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| 1 | 指南2.0:为成功制定指南而系统研发的全面清单显示文摘背景虽然当前已有一些评估卫生保健指南可靠性的工具,但仍缺乏针对制定指南实际步骤的指导。针对指南制定者们所需考虑的相关资源和工具,我们系统研发了一份全面的条目清单,但这并不意味着每篇指南都需遵守该清单的所有条目。方法我们检索了国际指南制定机构的指南制定手册、指南的指南(主要是来自国际和国家机构以及专业学会的方法学报告),以及提供系统指导的最新文章。经过反复评价这些资料,尽可能全面地罗列和提取条目,并制定与指南有关的重要主题。通过反复讨论,我们对条目进行评价以去重和补漏,同时邀请指南制定专家对所增加的条目进行修改并提出建议。结果我们制定了一份包含18个主题、146个条目的清单,并建立了帮助指南制定者应用这些条目的网站。这些主题和条目涵盖了指南从规划、完成、实施和评估的全过程。最终的清单版本也包括了培训所需的资料以及应用这些条目时用到的方法学参考文献的链接。解释本清单将提供给指南制定者用作参考。仔细考虑清单中的条目将有助于指南的制定、实施和评估,我们也将会通过大众反馈来修订并持续更新清单。 | Holger J. Schunemann Wojtek Wiercioch Itziar Etxeandia Maicon Falavigna Nancy Santesso Reem Mustafa Matthew Ventresca Romina Brignardello-petersen] Kaja-Triin Laisaar Sergio Kowalski Tejan Baldeh Yuan Zhang Uiia Raid Ignacio Neumann Susan L. Norris Judith Thornton Robin Harbour Shaun Treweek Gordon Guyatt Pablo Alonso-Coello Marge Reinap Jan Brozek Andrew Oxman Elie A. Akl | 2014 | 中国循证医学杂志2014，14，9： | 26 |
| 2 | Differences in energy and corneal endothelium between femtosecond laser-assisted and conventional cataract surgeries:prospective,intraindividual,randomized controlled trial显示文摘AIM: To compare intraoperative phacoemulsification parameters and its effect on the corneal endothelium of eyes undergoing femtosecond laser-assisted cataract surgery(FLACS) versus conventional phacoemulsification(CP) cataract surgery.METHODS: Two hundred eyes from one hundred patients were included in a prospective, non-blinded, randomized, controlled, intraindividual clinical study. One hundred eyes underwent FLACS while their one hundred fellow eyes underwent CP. All surgeries were performed using the Victus? femtosecond laser platform and Infinity? Vision System phacoemulsification machine. Primary outcome measure was endothelial cell density 6 mo after surgery. Secondary outcome measures included central corneal thickness(CCT), average cell area, standard deviation, coefficient of variation and hexagonality before surgery and 6 mo after surgery and endothelial cell density loss during this period were also evaluated. Intraoperative efficiency parameters [cumulative dissipated energy(CDE), total intraocular surgery time, total ultrasound time, total phacoemulsification time, total torsional energy time, total aspiration time, ultrasound energy, torsional amplitude and fluid required during surgery] were also collated. RESULTS: Data from these patients was not considered for analysis. Data from 92 patients were analysed. Postoperative endothelial cell density(cells/mm2) between groups(2211.88±392.49 CP; 2246.31±403.48 FLACS) was not statistically significant(P=0.869). Total ultrasound time, torsional energy time, CDE and fluid requirements were significantly lower the FLACS group(P<0.05). Other parameters did not show statistically significant difference between FLACS and CP.CONCLUSION: FLACS displays significant improvements in phacoemulsification parameters in comparison to CP. There are no significant differences in corneal endothelium measures between FLACS and CP. | Lucia Bascaran Txomin Alberdi Itziar Martinez-Soroa Cristina Sarasqueta Javler Mendlcute | 2018 | International Journal of Ophthalmology(English edition)2018，11，8： | 5 |
| 3 | Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet显示文摘 | Goiuri Alberdi Víctor M. Rodríguez M. Teresa Macarulla Jonatan Miranda Itziar Churruca María P. Portillo | 2013 | Nutrition2013，，： | 3 |
| 4 | Phytoextraction: a cost-effective plant-based technology for the removal of metals from the environment显示文摘 | Carlos Garbisu Itziar Alkorta | 2001 | Bioresource Technology2001，，3： | 2 |
