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| 1 | 肿瘤浸润髓系细胞上表达的共抑制分子B7S1抑制抗肿瘤CD8 T细胞的功能显示文摘文章简介近年来,肿瘤免疫治疗蓬勃发展,为人类战胜癌症带来了一线曙光。阻断PD-1/PD-L1通路的抗体药物可以提高CD8 T细胞的抗肿瘤活性,疗效显著优于传统治疗手段。然而,只有小部分实体瘤病人可以对PD-1/PD-L1免疫治疗产生应答. | 黎静 Younghee Lee Yanjian Li Yu Jiang Huiping Lu Wenjuan Zang Xiaohong Zhao Liguo Liu Yang Chen Haidong Tan 杨志英 Michael Q Zhang Tak W.Mak Ling Ni 董晨 | 2019 | 科学新闻2019，0，2： | 6 |
| 2 | Application of waste frying oils in the biosynthesis of biodemulsifier by a demulsifying strain Alcaligenes sp.S-XJ-1显示文摘Exploration of biodemulsifiers has become a new research aspect.Using waste frying oils(WFOs) as carbon source to synthesize biodemulsifiers has a potential prospect to decrease production cost and to improve the application of biodemulsifiers in the oilfield.In this study,a demulsifying strain,Alcaligenes sp.S-XJ-1,was investigated to synthesize a biodemulsifier using waste frying oils as carbon source.It was found that the increase of initial pH of culture medium could increase the biodemulsifier yield but decrease the demulsification ratio compared to that using paraffin as carbon source.In addition,a biodemulsifier produced by waste frying oils and paraffin as mixed carbon source had a lower demulsification capability compared with that produced by paraffin or waste frying oil as sole carbon source.Fed-batch fermentation of biodemulsifier using waste frying oils as supplementary carbon source was found to be a suitable method.Mechanism of waste frying oils utilization was studied by using tripalmitin,olein and tristearin as sole carbon sources to synthesize biodemulsifier.The results showed saturated long-chain fatty acid was diffcult for S-XJ-1 to utilize but could effectively enhance the demulsification ability of the produced biodemulsifier.Moreover,FT-IR result showed that the demulsification capability of biodemulsifiers was associated with the content of C=O group and nitrogen element. | Jia Liu Kaiming Peng Xiangfeng Huang Lijun Lu Hang Cheng Dianhai Yang Qi Zhou Huiping Deng | 2011 | Journal of Environmental Sciences2011，23，6： | 4 |
| 3 | miR-30a-5p promotes glomerular podocyte apoptosis via DNMT1-mediated hypermethylation under hyperhomocysteinemia显示文摘Abnormal elevation of homocysteine(Hcy)level is closely related to the development and progression of chronic kidney disease(CKD),with the molecular mech2anisms that are not fully elucidated.Given the demonstration that miR-30a-5p is specifically expressed in glomerular podocytes,in the present study we aimed to investigate the role and potential underlying mechanism of miR-30a-5p in glomerular podocyte apoptosis induced by Hcy.We found that elevated Hcy downregulates miR-30a-5p expression in the Cbs^(+/-)-mice and Hcy-treated podocytes,and miR-30a-5p directly targets the 3′-untranslated region(3′-UTR)of the forkhead box A1(FOXA1)and overexpression of miR-30a-5p inhibits FOXA1 expression.By nMS-PCR and MassARRAY quantitative methylation analysis,we showed the increased DNA methylation level of miR-30a-5p promoter both in vivo and in vitro.Meanwhile,dual-luciferase reporter assay showed that the region between--1400 and--921 bp of miR-30a-5p promoter is a possible regulatory element for its transcription.Mechanistic studies indicated that DNA methyltransferase enzyme 1(DNMT1)is the key regulator of miR-30a-5p,which in turn enhances miR-30a-5p promoter methylation level and thereby inhibits its expression.Taken together,our results revealed that epigenetic modification of miR-30a-5p is involved in glomerular podocyte injury induced by Hcy,providing a diagnostic marker candidate and novel therapeutic target in CKD induced by Hcy. | Ning Ding Lin Xie Fei Ma Shengchao Ma Jiantuan Xiong Guanjun Lu Huiping Zhang Yideng Jiang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 4 |
