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| 1 | An ACC Oxidase Gene Essential for Cucumber Carpel Development显示文摘在植物的性决心产生便于 outcrossing 并且提高基因差异的单性的花。在黄瓜和甜瓜,乙烯支持心皮开发并且逮捕雄蕊开发。五性决心基因被识别了,包括四个编码在乙烯生合成催化限制率的步骤的 1-aminocyclopropane-1-carboxylate (ACC ) synthase,和抄写因素基因在甜瓜对应于孟德尔的地点 gynoecious 并且是女性的一个否定管理者的 CmWIP1。ACC oxidase (ACO ) 把 ACC 变换成乙烯;然而,它留下逃犯在黄瓜染色体的基因为性决心是它 ACO 并且怎么批评的 CmWIP1 镇压女花的开发。在这研究,我们在 ACO 基因发现了那个变化, CsACO2,在忍受仅仅男的花的黄瓜授与 androecy。变化破坏 CsACO2 的酶的活动,导致从射击尖端的 50% 更少的乙烯排放。CsACO2 在心皮 primordia 被表示,它的表示为性决心在关键阶段在女花与 CsACS11 的重叠了,大概提供为合适的 CsACS2 要求的足够的乙烯表示。CmACO3, CsACO2 的 ortholog,在心皮区域显示出一个类似的表示模式,建议 CsACO2/CmACO3 的保存功能。我们表明了那 CsWIP1, CmWIP1 的 ortholog,能直接绑 CsACO2 的倡导者并且镇压它的表示。一起拿,我们建议由 WIP1 抄写因素和 ACO 组成的一个大概保存的规章的模块在黄瓜和甜瓜控制单性的花开发。 | Huiming Chen Jinjing Sun Shuai Li Qingzhi Cui Huimin Zhang Fengjiao Xin Huaisong Wang Tao Lin Dongli Gao Shenhao Wang Xia Li Donghui Wang Zhonghua Zhang Zhihong Xu Sanwen Huang | 2016 | Molecular Plant2016，9，9： | 16 |
| 2 | Low-threshold topological nanolasers based on the second-order corner state显示文摘Topological lasers are immune to imperfections and disorder.They have been recently demonstrated based on many kinds of robust edge states,which are mostly at the microscale.The realization of 2D on-chip topological nanolasers with a small footprint,a low threshold and high energy efficiency has yet to be explored.Here,we report the first experimental demonstration of a topological nanolaser with high performance in a 2D photonic crystal slab.A topological nanocavity is formed utilizing the Wannier-type 0D corner state.Lasing behaviour with a low threshold of approximately 1μW and a high spontaneous emission coupling factor of 0.25 is observed with quantum dots as the active material.Such performance is much better than that of topological edge lasers and comparable to that of conventional photonic crystal nanolasers.Our experimental demonstration of a low-threshold topological nanolaser will be of great significance to the development of topological nanophotonic circuitry for the manipulation of photons in classical and quantum regimes. | Weixuan Zhang Xin Xie Huiming Hao Jianchen Dang Shan Xiao Shushu Shi Haiqiao Ni Zhichuan Niu Can Wang Kuijuan Jin Xiangdong Zhang Xiulai Xu | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 3 | The High Energy X-ray telescope (HE) onboard the Insight-HXMT astronomy satellite显示文摘The Insight-Hard X-ray Modulation Telescope(Insight-HXMT) is a broadband X-ray and γ-ray(1-3000 ke V) astronomy satellite. One of its three main telescopes is the High Energy X-ray telescope(HE). The main detector plane of HE comprises 18 Na I(Tl)/Cs I(Na) phoswich detectors, where Na I(Tl) is used as the primary detector to measure ~ 20-250 ke V photons incident from the field of view(FOV) defined by collimators, and Cs I(Na) is used as the active shielding detector to Na I(Tl) by pulse shape discrimination. Additionally, Cs I(Na) is used as an omnidirectional γ-ray monitor. The HE collimators have a diverse FOV,i.e. 1.1°×5.7°(15 units), 5.7°×5.7°(2 units), and blocked(1 unit). Therefore, the combined FOV of HE is approximately5.7°×5.7°. Each HE detector has a diameter of 190 mm resulting in a total geometrical area of approximately 5100 cm2, and the energy resolution is ~15% at 60 ke V. For each recorded X-ray event by HE, the timing accuracy is less than 10 μs and the deadtime is less than 10 μs. HE is used for observing spectra and temporal variability of X-ray sources in the 20-250 ke V band either by pointing observations for known sources or scanning observations to unveil new sources. Additionally, HE is used for monitoring the γ-ray burst in 0.2-3 Me V band. This paper not only presents the design and performance of HE instruments but also reports results of the on-ground calibration experiments. | CongZhan Liu YiFei Zhang XuFang Li XueFeng Lu Zhi Chang ZhengWei Li AiMei Zhang YongJie Jin HuiMing Yu Zhao Zhang MinXue Fu YiBao Chen JianFeng Ji YuPeng Xu JingKang Deng RenCheng Shang GuoQing Liu FangJun Lu ShuangNan Zhang YongWei Dong TiPei Li Mei Wu YanGuo Li HuanYu Wang BoBing Wu YongJie Zhang Zhi Zhang ShaoLin Xiong Yuan Liu Shu Zhang HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 9 |
