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| 1 | Ridge subduction and porphyry copper-gold mineralization:An overview显示文摘Many large porphyry Cu-Au deposits are connected to adakitic rocks known to be closely associated with ridge subduction. For example, there are several subducting ridges along the east Pacific margin, e.g., in Chile, Peru, and South America, most of which are associated with large porphyry Cu-Au deposits. In contrast, there are much fewer ridge subductions on the west Pacific margin and porphyry Cu-Au deposits are much less there, both in terms of tonnage and the number of deposits. Given that Cu and Au are moderately incompatible elements, oceanic crust has much higher Cu-Au concentrations than the mantle and the continental crust, and thus slab melts with their diagnostic adakitic chemistry have systematically higher Cu and Au, which is favorable for mineralization. Considering the geotherm of subducting slabs in the Phanerozoic, ridge subduction is the most favorable tectonic setting for this. Therefore, slab melting is the likely link in the spatial association between ridge subduction and Cu-Au deposits. Geochemical signatures of slab melting and hence maybe ridge subduction in less eroded regions in eastern China, the central Asian orogenic belt etc. may indicate important exploration targets for large porphyry Cu-Au deposits. | SUN WeiDong LING MingXing YANG XiaoYong FAN WeiMing DING Xing LIANG HuaYing | 2010 | Science China Earth Sciences2010，53，4： | 97 |
| 2 | Production of high-quality agarwood in Aquilaria sinensis trees via whole-tree agarwood-induction technology显示文摘我们使用了整个树的 agarwood 感应的技术在 20 个月以内从 Aquilaria sinensis 树生产 agarwood,并且评估了这 agarwood 的质量。结果证明它的特征以质地,化学成分,香精油内容,和乙醇可溶的摘录内容类似于高级野 agarwood 的那些,与远超过繁体中文药 agarwood 的要求的最後的质量,作为在中国药典 2010 显示了。就我们的知识而言,这是第一研究证明高质量的 agarwood 能在整个 A 被生产。经由一种化学上导致的技术的 sinensis 树。 | Xing Li Zhang Yang Yang Liu Jian He Wei Yun Yang Zheng Zhang Jun Qing Huang Huai Qiong Chen Yu Jun Liu | 2012 | Chinese Chemical Letters2012，23，6： | 28 |
| 3 | NUMERICAL SIMULATION AND ANALYSIS OF PRESSURE PULSATION IN FRANCIS HYDRAULIC TURBINE WITH AIR ADMISSION显示文摘In this article, the three-dimensional unsteady multiphase flow is simulated in the whole passage of Francis hydraulic turbine. The pressure pulsation is predicted and compared with experimental data at positions in the draft tube, in front of runner, guide vanes and at the inlet of the spiral case. The relationship between pressure pulsation in the whole passage and air admission is analyzed. The computational results show: air admission from spindle hole decreases the pressure difference in the horizontal section of draft tube, which in turn decreases the amplitude of low-frequency pressure pulsation in the draft tube; the rotor-stator interaction between the air inlet and the runner increases the blade-frequency pressure pulsation in front of the runner. | QIAN Zhong-dong YANG Jian-dong HUAI Wen-xin | 2007 | Journal of Hydrodynamics2007，19，4： | 24 |
| 4 | Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo显示文摘BACKGROUND:12-lipoxygenase(12-LOX) has been reported to be an important gene in cancer cell proliferation and survival,and tumor metastasis.However,its role in hepatocellular carcinoma(HCC) cells remains unknown.METHODS:Expression of 12-LOX was assessed in a diethylnitrosamine-induced rat HCC model,and in SMMC-7721,HepG2 and L-02 cells using immunohistochemical staining and reverse transcriptase-polymerase chain reaction(RT-PCR).GST-π and Ki-67 were determined in vivo by immunohistochemical staining.Apoptosis was evaluated by TUNEL assay.Cell viability and apoptosis were determined by MTT assay and flow cytometry,respectively.Apoptosis-related proteins in SMMC-7721 and HepG2 cells were detected by Western blotting.RESULTS:Immunohistochemical staining and RT-PCR showed that 12-LOX was over-expressed in rat HCC and two HCC cell lines,while the expression was inhibited by baicalein,a specific inhibitor of 12-LOX.Baicalein inhibited cell