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| 1 | Immunodominance and functional alterations of tumor‐associated antigen‐specific CD8+ T‐cell responses in hepatocellular carcinoma显示文摘 | Tobias Flecken Nathalie Schmidt Sandra Hild Emma Gostick Oliver Drognitz Robert Zeiser Peter Schemmer Helge Bruns Thomas Eiermann David A. Price Hubert E. Blum Christoph Neumann‐Haefelin Robert Thimme | 2014 | Hepatology2014，，： | 2 |
| 2 | Malignant ascites: Systematic review and guideline for treatment显示文摘 | Gerhild Becker Daniel Galandi Hubert E. Blum | 2005 | European Journal of Cancer2005，，5： | 2 |
| 3 | Hepatitis C virus-induced hepatocarcinogenesis显示文摘 | Birke Bartosch Robert Thimme Hubert E. Blum Fabien Zoulim | 2009 | Journal of Hepatology2009，，4： | 2 |
| 4 | Hepatitis C virus-induced hepatocarcinogenesis显示文摘 | Birke Bartosch Robert Thimme Hubert E. Blum Fabien Zoulim | 2009 | Journal of Hepatology2009，，4： | 1 |
| 5 | Virus-host Interactions during Hepatitis C Virus Entry-Implications for Pathogenesis and Novel Treatment Approaches显示文摘Hepatitis C virus (HCV) is a member of the Flaviviridae family and causes acute and chronic hepatitis. Chronic HCV infection may result in severe liver damage including liver cirrhosis and hepatocellular carcinoma. The liver is the primary target organ of HCV, and the hepatocyte is its primary target cell. Attachment of the virus to the cell surface followed by viral entry is the first step in a cascade of interactions between the virus and the target cell that is required for successful entry into the cell and initiation of infection. This step is an important determinant of tissue tropism and pathogenesis; it thus represents a major target for antiviral host cell responses, such as antibody-mediated virus neutralization. Following the development of novel cell culture models for HCV infection our understanding of the HCV entry process and mechanisms of virus neutralization has been markedly advanced. In this review we summarize recent developments in the molecular biology of viral entry and its impact on pathogenesis of HCV infection, development of novel preventive and therapeutic antiviral strategies. | Joachim Lupberger Mirjam B. Zeisel Anita Haberstroh Eva K. Schnober Sophie Krieger Eric Soulier Christine Thumann Cathy Royer Samira Fafi-Kremer Catherine Schuster Franoise Stoll-Keller Hubert E. Blum Thomas F. Baumert | 2008 | Virologica Sinica2008，23，2： | 1 |
| 6 | Hepatitis C virus-induced hepatocarcinogenesis显示文摘 | Birke Bartosch Robert Thimme Hubert E. Blum Fabien Zoulim | 2009 | Journal of Hepatology2009，，4： | 1 |
| 7 | Current and evolving therapies for hepatitis C显示文摘 | Darius Moradpour Hubert E. Blum | 1999 | European Journal of Gastroenterology & Hepatology1999，，11： | 1 |
| 8 | Factors that Determine the Antiviral Efficacy of HCV-Specific CD8+ T cells Ex Vivo显示文摘 | Bianca Seigel Bertram Bengsch Volker Lohmann Ralf Bartenschlager Hubert E. Blum Robert Thimme | 2012 | Gastroenterology2012，，： | 1 |
| 9 | Expression of hepatitis c virus proteins inhibits interferon α signaling in the liver of transgenic mice显示文摘 | Alex Blindenbacher Francois H.T. Duong Lukas Hunziker Simone T.D. Stutvoet Xueya Wang Luigi Terracciano Darius Moradpour Hubert E. Blum Tonino Alonzi Marco Tripodi Nicola La Monica Markus H. Heim | 2003 | Gastroenterology2003，，5： | 1 |
| 10 | Expression of hepatitis c virus proteins inhibits interferon α signaling in the liver of transgenic mice显示文摘 | Alex Blindenbacher Francois H.T. Duong Lukas Hunziker Simone T.D. Stutvoet Xueya Wang Luigi Terracciano Darius Moradpour Hubert E. Blum Tonino Alonzi Marco Tripodi Nicola La Monica Markus H. Heim | 2003 | Gastroenterology2003，，5： | 1 |