| 4 | WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells显示文摘POU 抄写因素 OCT4 不仅在维持 pluripotent 和房间而且幕作为通过基因剂量的一个房间命运决定因素完成的胚胎的茎(ES ) 的自我更新的状态起一个必要作用。然而,控制细胞内部的 OCT4 蛋白质水平的分子的机制留下逃犯。这里,我们报导那人的 WWP2, E3 ubiquitin (Ub ) 蛋白质 ligase,通过它的 WW 领域明确地与 OCT4 交往并且在 vitro 并且在 vivo 提高 OCT4 的 Ub 修正。我们首先证明在人的 ES 房间的内长的 OCT4 能被 Ub post-translationally 修改。而且,我们发现 WWP2 以一种剂量依赖者方式,和 WWP2 的活跃地点半胱氨酸残余通过 26S proteasome 支持了 OCT4 的降级在 OCT4 上为它的酶的活动和解朊的效果被要求。显著地,我们当 WWP2 表示是由特定的 RNA 干扰(RNAi ) 的 downregulated 时,内长的 OCT4 蛋白质水平显著地被提高的数据表演,建议那 WWP2 是为在人的 ES 房间维持合适的 OCT4 蛋白质水平的一个重要管理者。而且,北污点分析证明 WWP2 抄本在多样的人的织物 / 器官是广泛地在场的并且高度在无差别的人的 ES 房间表示了。然而,它的表示水平快速在区分的人的 ES 房间以后被减少,显示 WWP2 表示力量发展地被调整。我们的调查结果证明 WWP2 是在人的 ES 房间的 OCT4 蛋白质水平的一个重要管理者。 | Huiming Xu Weicheng Wang Chunliang Li Hongyao Yu Acong Yang Beibei Wang Ying Jin | 2009 | Cell Research2009，19，5： | 8 |
| 5 | Fekete and Szego problem for a subclass of quasi-convex mappings in several complex variables显示文摘让 K 是在联合起来的磁盘的规范的凸的函数的熟悉的类。Keogh 和 Merkes 证明了著名结果是那最大 ? fK|a3−λa22|≤max ?{ 1/3 ,|λ−1|},λ? ,并且估计为每 λ
是锋利的。我们为在一个复杂 Banach 空格或在联合起来的 polydisk 上在联合起来的球定义在的类型 B 的伪凸的 mappings 的一个子类调查相应问题 ? n。这些结果的证明使用一些限制假设,在一建筑群的情况中,变量它自动地满足。 | Qinghua XU Ting YANG Taishun LIU Huiming XU | 2015 | Frontiers of Mathematics in China2015，10，6： | 5 |
| 6 | New possible silver lining for pancreatic cancer therapy:Hydrogen sulfide and its donors显示文摘As one of the most lethal diseases,pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities.Furthermore,pancreatic cancer escapes early detection during the curable period because early symptoms rarely emerge and specific markers for this disease have not been found.Although combinations of new drugs,multimodal therapies,and adjuvants prolong survival,most patients still relapse after surgery and eventually die.Consequently,the search for more effective treatments for pancreatic cancer is highly relevant and justified.As a newly re-discovered mediator of gasotransmission,hydrogen sulfide(H2S)undertakes essential functions,encompassing various signaling complexes that occupy key processes in human biology.Accumulating evidence indicates that H2S exhibits bimodal modulation of cancer development.Thus,endogenous or low levels of exogenous H2S are thought to promote cancer,whereas high doses of exogenous H2S suppress tumor proliferation.Similarly,inhibition of endogenous H2S production also suppresses tumor proliferation.Accordingly,H2S biosynthesis inhibitors and H2S supplementation(H2S donors)are two distinct strategies for the treatment of cancer.Unfortunately,modulation of endogenous H2S on pancreatic cancer has not been studied so far.However,H2S donors and their derivatives have been extensively studied as potential therapeutic agents for pancreatic cancer therapy by inhibiting cell proliferation,inducing apoptosis,arresting cell cycle,and suppressing invasion and migration through exploiting multiple signaling pathways.As far as we know,there is no review of the effects of H2S donors on pancreatic cancer.Based on these concerns,the therapeutic effects of some H2S donors and NO-H2S dual donors on pancreatic cancer were summarized in this paper.Exogenous H2S donors may be promising compounds for pancreatic cancer treatment. | Xu Hua Yan Xiao Jianan Sun Bao Ji Shanshan Luo Bo Wu Chao Zheng Peng Wang Fanxing Xu Keguang Cheng Huiming Hua Dahong Li | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 4 |
