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| 1 | Effects of Traditional Herbal Formulae on Human CYP450 Isozymes显示文摘Objective:To assess the effects of traditional herbal formulae Sijunzi Decoction(四君子汤,Sagunja-tang,SJZD),Siwu Decoction(四物汤,Samul-tang,SWD),Bawu Decoction(八物汤,Palmul-tang,BWD)and Shiquan Dabu Decoction(十全大补汤,Sipjeondaebo-tang,SDD) on the activities of human cytochrome P450(CYP450),a drug-metabolizing enzyme.Methods:Herbal formula water extracts were filtered and lyophilized after the powder extracts were dissolved in distilled water.The activities of major human CYP450isozymes(CYP3A4,CYP2C19,CYP2D6 and CYP2E1) were measured using in vitro fluorescence-based enzyme assays.The inhibitory effects of the herbal formulas on the activities of CYP450 were characterized as half maximal inhibition concentration(IC_(50)) values.Results:All the tested herbal formulae inhibited CYP2C19activity(IC_(50):SJZD,83.28 μg/mL;SWD,235.54 μg/mL;BWD,166.82 μg/mL;SDD,178.19 μg/mL);SJZD(lC_(50) = 196.46 μ g/mL),SWD(IC_(50) = 333.42 μ g/mL) and SDD(IC_(50) = 163.42 μg/mL) inhibited CYP2E1-mediated metabolism;whereas BWD exhibited comparatively weak inhibition of CYP2E1(IC_(50) = 501.78 μg/mL).None of the four herbal formulas significantly affected CYP3A4 or CYP2D6.Conclusions:These results suggest that SJZD,SWD,BWD and SDD could potentially inhibit the metabolism of co-administered synthetic drugs whose primary route of elimination is via CYP2C19.In addition,clinically relevant pharmacokinetic interactions could occur when SJZD,SWD or SDD is co-administered with drugs metabolized by CYP2E1.Our findings provide information for the safety and effective clinical use of these four classic herbal formulas. | Seong Eun Jin Hyekyung Ha Hyeun-Kyoo Shin | 2017 | Chinese Journal of Integrative Medicine2017，23，1： | 3 |
| 2 | Bank Nationalization,Restructuring and Reprivatization:The Case of Korea since the Asian Financial Crisis显示文摘 | Cho Hyekyung Thomas Kalinowski | | 0，，01： | 1 |
| 3 | Sterol regulation element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acid显示文摘 | Xu Jing Manabu T Nakamura Hyekyung P Cho | 1999 | J Biol Chem1999，274，23： | 1 |
| 4 | Student Motivation, Parental Attitudes, and Involve- ment in the Learning of Asian Languages in Elementary and Secondary Schools 显示文摘 | SUNG HYEKYUNG & PADILLAa AMADO M | 1998 | The Modem Language Journal1998，，2： | 1 |
| 5 | Study of Substance Changes in Flowers of Pueraria Thunbergiana 显示文摘 | CHUNG SOOK K SUNMI S HYEKYUNG H | 2003 | Arch Pharm Res2003，26，： | 1 |
| 6 | Cloning, Expression, and nutritional regulation of the mammalian delta-6 desaturase显示文摘 | Hyekyung P Cho Manabu T Nakamura Steven D Clarke | 1999 | J Bio Chem1999，274，1： | 1 |
| 7 | Metabolism and functions of highly unsaturated fatty acids: An update显示文摘 | Manabu T. Nakamura Hyekyung P. Cho Jing Xu Zhongren Tang Steven D. Clarke | 2001 | Lipids2001，，9： | 1 |
| 8 | Quality of parent-child relationship, fami- ly conflict, peer pressure, and drinking behaviors of adolescents in an asian context : the case of singapore 显示文摘 | HYEKYUNG C DANIEL S | 2013 | Soc Indic Res2013，110，3： | 1 |
| 9 | Antiprolifera- tire activity of triterpenoids from Eelipta prostrate on hepatic stel- late cells显示文摘 | Mi Kyeong Lee Na Ry Ha Hyekyung Yang | 2008 | Phytomedicine2008，15，： | 1 |
| 10 | Degree of foreign accent in English sentences produced by Korean children and adults显示文摘 | James Emil Flege David Birdsong Ellen Bialystok Molly Mack Hyekyung Sung Kimiko Tsukada | 2005 | Journal of Phonetics2005，，2： | 1 |
| 11 | Stimulatory activity of lignans from Machilus thunbergii on osteoblast differentiation显示文摘 | Mi kyeong lee Hyekyung yang Choong je ma | 2007 | Biol Pbarm Bull2007，30，4： | 1 |
| 12 | The relationship of storage and viability of lily pollen显示文摘 | Rhee HyeKyung Lim JinHee Cho HaeRyong | 2003 | Acta Horticulturae2003，620，： | 1 |
| 13 | Antifibrotic phenanthrenes from Dendrobium nobile 显示文摘 | Hyekyung Y Sang H S Young C K | 2007 | J Nat Prod2007，70，12： | 1 |
| 14 | Form- ononetin prevents ovariectomy-induced bone loss in rats显示文摘 | Hyekyung H Young LH Jehyun L | 2010 | Arch Pharm Res2010，33，4： | 1 |
| 15 | Dietary phytic acid lowers the blood glucose level in diabetic KK mice 显示文摘 | LEE Sunghyen PARK Hongju CHUN Hyekyung | 2006 | Nutrition Research2006，26，9： | 1 |
| 16 | Stimulatory Constituents of Eclipata prostrata on Mouse Osteoblast Differentiation 显示文摘 | Mi Kyeong Lee Na Ry Ha Hyekyung | 2009 | Wiley InterScience2009，6，23： | 1 |
| 17 | Sterol regulation element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acid显示文摘 | Xu Jing Manabu T N Hyekyung P | 1999 | J Biol Chem1999，274，23： | 1 |
| 18 | A developmental study of English vowel production and perception by native Korean adults and children显示文摘 | Kimiko Tsukada David Birdsong Ellen Bialystok Molly Mack Hyekyung Sung James Flege | 2004 | Journal of Phonetics2004，，3： | 1 |
| 19 | Stimulatory Constituents of Eclipta prostrate on Mouse Osteoblast Differentia- tion显示文摘 | Mi Kyeong Lee Na Ry Ha Hyekyung Yang | 2009 | Phytotherapy Research2009，23，： | 1 |
| 20 | The Political Economy of Financial Market Liberalization in South Korea: State, Big Business, and Foreign Investors 显示文摘 | Thomas Kalinowski Hyekyung Cho | 2009 | Asian Survey2009，49，2： | 1 |
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