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| 1 | Long noncoding RNA(lncRNA)HOTAIR:Pathogenic roles and therapeutic opportunities in gastric cancer显示文摘Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease.Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer.HOTAIR is an effective epigenetic agent known as long noncoding RNA(lncRNA).HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors,leading to genomic stability,proliferation,survival,invasion,migration,metastasis,and drug resistance.In the present article,we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer,whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes,leading to the development of potential therapeutic strategies. | Wencheng Kong Guang Yin Sixin Zheng Xinchun Liu Akao Zhu Panpan Yu Jian Zhang Yuqiang Shan Rongchao Ying Huicheng Jin | 2022 | Genes & Diseases2022，9，5： | 3 |
| 2 | The effects of phenolic acid on nitrogen metabolism in Populus 3 euramericana ‘Neva’显示文摘The declines in soil fertility and productivity in continuously cropped poplar plantations are related to phenolic acid accumulation in the soil.Nitrogen is a vital life element for poplar and whether the accumulation of phenolic acid could influence nitrogen metabolism in poplar and thereby hinder continuous cropping is not clear.In this study, poplar cuttings of Populus × euramericana‘Neva’ were potted in vermiculite, and phenolic acids at three concentrations(0 X, 0.5 X and 1.0 X) were added according to the actual content(1.0 X) in the soil of a second-generation poplar plantation.Each treatment had eight replicates.We measured gas exchange parameters and the activities of key enzymes related to nitrogen metabolism in the leaves.Leaf photosynthetic parameters varied with the concentration of phenolic acids.The net photosynthetic rate(P_N) significantly decreased with increasing phenolic acid concentration, and non-stomatal factors might have been the primary limitation for P_N.The activities of nitrate reductase(NR), glutamine synthetase(GS) and glutamate synthase(GOGAT), as well as the contents of nitrate nitrogen, ammonium nitrogen, and total nitrogen in the leaves decreased with increasing phenolic acid concentration.This was significantly and positively related to P_N(P<0.05).The low concentration of phenolic acids mainly affected the transformation process of NO_3^- to NO_2^-, while the high concentration of phenolic acids affected both processes, where NO_3^- was transferred to NO_2^- and NH_4^+ was transferred to glutamine(Gln).Overall, phenolic acid had significant inhibitory effects on the photosynthetic productivity of Populus × euramericana‘Neva’.This was probably due to its influence on the activities of nitrogen assimilation enzymes, which reduced the amount of amino acids that were translated into protein and enzymes.Improving the absorption and utilization of nitrogen by plants could help to overcome the problems caused by continuous cropping. | Hui Li Huicheng Xie Zilong Du Xianshuang Xing Jie Zhao Jing Guo Xia Liu Shuyong Zhang | 2018 | Journal of Forestry Research2018，29，4： | 2 |
| 3 | Recent advances in wireless epicortical and intracortical neuronal recording systems显示文摘An implantable brain-computer interface(BCI)has proven to be effective in the field of sensory and motor function restoration and in the treatment of neurological disorders.Using a BCI recording system,we can transform current methods of human interaction with machines and the environment,especially to help those with cognitive and mobility disabilities regain mobility and reintegrate into society.However,most reported work has focused on a simple aspect of the whole system,such as electrodes,circuits,or data transmission,and only a very small percentage of systems are wireless.A miniature,lightweight,wireless,implantable microsystem is key to realizing long-term,real-time,and stable monitoring on freely moving animals or humans in their natural conditions.Here,we summarize typical wireless recording systems,from recording electrodes,processing chips and controllers,wireless data transmission,and power supply to the system-level package for either epicortical electrocorticogram(ECoG)or intracortical local field potentials(LFPs)/spike acquisition,developed in recent years.Finally,we conclude with our vision of challenges in next-generation wireless neuronal recording systems for chronic and safe applications. | Bowen JI Zekai LIANG Xichen YUAN Honglai XU Minghao WANG Erwei YIN Zhejun GUO Longchun WANG Yuhao ZHOU Huicheng FENG Honglong CHANG Jingquan LIU | 2022 | Science China(Information Sciences)2022，65，4： | 2 |
