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| 1 | Fusobacterium 's link to colorectal neoplasia sequenced: A systematic review and future insights显示文摘AIM To critically evaluate previous scientific evidence on Fusobacterium's role in colorectal neoplasia development.METHODS Two independent investigators systematically reviewed all original scientific articles published between January,2000,and July,2017,using Pub Med,EMBASE,and MEDLINE. A total of 355 articles were screened at the abstract level. Of these,only original scientific human,animal,and in vitro studies investigating Fusobacterium and its relationship with colorectal cancer(CRC) were included in the analysis. Abstracts,review articles,studies investigating other colonic diseases,and studies written in other languages than English were excluded from our analysis. Ninety articles were included after removing duplicates,resolving disagreements between the two reviewers,and applying the above criteria.RESULTS Studies have consistently identified positive associations between Fusobacterium,especially Fusobacterium nucleatum(F. nucleatum),and CRC. Stronger associations were seen in CRCs proximal to the splenic flexure and Cp G island methylator phenotype(CIMP)-high CRCs. There was evidence of temporality and a biological gradient,with increased F. nucleatum DNA detection and quantity along the traditional adenoma-carcinoma sequence and in CIMP-high CRC precursors. Diet may have a differential impact on colonic F. nucleatum enrichment;evidence suggests that high fiber diet may reduce the risk of a subset of CRCs that are F. nucleatum DNA-positive. Data also suggest shorter CRC and disease-specific survival with increased amount of F. nucleatum DNA in CRC tissue. The pathophysiology of enrichment of F. nucleatum and other Fusobacterium species in colonic tissue is unclear;however,the virulence factors and changes to the local colonic environment with disruption of the protective mucus layer may contribute. The presence of a host lectin(Gal-Gal NAc) in the colonic epithelium may also mediate F. nucleatum attachment to CRC and precursors through interaction with an F. nucleatum protein,fibroblast activation protein 2(FAP2). The clinical significance of detection or enrichment of Fusobacterium in colorectal neoplasia is ambiguous,but data suggest a procarcinogenic effect of F. nucleatum,likely due to activation of oncogenic and inflammatory pathways and modulation of the tumor immune environment. This is hypothesized to be mediated by certain F. nucleatum strains carrying invasive properties and virulence factors such as Fad A and FAP.CONCLUSION Evidence suggests a potential active role of Fusobacterium,specifically F. nucleatum,in CRC. Future prospective and experimental human studies would fill an important gap in this literature. | Hisham Hussan Steven K Clinton Kristen Roberts Michael T Bailey | 2017 | World Journal of Gastroenterology2017，23，48： | 9 |
| 2 | Multiple Tuned Mass Damper Based Vibration Mitigation of Offshore Wind Turbine Considering Soil–Structure Interaction显示文摘The dynamics of jacket supported offshore wind turbine(OWT) in earthquake environment is one of the progressing focuses in the renewable energy field. Soil–structure interaction(SSI) is a fundamental principle to analyze stability and safety of the structure. This study focuses on the performance of the multiple tuned mass damper(MTMD) in minimizing the dynamic responses of the structures objected to seismic loads combined with static wind and wave loads. Response surface methodology(RSM) has been applied to design the MTMD parameters. The analyses have been performed under two different boundary conditions: fixed base(without SSI) and flexible base(with SSI). Two vibration modes of the structure have been suppressed by multi-mode vibration control principle in both cases. The effectiveness of the MTMD in reducing the dynamic response of the structure is presented. The dynamic SSI plays an important role in the seismic behavior of the jacket supported OWT, especially resting on the soft soil deposit.Finally, it shows that excluding the SSI effect could be the reason of overestimating the MTMD performance. | Mosaruf HUSSAN Faria SHARMIN Dookie KIM | 2017 | China Ocean Engineering2017，31，4： | 5 |