| 5 | Plants against the global epidemic of arsenic poisoning显示文摘 | Itziar A Javier H A Carlos G | 2004 | Environment International2004，30，： | 1 |
| 6 | Simultaneous manifestation of fulminant infectious mononucleosis with haemophagocytic syndrome and B-cell lymphoma in X-linked lymphoproliferative disease显示文摘 | Boris Hügle Itziar Astigarraga Jan-Inge Henter Anna Porwit-MacDonald Alfons Meindl Volker Schuster | 2007 | European Journal of Pediatrics2007，，6： | 1 |
| 7 | Data mining for quality control: Burr detection in the drilling process显示文摘 | Susana Ferreiro Basilio Sierra Itziar Irigoien | 2011 | Computers & Industrial Engineering2011，60，4： | 1 |
| 8 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 9 | Effects of a dust deposition event on coastal marine microbial abundance and activity, bacterial community structure and ecosystem function 显示文摘 | Itziar L Thomas L Estela R | 2010 | Journal of Plankton Research2010，32，4： | 1 |
| 10 | Application of relative quantification TaqMan real-time polymerase Chain reaction technology for the identification and quantification of thunnus alalunga and thunnus albacares显示文摘 | Itziar Lopez Miguel Angel Pardo | 2005 | Agric Food Chem2005，53，11： | 1 |
| 11 | Soil enzyme aetivities as biological indicators of soil health显示文摘 | Itziar A Arm A Patrick R | 2003 | Reviews on Environmental Health2003，18，1： | 1 |
| 12 | High-Frequency Ultrasound Imaging for Longitudinal Evaluation of Non-Alcoholic Fatty Liver Disease Progression in Mice显示文摘 | Itziar Fernández-Domínguez J. Javier Echevarria-Uraga Nieves Gómez Zigmund Luka Conrad Wagner Shelly C. Lu José M. Mato Maria L. Martínez-Chantar Juan Rodríguez-Cuesta | 2011 | Ultrasound in Medicine & Biology2011，，7： | 1 |
| 13 | Dynamic modeling of planar parallel robots considering passive joint sensor data显示文摘 | Asier Z Itziar C Marga M | 2010 | Robotica2010，28，5： | 1 |
| 14 | Tacrolimus pharmacokinet- ics in the early post - liver transplantation period and clinical applicabil- ity via Bayesian Prediction显示文摘 | Itziar Oteo John C Lukas Nerea Leal | 2013 | Eur J C lin Pharmacol2013，69，： | 1 |
| 15 | Phytoextraction: a cost-effective plant-based technology for the removal of metals from the environment 显示文摘 | Carlos G Itziar A | 2001 | Bioresource Technology2001，77，3： | 1 |
| 16 | Mapping the importance of the real world : the validity of connectivity analy- sis of patent citations networks 显示文摘 | DAVID B T FERNANDO J S ITZIAR C M | 2011 | Research Policy2011，40，3： | 1 |
| 17 | Quantitative analysis of the effect of zidovudine,efavirenz,and ritonavir on insulin aggregation by multivariate curve resolution alternating least squares of infrared spectra显示文摘 | MARTI-ALUJA Idois RUISN Itziar LARRECHI M Soledad | 2013 | Analytica Chimica Acta2013，760，： | 1 |
| 18 | Soil enzyme activities as biological indicators of soil health显示文摘 | Itziar A Ana A Patrick R | | 0，，01： | 1 |
| 19 | The oncogene EVI1 enhances transcriptional and biological responses of human myeloid cells to all-trans retinoic acid显示文摘 | Birgit Steinmetz Hubert Hackl Eva Slabáková Ilse Schwarzinger Monika Smějová Andreas Spittler Itziar Arbesu Medhat Shehata Karel Sou?ek Rotraud Wieser | 2014 | Cell Cycle2014，，： | 1 |
| 20 | Phytoextraction:a cast-effective plantbased technology for the removal ofmetals from the environment显示文摘 | Carlos Garbisu Itziar Alkorta | 2001 | Bioresource Technology2001，77，： | 1 |
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