| 4 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 5 | Dynamic flow resistivity based model for sound absorption of multi-layer sintered fibrous metals显示文摘The sound absorbing performance of the sintered fibrous metallic materials is investigated by employing a dynamic flow resistivity based model,in which the porous material is modeled as randomly distributed parallel fibers specified by two basic physical parameters:fiber diameter and porosity.A self-consistent Brinkman approach is applied to the calculation of the dynamic resistivity of flow perpendicular to the cylindrical fibers.Based on the solved flow resistivity,the sound absorption of single layer fibrous material can be obtained by adopting the available empirical equations.Moreover,the recursion formulas of surface impedance are applied to the calculation of the sound absorption coefficient of multi-layer fibrous materials.Experimental measurements are conducted to validate the proposed model,with good agreement achieved between model predictions and tested data.Numerical calculations with the proposed model are subsequently performed to quantify the influences of fiber diameter,porosity and backed air gap on sound absorption of uniform(single-layer)fibrous materials.Results show that the sound absorption increases with porosity at higher frequencies but decreases with porosity at lower frequencies.The sound absorption also decreases with fiber diameter at higher frequencies but increases at lower frequencies.The sound absorption resonance is shifted to lower frequencies with air gap.For multi-layer fibrous materials,gradient distributions of both fiber diameter and porosity are introduced and their effects on sound absorption are assessed.It is found that increasing the porosity and fiber diameter variation improves sound absorption in the low frequency range.The model provides the possibility to tailor the sound absorption capability of the sintered fibrous materials by optimizing the gradient distributions of key physical parameters. | MENG Han AO QingBo TANG HuiPing XIN FengXian LU TianJian | 2014 | Science China(Technological Sciences)2014，57，11： | 3 |
| 6 | 3-photon fluorescence and third-harmonic generation imaging of myelin sheaths in mouse digital skin in vivo:A comparative study显示文摘Myelin sheaths wrapping axons are key structures that help maintain the propagation speed of action potentials in both central and peripheral nervous systems(CNS and PNS).However,noninvasive,deep imaging technologies visualizing myelin sheaths in the digital skin in vivo are lacking in animal models.3-photon°uorescence(3PF)imaging excited at the 1700-nm window enables deep imaging of myelin sheaths,but necessitates labeling by exogenous°uorescent dyes.Since myelin sheaths are lipid-rich structures which generate strong third-harmonic signals,in this paper,we perform a detailed comparative experimental study of both third-harmonic generation(THG)and 3PF imaging in the mouse digital skin in vivo.Our results show that THG imaging also enables visualization of myelin sheaths deep in the mouse digital skin,which shows colocalization with 3PF signals from labeled myelin sheaths.Besides its superior label-free advantage,THG does not su®er from photobleaching due to its 3PF property. | Ke Wang Yi Pan Xinlin Chen Shen Tong Huiping Liang Yuan Lu Ping Qiu | 2022 | Journal of Innovative Optical Health Sciences2022，15，1： | 2 |
| 7 | Chirped Femtosecond Solitonlike Laser Pulse form with Self-frequency Shift显示文摘 | LI ZHONG HAO LI LU? TIAN HUIPING | 2002 | Phys Rev Lett2002，，26： | 1 |
| 8 | Simultaneous determination of icariin, icariside 1I and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC-MS/MS显示文摘 | Man Liu Huiping Liu Xiumei Lu | 2007 | J Chromatogr B2007，860，2： | 1 |
| 9 | Extracellular-superoxide dismutase DNA methylation promotes oxidative stress in homocysteine-induced atherosclerosis显示文摘In the present study,we investigate the effect of homocysteine(Hcy)on extracellular-superoxide dismutase(ECSOD)DNA methylation in the aorta of mice,and explore the underlying mechanism in macrophages,trying to identify the key targets of Hcy-induced EC-SOD methylation changes.ApoE--mice are fed different diets for 15 weeks,EC-SODand DNAmethyltransferase1(DNMT1)expression levels aredetected byRT-PCRandwestern blot analysis.EC-SOD methylation levels are assessed by ntMS-PCR.After EC-SOD overexpression or knockdown in macrophages,following the transfection of macrophages with pEGFP-N1-DNMT1,the methylation