|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B显示文摘AIM:To investigate the predictors of proximal kidney tubular dysfunction(PKTD)induced by adefovir dipivoxil(ADV)treatment for chronic hepatitis B.METHODS:Seventy-nine patients(age at the evaluation of PKTD:56.9±10.7 years)with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited.PKTD was defined by the presence of at least two of the following five abnormalities:phosphate diabetes,nondiabetic glucosuria,metabolic acidosis,β2-microglobulinuria,or renal hypouricemia.The single-nucleotide polymorphisms(SNPs)in the SLC22A6 gene encoding human organic anion transporter 1(h OAT1)and ABCC2 encoding multidrug resistance protein 2(MRP2)were analyzed using the Taq Man Allelic Discrimination Demonstration Kit.RESULTS:Nine(30.0%)of the 30 ADV-treated patients were diagnosed with PKTD,while no patients without ADV developed PKTD(P<0.001).Three patients with ADV were diagnosed with symptomatic osteomalacia.Among the patients who took ADV,those with PKTD were of higher age at initiation,had significantly longer treatment duration,and had a significantly lower body mass index than those without PKTD.The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration.In contrast,the SNPs were not correlated with PKTD.Logistic regression analysis extracted older age at initiation(OR=5.0,95%CI:1.1-23.4;P=0.040)and longer treatment duration(OR=3.2,95%CI:1.2-8.6;P=0.020)as significant factors associated with PKTD.CONCLUSION:Our results suggest that the tubular function of the kidney of older patients undergoing longterm ADV treatment should be carefully evaluated. | Motohiro Shimizu Norihiro Furusyo Hiroaki Ikezaki Eiichi Ogawa Takeo Hayashi Takeshi Ihara Yuji Harada Kazuhiro Toyoda Masayuki Murata Jun Hayashi | 2015 | World Journal of Gastroenterology2015，21，7： | 18 |
| 2 | Cardiac marker responses to coronary artery bypass graft surgery with cardiopulmonary bypass and aortic cross-clamping显示文摘 | Takeda S Nakanishi K Ikezaki H | 2002 | J Cardiothorac Vase Anesth2002，16，4： | 1 |
| 3 | A clinical comparison of definite moyamoya disease between South Korea and Japan显示文摘 | Ikezaki K Han DH Kawano T | | 0，，： | 1 |
| 4 | Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors 显示文摘 | Ikezaki K Ono M | 1995 | Cancer Res1995，55，： | 1 |
| 5 | Defining thoptimal dose of radiation after incomplete resection of central neurocytomase 显示文摘 | RADES D SCHILD SE IKEZAKI K | 2003 | Radiat Oncol Biol Phys2003，55，2： | 1 |
| 6 | A novel susceptibility locus for moyamoya disease on chromosome 8q23显示文摘 | Kaoru Sakurai Yasue Horiuchi Hidetoshi Ikeda Kiyonobu Ikezaki Takashi Yoshimoto Masashi Fukui Tadao Arinami | 2004 | Journal of Human Genetics2004，，5： | 1 |
| 7 | Partial Mastoid Oblitera- tion Combined With Soft-wall Reconstruction for Middle Ear Chol- esteatoma显示文摘 | Suzuki H Ikezaki S Imazato K | 2014 | Ann Otol Rhinol Laryngol2014，123，8： | 1 |
| 8 | Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents显示文摘 | Ikezaki A Hosoda H Ito K | 2002 | Diabetes2002，，12： | 1 |
| 9 | Genetic networks regulated by ASYMMETRIC LEAVESI(AS1) and AS2 in leaf development in Arabidopsis thaliana :KNOX genes control five morphological events显示文摘 | IKEZAKI M KOJIMA M SAKAKIBARA H | 2010 | The Plant Journal2010，61，1： | 1 |
| 10 | Type V phosphodiesterase expression in cerebral arteries with vasospasm after subarachnoid hemorrhage in a canine model显示文摘 | Inoha S Inamura T Ikezaki | 2002 | Neurol Res2002，24，： | 1 |
| 11 | Clinical comparison of definite moyamoya diseases between South Korea and Japan显示文摘 | Han DH Kawano T | 1997 | Stroke1997，28，： | 1 |
| 12 | Cardiac marker responses to coronary artery bypass graft surgery with cardiopulmonary bypass and aortic cross-clamping显示文摘 | Shinhiro Takeda Kazuhiro Nakanishi Hiroyuki Ikezaki Chol Kim Atsuhiro Sakamoto Keiji Tanaka Ryo Ogawa | 2002 | Journal of Cardiothoracic and Vascular Anesthesia2002，，4： | 1 |
| 13 | Linkage analysis of moyamoya disease on chromosome 6显示文摘 | Inoue TK Ikezaki K Sasazuki T etal | 2000 | J Child Neurol2000，15，3： | 1 |
| 14 | A clinicalcomparison of definite moyamoya disease between South Korea andJapan显示文摘 | Han DH Kawano T | 1997 | Stroke1997，28，： | 1 |
| 15 | Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors显示文摘 | SAMOTO K IKEZAKI K ONO M | 1995 | Cancer Res1995，55，5： | 1 |
| 16 | Charge stability of TPX film electrets 显示文摘 | Ikezaki K Iritani K Nakamura T | 1995 | J Eleetmstat1995，35，： | 1 |
| 17 | Analysis of sake taste using multielectrode taste sensor显示文摘 | Arikawa Y Toko K Ikezaki H | 1995 | Sens Materials1995，，7： | 1 |
| 18 | The efficacy of bypass surgery for the patients with hemorrhagic Momamoya disease 显示文摘 | Fujii K Ikezaki K Irikura K | 1997 | Clin neurol Neurosurg1997，99，： | 1 |
| 19 | Anomalous thermally stimulated currents in polypropylene films显示文摘 | Kazuo Ikezaki Yusuke Kudo Yuji Murata | 2010 | IEEE Transactions on Dielectrics and Electrical Insulation2010，17，4： | 1 |
| 20 | Evaluation of the astringency of black tea by a taste sensor system:Scope and limitation 显示文摘 | HAYASHI N CHEN R IKEZAKI H | 2007 | Bioscience Biotechnology and Biochemistry2007，71，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员