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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Hypolipidemic effect ofPleurotus eryngii extract in fat-loaded mice 显示文摘 | MIZUTANI T INATOMI S INAZU A | 2010 | J Nutr Sci Vitaminol2010，56，1： | 1 |
| 3 | Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol显示文摘 | Inazu A Jiang XC Haraki T | 1994 | J Clin Invest1994，94，5： | 1 |
| 4 | Cholesteryl ester transfer protein (CETP) deficiency and CETP inhibitors 显示文摘 | MABUCHI H NOHARA A INAZU A | 2014 | Mol Cells2014，37，11： | 1 |
| 5 | A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels,including those with plasma cholesteryl ester transfer protein deficiency显示文摘 | Moriyama Y Okamura T Inazu A | 1998 | Prev Med1998，27，51： | 1 |
| 6 | Monkey 3-deoxyglucosone reductase : tissue distribution and purification of three multiple forms of the kidney enzyme that are identical with dihydrodiol dehydrogen- ase, aldehyde reductase, and aldose reductase 显示文摘 | Sato K Inazu A Yamaguchi S | 1993 | Archives of biochemistry and biophysics1993，307，2： | 1 |
| 7 | Double deletions and missense mutations in the first nucleotide-binding fold of the ATP-binding cassette transporter AI(ABCA1) gene in Japanese patients with Tangier disease显示文摘 | GUO Z INAZU A YU W | 2002 | J Hum Genet2002，47，6： | 1 |
| 8 | 显示文摘 | Inazu A Kawashiri MA | 2003 | Am J Physiol Endocrinol Metab2003，25，： | 1 |
| 9 | Characteristics of methoxycarbonylation of aromatic diamine with dimethyl carbonate to dicarbamate using a zinc acetate catalyst 显示文摘 | Baba T Kobayashi A Kawanami Y Inazu K Ishikawa A Echizerm T Murai K Aso S Inomata M | 2005 | Green Chemistry2005，7，3： | 1 |
| 10 | Long-term treatment with Pitavastatin (NK-104),a new HMG-CoA reductase inhibitor,of patients with heterozygous familial hypercholesterolemia显示文摘 | Noji Y Higashikata T Inazu A | 2002 | Atherosclerosis2002，163，1： | 1 |
| 11 | Long- term treatment with pitavastatin( NK- 104), a new HMG- CoA reductase inhibitor, of patients with heterozygous familial hypercholesterolemia显示文摘 | Noji Y Higashikata T Inazu A | 2002 | Atherosclerosis2002，163，1： | 1 |
| 12 | Identification of ABC1 gene mutations in three Japanese patients with Tangier disease显示文摘 | GUO Z G INAZU A YU W X | 2000 | Circulation2000，102，： | 1 |
| 13 | Rapid detection and prevalence of cholesteryl ester transfer protein deficiency caused by an intron 14 splicing defect in hyperalphalipoproteinemia 显示文摘 | Inazu A Koizumi J Haraki T | 1993 | Hum Genet1993，91，： | 1 |
| 14 | Double deletions and missense mutations in the first nucleotide-binding fold of the ATP-binding cassette transporter1 A1 (ABCA1) gene in Japanese patients with Tangier disease显示文摘 | GUO Z G INAZU A YU W X | 2002 | J Human Genet2002，47，9： | 1 |
| 15 | Molecular basis of li p id transfer protein deficiency in a family with increased highdensity lipoproteins显示文摘 | Brown ML Inazu A Hesler CB | 1989 | Nature1989，342，： | 1 |
| 16 | Association of estrogen receptor-alpha gene polymorphisms with coronary artery disease in patients with familial hypercholesterolemia显示文摘 | Lu H Higashikata T Inazu A | 2002 | Arterioscler Thromb Vasc Biol2002，22，5： | 1 |
| 17 | Monkey 3-Deoxyglucosone Reductase : tissue distribution and purification of three multiple forms of the kidney enzyme that are identical with dihydrodiol dehydrogenase, aldehyde reduetase, and aldose reductase 显示文摘 | Sato K Inazu A Yamaguchi S | 1993 | Archives of biochemistry and biophysics1993，307，2： | 1 |
| 18 | Effects of hepatic lipase gene promoter nucleotide variations on serum HDL cholesterol concentration in the general Japanese population显示文摘 | Nishimura Y Terada Y | 2001 | J Hum Genet2001，46，4： | 1 |
| 19 | Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins显示文摘 | Brown ML Inazu A Hesler CB | 1989 | Nature1989，342，： | 1 |
| 20 | Cholesteryl ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia显示文摘 | Huang Z Inazu A Nohara A Higashikata T Mabuchi H | 2002 | Clin Sci2002，103，： | 1 |
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