| 1 | (−)- and (+)-Securidanes A and B, Natural Triarylmethane Enantiomers: Structure and Bioinspired Total Synthesis显示文摘Two pairs of enantiomers,(−)and(+)-securidanes A(1 and 2)and B(3 and 4)featuring unprecedented triarylmethane(TAM)skeletons,were isolated from Securidaca inappendiculata.Teir structures were established by spectroscopic data,X-ray crystallography,and CD analysis.A plausible biosynthetic pathway for 1−4 based on the co-isolated precursors was proposed.Bioinspired total synthesis of 1−4was completed in high yield,which in turn corroborated the biosynthetic hypothesis.Compounds 1−4 showed good inhibition against protein tyrosine phosphatase 1B(PTP1B).Te molecular docking demonstrated that the strongest inhibitor 3(IC50=7.52�M)reaches deeper into the binding pocket and has an additional H-bond. | B.Zhou D.X.Liu X.J.Yuan J.Y.Li Y.C.Xu J.Li YLi J.M.Yue | 2018 | Research2018，，1： | 2 |
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