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| 1 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 2 | Molecular cloning and characterization of the endothelin 3 gene in black bone sheep显示文摘Background: Black bone sheep was first discovered in Yunnan province of China in 1970, with unique black pigmentation on the body and internal organs. Endothelin 3(EDN3) has been known as a key gene causing hyperpigmentation in black bone chicken, the Silky fowl.Methods: In this study, EDN3 was employed as a candidate gene for regulating black color pigmentation. First,EDN3 was cloned from sheep to obtain the full-length cDNA by using the rapid amplification of cDNA ends(RACE).Genomic EDN3 was screened and a total of thirty predicted single nucleotide polymorphisms(SNPs) were genotyped for allele and genotype frequency analysis in a case-control study involving two black bone sheep populations. Genomic copy number analysis of EDN3 in sheep was conducted to measure the variation in copy number. EDN3 expression levels were observed among the groups in adult liver, lymph node, and kidney tissues, as well as embryo kidney samples. Also, among the tissues of black bone and non-black bone sheep.Results: The size of the full-length cDNA was 1,578 bp, which included 426 bp of 5′-untranslated region(5′-UTR),an open reading frame(ORF) of 639 bp encoding a protein of 212 amino acids, and a 3′-UTR of 513 bp. Genotype and allele frequencies of all the discovered SNPs were found insignificantly different in black bone and non-black bone sheep(P > 0.05). Genomic copy number analysis of EDN3 in sheep revealed no significant difference between the two sheep groups. No significant variations were found in the adult liver and kidney embryo samples. However,the expression in lymph node and kidney tissue was significantly higher in black bone sheep than that in non-black bone sheep(P < 0.05). Significant variations in the EDN3 expression levels were observed among the tissues of nonblack bone sheep.Conclusions: The findings of the present study indicate that unlike in Silky chickens, EDN3 is not responsible for hyperpigmentation but may play a key functional role in immune and excretory systems of black bone sheep. | Hesham Y.A.Darwish Yuanyuan Zhang Kai Cui Zu Yang Deping Han Xianggui Dong Huaming Mao Weidong Deng Xuemei Deng | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 2 |
| 3 | Intercalated 2D nanoclay for emerging drug delivery in cancer therapy显示文摘自然二维(2D ) kaolinite nanoclay 被合并了到一个新兴的药交货系统。kaolinite nanoclay 的基础间距通过不同的链长度的各种各样的器官的客人种类的置闰从 0.72 ~ 4.16 nm 被扩展,它能在药交货增加效率并且减少 doxorubicin (纪录影片) 的毒性。原来的 kaolinite (白陶土) 和白陶土置闰混合物向胰腺的癌症,胃的癌症,前列腺癌症,乳癌, colorectal 癌症,食道的癌症,和区分的甲状腺的房间展出了 biocompatibility 和很低的毒性的高水平癌症。然而,肺癌症和 hepatocellular 癌症房间为药交货搬运人需要更严格的组合、结构、词法的调整。纪录影片白陶土和纪录影片白陶土置闰混合物比处于中立状况在中等酸的答案显示出戏剧性地更快的药版本,并且以一种剂量依赖者方式对十种模型癌症房间文化展出了提高的治疗学的效果。为一个新奇的药交货系统的 2D nanoclay 材料的使用能 feasibly 向高效的 nanotherapeutics 铺平一条道路,与优异 antitumor 功效并且显著地减少副作用。 | Yi Zhang Mei Long Peng Huang Huaming Yang Shi Chang Yuehua Hu Aidong Tang Linfeng Mao | 2017 | Nano Research2017，10，8： | 2 |
| 4 | Construction of a few-layer g-C_3N_4/α-MoO_3 nanoneedles all-solid-state Z-scheme photocatalytic system for photocatalytic degradation显示文摘The suppression of the recombination of electrons and holes(e–h) and the enhancement of the light absorption of semiconductors are two key points toward efficient photocatalytic degradation.Here,we report a few-layer g-C_3N_4/α-MoO_3 nanoneedles(flg-C_3N_4/α-MoO_3 NNs) all-solid-state Z-scheme mechanism photocatalyst synthesized via a typical hydrothermal method in a controlled manner.The recombination of the photo-induced e–h pairs could be effectively restrained by the Z-scheme passageway between the flg-C_3N_4 and α-MoO_3 NNs in the composite,which could also promise a high redox ability to degrade pollutants.And it became possible for the prepared photocatalyst to absorb light in a wide range of wavelengths.The detailed mechanism was studied by electron spin-resonance spectroscopy(ESR).The low-dimensional nanostructure of the two constituents(α-MoO_3 NNs with one-dimensional structure and flg-C_3N_4 with two-dimensional structure) endowed the composite with varieties of excellent physicochemical properties,which facilitated the transfer and diffusion of the photoelectrons and increased the specific surface area and the active sites.The 10 wt% flg-C_3N_4/α-MoO_3 NNs showed the best photocatalytic performance toward RhB degradation,the rate of which was 71.86%,~2.6 times higher than that ofα-MoO_3 NNs. | Xiaoni Zhang Jianjian Yi Hanxiang Chen Mao Mao Liang Liu Xiaojie She Haiyan Ji Xiangyang Wu Shouqi Yuan Hui Xu Huaming Li | 2019 | Journal of Energy Chemistry2019，28，2： | 2 |