| 4 | Analyzing the Relation Between Earthquakes and Active Faults Based on the Parameter Optimization Model显示文摘The gestation and occurrence of strong earthquakes are closely related to fault activity, which is not only revealed by abundant experimentation and seismism but also proved by modern seismology. On the Chinese mainland, the relation between earthquake activity and active faults is one of the bases for partitioning potential seismic sources, analyzing the seismotectonics and estimating location of strong earthquakes.Due to the nonuniformity of earth media, instability of observation systems and disturbance of the environment, etc, the variety of observational data is complicated, that is, there is no absolutely 'normal' or 'abnormal', and seismic anomalies can be divided into many mutually exclusive 'abnormal states'. In different conditions of combined time-space-strength, determining seismic anomalies by different monomial forecast methods and its efficiency could be different due to the uncertainty of a precursor itself or complexity of the relationship between a precursor and earthquake gestation. It is very difficult to discover and dispose of this difference in actual application in a 'two-state' model. But in a 'multi-state' model, the difference can be easily reflected and the optimal combination of forecasting parameters for a forecast method can also be determined easily.Based on the 'multi-state' precursory model and the optimization method for parameters of earthquake forecast model under the condition of optimal forecast efficiency, the relationship of the spatial location of earthquake with M≥6.0 and active faults in three seismic belts are analyzed. The results demonstrate that in the Hetao Seismic Belt, seismicity is mostly concentrated in the range of 20 km along the fault, the optimization model can forecast the location of potential earthquakes of M≥6.0 near the faults with a relatively high accuracy and the reliability is 0.5; while in the Qilian Mt. Seismic Belt, the reliability only reaches 0.14 when we use the model to estimate earthquakes within 30 km range along the faults. The 'multi-state' precursory model, the efficiency-evaluating model and the parameter selection of individual earthquake forecast model based on optimal efficiency are of certain revelatory and practicable meanings for developing knowledge about precursors, investigating the laws of earthquake preparation and searching for optimal forecasting methods. | Shao Huicheng Liu Huafeng Yue Zhufeng | 2007 | Earthquake Research in China2007，21，2： | 1 |
| 5 | Smart nanoprobe based on two-photon sensitized terbium-carbon dots for dual-mode fluorescence thermometer and antibacterial显示文摘Accurate temperature measurement plays an important role in a variety of industrial processes and scientific researches.In our work,the dual-mode temperature response nanoprobe CDs-Tb-TMPDPA containing a two-photon ligand(4-(2,4,6-trimethoxyphenyl)-pyridine-2,6-dicarboxylic acid,TMPDPA)sensitized Tb3+as a temperature-sensitive unit and carbon dots(CDs)as photothermal reagent and a fluorescence reference unit,have been designed and synthesized.In this system,both the fluorescence intensity ratio and the fluorescence lifetime have a good response to temperature.In additio n,due to the excellent photothermal conversion capability of CDs,photothermal antibacterial ability was also tested.Based on the temperature dependence of the fluorescence and the two-photon excitation characteristics of CDs-Tb-TMPDPA,the nanoprobe can also be used in the anti-counterfeiting.Our finding opens a new prospect for the use of two-photon sensitized dual-mode fluorescence thermometers. | Huicheng Yan Hongyuhang Ni Yiwei Yang Changfu Shan Xiaoxi Yang Xiangkai Li Jing Cao Wenyu Wu Weisheng Liu Yu Tang | 2020 | Chinese Chemical Letters2020，31，7： | 1 |
| 6 | Antioxidant and biochemical properties of protein hydrolysates prepared from Silver carp ( Hypophthalmichthys molitrix )显示文摘 | Shiyuan Dong Mingyong Zeng Dongfeng Wang Zunying Liu Yuanhui Zhao Huicheng Yang | 2007 | Food Chemistry2007，，4： | 1 |
| 7 | Antioxidant and biochemical properties of protein hydrolysates prepared from Silver carp ( Hypophthalmichthys molitrix )显示文摘 | Shiyuan Dong Mingyong Zeng Dongfeng Wang Zunying Liu Yuanhui Zhao Huicheng Yang | 2007 | Food Chemistry2007，，4： | 1 |
| 8 | A smart nanoprobe based on luminescent terbium metal-organic framework coated gold nanorods for monitoring and photo-stimulated combined thermal-chemotherapy显示文摘Real-time monitoring and accurate treatment are of great significance for reducing the side effects during the cancer therapy.In this work,we rationally prepared a smart nanoprobe based on core-shell terbium metal-organic gramework(MOF)with highly effective photothermal conversion capacity and drug release efficiency under near-infrared light irradiation for real-time fluorescence imaging-guided multimodal therapy.The nanoprobe can achieve prominent photothermal therapy and controllable drug release,act as a fluorescence thermometer,and also real-time feedback of temperature is expected to be achieved.At the same time,the two-photon ligand design significantly improves the tissue penetration ability of the nanoprobe.Our work is expected to provide a reference for precise treatment and real-time monitoring of tumors and at the same time provide new ideas for the formulation of individualized treatment plans. | Tong Zhang Liying Qin Liangliang Liu Meina Zhang Tianyi Du Yifan Fan Huicheng Yan Pingru Su Ping Zhou Yu Tang | 2022 | Journal of Rare Earths2022，40，9： | 0 |