levels of ECSOD are detected.Our data show that the concentrations of Hcy and the area of atherogenic lesions are significantly increased in ApoE--mice fed with a high-methionine diet,and have a positive correlation with the levels of superoxide anions,which indicates that Hcy-activated superoxide anions enhance the development of atherogenic lesions.EC-SOD expression is suppressed by Hcy,and the content of superoxide anion is increased when EC-SOD is silenced by RNAi in macrophages,suggesting that EC-SOD plays a major part in oxidative stress induced by Hcy.Furthermore,the promoter activity of EC-SOD is increased following transfection with the-1/-110o fragment,and EC-SOD methylation level is significantly suppressed by Hcy,and more significantly decreased upon DNMT1 overexpression.In conclusion,Hcy may alter the DNA methylation status and DNMT1 acts as the essential enzyme in the methyl transfer process to disturb the status of EC-SOD DNA methylation,leading to decreased expression of Ec-sODandincreasedoxidativestressandatherosclerosis. | Shengchao Ma Guanjun Lu Qing Zhang Ning Ding Yuzhen Jie Hui Zhang Lingbo Xu Lin Xie Xiaoling Yang Huiping Zhang Yideng Jiang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 1 |
| 10 | A reagentless amperometric immunosensor for α-1-fetoprotein based on gold nanowires and ZnO nanorods modified electrode 显示文摘 | Xuxiao Lu Huiping Bai Ping He | 2008 | Analytica Chimica Acta2008，615，2： | 1 |
| 11 | Gene variants in the folate-mediated one-carbon metabolism(FOCM)pathway as risk factors for conotruncal heart defects显示文摘 | ZHU Huiping YANG Wei LU Wei | 2012 | Am J Med Genet A2012，158，5： | 1 |
| 12 | Dickkopf-1 autoantibody is a novel serological biomarker for non-small cell lung cancer显示文摘 | Xiao Yao Hua Jiang Cuizhen Zhang Huamao Wang Lin Yang Yongfeng Yu Junming Yu Bizhi Shi Zhijun Shen Huiping Gao Zhiwei Chen Shujun Tian Shun Lu Zonghai Li Jianren Gu | 2010 | Biomarkers2010，，2： | 1 |
| 13 | A reagentless amperometricimmunosensor for α -1-fetoprotein based on gold nanowires and ZnOnanorods modified electrode显示文摘 | LU Xuxiao BAI Huiping HE Ping | 2008 | Analytica Chimica Acta2008，615，2： | 1 |
| 14 | Control of an Intermittent Outbreak Caused by an Emerging Pandrug-Resistant Acinetobacter baumannii Clone ST457 in a Tertiary Hospital显示文摘Acinetobacter baumannii is a frequent cause of nosocomial infections.Here we report an intermittent outbreak caused by the emerging carbapenem-resistant A.baumannii(CRAB)clone ST457 and assess the effectiveness of patient screening for outbreak control.CRAB isolates were collected from 74 patients admitted to the respiratory intensive care unit of a tertiary hospital between May 2018 and March 2019.Fourteen CRAB isolates were assigned to ST457,and 13 belonged to an outbreak clone,as determined by phylogenomic analysis.Strict patient screening was started at the respiratory intensive care unit on May 2019,through which a ST457-positive patient transferred from the intensive care unit was detected.No positive patients were detected within 3months onwards.The results of this study highlight the importance of rigorous infection prevention and control measures,combined with patient screening,in controlling the CRAB outbreak. | Chuqiu Zhang Tingting Xu Yang Ji Wenping Zheng Jingsong Wu Yuemei Lu Huiping Li Rongchang Chen Chen Qiu Kai Zhou | 2021 | Infectious Microbes & Diseases2021，3，4： | 1 |
| 15 | Hydrothermal synthesis of zeolitic material from circulating fluidized bed combustion fly ash for the highly efficient removal of lead from aqueous solution显示文摘The utilization of coal fly ash derived from circulating fluidized bed combustion(CFBFA)still faces great challenges because of its unique characteristics.In this study,a zeolitic material with Na-P1 zeolite as the main phase was successfully synthesized via a hydrothermal method by using CFBFA as the raw material.The effects of hydrothermal temperature,time,and added CTAB amount on the characterizations of synthesized materials were investigated by XRD,SEM,and XPS.The properties of the optimal zeolitic material and its adsorption performance for Pb^(2+)in aqueous solution were