| 7 | In situ synthesis and phase analysis of low density O'-sialon-based multiphase ceramics显示文摘In situ formed low density O'-sialon-based multiphase ceramics were prepared by liquid-phase sintering method at 1400°C with Si3N4, SiO2 and Al2O3 as raw materials.Crystalline phases were identified by X-ray diffraction(XRD).The quantitative phase analysis was finished by matrix-flushing method and the substitution parameter x value of O'-sialon was estimated.The effects of sintering additives on the phase composition of the material were studied.The results show that, when using Y2O3 alone, Al6Si2O13 phase can be formed in the material, but when using Y2O3 and MgO, MgAl2O4 phase can be preferentially formed and the Al6Si2O13 is not observed.The mechanical properties of the material were measured and the relationships between microstructure and mechanical properties were discussed.The sample with Y2O3 and MgO sintering additives, using fused quartz alone as SiO2 source, displays a combination of high bending strength(163 MPa) and good fracture toughness(3.11 MPa·m1/2).Bending strength and fracture toughness of the samples increase with the increase of the content and aspect ratio of elongated grains and decrease with the increase of the porosity. | XU Xiongwen, LIANG Hui, LI Xiaolei, JI Huiming, LU Huixiang, and WAN Yizao Key Laboratory for Advanced Ceramics and Machining Technology(Ministry of Education), Tianjin University, Tianjin 300072, China | 2010 | Rare Metals2010，29，2： | 3 |
| 8 | A New Gene Conferring the Glabrous Trait in Cucumber Identified Using MutMap显示文摘Tubercles and spines on fruit peel are important commercial traits in cucumber(Cucumis sativus L.). From an ethyl methane sulfonate cucumber mutant library,we discovered a new glabrous mutant that bears no tubercle or spine on fruit peel and fewer and smaller trichomes on the stem and leaves. The new locus is here designated as glabrous2(gl2). Genome sequencing of the mutant and linkage analysis revealed that a non-synonymous mutation in the Csa1G056960 gene rendered the gl2 phenotype. The mutated gene encodes a C-type lectin receptor-like tyrosine protein kinase. This study provides a novel allele for elucidating the genetic basis of wart and trichome development and a new tool for breeding glabrous cucumber varieties. | XU Mengnan WANG Shenhao ZHANG Shu CUI Qingzhi GAO Dongli CHEN Huiming HUANG Sanwen | 2015 | Horticultural Plant Journal2015，1，1： | 2 |
| 9 | Genomic and Phenotypic Diversity of Carbapenemase-Producing Enterobacteriaceae Isolates from Bacteremia in China: A Multicenter Epidemiological, Microbiological, and Genetic Study显示文摘Carbapenemase-producing Enterobacteriaceae(CPE) isolates are recognized as one of the most severe threats to public health. However, the population structure and genetic characteristics of CPE isolates among bloodstream infections(BSIs) are largely unknown. To address this knowledge gap, in this study,we included patients with clinically significant BSIs due to Enterobacterales isolates, recruited from 26 sentinel hospitals in China(2014–2015). CPE isolates were microbiologically and genomically characterized,including their susceptibility profiles, molecular typing, phylogenetic features, and genetic context analysis of carbapenemase-encoding genes. Of the 2569 BSI Enterobacterales isolates enrolled, 42(1.6%) were carbapenemase-positive. Moreover, among the 2242 investigated isolates, 1111(49.6%) extendedspectrum β-lactamase(ESBL)-producing isolates were identified in Escherichia coli(E. coli), Klebsiella pneumoniae(K. pneumoniae), Proteus mirabilis(P. mirabilis), and Klebsiella oxytoca. Whole genome sequencing analysis showed the clonal spread of K. pneumoniae carbapenemase(KPC)-2-producing K. pneumoniae sequence type(ST) 11 and New Delhi metallo-β-lactamase(NDM)-5-producing E. coli ST167 in our collection. Plasmid analysis revealed that carbapenemase-encoding genes were located on multiple plasmids. A high prevalence of biofilm-encoding type 3 fimbriae clusters and yesiniabactin-associated genes was observed in K. pneumoniae isolates. This work demonstrates the high prevalence of ESBLs and the wide dissemination of CPE among BSI isolates in China, which represent real clinical threats. Moreover, our findings first illustrate a more comprehensive genome scenario of CPE isolates among BSIs. The clonal spread of KPC-2-producing K. pneumoniae ST11 and NDM-5-producing E. coli ST167 needs to be closely monitored. | Beiwen Zheng Hao Xu Lihua Guo Xiao Yu Jinru Ji Chaoqun Ying Yunbo Chen Ping Shen Huiming Han Chen Huang Shuntian Zhang Tao Lv Yonghong Xiao | 2022 | Engineering2022，8，5： | 2 |
