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| 1 | Novel Recombinant Seneca Valley Virus Isolated from Slaughtered Pigs in Guangdong Province显示文摘Dear Editor,Since the first outbreak in Brazil in 2015,Seneca Valley virus(SVV)associated with porcine idiopathic vesicular disease,has shown increasing geographic distribution.Cases of SVV have been reported from several countries including the United States(US),Colombia,Thailand,Canada,and China(Pasma et al.2008;Zhang et al.2015;Sun et al.2017;Wu et al.2017;Liu et al.2018;Saeng-Chuto et al.2018).SVV was first identified in the US in 2002 and is the only member of the genus Senecavirus in the family Picomaviridae(Hales et al.2008;Leme et al.2017).The SVV genome contains a large open reading frame(ORF)encoding a polyprotein,which is cleaved into various mature viral proteins including the leader protein(L),structural proteins(VP1,VP2,VP3,and VP4),and non-structural proteins(2A,2B,2C,3A,3B,3C,and 3D)(Hales et al 2008).Structural proteins bind to their receptor,anthrax toxin receptor 1,to mediate viral invasion and stimulate specific immunity of the host(Jayawardena et al.2018).Non-structural proteins such as 3C suppress innate immune responses by degrading interferon regulatory factor 3(IRF 3)and IRF7 and inhibit the activation of RIG-1,TBK1,and TRAF3 through deubiquitination(Xue et al 2018). | Jianxin Liu Yunfeng Zha Huizi Li Yanwei Sun Fuguang Wang Rong Lu Zhangyong Ning | 2019 | Virologica Sinica2019，34，6： | 7 |
| 2 | Contributions of climate, varieties, and agronomic management to rice yield change in the past three decades in China显示文摘和一个庄稼模拟模型,在四个代表性的 agro 气象学的车站的长期的地实验数据被用来在过去的三十年解开大米收益变化的气候变化,变化更新,和授精管理的贡献。我们发现在 1981-2009 变化期间,更新由 16%-52% 增加了米饭产量,管理改进由产量从 16% ~ 10% 改变了的米饭的气候变化的 0-16% ,和贡献增加了产量。变化更新和气候的否定影响在米饭生产上改变的管理改进偏移量。在主要气候变量之中,在太阳的放射的减少到 0.1%per 年平均减少了米饭产量。温度变化的影响有一个明确的空间模式。它在 Tongcheng 车站在 Xinbin 和 Ganyu 车站并且为迟了的米饭为单个米饭每年由 0.04%-0.4% 增加了产量,由在 Tongcheng 在 Mianyang 车站和早米饭为单个米饭每年由 0.2%-0.4% 对比减少的产量车站。在 1981-2009 期间,米饭变化更新被热要求的增加描绘,谷物数字每尖铁和收获索引。新变化比旧的对气候变化不太敏感。高热的要求,高收益潜力和热的发展和农学的管理的改进,容忍的米饭变化应该被鼓励在未来遇见气候变化和增加的食物需求的挑战。 | He ZHANG Fulu TAO Dengpan XIAO Wenjiao SHI Fengshan LIU Shuai ZHANG Yujie LIU Meng WANG Huizi BAI | 2016 | Frontiers of Earth Science2016，10，2： | 5 |
| 3 | Specific Recognition of Breast Cancer Cells In Vitro Using Near Infrared-Emitting Long-Persistence Luminescent Zn_3Ga_2Ge_2O_(10):Cr^(3+)Nanoprobes显示文摘In this paper, near-infrared emitting long-persistence luminescent Zn3Ga2Ge2O10:Cr3?(ZGG) nanoparticles with diameters of 30–100 nm and bright luminescence were prepared by a sol–gel synthesis method. After the surface amination, the nanoparticles were further bioconjugated with breast cancer-specific monoclonal antibody(anti-Ep CAM) to form ZGG-Ep CAM nanoprobes which can specifically target breast cancer cell lines(MCF7) in vitro. The results of in vitro images show that the luminescence signals from the cells treated with ZGG-Ep CAM nanoprobes are stronger than those from cells treated with ZGG-unconjugated antibody, indicating that the prepared ZGG-Ep CAM nanoprobes possessed excellent specific recognition capability. Furthermore, due to their long afterglow properties, the imaging could persist more than 1 h. Therefore, these nanoprobes could not only provide a high specificity detection method for cancer cells but also realize the long-time monitoring. Developed near-infrared emitting long-persistence luminescent nanoprobes will be expected to find new perspectives for cell therapy research and diagnosis applications. | Jinlei Li Junpeng Shi Jiangshan Shen Huizi Man Mingxi Wang Hongwu Zhang | 2015 | Nano-Micro Letters2015，7，2： | 4 |
