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| 1 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 2 | Risk stratification for ST segment elevation myocardial infarction in the era of primary percutaneous coronary intervention显示文摘Acute coronary syndromes presenting with ST elevation are usually treated with emergency reperfusion/revascularisation therapy. In contrast current evidence and national guidelines recommend risk stratification for non ST segment elevation myocardial infarction(NSTEMI) with the decision on revascularisation dependent on perceived clinical risk. Risk stratification for STEMI has no recommendation. Statistical risk scoring techniques in NSTEMI have been demonstrated to improve outcomes however their uptake has been poor perhaps due to questions over their discrimination and concern for application to individuals who may not have been adequately represented in clinical trials. STEMI is perceived to carry sufficient risk to warrant emergency coronary intervention [by primary percutaneous coronary intervention(PPCI)] even if this results in a delay to reperfusion with immediate thrombolysis. Immediate thrombolysis may be as effective in patients presenting early, or at low risk, but physicians are poor at assessing clinical and procedural risks and currently are not required to consider this. Inadequate data on risk stratification in STEMI inhibits the option of immediate fibrinolysis, which may be cost-effective. Currently the mode of reperfusion for STEMI defaults to emergency angiography and percutaneous coronary intervention ignoring alternative strategies. This review article examines the current risk scores and evidence base for risk stratification for STEMI patients. The requirements for an ideal STEMI risk score are discussed. | Richard A Brogan Christopher J Malkin Philip D Batin Alexander D Simms James M McLenachan Christopher P Gale | 2014 | World Journal of Cardiology2014，6，8： | 6 |
| 3 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 4 | The interaction between water movement,sediment dynamics and submersed macrophyte显示文摘 | MADSEN J D CHAMBERS P A JAMES W F | 2001 | Hydrobiologia2001，，444： | 1 |
| 5 | The effect of cultural conditions on growth and secondary metabolism in Streptomycesth ermovilaceus显示文摘 | JAMES P D A EDWARDS C | 1988 | FEMS Microbiol Lett1988，52，： | 1 |
| 6 | The effect of cultural conditions on growth and secondary metabolism in Strepto- mycesth ermovilaceus显示文摘 | James P D A Edwards C | 1998 | FEMS Microbiol Lett1998，52，： | 1 |
| 7 | A novel EPO receptor agonist improves glucose tolerance via glucose uptake in skeletal muscle in a mouse model of diabetes显示文摘 | Scully M S Ort T A James I E Bugelski P J Makropoulos D A Deutsch H A | 2011 | Exp Diabetes Res2011，，91： | 1 |
| 8 | Combined Forced and Natural Convection with Low-Speed Air Flow over Hori- zontal Cylinders 显示文摘 | Hatton A P James D D Swire H W | 1970 | Journal of Fluid Mechanics1970，42，： | 1 |
| 9 | Body burden measurements and models to assess inhalation exposure to methyl tertiary butyl ether (MTBE)显示文摘 | Timothy J B James D P David A | 1997 | Air and Waste Manage1997，47，7： | 1 |
| 10 | Distributed frameworks and parallel algorithms for processing largescale geographic data显示文摘 | Hawick K A Coddington P D James H A | | 0，，10： | 1 |
| 11 | Catalysis at the metal-support interface exemplified by the photocatalytic reforming of methanol on Pd/TiO2显示文摘 | BOWKER M JAMES D STONE P BENNETT R PERKINS N MILLARD L GREAVES J DICKINSON A | 2003 | J Catal2003，217，2： | 1 |
| 12 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 13 | Production of monoclonal antibodies to mycotoxins Fumonisins B1, B2,B3显示文摘 | Azcona-O Mohamed M A Ronald D P James J P | 1992 | J Agric Food Chem1992，40，： | 1 |
| 14 | Podcasting for Your Class 显示文摘 | Richard P Mikat Raymond D Martinez James A Jorstad | 2007 | Journal of Physical Education2007，78，5： | 1 |
| 15 | Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding显示文摘 | Joseph L Kim Kurt A Morgenstern James P Griffith Maureen D Dwyer John A Thomson Mark A Murcko Chao Lin Paul R Caron | 1998 | Structure1998，，1： | 1 |
| 16 | Fluid dynamics of cricket ball swing 显示文摘 | SCOBIE JAMES A PICKERING SIMON G ALMOND DARRYL P LOCK GARY D | 2013 | Proceedings of the Institution of Mechanical Engineers Part P: Journal of Sports Engineering and Technology2013，227，3： | 1 |
| 17 | Evidence for inflammation in asthma显示文摘 | Hogg J C James A L Pare P D | 1991 | Am Rev Respir Dis1991，143，32： | 1 |
| 18 | Struvite Formation, Control and Recovery 显示文摘 | James D D Simon A P | 2002 | Wat Res2002，36，： | 1 |
| 19 | The interaction between water movement,sediment dynamics and sub- mersed macrophytes显示文摘 | Madsen J D Chambers P A James W F | 2001 | Hydrobiologia2001，444，123： | 1 |
| 20 | Versus informal knowledge networks in R&D: a case study using social network analysis 显示文摘 | ALLEN J JAMES A D FORMAL P G | 2007 | R & D Management2007，37，3： | 1 |
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