proliferation and induced apoptosis in rat HCC and both cell lines in a dose-and time-dependent manner.Our in vivo study demonstrated that baicalein also reduced neoplastic nodules.Mechanistically,baicalein reduced Bcl-2 protein expression coupled with a slight increase of the expression of Bax and activation of caspase-3.Furthermore,baicalein inhibited the activation of ERK-1/2(phosphorylated).Interestingly,the effects of baicalein were reversed by 12(S)-HETE,a metabolite of 12-LOX.CONCLUSIONS:Inhibition of 12-LOX leads to reduced numbers of HCC cells,partially caused by increased apoptosis.12-LOX may be a potential molecular target for HCC prevention and treatment. | Xi-Ming Xu,Guang-Jin Yuan,Jun-Jian Deng,Hong-Ting Guo,Miao Xiang,Fang Yang,Wei Ge and Shi-You Chen Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China Cancer Center, the 82nd Hospital of the Chinese PLA, Huai’an 223001, China Department of Physiology, Medical College of Wuhan University, Wuhan 430071, China Department of Physiology & Pharmacology, University of Georgia, Athens, GA 30602, USA | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 20 |
| 5 | Flow dynamics and sediment transport in vegetated rivers:A review显示文摘The significance of riparian vegetation on river flow and material transport is not in dispute.Conveyance laws,sediment erosion and deposition,and element cycling must all be adjusted from their canonical rough-wall boundary layer to accommodate the presence of aquatic plants.In turn,the growth and colonization of riparian vegetation are affected by fluvial processes and river morphology on longer time scales.These interactions and feedbacks at multiple time scales are now drawing significant attention within the research community given their relevance to river restoration.For this reason,a review summarizing methods,general laws,qualitative cognition,and quantitative models regarding the interplay between aquatic plants,flow dynamics,and sediment transport in vegetated rivers is in order.Shortcomings,pitfalls,knowledge gaps,and daunting challenges to the current state of knowledge are also covered.As a multidisciplinary research topic,a future research agenda and opportunities pertinent to river management and enhancement of ecosystem services are also highlighted. | Wen-xin Huai Shuolin Li Gabriel G.Katul Meng-yang Liu Zhong-hua Yang | 2021 | Journal of Hydrodynamics2021，33，3： | 20 |
| 6 | A carbon-oxygen-bridged ladder-type building block for efficient donor and acceptor materials used in organic solar cells显示文摘A carbon-oxygen-bridged ladder-type donor unit(CO5) was invented and prepared via an ‘‘intramolecular demethanolization cyclization' approach. Its single crystal structure indicates enhanced planarity compared with the carbon-bridged analogue indacenodithiophene(IDT). Owing to the stronger electron-donating capability of CO5 than IDT, CO5-based donor and acceptor materials show narrower bandgaps. A donor-acceptor(D-A) copolymer donor(PCO5TPD) and an A-D-A nonfullerene acceptor(CO5IC) demonstrated higher performance than IDT-based counterparts, PIDTTPD and IDTIC, respectively. The better performance of CO5-based materials results from their stronger light-harvesting capability and higher charge-carrier mobilities. | Zuo Xiao Fan Liu Xinjian Geng Jianqi Zhang Shizhe Wang Yujun Xie Zhen Li Huai Yang Yongbo Yuan Liming Ding | 2017 | Science Bulletin2017，62，19： | 16 |
| 7 | Modeling framework of voltage-source converters based on equivalence with synchronous generator显示文摘Along with the increasing penetration of distributed generation with voltage-source converters(VSCs),there are extensive concerns over the potential virtual rotor angle stability, which is characterized by oscillations of power and frequency during the dynamic process of synchronization in the grid. Several control strategies have been developed for VSCs to emulate rotating inertia as well as damping of oscillations. This paper classifies these strategies and provides a small-signal modeling framework