| 4 | Spatial-temporal Patterns and Evolution History of Rural Settlements from the Perspective of Inheritance——A Case Study of Lianzhou City,Guangdong Province显示文摘Formation and evolution of rural settlement patterns in Lianzhou City,Guangdong Province were analyzed from the perspective of space and time,on the basis of its gazetteer and relevant historical data.The results show that Lianzhou was first founded in the sixth year of Yuanding Period of the Western Han Dynasty,and its development could be roughly classified into 6 stages according to the construction of south–north traffic lines and regional development progress,and it witnessed the fastest development in the Ming and Qing Dynasty.In terms of spatial distribution,rural settlements in the local area show spatial continuity,Lianzhou Town is the core of rural settlement growth in the city,and towns with the most concentrated rural settlements in all stages are located in central-west and northeast parts of the city,and those with lower density of rural settlements are mostly located in minority regions in the north and mountainous areas in the east.On the basis of the above facts,the paper studies the influence of natural geological conditions,immigrant,traffic,economic development and ethnic composition on the establishment and development of rural settlements in Lianzhou City. | CAO Xiaoshu REN Huizi HUANG Xiaoyan LIU Jieyu | 2013 | Journal of Landscape Research2013，5，6： | 3 |
| 5 | DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer显示文摘 | Zheng Li Huizi Lei Min Luo Yi Wang Lei Dong Yanni Ma Changzheng Liu Wei Song Fang Wang Junwu Zhang Jianxiong Shen Jia Yu | 2015 | Gastric Cancer2015，，1： | 2 |
| 6 | Ratiometric sensing lysosomal pH in inflammatory macrophages by a BODIPY-rhodamine dyad with restrained FRET显示文摘Inflammation,as the pathophysiological response of body to harmful stimuli,leads to changes in cellular microenvironment.To research pH changes in lysosomes of macrophages during inflammation,we designed a FRET(F(o|')rster resonance energy transfer)based probe,BDP-RhB.The probe showed good lysosome targeting ability,wide response range of pH from 8.0 to 4.0 with significant ratio(I582/I518)change from 0.6 to 3.4,and good reversibility and sustainability.By applying BDP-RhB,we found a decrease of lysosomal pH of macrophages during inflammation. | Yu Yan Xiaodong Zhang Xinfu Zhang Ning Li Huizi Man Lingcheng Chen Yi Xiao | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 7 | Impacts of climate warming and crop management on maize phenology in northern China显示文摘Climate warming has and will continue to exert a significantly impact on crop phenology in the past and coming decades.Combining observed data of phenology and a crop growth model provides a good approach for quantitating the effects of climate warming and crop management on crop phenology.The purpose of this study is to determine the impacts of temperature change, sowing date(SD) adjustment and cultivar shift on maize phenology in northern China during 1981–2010.Results indicated that climate warming caused anthesis date(AD) and maturity date(MD) of maize to advance by 0.2-5.5 and 0.6-11.1 d/10 a, respectively.Due to climate-driven changes in maize phenology, three growth periods of maize, i.e., vegetative growth period(VGP;from sowing to anthesis), reproductive growth period(RGP;from anthesis to maturity) and whole growth period(WGP;from sowing to maturity) shortened by 0.2-5.5, 0.4-5.6 and 0.6-11.1 d/10 a, respectively.With SD adjustment(i.e., SD advancement), AD and MD occurred early by 0.5-2.6 and 0.1-3.4 d/10 a, respectively.SD adjustment caused duration of VGP of maize to prolong.However, duration of RGP slightly shortened by 0.1-1.3 d/10 a.Furthermore, due to cultivar shift, MD of maize significantly delayed by 4.9-12.2 d/10 a.Durations of VGP, RGP and WGP of maize prolonged by 0.2-4.1, 1.6-8.4 and 4.3-11.8 d/10 a, respectively.In conclusion, our results indicated that cultivar shift, to some extent, could mitigate the negative impact of climate warming on maize phenology. | XIAO Dengpan ZHAO Yanxi BAI Huizi HU Yukun CAO Jiansheng | 2019 | Journal of Arid Land2019，11，6： | 2 |
