良神经电生理监测离断方案指导下SL-SDR治疗的痉挛性脑瘫患儿的临床资料,重点关注术中肌电图判读及其与术前临床表现的相关性,以及比较采用不同神经电生理监测离断方案解读术中肌电图时的神经后根选择差异。结果共纳入318例患儿,男性231例、女性87例,平均年龄5.9岁,32例为偏瘫、161例为双侧瘫、125例为四肢瘫。每例患儿有2~8组目标肌群(术前肌张力≥2级)。术中神经电生理监测结果显示,探测的21728枚神经小根[(68.3±8.2)枚/例]中6272枚(28.9%)与肛门括约肌相关,15456枚[(48.6±7.6)枚/例]与下肢肌群相关,其中,神经后根11009枚[(34.6±7.4)枚/例]。共有3370枚[(10.6±4.7)枚/例]符合改良神经后根离断方案,其中3061枚50%部分离断、309枚75%部分离断。术前粗大运动功能分级(GMFCS)分级Ⅰ~Ⅴ级的离断率(部分离断的神经后根数/下肢肌群相关神经后根数)分别为15.8%、22.3%、33.4%、41.8%和45.7%。75%部分离断的离断率随术前GMFCS分级的递增而增加,分别为1.5%、4.8%、8.5%、14.1%和15.2%。术后3周,2068组目标肌群肌张力显著降低[(1.7±0.5)级对(2.7±0.6)级]。术前GMFCS分级Ⅰ和Ⅱ级患儿采用传统离断方案约有20%的病例无法识别任何1枚约20%需离断的神经后根,而随着患儿术前GMFCS分级的递增,传统与改良方案离断的符合率逐步提高,分别为39.5%、41.3%、52.2%、54.1%和62.8%。结论由于SL-SDR完全依赖于术中肌电图判读,使得术中神经电生理监测显得至关重要。改良神经电生理监测离断方案指导下的SL-SDR可以安全、有效治疗痉挛性脑瘫。SL-SDR术中肌电图及其与临床表现相关的预后,可以使临床医师更好地理解此类患儿脊髓神经元环路的运作模式。 | Xiao B Constatntini S Browd SR Zhan Q Jiang W Mei R 詹琪佳(编译) | 2020 | 中国现代神经疾病杂志2020，20，4： | 4 |
| 12 | 利用抗高血压药相关的遗传变异发现其潜在的功效和副作用显示文摘通过研究药物靶蛋白基因的自然变异可以了解药物的功效。本研究旨在利用这种方法探索抗高血压药的潜在副作用和再利用潜力。研究者首先确定了血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)、β受体阻滞剂和钙拮抗剂的合适代表基因。 | 刘青(译) 叶鹏(校) Gill D Georgakis MK Koskeridis F Jiang L Feng Q Wei WQ Theodoratou E Elliott P Denny JC Malik R Evangelou E Dehghan A Dichgans M Tzoulaki I | 2019 | 中华高血压杂志2019，0，9： | 3 |
| 13 | 基于工作地点的分组干预对高血压控制的影响:一项随机临床研究显示文摘基于工作地点的干预可能为一种管理高血压的有效方法。但是目前缺少针对中国工作人群高血压控制情况的研究。本研究旨在评估基于工作地点的多组分别干预策略对改善血压控制的影响。研究设计及受试者:研究者在2013年1月至2014年12月于中国20个城区的60个工作地点进行了一系列高血压管理的随机临床试验。工作地点随机分为干预组(n=40)和对照组(n=20)。每个工作地点的受试者都需要完成一项横断面调查。 | 袁源(摘译) 叶鹏(审校) Wang Z Wang X Shen Y Li S Chen Z Zheng C Kang Y Jiang L Hao G Chang C Gao R | 2020 | 中华高血压杂志2020，28，6： | 3 |
| 14 | Tissue expression and developmental regulation of chicken cathelicidin antimicrobial peptides显示文摘Cathelicidins are a major family of antimicrobial peptides present in vertebrate animals with potent microbicidal and immunomodulatory activities. Four cathelicidins, namely fowlicidins 1 to 3 and cathelicidin B1, have been identified in chickens. As a first step to understand their role in early innate host defense of chickens, we examined the tissue and developmental expression patterns of all four cathelicidins. Real-time PCR revealed an abundant expression of four cathelicidins throughout the gastrointestinal, respiratory, and urogenital tracts as well as in all primary and secondary immune organs of chickens. Fowlicidins 1 to 3 exhibited a similar tissue expression pattern with the highest expression in the bone marrow and lung, while cathelicidin B1 was synthesized most abundantly in the bursa of Fabricius. Additionally, a tissue-specific regulatory pattern was evident for all four cathelicidins during the first 28 days after hatching. The expression of fowlicidins 1 to 3 showed an age-dependent increase both in the cecal tonsil and lung, whereas all four cathelicidins were peaked in the bursa on day 4 after hatching, with a gradual decline by day 28. An abrupt augmentation in the expression of fowlicidins 1 to 3 was also observed in the cecum on day 28, while the highest expression of cathelicidin B1 was seen in both the lung and cecal tonsil on day 14. Collectively, the presence of cathelicidins in a broad range of tissues and their largely enhanced expression during development are suggestive of their potential important role in early host defense and disease resistance of chickens. | Mallika Achanta Lakshmi T Sunkara Gan Dai Yugendar R Bommineni Weiyu Jiang Guolong Zhang | 2012 | Journal of Animal Science and Biotechnology2012，3，2： | 3 |