including all kinds of VSCs in different applications for virtual rotor angle stability. A unified perspective based on the famous Phillips–Heffron model is established for various VSCs. Thus, the concepts of equivalent inertia and the synchronizing and damping coefficients in different VSCs are highlighted, based on the similarities with the synchronous generator(SG) system in both physical mechanisms and mathematical models. It revealed the potentiality of various VSCs to achieve equivalence with the SG. This study helps promote the unity of VSCs and traditional SGs in both theories and methods for analyzing the dynamic behavior and enhancing the stability. Finally,future research needs and new perspectives are addressed. | Shulong TAN Hua GENG Geng YANG Huai WANG Frede BLAABJERG | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，6： | 15 |
| 8 | Finite element investigation of the poroelastic effect on the Xinfengjiang Reservoir-triggered earthquake显示文摘Coulomb failure stress changes (ΔCFS) are used in the study of reservoir-induced seismicity (RIS) generation.The threshold value of ΔCFS that can trigger earthquakes is an important issue that deserves thorough research.The M s 6.1 earthquake in the Xinfengjiang Reservoir in 1962 is well acknowledged as the largest reservoir-induced earthquake in China.Therefore, it is a logical site for quantitative calculation of ΔCFS induced by the filling of the reservoir and for investigating the magnitude of CFS that can trigger reservoir seismic activities.To better understand the RIS mechanism, a three-dimensional poroelastic finite element model of the Xinfengjiang Reservoir is proposed here, taking into consideration of the precise topography and dynamic water level.We calculate the instant changes of stress and pore pressure induced by water load, and the time variation of effective stresses due to pore water diffusion.The CFS on the seismogenesis faults and the accumulation of strain energy in the reservoir region are also calculated.Primary results suggest that the reservoir impoundment increases both pore pressure and CFS on the fault at the focal depth.The diffusion of pore pressure was likely the main factor that triggered the main earthquake, whereas the elastic stress owing to water load was relatively small.The magnitude of CFS on seismogenesis fault can reach approximately 10 kPa, and the ΔCFS values at the hypocenter can be about 0.7-3.0 kPa, depending on the fault diffusion coefficient.The calculated maximum vertical subsidence caused by the water load in the Xinfengjiang Reservoir is 17.5 mm, which is in good agreement with the observed value of 15 mm.The accumulated strain energy owing to water load was only about 7.3×10 11 J, even less than 1% of the seismic wave energy released by the earthquake.The reservoir impoundment was the only factor that triggered the earthquake. | CHENG HuiHong ZHANG Huai ZHU BoJing SUN YuJun ZHENG Liang YANG ShaoHua SHI YaoLin | 2012 | Science China Earth Sciences2012，55，12： | 11 |
| 9 | Constraint-induced movement therapy in treatment of acute and sub-acute stroke: a meta-analysis of 16 randomized controlled trials显示文摘OBJECTIVE: The aim of this meta-analysis was to evaluate the clinical efficacy of constraint-induced movement therapy in acute and sub-acute stroke.DATA SOURCES: The key words were stroke, cerebrovascular accident, constraint-induced therapy, forced use, and randomized controlled trial. The databases, including China National Knowledge Infrastructure, Wan Fang, Weipu Information Resources System, Chinese Biomedical Literature Database, Pub Med, Medline, Embase, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews, were searched for studies on randomized controlled trials for treating acute or sub-acute stroke published before March 2016. DATA SELECTION: We retrieved relevant randomized controlled trials that compared constraint-induced movement therapy in treatment of acute or sub-acute stroke with traditional rehabilitation therapy(traditional occupational