| 8 | Separate deposition of gold and palladium nanoparticles on ordered mesoporous carbon and evaluation of their catalytic activity for cinnamaldehyde hydrogenation under atmospheric condition显示文摘 | Gu Huizi Xu Xiangsheng Chen Aoang | 2013 | Catalysis Communications2013，41，： | 1 |
| 9 | Identification of characteristic aroma- active compounds in steamed mangrove crab (Scylla serrata)显示文摘 | YU Huizi CHEN Shunsheng | 2010 | Food Research International2010，43，8： | 1 |
| 10 | A Novel Transfer Hydrogenation with High Hydrogen Utilization for the Hydrogenation of Halogenated Nitrobenzene without Hydrodehalogenation显示文摘 | Li Zhou Huizi Gu Xinhuan Yan | 2009 | Catalysis Letters (-)2009，，12： | 1 |
| 11 | Alkaloids from Stephania epigaea 显示文摘 | Jin Huizi Wang Hongbing Wang Yubo | 2007 | Chin J Nat Med2007，5，2： | 1 |
| 12 | Anti-inflammatory and analgesic effects of Daphne retusa Hemsl显示文摘 | Xiaojia Hu Huizi Jin Wenzheng Xu Wei Zhang Xiaohua Liu Shikai Yan Ming Chen Jianqiang Li Wei-dong Zhang | 2008 | Journal of Ethnopharmacology2008，，1： | 1 |
| 13 | Analysis of the bioac- tive constituents of Chan Su in rat plasma by high performance liq- uid chromatography with mass spectrometric detection 显示文摘 | Xia Xiaolin Jin Huizi Yan Shikai | 2010 | J Pharm Biomed Anal2010，53，： | 1 |
| 14 | JaponiconeA induces apoptosis of bortezomib-sensitive and -resistant myeloma cells in vitro and in vivo by targeting IKKβ显示文摘Objective:Multiple myeloma(MM)remains incurable with high rates of relapse.New therapeutic drugs are therefore urgently needed to improve the prognosis.JaponiconeA(JA),a natural product isolated from Inula japonica Thunb,has shown good anti-MM potential.A comprehensive study should therefore be conducted to identify both the in vitro and in vivo mechanisms of the anti-MM effects of JA.Methods:CCK8 assays and flow cytometry were used to detect the proliferation,apoptosis,and cell cycle of MM cell lines when treated with JA.In vivo experiments were conducted using subcutaneous xenograft mouse models.We also identified possible targets and the mechanism of JA using RNA-seq and c-Map databases,and identified the specific targets of JA in bortezomib-sensitive and-resistant MM cell lines using CETSA,DARTS,and rescue experiments.Furthermore,JA and bortezomib were used separately or together to characterize their possible synergistic effects.Results:In vitro,JA inhibited proliferation,and induced apoptosis and G2/M phase arrest in MM cell lines,and selectively killed primary CD138+MM cells.In vivo,JA also demonstrated a strong anti-tumor effect with no observable toxicity.In addition,JA showed synergetic effects in combination with bortezomib,and enhanced the anti-tumor effect of bortezomib in bortezomibresistant cells.CETSA and DARTS confirmed direct binding of JA to NF-κB inhibitor kinase beta(IKKβ),and overexpression of IKKβor knockdown of IκBαpartially rescued the apoptosis induced by JA.Conclusions:JA exhibited strong anti-tumor effects in MM.It sensitized myeloma cells to bortezomib and overcame NF-κB-induced drug resistance by inhibiting IKKβ,providing a new treatment strategy for MM patients. | Zilu Zhang Chenjing Ye Jia Liu Wenbin Xu Chao Wu Qing Yu Xiaoguang Xu Xinyi Zeng Huizi Jin Yingli Wu Hua Yan | 2022 | Cancer Biology & Medicine2022，19，5： | 1 |