evaluated.The influences of pH,initial concentration,dosage,and temperature on Pb^(2+)adsorption were also examined.Results revealed the following optimal parameters for the synthesis of zeolitic material:NaOH concentration of 2 mol·L^(-1),solid-to-liquid ratio of 1:10 g·ml^(-1),hydrothermal temperature of 110℃,hydrothermal time of 9 h,and CTAB amount of 1 g(per 100 ml solution).The adsorption capacities of the zeolitic material reached 329.67,424.69,and 542.22 mg·g^(-1) when the pH values of aqueous solution were 5,6,and 7,respectively.The Pb^(2+)removal efficiency can reach more than 99%in aqueous solution with the initial concentrations of 100-300 mg·L^(-1) under pH 6 and suitable adsorbent dosage.The adsorption and kinetics of Pb^(2+)on the zeolitic material can be described by Langmuir isotherm and pseudo-second-order kinetic models,respectively.The ion exchange between Pb^(2+)and Na^(+)and chemisorption are the main adsorption mechanism.All these findings imply that the synthesis of low-cost adsorbent for Pb^(2+)removal from weak acid and neutral aqueous solution provides a highly effective method to utilize CFBFA. | Zhibin Ma Xueli Zhang Guangjun Lu Yanxia Guo Huiping Song Fangqin Cheng | 2022 | Chinese Journal of Chemical Engineering2022，35，7： | 0 |
| 16 | The impacts of base level and lithology on fluvial geomorphic evolution at the tectonically active Laohu and Hasi Mountains,northeastern Tibetan Plateau显示文摘Previous researches had emphasized tectonic impacts on the fluvial system at the tectonically active areas,while the effects of lithology and local base level change have received relatively rare attention.Here we investigated fluvial landforms at different spatial scales,focusing on knickpoints and channel network reorganization from an area affected by the Haiyuan Fault in the northeastern Tibetan Plateau.The geomorphic indices,i.e.,drainage pattern andχanomalies,were calculated and investigated.The results show that two regional radial drainages formed around the Laohu and Hasi Mountains.Within the interior of the radial drainage,tributaries from the southeast side of the Laohu Mountain experienced near 180°direction change.We interpret this as the gradual drainage capture originating from the height difference(~190 m)of the local base level between the two catchments.Some tributaries from the Hasi Mountain show alternating gorges and broad valleys controlled by lithology.Besides,tectonic uplift and the lowering of base level(from the incision of the Yellow River)triggered an autogenic positivefeedback transition from parallel to dendritic drainage patterns.These observations suggest that base level change and lithology play a crucial role in landscape evolution,even in a tectonically active region. | Zhengchen LI Xianyan WANG Yang YU Huiping ZHANG Qi SU Xiaodong MIAO Huayu LU | 2021 | Science China Earth Sciences2021，64，6： | 0 |
| 17 | A Trusted Edge Resource Allocation Framework for Internet of Vehicles显示文摘With the continuous progress of information technique,assisted driving technology has become an effective technique to avoid traffic accidents.Due to the complex road conditions and the threat of vehicle information being attacked and tampered with,it is difficult to ensure information security.This paper uses blockchain to ensure the safety of driving information and introduces mobile edge computing technology to monitor vehicle information and road condition information in real time,calculate the appropriate speed,and plan a reasonable driving route for the driver.To solve these problems,this paper proposes a trusted edge resource allocation framework for assisted driving service,which includes two stages:the blockchain generation stage(the first stage)and assisted driving service stage(the second stage).Furthermore,in the first stage,a delay-and-throughput-oriented block generation model for the mobile terminal is designed.In the second stage,a balanced offloading algorithm for assisted driving service based on edge collaboration is proposed to solve the problems of unbalanced load of cluster mobile edge computing(MEC)servers and low resource utilization of the system.And this paper optimizes the throughput of blockchain and delay of the transportation network through deep reinforcement learning(DRL)algorithm.Finally,compared with joint computation and communication resources’allocation(JCCR)and resource allocation method based on binary offloading(RAB),our proposed scheme can optimize the delay by 7.4%and 26.7%,and support various application services of the vehicular networks more effectively. | Yuxuan Zhong Siya Xu Boxian Liao Jizhao Lu Huiping Meng Zhili Wang Xingyu Chen Qinghan Li | 2023 | Computers, Materials & Continua2023，77，11： | 0 |