| 15 | Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8^+ T cells during pregnancy显示文摘Listeria monocytogenes (Lm ) 为发展中的胎儿在怀孕和疾病的后果期间是有为全身的母亲的感染的唯一的倾向的一个细胞内部的细菌。给与出生前的 Lm 感染联系的高死亡,为在怀孕的极其脆弱的经期期间扩充保护的免疫的策略着急地被需要。此处,保护由在对随后的剧毒的 Lm 出生前的感染的怀孕被评估以前,管理的稀释 Lm 交谈了。因为显著地更多的细菌从母亲的纸巾被恢复,我们证明对在非怀孕的老鼠的第二等的 Lm 感染的保护严厉地在 allogeneic 怀孕期间被节制,尽管有病原体特定的 CD8 + T 房间的数字、功能的保藏。更重要地,因为各在怀孕和天真的怀孕控制以前与稀释 Lm 接种的老鼠在怀孕期间在 Lm 感染以后从单个 concepti 显示出近完全的胎儿的再吞和病原体恢复, preconceptual priming 不在 utero 侵略或胎儿的消耗量免于。显著地,对有在 allogeneic 怀孕的 preconceptual priming 的出生前的 Lm 感染的保护的缺乏在 syngeneic 怀孕期间被恢复。因此,母亲胎儿的抗原不和在出生前的 Lm 感染以后对胎儿的复杂并发症支配 preconceptual 种痘的低效率,尽管有病原体特定的 CD8 + T 房间的数字、功能的保藏。 | Dayna R Clark Vandana Chaturvedi Jeremy M Kinder Tony T Jiang Lijun Xin James M Ertelt Sing Sing Way | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 16 | XPS和TOF-SIMS在硬盘驱动器(HDD)磁头表面微污染分析中的应用显示文摘XPS和 TOF- SIMS表面分析仪器联用分析磁头臂焊接位表面有机微污染物成分 ,找出污染物的来源 ;XPS能够提供污染物中元素组成及价态信息 ,而 TOF- SIMS能够提供其分子信息。试验证明两者联用是分析表面有机微污染物强有力的手段。 | 刘义为 Moulder J F Vlasak P R 蒋致诚 JIANG Zhi-cheng | 2001 | 理化检验(化学分册)2001，37，2： | 3 |
| 17 | Comparison Between AFLP and RFLP Markers in Detecting the Diversity of Rice(Oryza sativa L.)显示文摘AFLP and RFLP were used to study the diversity of 20 rice cultivars. 15 primer combinations were used in the AFLP analysis and 47 - 118 bands were amplified in each lane. A total of 107 polymorphic bands were detected in the RFLP analysis using 49 RFLP probes. The cluster analysis based on RFLP data showed that 20 rice cultivars could be divided into an indica group and a japonica group, as did the AFLP data; however AFLP is more suitable in detecting the difference of pedigree and ecotype among the 20 cultivars.The genetic distance based on AFLP and RFLP data showed the same tendency, but AFLP markers increased the measure of genetic distance among intra-subspecific cultivars and decreased the measure of genetic distance among inter-subspecific cultivars relative to RFLP markers. That indicated that AFLP is more suitable than RFLP in the diversity study and RFLP is more suitable to study the indica-japonica differentiation of cultivars. | CHEN Liang, LIANG Chun-yang, SUN Chuan-qing, JIN De-min, JIANG Ting-bo, WANG Bin and WANG Xiang-kun( China Agricultural University, Beijing 100094 , P. R . China Institute of Genetics and Developmental Biology, Chinese Academy of Science , Beijing 100101, P.R.China) | 2002 | Agricultural Sciences in China2002，1，7： | 2 |
| 18 | Validation and Scenario Analysis of a Soil Organic Carbon Model显示文摘A model developed by the authors was validated against independent data sets. The data sets were obtained from field experiments of crop residue decomposition and a 7-year soil improvement in Yixing City, Jiangsu Province. Model validation indicated that soil organic carbon dynamics can be simulated from the weather variables of temperature, sunlight and precipitation, soil clay content and bulk density, grain yield of previous crops, qualities and quantities of the added organic matter. Model simulation in general agreed with the measurements. The comparison between computed and measured resulted in correlation coefficient γ2 values of 0.9291 * * * (n = 48) and 0. 