therapy). Patients were older than 18 years, had disease courses less than 6 months, and were evaluated with at least one upper extremity function scale. Study quality was evaluated, and data that met the criteria were extracted. Stata 11.0 software was used for the meta-analysis. OUTCOME MEASURES: Fugl-Meyer motor assessment of the arm, the action research-arm test, a motor activity log for amount of use and quality of movement, the Wolf motor function test, and a modified Barthel index.RESULTS: A total of 16 prospective randomized controlled trials(379 patients in the constraint-induced movement-therapy group and 359 in the control group) met inclusion criteria. Analysis showed significant mean differences in favor of constraint-induced movement therapy for the Fugl–Meyer motor assessment of the arm(weighted mean difference(WMD) = 10.822; 95% confidence intervals(95% CI): 7.419–14.226), the action research-arm test(WMD = 10.718; 95% CI: 5.704–15.733), the motor activity log for amount of use and quality of movement(WMD = 0.812; 95% CI: 0.331–1.293) and the modified Barthel index(WMD = 10.706; 95% CI: 4.417–16.966). CONCLUSION: Constraint-induced movement therapy may be more beneficial than traditional rehabilitation therapy for improving upper limb function after acute or sub-acute stroke. | Xi-hua Liu Juan Huai Jie Gao Yang Zhang Shou-wei Yue | 2017 | Neural Regeneration Research2017，12，9： | 9 |
| 10 | Spectral element analysis on the characteristics of seismic wave propagation triggered by Wenchuan M_s8.0 earthquake显示文摘The 2008 Wenchuan earthquake occurred in an active earthquake zone, i.e., Longmenshan tectonic zone. Seismic waves triggered by this earthquake can be used to explore the characteristics of the fault rupture process and the hierarchical structure of the Earth's interior. We employ spectral element method incorporated with large-scale parallel computing technology, to investigate the characteristics of seismic wave propagation excited by Wenchuan earthquake. We calculate synthetic seismograms with one-point source model and three-point source model respectively. The AK135 model is employed as a prototype of our numerical global Earth model. The Earth's ellipticity, Earth’s medium attenuation, and topography data are taken into consideration. These wave propagation processes are simulated by solving three-dimensional elastic wave governing equations. Three-dimensional visualization of our numerical results displays the profile of the seismic wave propagation. The three-point source, which is proposed from the latest investigations through field observation and reverse estimation, can better demonstrate the spatial and temporal characteristics of the source rupture process than the one-point source. We take comparison of synthetic seismograms with observational data recorded at 16 observatory stations. Primary results show that the synthetic seismograms calculated from three-point source agree well with the observations. This can further reveal that the source rupture process of Wenchuan earthquake is a multi-rupture process, which is composed by at least three or more stages of rupture processes. | YAN ZhenZhen ZHANG Huai YANG ChangChun SHI YaoLin | 2009 | Science China Earth Sciences2009，52，6： | 9 |
| 11 | Different Effects of Pravastatin on Preeclampsia-like Symptoms in Different Mouse Models显示文摘 | Jing Huai Zi Yang Yan-Hong Yi Guang-Jiao Wang | 2018 | Chinese Medical Journal2018，，4： | 9 |