| 3 | Predictors of double balloon endoscopy outcomes in the evaluation of gastrointestinal bleeding显示文摘AIM:To identify patients' characteristics associated with double balloon endoscopy(DBE)outcomes in investigation of obscure gastrointestinal bleeding(OGIB).METHODS:Retrospective study performed at an academic tertiary referral center.Evaluated endpoints were clinical factors associated with no diagnostic yield or non-therapeutic intervention of DBE performed for OGIB evaluation.RESULTS:We included fifty-five DBE between August 2010 and April 2012.The mean age of the sample was 67 with 32 males(58.2%).Twenty-four DBE had no diagnostic yield and 30 DBE did not require therapy.Non-diagnostic yield was associated with performing two or more DBE studies in one day [odds ratio(OR):13.72,P=0.008],absence of blood transfusions within a year of the DBE(OR:7.16,P=0.03)and absence of ulcers or arteriovenous malformations(AVMs)on prior esophagogastroduodenoscopy(EGD)or colonoscopy(OR:19.30,P=0.033).Non-therapeutic DBE was associated with performing two or more DBE per day(OR:18.579,P=0.007),gastrointestinal bleeding episode within a week of the DBE(OR:11.48,P=0.003),fewer blood transfusion requirements prior to DBE(OR:4.55,P=0.036)and absence of ulcers or AVMs on prior EGD or colonoscopy(OR:8.47,P=0.027).CONCLUSION:Predictors of DBE yield and therapeutic intervention on DBE include blood transfusion requirements,previous endoscopic findings and possibly endoscopist fatigue. | Hisham Hussan Nicholas R Crews Caroline M Geremakis Soubhi Bahna Jennifer L LaBundy Christine Hachem | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，6： | 3 |
| 4 | Coherent structures-reality and myth 显示文摘 | Hussan A E | 1983 | Physics of Fluids1983，26，10： | 1 |
| 5 | Morbid Obesity is Associated with Increased Mortality, Surgical Complications, and Incremental Health Care Utilization in the Peri-Operative Period of Coloreetal Cancer Surgery显示文摘 | Hussan H Gray DM Hinton A | 2016 | World journal of surgery2016，44，4： | 1 |
| 6 | Inhibition of a-glucosidase by oleanolic acid and its synthetic derivatives 显示文摘 | Ali MS Jahangir M Hussan SS | 2002 | Phytochemistry2002，60，3： | 1 |
| 7 | Screening of soil fungi forin vitro degradation of endosulfan显示文摘 | Hussan S Arshad M Saleem M | 2007 | World J Microbiol Biotechnol2007，23，： | 1 |
| 8 | Heat Transfer to Supercritical Fluids Flowing in Channels-Empirical Correlations(Survey)显示文摘 | Igor L Pioro Hussan F Khartabil | 2004 | Nuclear Engineering and Design2004，230，： | 1 |
| 9 | Inflammation and cancer:an ancient link with novel potentials显示文摘 | Hussan SP Harriscc | | 0，，11： | 1 |
| 10 | Mesenteric venous thrombosis显示文摘 | Hussan HA Raufman JP | 1999 | South Med J1999，92，6： | 1 |
| 11 | Evaluation of clinical measures of quilibrium显示文摘 | Hussan K Kashlan E Sheppard NT | 1998 | Aryngoscope1998，108，3： | 1 |
| 12 | Inhibitition of a-glucosidase by oleanolic acid and its synthetic derivatives显示文摘 | ALI M S JAHANGIR M HUSSAN S S | 2002 | Phytochemistry2002，60，3： | 1 |
| 13 | A new modeling approach for water resources policy analysis显示文摘 | Slobadan P Hussan F | 1999 | Water Resources Research1999，35，1： | 1 |
| 14 | Occurrence in chemical composition and nutritional value of truffles:overview显示文摘 | Hussan G Al-Ruqaie I M | | 0，，2： | 1 |
| 15 | Performance of reinforced concrete t-girders strengthened in shear with carbon fiber-reinforced polymer fabric显示文摘 | CHAALLAL O SHAHAWY M HUSSAN M | 2002 | ACI Structural Journal2002，99，3： | 1 |
| 16 | Inhibition of a-glucosidase by oleanolic acid and its synthetic derivatives显示文摘 | ALl M S JAHANGIR M HUSSAN S S | 2002 | Phy- tochemistry2002，60，3： | 1 |
| 17 | Inhibition of α-glucosidase by oleanolic acid and its synthetic derivatives 显示文摘 | Ali M S Jahangir M Hussan S S | 2002 | Phytochemistry2002，60，： | 1 |
| 18 | Evaluation of clinical measures of equilibrium显示文摘 | Hussan K Kashlan E Shepard NT | 1998 | Laryngoscope1998，108，3： | 1 |
| 19 | The in sidious onset of dyspnea and right lung collapse in a35-year-old man显示文摘 | Hussan S F Salabuddin N Khan A | 2005 | Chesl2005，27，23： | 1 |
| 20 | Effect of feeding Yucca schidigera extract in diets varying in crude Protein and urea contents on growth performance and cecum and blood Urea and ammonia concentrations of rabbits显示文摘 | Hussan I Ismail AM Cheek PR | | 0，，2： | 1 |
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