| 18 | Transfer Ionization Processes in Collisions between S^(q+) and H_2, He显示文摘Molecular H2 is extensively existing in interstellar plasma and play an important role in various charge exchange processes. Collisions between multiply charged S ions and H2, atomic H and He are key processes in investigation of the plasma related to Jupiter. The present work is focusing on the mechanism of collisions between Sq and H2, He. Although both the targets have two electrons, the outgoing channels are quite different, because molecular hydrogen can undergo dissociation and Coulombic explosion after charge transfer: | Wang Zhenglin Ma Xinwen Wei Baoren Chen Ximen Liu Huiping Yang Zhihu Yu Deyang Lu Rongchun Liu Zhaoyuan | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
| 19 | Nutritional Elements Related to Leaf Blight of Pearl Plum in Longtan Town显示文摘[Objectives]This study was conducted to investigate the correlation between leaf blight of pearl plum and nutrient elements from the perspective of plant nutrition.[Methods]Branch and leaf samples of pearl plum plants infected by or free of leaf blight and the corresponding 0-30 cm cultivated soil were collected,and statistical analysis was conducted according to the changes in nutrient contents and the incidence of leaf blight,so as to look for nutrients in pearl plum plants associated with leaf blight,as well as soil constraint factors.[Results]Phosphorus,iron and manganese in nutrients may be related to leaf blight,and the factors affecting leaf blight may be the ratios of P/Fe and P/Mn in leaves.[Conclusions]This study provides a basis for further research on the relationship between phosphorus,iron and manganese on the effect of leaf blight in pearl plum trees. | Xiaohui ZHU Jinsheng HUANG Yan ZENG Liuqiang ZHOU Rulin XIE Jiayu PENG Huiping OU Zhongning LI Hongmei LU | 2022 | Agricultural Biotechnology2022，11，4： | 0 |
| 20 | Control of Surface Wrinkles on Shape Memory PLA/PPDO Micro‑nanofibers and Their Applications in Drug Release and Anti‑scarring显示文摘Micro-and nano-fibers of shape memory polymers(SMP)offer multiple advantages like high specific surface area,poros-ity,and intelligence,and are suitable for biomedical applications.In this study,biodegradable poly(p-dioxanone)(PPDO)materials were incorporated to improve the brittleness of shape memory polylactic acid(PLA),and plasticizers were used to reduce the transition temperature of SMP composites such that their transitions could be induced close to body temperature.Furthermore,an electrostatic spinning technology was applied to prepare SMP fibers with wrinkled structures and regulate their microstructures and morphologies such that the intelligent transition of wrinkled and smooth morphologies can be achieved on the fiber surface.The application of this controllable-morphology fiber membrane in intelligent controlled drug release and scar inhibition after Ahmed Glaucoma Valve(AGV)implantation was also studied.The drug release from the stretched and deformed drug-loaded fiber membranes was faster than those from membranes with the original shape.This membrane with micro-and nano-fibers had good anti-scarring effects that improved after drug loading.The achievement of intelligent controlled drug release and the evident anti-scarring effects of the membrane broaden the application of SMP fibers in the biomedical field. | Lu Wang Jingyi Ma Tao Guo Fenghua Zhang Aimeng Dong Shiqi Zhang Yanju Liu Huiping Yuan Jinsong Leng | 2023 | Advanced Fiber Materials2023，5，2： | 0 |
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