| 12 | Adsorption characteristics of a novel ceramsite for heavy metal removal from stormwater runoff显示文摘Urban sediments have rapidly increased in recent years around the world,and their effective management has become an important problem.To remove heavy metals from stormwater runoff and use sediments as a resource,a novel ceramsite was developed using sewer pipe sediments(SPS),river bed sediments(RBS),urban water supply treatment sludge(WSTS),and wastewater treatment plant excess sludge(WWTS).The optimal composition was determined based on the Brunauer–Emmett–Teller specific surface area and an orthogonal test design.The adsorption characteristics of the novel ceramsite for dissolved heavy metals(Cu^(2+)and Cd^(2+)) were investigated through adsorption isotherms and kinetic experiments at(25±1)℃.Both Cu^(2+) and Cd^(2+) were effectively removed by the novel ceramsite,and their equilibrium adsorption was 4.96 mg·g^(-1) and 3.84 mg·g^(-1),respectively.Langmuir isotherms and a pseudo-first-order kinetic equation described the adsorption process better than other techniques.Characterization analysis of the ceramsite composition before and after heavy metal adsorption showed that the Cu^(2+) and Cd^(2+) contents in the ceramsite increased after adsorption.The results revealed that adsorption is both a physical and chemical process,and that ceramsite can be used as a bioretention medium to remove heavy metals from stormwater runoff while simultaneously converting problematic urban sediments into a resource. | Jianlong wang Yuanling Zhao Pingping Zhang Liqiong Yang Huai'ao Xu Guangpeng Xi | 2018 | Chinese Journal of Chemical Engineering2018，26，1： | 9 |
| 13 | Effects of GSM 1800 MHz on dendritic development of cultured hippocampal neurons显示文摘目的:为活动通讯( GSM )评估全球系统的效果在在在 rats.Methods 的有教养的海马趾的神经原的开发期间的树枝状的 filopodia ,树枝状的树枝状,和脊骨成熟上的 1800 MHz 微波:分别地,有教养的海马趾的神经原与 2.4 和 0.8 W/kg 暴露于 GSM 1800 MHz 微波为 15 min ,从 6 天在试管内( DIV6 ),到 DIV14.The ,树突的微妙的结构被 transfection 每天与 farnesylated 显示提高的绿荧光灯的蛋白质( F-GFP )和进海马趾的 neurons.Results 的 DIV5 上的GFP肌动朊:在在 DIV8 的树枝状的 filopodia 的密度和活动性有重要减少并且与 2.4 W/kg.In 增加在在在神经原的 DIV14 的成熟脊骨的密度暴露了到 GSM 1800 MHz 微波,树突的平均长度每在 DIV10 和 DIV14 的神经原被减少,当树枝状的树枝状在这些神经原是未改变的时。然而,没有重要变化,在与 0.8 W/kg.Conclusion 暴露于 GSM 1800 MHz 微波的神经原发现:这些数据显示到 2.4 W/kg GSM 1800 MHz 微波的长期的暴露可以在文化在早发展的阶段期间影响树枝状的开发和海马趾的神经原的有刺激性的触处的形成。 | Wei NING Shu-jun XU Huai CHIANG Zheng-ping XU Su-ya ZHOU Wei YANG Jian-hong LUO | 2007 | Acta Pharmacologica Sinica2007，28，12： | 8 |
| 14 | Response regimes of narrow-band stochastic excited linear oscillator coupled to nonlinear energy sink显示文摘This paper draws attention to the issue of the vibration absorption of nonlinear mechanical system coupled to nonlinear energy sink(NES) under the impact of the narrow band stochastic excitation. Firstly, based on the complex-averaging method and frequency detuning methodology,response regimes of oscillators have been researched under the linear impact of coupling a nonlinear attachment with less relativistic mass and an external sinusoidal forcing, of which results turn out that the quasi-periodicity response regime of system which occurs when the external excitation amplitude exceeds the critical values will be the precondition of the targeted energy transfer.Secondly, basing on the path integration method, vibration suppression of NES has been researched when it is affected by a main oscillator with a narrow band stochastic force in the form of trigonometric functions, of which results show that response regimes are affected by the amplitude of stochastic excitation and the disturbance strength. Finally, all these conclusions have been approved by the numerical verification and coincided with the theoretical analysis; meanwhile, after the comparing analysis with the optimal linear absorber, it turns out that the NES which is affected by the narrow band stochastic force could also suppress the vibration of system with a better effect. | Xiong Huai Kong Xianren Yang Zhenguo Liu Yuan | 2015 | Chinese Journal of Aeronautics2015，28，2： | 7 |
