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| 1 | Alcohol metabolites and lipopolysaccharide: Roles in the development and/or progression of alcoholic liver disease显示文摘The onset of alcoholic liver disease (ALD) is initiated by different cell types in the liver and a number of different factors including: products derived from ethanol-induced inflammation, ethanol metabolites, and the indirect reactions from those metabolites. Ethanol oxidation results in the production of metabolites that have been shown to bind and form protein adducts, and to increase inflammatory, fibrotic and cirrhotic responses. Lipopolysaccharide (LPS) has many deleterious effects and plays a significant role in a number of disease processes by increasing inflammatory cytokine release. In ALD, LPS is thought to be derived from a breakdown in the intestinal wall enabling LPS from resident gut bacterial cell walls to leak into the blood stream. The ability of adducts and LPS to independently stimulate the various cells of the liver provides for a two-hit mechanism by which various biological responses are induced and result in liver injury. Therefore, the purpose of this article is to evaluate the effects of a two-hit combination of ethanol metabolites and LPS on the cells of the liver to increase inflamma-tion and fi brosis, and play a role in the development and/or progression of ALD. | Courtney S Schaffert Michael J Duryee Carlos D Hunter Bartlett C Hamilton 3rd Amy L DeVeney Mary M Huerter Lynell W Klassen Geoffrey M Thiele | 2009 | World Journal of Gastroenterology2009，15，10： | 20 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | Laparoscopicmanagement of bile ducts tones显示文摘 | Hunter G Soper J | 1992 | Surg Chin North Am1992，72，： | 2 |
| 4 | High-temperature phases of SrRuO3 显示文摘 | Kennedy B J Hunter B A | 1997 | Phys Rev B1997，58，2： | 2 |
| 5 | Peripheral nerve explants grafted into the vitreous body of the eye promote the regeneration of retinal ganglion cell axons severed in the optic nerve显示文摘 | Berry M Carlile J Hunter A | 1996 | J Neurocytol1996，25，2： | 1 |
| 6 | The Spawning frequency of skipjack tuna, Katsuwonus pelamis, from the South Pacific 显示文摘 | HUNTER J R MACEWICZ B J SIBERT J R | 1986 | Fishery Bulletin1986，84，4： | 1 |
| 7 | The immediate psychological and occupational impact of the 2003 SARS outbreak in a teaching hospital显示文摘 | Maunder R Hunter J Vincent L | 2003 | CMAJ2003，168，10： | 1 |
| 8 | Apramycin-resistant Escheriehia coli isolated from pigs and a stockman显示文摘 | Hunter J E B Bennett M Hart C A | 1994 | Epidemiol infect1994，112，： | 1 |
| 9 | An improved closed -form approximation to the inverse black body radiation problem at microwave frequencies显示文摘 | HUNTER J D | 1986 | IEEE Trans Antennas Propagat1986，34，： | 1 |
| 10 | Dietary fiber intake and risk of colorectal cancer:a pooled analysis of prospective cohort studies显示文摘 | PARK Y HUNTER D J SPIEGELMAN D | 2005 | JAMA2005，294，： | 1 |
| 11 | Long-circulating and target-specific nanoparticles :theory to practice显示文摘 | MOGHIMI S M HUNTER A C MURRAY J C | 2001 | Pharmacol Rev2001，53，2： | 1 |
| 12 | Escherichia coli iron superoxide dismutase targeted to the mitochondria of yeast ceils protects the cells against oxidative stress 显示文摘 | Balzan R Bannister W H Hunter G J | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 13 | Leukocyte - and platelet -derived microvesicle interactions following in vitro and in vivo acti-vation of toll - like receptor 4 by lipopolysaccharide 显示文摘 | Xiong J Miller VM Hunter LWf | 2011 | PLos One2011，6，25： | 1 |
| 14 | Current advances in the pathogenesis of varicose veins 显示文摘 | Naoum JJ Hunter GC Woodside K J | 2007 | J Surg Res2007，141，2： | 1 |
| 15 | Effects of early use of pio- glitazone in combination with mefformin in patients with newly diagnosed type 2 diabetes显示文摘 | Chalmers J Hunter JE Robertson SJ | 2007 | Curr Med Res Opin2007，23，8： | 1 |
| 16 | Re-mapping client journeys and professional identities:A review of the literature on clinical pathways 显示文摘 | Hunter B Segrott J | 2008 | Int J Nurs Stud2008，45，4： | 1 |
| 17 | Effect of intrathecal magnesium in the presence or absence of local anaesthetic with and without lipophilic opioids : a systematic review and meta-a- nalysis显示文摘 | Morrison A Hunter J Halpern S | 2013 | British Journal of Anaesthesia2013，3，12： | 1 |
| 18 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 19 | PremenstrualSyndrome 显示文摘 | Dickerson L M Mazyck P J Hunter M H | 2003 | American Family Physician2003，67，8： | 1 |
| 20 | The ABC ontology and model显示文摘 | LAGOZE C HUNTER J | 2001 | Journal of Digital Information2001，1，2： | 1 |
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