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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Cytoplasmic accumu- lation of the RNA binding protein HuR is central to tamoxifen re- sistance in estrogen receptor positive breast cancer cells 显示文摘 | Hostetter C Licata LA Witkiewicz A | 2008 | Cancer Biol Ther2008，7，9： | 1 |
| 3 | Staging of chronic kidney disease:time for a course correction显示文摘 | Bauer C Melamed ML Hostetter TH | 2008 | J Am Soc Nephrol2008，19，5： | 1 |
| 4 | Staging of chronic kidney disease:Time for a course correlation 显示文摘 | Bauer C Melamed ML Hostetter TH | 2008 | J Am Soc Nephrol2008，19，5： | 1 |
| 5 | eGFR:is it ready for early identification of CKD显示文摘 | Melamed ML Bauer C Hostetter TH | | 0，，05： | 1 |
| 6 | Cytoplasmic accumu- lation of the RNA binding protein HuR is central to tamoxifen re- sistance in estrogen receptor positive breast cancer cells 显示文摘 | Hostetter C Licata LA Witkiewicz A | 2008 | Cancer Biol Ther2008，7，9： | 1 |
| 7 | Cytoplasmic accumu- lation of the RNA binding protein HuR is central to tamoxifen re- sistance in estrogen receptor positive breast cancer cells 显示文摘 | Hostetter C Licata LA Witkiewicz A | 2008 | Cancer Biol Ther2008，7，9： | 1 |
| 8 | Staging of chronic kidneydisease: time for a course correction显示文摘 | Bauer C Melamed ML Hostetter TH | 2008 | J Am Soc Nephrol2008，19，5： | 1 |
| 9 | Inactivation of representative species of entomo-pathogenic viruses, a bacterium, fungs and protozoan by an ultraviolet light source显示文摘 | Ignoffo C M Hostetter D L Sikorowski P P | 2007 | Environ Entomli2007，6，3： | 1 |
| 10 | Access, Utility, Imperfection: The Impact of Videoconferencing on Perceptions of Social Presence显示文摘 | LOWDEN R J HOSTETTER C | 2012 | Computers in Human Behavior2012，28，2： | 1 |
| 11 | Susceptibility of the cabbage looper, Trichoplusia ni, and the velvet-bean cater pillar, Anticarsia gemmatalis, to several isolates of the entomopathoge-nic fungus Nomuraea rileyi 显示文摘 | Ignoffo C M Puttler B Hostetter D L | 1976 | J Invertebr Pathol1976，28，： | 1 |
| 12 | Continuous ultrasound-guided adductor canal block for total knee arthroplasty: a randomized, double-blind trial 显示文摘 | Hanson NA Alien C J Hostetter LS | 2014 | Anesth Analg2014，118，6： | 1 |
| 13 | Staging of chronic kidney disease:time for a course correlation显示文摘 | Bauer C Melamed ML Hostetter TH | 2008 | J Am Soc Nephrol2008，19，5： | 1 |
| 14 | Inactivation of representative species of entomopathogenic viruses, a bacterium, fungus, and protozoan by an ultraviolet light source显示文摘 | Ignoffl C L Hostetter D L Sikorowski P P | 1977 | Environ Entomol1977，，6： | 1 |
| 15 | Cytoplasmic accumulatian of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer ceils 显示文摘 | Hostetter C Licata LA Witkiewicz A | 2008 | Cancer Biol Ther2008，7，9： | 1 |
| 16 | Measuring up On- line: The Relationship between Social Presence and Student Learning Satisfaction显示文摘 | HOSTETTER C BUSCH M | 2006 | Journal of Schol- arship of Teaching and Learning2006，6，2： | 1 |
| 17 | Gustatory stimulant, sunlight protectant, evaporation retardant: three characteristics of a microbial insecticidal adjuvant 显示文摘 | Ignoffo C M Hostetter D L Smith D B | 1976 | Ibid1976，69，： | 1 |
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