| 15 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 16 | CURVED OPEN CHANNEL FLOW ON VEGETATION ROUGHENED INNER BANK显示文摘A RNG numerical model together with a laboratory measurement with Micro ADV are adopted to investigate the flow through a 180o curved open channel(a 4 m straight inflow section,a 180o curved section,and a 4m straight outflow section)partially covered with rigid vegetations on its inner bank.Under the combined action of the vegetation and the bend flow,the flow structure is complex.The stream-wise velocities in the vegetation region are much smaller than those in the non-vegetation region due to the retardation caused by the vegetation.For the same reason,no clear circulation is found in the vegetated region,while in the non-vegetation region,a slight counter-rotating circulation is found near the outer bank at both 90o and downstream curved cross-sections.A comparison between the numerical prediction and the laboratory measurement shows that the RNG model can well predict the flow structure of the bend flow with vegetation.Furthermore,the shear stress is analyzed based on the numerical prediction.The much smaller value in the inner vegetated region indicates that the vegetation can effectively protect the river bank from scouring and erosion,in other words,the sediment is more likely to be deposited in the vegetation region. | HUAI Wen-xin LI Cheng-guang ZENG Yu-hong QIAN Zhong-dong YANG Zhong-hua | 2012 | Journal of Hydrodynamics2012，24，1： | 6 |
| 17 | Role of mammalian target of rapamycin signaling pathway in regulation of fatty acid oxidation in a preeclampsia-like mouse model treated with pravastatin显示文摘Background: Fatty acid oxidation (FAO) disorder is involved in the pathogenesis of some cases of preeclampsia (PE). Several show that mammalian target of rapamycin (mTOR) signaling pathway is related to FAO. Pravastatin (Pra) can promote FAO in Nio-nitro-L-arginine methyl ester (L-NAME) PE-like mouse model in our previous study. This study aimed to investigate the effect of mTOR signaling pathway in PE-like model treated with Pra. Methods: Pregnant mice were randomly injected with L-NAME as PE-like model group or saline as control group respectively, from gestational 7th to 18th day. Giving Pra (L-NAME + Pra, Control + Pra, n= 8) or normal saline (NS;L-NAME + NS, Control + NS, n = 8) from gestational 8th to 18th day, the mice were sacrificed on day 18 and their liver and placental tissues were collected. Then the activation of mTOR and its substrates in the liver and placenta were detected. And the association between mTOR activation and mice were randomly injected with L-NAME as PE-like model group or saline as control group respectively, from serum free fatty acid (FFA) levels and the expression of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) were evaluated using Pearson correlation test. Differences between groups were analyzed using independent t-test or one-way analysis of variance (ANOVA). Results: Both in the maternal liver and placenta, the activation of mTOR protein and its effect on substrates increased significantly in the L-NAME + NS group and decreased significantly in the L-NAME + Pra group. The p-mTOR/mTOR protein ratio decreased in the L-NAME + Pra group significantly than that in the L-NAME + NS group both in liver and placenta (liver: 0.74±0.08 vs. 0.85± 0.06, t=2.95, P<0.05;placenta: 0.63±0.06 vs.0.77±0.06, t=4.64, P<0.05). The activation of mTOR protein in the liver and placenta negatively correlated with the expression of LCHAD in the L-NAME + NS group (liver: r=—0.745, P<0.05;placenta: r=-0.833, P< 0.05) and that in the maternal liver negatively correlated with the expression of LCHAD (r=—0.733, P<0.05) and serum FFA levels positively with the (r=0.841, P< 0.05) in the L-NAME+ Pra group. Conclusion: The inhibition of mTOR signaling pathway might be involved in the regulation of FAO in mouse model treated with Pra. | Jing Huai Zi Yang Yan-Hong Yi Guang-Jiao Wang | 2019 | Chinese Medical Journal2019，，6： | 6 |