| 9 | DAPK1(death associated protein kinase 1)mediates mTORC1 activation and antiviral activities in CD8^(+)T cells显示文摘Mechanistic target of rapamycin complex 1(mTORCt)regulates CD8^(+)T-cell differentiation and function.Despite the links between PI3K-AKT and mTORCI activation in CD8^(+)T cells,the molecular mechanism underlying mTORCI activation remains undear.Here,we show that both the kinase activity and the death domain of DAPK1 are required for maximal mTOR activation and CD8^(+)T-cell function.We found that TCR-induced activation of calcineurin activates DAPK1,which subsequently interacts with TSC2 via its death domain and phosphorylates TSC2 to mediate mTORCI activation.Furthermore,both the kinase domain and death domain of DAPK1 are required for CD8^(+)T-cell antiviral responses in an LCMV infection model.Together,our data reveal a novel mechanism of mTORCI activation that mediates optimal CD8^(+)T-cell function and antiviral activity. | Zhengping Wei Pingfei Li Ran He Huicheng Liu Na Liu Yu Xia Guoyu Bi Qiuyang Du Minghui Xia Lei Pei Jing Wang Guihua Wang Zhao-Hui Tang Xiang Cheng Huabin Li Zhuoya Li Lilin Ye Arian Laurence Youming Lu Xiang-Ping Yang | 2021 | Cellular & Molecular Immunology2021，18，1： | 0 |
| 10 | Lattice confined Ru single sites in hollow Co_(9)S_(8)polyhedron triggering Co-S-Ru catalytic centers for rechargeable Zn-air battery显示文摘Single-atom catalysts with precise structure and tunable coordination nature provide opportunities for developing novel catalytic centers and understanding reaction mechanisms.Herein,hollow Co_(9)S_(8)polyhedrons with lattice-confined Ru single atoms(Ru-Co_(9)S_(8))are fabricated.Aberration-corrected scanning transmission electron microscopy and X-ray absorption spectroscopy verify the isolated Ru atoms are confined in Co_(9)S_(8)to form Co-S-Ru catalytic centers.Theoretical calculations indicate that the oxygen evolution reaction(OER)and oxygen reduction reaction(ORR)energy barriers are extensively reduced,the d-band center of Co_(9)S_(8)downshifts from the Fermi level,therefore boosting the desorption of O-containing intermediates.Consequently,the Ru-Co_(9)S_(8)exhibits an ultralow overpotential of 163 mV at 10 mA·cm^(−2)for OER and could catalyze a rechargeable Zn-air battery with a high-power density of 92.0 mW·cm^(−2).This work provides a promising approach for designing novel bifunctional catalytic active centers for energy conversion. | Xuan Liu Siru Chen Huicheng Wang Anmin Liu Shizheng Wen Liwei Mi Yanqiang Li | 2023 | Nano Research2023，16，5： | 0 |
| 11 | Phytic acid-modified CeO_(2) as Ca^(2+) inhibitor for a security reversal of tumor drug resistance显示文摘Ca^(2+)plays critical roles in the development of diseases,whereas existing various Ca regulation methods have been greatly restricted in their clinical applications due to their high toxicity and inefficiency.To solve this issue,with the help of Ca overexpressed tumor drug resistance model,the phytic acid(PA)-modified CeO_(2) nano-inhibitors have been rationally designed as an unprecedentedly safe and efficient Ca2+inhibitor to successfully reverse tumor drug resistance through Ca^(2+)negative regulation strategy.Using doxorubicin(Dox)as a model chemotherapeutic drug,the Ca^(2+)nano-inhibitors efficiently deprived intracellular excessive free Ca2+,suppressed P-glycoprotein(P-gp)expression and significantly enhanced intracellular drug accumulation in Dox-resistant tumor cells.This Ca^(2+)negative regulation strategy improved the intratumoral Dox concentration by a factor of 12.4 and nearly eradicated tumors without obvious adverse effects.Besides,nanocerias as pH-regulated nanozyme greatly alleviated the adverse effects of chemotherapeutic drug on normal cells/organs and substantially improved survivals of mice.We anticipate that this safe and effective Ca^(2+)negative regulation strategy has potentials to conquer the pitfalls of traditional Ca inhibitors,improve therapeutic efficacy of common chemotherapeutic drugs and serves as a facile and effective treatment platform of other Ca^(2+) associated diseases. | Zhimin Tian Junlong Zhao Shoujie Zhao Huicheng Li Zhixiong Guo Zechen Liang Jiayuan Li Yongquan Qu Dongfeng Chen Lei Liu | 2022 | Nano Research2022，15，5： | 0 |
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