| 11 | Pathogenesis of hepatocellular carcinoma显示文摘 | Darius Moradpour Hubert E. Blum | 2005 | European Journal of Gastroenterology & Hepatology2005，，： | 1 |
| 12 | Analysis of CD8 + T-Cell–Mediated Inhibition of Hepatitis C Virus Replication Using a Novel Immunological Model显示文摘 | Juandy Jo Ulrike Aichele Nadine Kersting Rahel Klein Peter Aichele Emmanuel Bisse Andrew K. Sewell Hubert E. Blum Ralf Bartenschlager Volker Lohmann Robert Thimme | 2009 | Gastroenterology2009，，4： | 1 |
| 13 | Immunoregulation of dendritic and T cells by alpha-fetoprotein in patients with hepatocellular carcinoma显示文摘 | Marcus Ritter Mona Y. Ali Christian F. Grimm Robert Weth Leonhard Mohr Wulf O. Bocher Katja Endrulat Heiner Wedemeyer Hubert E. Blum Michael Geissler | 2004 | Journal of Hepatology2004，，6： | 1 |
| 14 | Klatskin tumor treated by inter-disciplinary therapies including stereotactic radiotherapy: A case report显示文摘In view of the poor prognosis of patients with cholangiocarcinoma (CCC), there is a need for new therapeutic strategies. Inter-disciplinary therapy seems to be most promising. Radiotherapy is an effective alternative to surgery for hilar CCC (Klatskin tumors) if an adequate radiation dose can be delivered to the liver hilus. Here,we describe a patient for whom we used a stereotactic radiotherapy technique in the context of an inter-disciplinary treatment concept. We report a 45-year-old patient with a locally advanced Klatskin tumor. Explorative laparotomy showed that the tumor was not resectable. A metallic stent was implanted and the patient was treated by stereotactic radiotherapy using a body frame. A total dose of 48 Gy (3x4 Gy/wk) was administered. Therapy was well tolerated. After 32 mo, local tumor recurrence and a chest wall metastasis developed and were controlled by radio-chemotherapy. After more than 56 mo with a good quality of life, the patient died of advanced neoplastic disease. Stereotactic radiotherapy led to a long-term survival of this patient with a locally advanced Klatskin tumor. In the context of inter-disciplinary treatment concepts, this radiotherapy technique is a promising choice of treatment for patients with hilar CCC. | Gerhild Becker Felix Momm Henning Schwacha Norbert Hodapp Henning Usadel Michael GeiBler Annette Barke Annette Schmitt-Gr(a|¨)ff Karl Henne Hubert E. Blum | 2005 | World Journal of Gastroenterology2005，11，31： | 0 |
| 15 | Molecular Therapy and Prevention of Liver Diseases显示文摘Molecular analyses have become an integral part of biomedical research as well as clinical medicine. The definition of the genetic basis of many human diseases has led to a better understanding of their pathogenesis and has in addition offered new perspectives for their diagnosis, therapy and prevention. Genetically, human diseases can be classified as hereditary monogenic, acquired monogenic and polygenic diseases. Based on this classification, gene therapy is based on six concepts: (1) gene repair, (2) gene substitution, (3) cell therapy, (4) block of gene expression or function, (5) DNA vaccination and (6) gene augmentation. While major advances have been made in all areas of gene therapy during the last years, various delivery, targeting and safety issues need to be addressed before these strategies will enter clinical practice. Nevertheless, gene therapy will eventually become part of the management of patients with various liver diseases, complementing or replacing existing therapeutic and preventive strategies. | Hubert E. Blum | 2008 | Virologica Sinica2008，23，2： | 0 |
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