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| 1 | Protein misfolding in neurodegenerative diseases:implications and strategies显示文摘A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse.Therapeutic options are currently being explored that target different steps in the production and processing of proteins implicated in neurodegenerative disease,including synthesis,chaperone-assisted folding and trafficking,and degradation via the proteasome and autophagy pathways.Other therapies,like mTOR inhibitors and activators of the heat shock response,can rebalance the entire proteostatic network.However,there are major challenges that impact the development of novel therapies,including incomplete knowledge of druggable disease targets and their mechanism of action as well as a lack of biomarkers to monitor disease progression and therapeutic response.A notable development is the creation of collaborative ecosystems that include patients,clinicians,basic and translational researchers,foundations and regulatory agencies to promote scientific rigor and clinical data to accelerate the development of therapies that prevent,reverse or delay the progression of neurodegenerative proteinopathies. | Patrick Sweeney Hyunsun Park Marc Baumann John Dunlop Judith Frydman Ron Kopito Alexander McCampbell Gabrielle Leblanc Anjli Venkateswaran Antti Nurmi Robert Hodgson | 2017 | Translational Neurodegeneration2017，6，1： | 4 |
| 2 | Saponins from the Roots of Platycodon grandiflorum Suppresses TGFβ1-Induced Epithelial-Mesenchymal Transition Via Repression of PI3K/Akt, ERK1/2 and Smad2/3 Pathway in Human Lung Carcinoma A549 Cells显示文摘 | JaeHo Choi YongPil Hwang HyungGyun Kim Tilak Khanal MinhTruong Do SunWoo Jin HwaJeong Han HyunSun Lee YoungChun Lee YoungChul Chung TaeCheon Jeong HyeGwang Jeong | 2014 | Nutrition and Cancer2014，，1： | 1 |
| 3 | Effects of various characteristics ofsocial commerce (s-commerce) on consumers’trust and trust performance显示文摘 | Sanghyun Kim Hyunsun Park | 2012 | International Journal of Information Management2012，，： | 1 |
| 4 | Determination of coccidiostats (Amprolium and Decoquinate) in cattle and chicken's muscle using high performance liquid chromatography 显示文摘 | Byung J K Hyunsun H Jin J L | 2012 | Bull Korean Chem2012，33，2： | 1 |
| 5 | Effects of various characteristics of social commerce (s-commerce) on consumers’ trust and trust performance显示文摘 | Sanghyun Kim Hyunsun Park | 2012 | International Journal of Information Management2012，，： | 1 |
| 6 | Effects of Various Characteristics of Social Commerce (S-commerce) on Con- sumers' Trust and Trust Performance 显示文摘 | Sanghyun Kim Hyunsun Park | 2013 | International Journal of Informa- tion Management2013，，2： | 1 |
| 7 | Stochastic and spatio-temporal analysis of the Middle East Respiratory Syndrome outbreak in South Korea, 2015显示文摘South Korea was free of the Middle East Respiratory Syndrome(MERS)until 2015.The MERS outbreak in South Korea during 2015 was the largest outbreak of the Coronavirus outside the Middle East.The major characteristic of this outbreak is inter-or intra-hospital transmission.This recent MERS outbreak in South Korea is examined and assessed in this paper.The main objectives of the study is to characterize the pattern of the MERS outbreak in South Korea based on a basic reproductive ratio,the probability of ultimate extinction of the disease,and the spatio-temporal proximity of occurrence between patients.The survival function method and stochastic branching process model are adapted to calculate the basic reproductive ratio and the probability of ultimate extinction of the disease.We further investigate the occurrence pattern of the outbreak using a spatio-temporal autocorrelation function. | Hyunsun Lee | 2019 | Infectious Disease Modelling2019，4，1： | 0 |
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