| 10 | Characterization of Oil Shale Processing Residues and Separated Products显示文摘 | Xu Yingmei He Demin Jiang Huiming | 2009 | Oil Shale2009，26，4： | 1 |
| 11 | Effect of water activity (a w ) and irradiation on the shelf-life of fresh noodles显示文摘 | Man Li Kexue Zhu Xu Guo Wei Peng Huiming Zhou | 2011 | Innovative Food Science and Emerging Technologies2011，，4： | 1 |
| 12 | WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells显示文摘 | Huiming Xu Weicheng Wang Chunliang Li Hongyao Yu Acong Yang Beibei Wang Ying Jin | 2009 | Cell Research2009，19，6： | 1 |
| 13 | Effect of Starch Dosage on the Properties of Modified Ground Calcium Carbonate显示文摘 | Fan Huiming Xu Binteng | 2014 | BioResources2014，9，3： | 1 |
| 14 | Performance Characteristics Around the TDC of Linear Compressor Based on Whole-process Sim- ulation显示文摘 | Huiming Zou Mingsheng Tang Hongbo Xu Shuangquan Shao Changqing Tian | 2014 | International Journal of Applied Electromagnet- ics and Mechanics2014，28，10： | 1 |
| 15 | Characterization of Oil Shale Processing Residues and Separated Products显示文摘 | Xu Yingmei He Demin Jiang Huiming | 2009 | Oil Shale2009，26，4： | 1 |
| 16 | Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold显示文摘 | GuoGang Tu ShaoHua Li HuiMing Huang Gang Li Fang Xiong Xi Mai HuaWei Zhu BinHai Kuang Wen Fang Xu | 2008 | Bioorganic & Medicinal Chemistry2008，，14： | 1 |
| 17 | Potential therapeutic target and independent prognostic marker of TROP2 in laryngeal squamous cell carcinoma显示文摘 | Hao Wu Huiming Xu Shu Zhang Xudong Wang Huijun Zhu Huilin Zhang Jin Zhu Jianfei Huang | 2013 | Head Neck2013，，10： | 1 |
| 18 | Characteristics of low altitude ionospheric electric field over Hainan Island,China显示文摘A sounding rocket experiment undertaken by the Chinese Meridian Project from a low latitude station on Hainan Island(19.5°N,109.1°E),China,measured the DC electric field during 05:45-05:52 LT on April 5,2013.The data observed using a set of electric field double probes,as part of the rocket's scientific payload,revealed the special profile of how the vectors of the DC electric field vary with altitude between 130 and 190 km.During the experiment,the vertical electric field was downward,and the maximum vertical electric field was nearly 5.1 mV/m near the altitude of 176 km.The zonal electric field was eastward and slightly less than 0.6 mV/m.The plasma drift velocity was estimated from the E×B motion,and the zonal drift velocity was eastward and of the order of 100 m/s.The zonal wind velocity was also estimated using the drift velocity near the maximum density height in the F1-region,and it was found to be nearly 120 m/s.This work constituted the first in situ measurement of the DC electric field conducted within the Fl-region(between 130 and 190 km) in the East Asian Sector. | LI RenKang CHEN Tao MAN Feng JIANG XiuJie LUO Jing HE ZhaoHai ZHANG HuiMing WANG LinFeng LIU Cheng Francisco Carlos de MENESES WANG GuoJun XU JiYao | 2017 | Science China Earth Sciences2017，60，4： | 1 |
| 19 | Deinococcus radio-durans PprI Switches on DNA Damage Response and Cellular Survi-val Networks after Radiation Damage 显示文摘 | Huiming Lu Guanjun Gao Guangzhi Xu et ai | 2009 | American Society for Bio-chemistry and Molecular Biology2009，8，： | 1 |
| 20 | Observations on mechanics properties of stitched foam-core sandwich by fiexural testing显示文摘 | Xie Wei Xu Fei Yan Huiming | 2012 | Advanced Materials Research2012，487，： | 1 |
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