| 15 | Camganoids A and B,two new sesquiterpenes with different carbon skeletons isolated from fruits of Cinnamomum migao显示文摘Objective:To isolate and identify the undescribed compounds from the fruits of Cinnamomum migao and evaluate its nitric oxide inhibition potential.Methods:The chromatographic techniques of silica gel,Sephadex,and HPLC were used for isolation and purification of the compounds,while HR-ESI-MS,1D NMR,2D NMR,ECD,and X-ray diffraction techniques were used to characterize and confirm the isolated compounds.Moreover,the antiinflammatory activity of the isolated compounds was carried out to check inhibitory potential against the production of nitric oxide with RAW264.7 cells stimulated by LPS.Results:Camganoid A(1),a novel sesquiterpene possessing an unprecedented skeleton,and camganoid B(2),containing a unique eight-membered sesquiterpene moiety with a new carbon skeleton,were isolated and identified from the fruits of C.migao.The absolute configurations of 1 and 2 were confirmed by single crystal X-ray diffraction and electronic circular dichroism(ECD)calculations.Among these compounds,compound 1 exhibited potent inhibitory activity against the production of nitric oxide with IC50value of 4.59μmol/L in RAW264.7 cells stimulated by LPS.Conclusion:The isolation of two new skeletons from the fruits part of C.migao possessed unique skeletons which have not been reported before. | Yongzhen Xiao Ishaq Muhammad Xianpeng Ma Huajun Yu Shikai Yan Xue Xiao Huizi Jin | 2022 | Chinese Herbal Medicines2022，14，4： | 1 |
| 16 | Study on Family Carbon Emissions Assessment and Optimization 显示文摘 | Li Huizi | 2011 | Procedia Environmental Sciences2011，，11： | 1 |
| 17 | Chemical constituents of plants from the genus Dracocephalum显示文摘 | ZENG Qi JIN Huizi QIN Jiangjiang | 2010 | Chemistry Biodiversity2010，7，8： | 1 |
| 18 | Tumor-penetrating peptide fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric cancer therapy显示文摘 | Huizi Sha Zhengyun Zou Kai Xin Xinyu Bian Xueting Cai Wuguang Lu Jiao Chen Gang Chen Leaf Huang Andrew M. Blair Peng Cao Baorui Liu | 2015 | Journal of Controlled Release2015，，： | 1 |
| 19 | Identification of characteristic aroma-active compounds in steamed mangrove crab {Scylla serra/a)显示文摘 | YU Huizi CHEN Shunsheng | 2010 | FoodResearch International2010，43，8： | 1 |
| 20 | The COVID-19 and the“European Solution”of Data-based Approach to Governance:Public Security or Data Protection?显示文摘To cope with the challenges of CoViD-19,europe has adopted relevant measures of a data-based approach to governance,on which scholars have huge differences,and the related researches are conducive to further discussion on the differences.By sorting out the challenges posed by the pandemic to public security and data protection in europe,we can summarize the“european Solution”of the data-based approach to governance,including legislation,instruments,supervision,international cooperation,and continuity.The“Solution”has curbed the spread of the pandemic to a certain extent.However,due to the influence of the traditional values of the EU,the“Solution”is too idealistic in the balance between public security and data protection,which intensifies the dilemma and causes many problems,such as ambiguous legislation,inadequate effectiveness and security of instruments,an arduous endeavor in inter national cooperation,and imperfect regulations on digital green certificates.Therefore,in a major public health crisis,there is still a long way to go in exploring a balance between public security and data protection. | 刘洋 李益斌 NIU Huizi(Translated) | 2022 | The Journal of Human Rights2022，21，3： | 0 |
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