| 18 | Distribution and drug resistance of pathogenic bacteria in emergency patients显示文摘BACKGROUND Antibiotic resistance has become a global threat for human health,calling for rational use of antibiotics.AIM To analyze the distribution and drug resistance of the bacteria,providing the prerequisite for use of antibiotics in emergency patients.METHODS A total of 2048 emergency patients from 2013 to 2017 were enrolled.Their clinical examination specimens were collected,followed by isolation of bacteria.The bacterial identification and drug susceptibility testing were carried out.RESULTS A total of 3387 pathogens were isolated.The top six pathogens were Acinetobacter baumannii(660 strains),Staphylococcus aureus(436 strains),Klebsiella pneumoniae(347 strains),Pseudomonas aeruginosa(338 strains),Escherichia coli(237 strains),and Candida albicans(207 strains).The isolation rates of these pathogens decreased year by year except Klebsiella pneumoniae,which increased from 7.1%to 12.1%.Acinetobacter baumannii is a widely-resistant strain,with multiple resistances to imipenem,ciprofloxacin,minocycline and tigecycline.The Staphylococcus aureus had high resistance rates to levofloxacin,penicillin G,and tetracycline.But the susceptibility of it to vancomycin and tigecycline were 100%.Klebsiella pneumoniae had high resistance rates to imipenem,cefoperazone/sulbactam,amikacin,and ciprofloxacin,with the lowest resistance rate to tigecycline.The resistance rates of Pseudomonas aeruginosa to cefoperazone/sulbactam and imipenem were higher,with the resistance rate to amikacin below 10%.Besides,Escherichia coli had high resistance rates to ciprofloxacin and cefoperazone/sulbactam and low resistance rates to imipenem,amikacin,and tigecycline.CONCLUSION The pathogenic bacteria isolated from the emergency patients were mainly Acinetobacter baumannii,Staphylococcus aureus,Klebsiella pneumoniae,Pseudomonas aeruginosa,Escherichia coli,and Candida albicans.The detection rates of drugresistant bacteria were high,with different bacteria having multiple drug resistances to commonly used antimicrobial agents,guiding the rational use of drugs and reducing the production of multidrug-resistant bacteria. | Wei Huai Qing-Bian Ma Jia-Jia Zheng Yang Zhao Qiang-Rong Zhai | 2019 | World Journal of Clinical Cases2019，7，20： | 6 |
| 19 | EXPERI MENTAL INVESTIGATION INTO HOT WATER SLOT JETS WITH NEGATIVELY BUOYANCYIN CROSS FLOW显示文摘An experiment was conducted to examine the near-field behavior of negatively bu oyant planar jets in flowing environment. Hot water jet was projected d ownwards at different angles from a slot into a uniform cross flow. Micro Acoust ic Doppler Velocimeter (Micro ADV) system is used to measure the velocity and tu rbulent fluxes of Reynolds stresses. The whole field temperatures were measured with fast response thermocouples. Pure jets experiments were made also to study the effect of buoyancy in negatively buoyant jets. It is found that the influenc ed area of hot jets is larger than which of pure jets when the jet angle is 90° and the influenced area of hot jets is smaller than which of pure jets when the jet angle is 45°. The difference is not obvious at 60° angle jets. This means that the rising of temperature has effect not only on negatively buoyancy, but also on the intensity of turbulence. The contrast of these two influences domina tes the trend of jet flow. | YANG Zhong-hua HUAI Wen-xin DAI Hui-chao | 2005 | Journal of Hydrodynamics2005，17，4： | 5 |
| 20 | Lattice Boltzmann method for simulating flows in open-channel with partial emergent rigid vegetation cover显示文摘Flows in open-channel with partial emergent rigid vegetation cover are simulated using the lattice Boltzmann method (LBM) described by the 2-D nonlinear shallow water equations. The effect of vegetation is represented with the vegetation roughness coefficient, which is related to the vegetation density, diameter of the vegetation elements and drag coefficient. The model is verified by three numerical tests: flow in a 180° curved open channel with partial vegetation cover at the outer bank, flow in a rectangular channel with a finite patch of vegetation and flow in a rectangular channel with a vegetated bank. Numerical results are compared with the experimental data, and the good agreement proved that the presented model can model the vegetated channel flows correctly. | Zhong-hua Yang Feng-peng Bai Wen-xin Huai Cheng-guang Li | 2019 | Journal of Hydrodynamics2019，31，4： | 5 |
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