| 5 | Designing all-solid-state Z-Scheme 2D g-C_3N_4/Bi_2WO_6 for improved photocatalysis and photocatalytic mechanism insight显示文摘Bi_2WO_6 was modified by two-dimensional g-C_3N_4(2D g-C_3N_4)via a hydrothermal method.The structure,morphology,optical and electronic properties were investigated by multiple techniques,including X-ray diffraction(XRD),X-ray photoelectron spectroscopy spectra(XPS),Fourier transform infrared spectroscopy(FT-IR),scanning electron microscopy(SEM),transmission electron microscopy(TEM),Ultravioletvisible diffuse reflection spectroscopy(DRS),photocurrent and electrochemical impedance spectroscopy(EIS),electron spin resonance(ESR),respectively.Rhodamine B(Rh B)was used as the target organic pollutant to research the photocatalytic performance of as-prepared composites.The Bi_2WO_6/2D g-C_3N_4exhibited a remarkable improvement compared with the pure Bi_2WO_6.The enhanced photocatalytic activity was because the photogenerated electrons and holes can quickly separate by Z-Scheme passageway in composites.The photocatalytic mechanism was also researched in detail through ESR analysis. | Mao Mao Shuowei Zhao Zhigang Chen Xiaojie She Jianjian Yi Kaixiang Xia Hui Xu Minqiang He Huaming Li | 2018 | Green Energy & Environment2018，3，3： | 1 |
| 6 | A 602-year Reconstruction of July-June Streamflow in the Kuqa River, China, Reveals the Changing Hydrological Signals of the Tarim Basin显示文摘A regional tree-ring width chronology of Schrenk spruce(Picea schrenkiana) was used to determine the annual(previous July to current June) streamflow of the Kuqa River in Xinjiang, China, for the period of 1414–2015. A linear transformation of the tree-ring data accounted for 63.9% of the total variance when regressed against instrumental streamflow during 1957–2006. The model was validated by comparing the regression estimates against independent data. High streamflow periods with a streamflow above the 602-year mean occurred from 1430–1442, 1466–1492, 1557–1586, 1603–1615, 1687–1717, 1748–1767, 1795–1819, 1834–1856, 1888–1910 and 1989–2015. Low streamflow periods(streamflow below the mean) occurred from 1419–1429, 1443–1465, 1493–1556, 1587–1602, 1616–1686, 1720–1747, 1768–1794, 1820–1833, 1857–1887 and 1911–1988. The reconstruction compares well with the tree-ring-based streamflow series of the Tizinafu River from the Kunlun Mountains;both show well-known severe drought events. The streamflow reconstruction also shows highly synchronous upward trends since the 1980 s, suggesting that streamflow is related to Central Asian warming and humidification. Thus, the influences of the extremes and the persistence of low streamflows on local society may be considerable. Climatic changes in the watershed may be responsible for the change in the hydrologic regime of the Tarim Basin observed during the late twentieth century. | SHANG Huaming CHEN Feng WEI Wenshou MAO Weiyi ZHANG Ruibo ZHANG Tongwen YU Shulong | 2020 | Acta Geologica Sinica(English Edition)2020，94，3： | 0 |
| 7 | Improving pathway prediction accuracy of constraints-based metabolic network models by treating enzymes as microcompartments显示文摘Metabolic network models have become increasingly precise and accurate as the most widespread and practical digital representations of living cells.The prediction functions were significantly expanded by integrating cellular resources and abiotic constraints in recent years.However,if unreasonable modeling methods were adopted due to a lack of consideration of biological knowledge,the conflicts between stoichiometric and other constraints,such as thermodynamic feasibility and enzyme resource availability,would lead to distorted predictions.In this work,we investigated a prediction anomaly of EcoETM,a constraints-based metabolic network model,and introduced the idea of enzyme compartmentalization into the analysis process.Through rational combination of reactions,we avoid the false prediction of pathway feasibility caused by the unrealistic assumption of free intermediate metabolites.This allowed us to correct the pathway structures of L-serine and L-tryptophan.A specific analysis explains the application method of the EcoETM-like model and demonstrates its potential and value in correcting the prediction results in pathway structure by resolving the conflict between different constraints and incorporating the evolved roles of enzymes as reaction compartments.Notably,this work also reveals the trade-off between product yield and thermodynamic feasibility.Our work is of great value for the structural improvement of constraints-based models. | Xue Yang Zhitao Mao Jianfeng Huang Ruoyu Wang Huaming Dong Yanfei Zhang Hongwu Ma | 2023 | Synthetic and Systems Biotechnology2023，8，4： | 0 |
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