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| 1 | Effects of salvianolic acid-A on NIH/3T3 fibroblast proliferation,collagen synthesis and gene expression显示文摘AIM To investigate the mechanisms ofsalvianolic acid A(SA-A)against liver fibrosisin vitro.METHODS NIH/3T3 fibroblasts were culturedroutinely,and incubated with 10-4mol/L-10-7mol/L SA-A for 22 h.The cell viability wasassayed by[3H]proline incorporation,cellproliferation by[3H]TdR incorporation,cellcollagen synthetic rate was measured with[3H]proline impulse and collagenase digestionmethod.The total RNA was prepared from thecontrol cells and the drug treated cellsrespectively,and α(1)I pro-collagen mRNAexpression was semi-quantitatively analyzedwith RT-PCR.RESULTS 10-4mol/L SA-A decreased cellviability and exerted some cytotoxiciy,while10-5mol/L-10-7mol/L SA-A did not affect cellviability,but inhibited cell proliferationsignificantly,and 10-6mol/L SA-A had the besteffect on cell viability among theseconcentrations of drugs.10-5mol/L-10-6mol/LSA-A inhibited intracellular collagen syntheticrate,but no significant influence on extracellularcollagen secretion.Both 10-5mol/L and10-6mol/L SA-A could decrease α(1)I pro-collagen mRNA expression remarkably.CONCLUSION SA-A had potent action againstliver fibrosis.It inhibited NIH/3T3 fibroblastproliferation,intracellular collagen syntheticrate and type I pro-collagen gene expression,which may be one of the main mechanisms of thedrug. | Liu CH Hu YY Wang XL Liu P Xu LM | 2000 | World Journal of Gastroenterology2000，6，3： | 25 |
| 2 | Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma显示文摘A previous report has confirmed the existence and clinical significance of vasculogenic mimicry(VM)in glioma.However,its conclusions about the negative clinical significance of VM in glioblastoma are based on a small group of patients and,thus,might be unconvincing.The aim of the present study was to reevaluate the clinical significance of VM in glioblastoma.Patients were classified as VM-positive or | Wang SY Ke YQ Lu GH Song ZH Yu L Xiao S Sun XL Jiang XD Yang ZL Hu CC | 2013 | 中国神经肿瘤杂志2013，11，3： | 22 |
| 3 | The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells显示文摘 | Liu X Wu JY Zhou F Sun XL Yao HH Yang Y Ding JH Hu G | 2006 | 中国生物学文摘2006，20，10： | 11 |
| 4 | Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes显示文摘 | Yang, JA Luan, XF Gui, HY Yan, P Yang, DF Song, XL Liu, W Hu, G Yah, BF | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 8 |
| 5 | Analytic EAM Model for the Thermodynamic Properties ofthe Disordered Solid Solution and Ordered Intermetallic Alloys of Iron Aluminides显示文摘A simple analytic embedded atom method for bcc Fe and fcc Al metals is used to calculate thethermodynamic properties of the disordered solid solution and ordered intermetallic alloys of Fe aluminides. The thermodynamic properties, such as the dilute-limit heats of solution, formation enthalpies of disordered solid solutions and intermetallic compounds (Fe3Al in the D03 structuretype, FeAl in the B2 structure type, and Fe13Al3) are in good agreement with the experimentaldata, and with the results calculated using the first principles and Miedema theory. | Hu, WY Zhang, BW Shu, XL Huang, BY | 1999 | Journal of Materials Science & Technology1999，15，4： | 4 |
| 6 | Repair of extended peripheral nerve lesions in rhesus monkeys using acellular allogenic nerve grafts implanted with autologous mesenchymal stem cells显示文摘 | Hu J Zhu QT Liu XL | 2007 | Exp Neurol2007，204，： | 1 |
| 7 | Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells显示文摘 | Guo XL Li D Hu F | 2012 | Cancer Lett2012，320，2： | 1 |
| 8 | Appearance of human meridian-like structure and acupoints and its time correlation by infrared thermal imaging显示文摘 | Yang HQ Xie SS Hu XL | 2007 | Am J Chin Med2007，35，2： | 1 |
| 9 | Zhang Y(2011)Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae显示文摘 | Yang XL Zhang S Hu QB | 2011 | JAntibiot (Tokyo)2011，64，： | 1 |
| 10 | Incorporating ultrasound-measured musculotendon parameters to subject-specific EMG-driven model to simulate voluntary elbow flexion for persons after stroke显示文摘 | Li L Tong KY Hu XL | | 0，，01： | 1 |
| 11 | A Systematic review and nalysis of unilateral versus bilateral pedicle screw fixation in transforaminal lumbar interbody fusion 显示文摘 | Hu XQ Wu XL Xu C | 2014 | PloS One2014，9，87： | 1 |
| 12 | Limbic epileptogenesis in a mouse model offiagile X syndrome 显示文摘 | Qiu LF Lu TJ Hu XL | 2009 | Cereb Cortex2009，19，7： | 1 |
| 13 | Crystal structure of HAb18G/CD147:implications for immunoglobulin superfamily ho mophilic adhesion显示文摘 | Yu XL Hu T Du JM | 2008 | J Biol Chem2008，283，18： | 1 |
| 14 | Clinical analysis of 13 cases of tuberculosis accompanied by aspergilloma显示文摘 | CHEN XL HU W | 2003 | J Clin Intern Med2003，20，6： | 1 |
| 15 | Effects of prolonged metoprolol treatment on neural remodeling and inducible ventricular arrhythmias after myocardial infarction in rabbits 显示文摘 | Yan SH Hu HS Wang XL | 2007 | Int J Cardiol2007，117，3： | 1 |
| 16 | Association between RUNX3promoter methylation and gastric cancer: a meta-analysis显示文摘 | Fan XY Hu XL Han TM | 2011 | BMCGastroenterol2011，11，： | 1 |
| 17 | High maternal serum estradiolenvironment in the first trimester is associated with the increasedrisk of small -for -gestational -age birth 显示文摘 | Hu XL Feng C Lin XH | 2014 | J Clin EndocrinolMetab2014，99，6： | 1 |
| 18 | Molecular cloning and expression analysis of interferon regulatory factor 8 ( IRF8 ) in turbot, Scophthalmus maximus显示文摘 | Chen XL Hu GB Dong XZ | 2012 | Veterinary Immunology and Immunopathology2012，149，12： | 1 |
| 19 | Newly generated neurons at 2 months post-status epilepticus are functionally integrated into neuronal circuitry in mouse hippocampus 显示文摘 | HU M ZHU K CHEN XL | 2015 | Exp Neurol 201 52015，273，2015： | 1 |
| 20 | The research development of orally disintergrating tablet 显示文摘 | Hu XL Huang H Li YB | 2005 | Chin J Hospital Pharm2005，25，2： | 1 |
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