6431 * * (n = 65) for the two experiments, respectively. Model prediction under three scenarios of no additional organic matter input, with an annual incorporation of rice and wheat straw at rates of 6.75t/ha and 9.0t/ha suggested that the soil organic carbon in Wanshi Township of Yixing City would be from an initial value of 7.85g/kg in 1983 to 6.30g/kg, 11.42g/kg and 13g/kg in 2014, respectively. Consequently, total nitrogen content of the soil was predicted to be respectively 0.49g/kg,0.89g/kg and 1.01g/kg under the three scenarios. | HUANG Yao, LIU Shi-Hang, SHEN Qi-rong, ZONG Liang-gang, JIANG Ding-an and HUANG Hong-guang(College of Resource and Environmental Sciences , Nanjing Agricultural University, Nanjing 210095 , P,R. China Institute of Atmospheric Physics , Chinese Academy of Sciences , Beijing 100029 , P. R . China Agricultural Bureau of Yixing City, Yixing 214209 , P.R. China ) | 2002 | Agricultural Sciences in China2002，1，4： | 2 |
| 19 | Isozyme inheritance and variation in Actinidia显示文摘 | Huang H W Fenny D Wang Z R Jiang Z W Huang R H Wang S M | 1997 | Heredity1997，78，： | 2 |
| 20 | Newly self-administered two-step tool for screening cognitive function in an ageing Chinese population:an exploratory cross-sectional study显示文摘Background Early screening of cognitive function is critical to dementia treatment and care.However,traditional tests require face-to-face administration and are often limited by implementation costs and biases.Aims This study aimed to assess whether the Thoven Cognitive Self-Assessment(TCSA),a novel,innovative two-step touchscreen-based cognition assessment tool,could identify early cognitive impairment due to dementia in older adults.Methods The TCSA was administered to 61 healthy controls(HCs),46 participants with mild cognitive impairment(MCI)and 44 participants diagnosed with dementia recruited from Shanghai.Two outcome measures were generated from the TCSA test:the TCSA_(primary task)score and the TCSA_(secondary task)score.Results The total average scores in the control group for the TCSA_(primary task)and TCSA_(secondary task)were significantly higher than those in the MCI and dementia groups(TCSA_(primary task):HCs vs MCI group vs dementia group,8.58±1.76 vs 5.40±2.67 vs 2.74±2.11,F=75.40,p<0.001;TCSA_(secondary task):HCs vs MCI group vs dementia group,23.02±3.31 vs 17.95±4.93 vs 11.93±5.50,F=76.46,p<0.001).Moreover,receiver operating characteristic analysis showed that a score below 7.5 for the TCSA_(primary task)and a score below 22.5 for the TCSA_(secondary task)were indicators of MCI.Conclusions The TCSA appears to be efficacious for the detection of cognitive impairment in older adults.It demonstrates the potential for large-scale cognition screening in community service settings. | Jing Nie Yang Yang Yining Gao Wenwen Jiang Aisikeer Aidina Fei Sun Lucas R Prieto Jie Yu Kang Ju Lisheng Song Xia Li | 2023 | General Psychiatry2023，36，1： | 2 |
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