|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Manipulation of Band Degeneracy and Lattice Strain for Extraordinary PbTe Thermoelectrics显示文摘Maximizing band degeneracy and minimizing phonon relaxation time are proven to be successful for advancing thermoelectrics.Alloying with monotellurides has been known to be an effective approach for converging the valence bands of PbTe for electronic improvements,while the lattice thermal conductivity of the materials remains available room for being further reduced.It is recently revealed that the broadening of phonon dispersion measures the strength of phonon scattering,and lattice dislocations are particularly effective sources for such broadening through lattice strain fluctuations.In this work,a fine control of MnTe and EuTe alloying enables a significant increase in density of electron states near the valence band edge of PbTe due to involvement of multiple transporting bands,while the creation of dense in-grain dislocations leads to an effective broadening in phonon dispersion for reduced phonon lifetime due to the large strain fluctuations of dislocations as confirmed by synchrotron X-ray diffraction.The synergy of both electronic and thermal improvements successfully leads the average thermoelectric figure of merit to be higher than that ever reported for p-type PbTe at working temperatures. | Yixuan Wu Pengfei Nan Zhiwei Chen Zezhu Zeng Siqi Lin Xinyue Zhang Hongliang Dong Zhiqiang Chen Hongkai Gu Wen Li Yue Chen Binghui Ge Yanzhong Pei | 2020 | Research2020，，1： | 6 |
| 2 | Fabrication of a hydroxyapatite-PDMS microfluidic chip for bone-related cell culture and drug screening显示文摘Bone is an important part of the human body structure and plays a vital role in human health.A microfluidic chip that can simulate the structure and function of bone will provide a platform for bone-related biomedical research.Hydroxyapatite(HA),a bioactive ceramic material,has a similar structure and composition to bone mineralization products.In this study,we used HA as a microfluidic chip component to provide a highly bionic bone environment.HA substrates with different microchannel structures were printed by using ceramic stereolithography(SLA)technology,and the minimum trench width was 50μm.The HA substrate with microchannels was sealed by a thin polydimethylsiloxane(PDMS)layer to make a HA-PDMS microfluidic chip.Cell culture experiments demonstrated that compared with PDMS,HA was more conducive to the proliferation and osteogenic differentiation of the human foetal osteoblast cell line(hFOB).In addition,the concentration gradient of the model drug doxorubicin hydrochloride(DOX)was successfully generated on a Christmas tree structure HA-PDMS chip,and the half maximal inhibitory concentration(IC50)of DOX was determined.The findings of this study indicate that the HA-PDMS microfluidic chip has great potential in the field of high-throughput bonerelated drug screening and bone-related research. | Qiangqiang Tang Xiaoyu Li Chen Lai Lei Li Hongkai Wu Yingjun Wang Xuetao Shi | 2021 | Bioactive Materials2021，6，1： | 5 |
| 3 | Analysis of severe human adenovirus infection outbreak in Guangdong Province,southern China in 2019显示文摘During 2018–2019,a severe human adenovirus(HAdV)infection outbreak occurred in southern China.Here,we screened 18 respiratory pathogens in 1704 children(≤14 years old)hospitalized with acute respiratory illness in Guangzhou,China,in 2019.In total,151 patients had positive HAdV test results;34.4%(52/151)of them exhibited severe illness.HAdV infection occurred throughout the year,with a peak in summer.The median patient age was 3.0(interquartile range:1.1–5.0)years.Patients with severe HAdV infection exhibited increases in12 clinical indexes(P≤0.019)and decreases in four indexes(P≤0.007),compared with patients exhibiting nonsevere infection.No significant differences were found in age or sex distribution according to HAdV infection severity(P>0.05);however,the distributions of comorbid disease and HAdV co-infection differed according to HAdV infection severity(P<0.05).The main epidemic types were HAdV-3(47.0%,71/151)and HAdV-7(46.4%,70/151).However,the severe illness rate was significantly higher in patients with HAdV-7(51.4%)than in patients with HAdV-3(19.7%)and other types of HAdV(20%)(P<0.001).Sequencing analysis of genomes/capsid genes of 13 HAdV-7 isolates revealed high similarity to previous Chinese isolates.A representative HAdV-7isolate exhibited a similar proliferation curve to the curve described for the epidemic HAdV-3 strain Guangzhou01(accession no.DQ099432)(P>0.05);the HAdV-7 isolate exhibited stronger virulence and infectivity,compared with HAdV-3(P<0.001).Overall,comorbid disease,HAdV co-infection,and high virulence and infectivity of HAdV-7 were critical risk factors for severe HAdV infection;these data can facilitate treatment,control,and prevention of HAdV infection. | Wenkuan Liu Shuyan Qiu Li Zhang Hongkai Wu Xingui Tian Xiao Li Duo Xu Jing Dai Shujun Gu Qian Liu Dehui Chen Rong Zhou | 2022 | Virologica Sinica2022，37，3： | 5 |
| 4 | Security in Wireless Mesh Neworks: Challenges and Solutions显示文摘Wireless mesh network is a new emerging field with its potential applications in extremely unpredictable and dynamic environments.However,it is particularly vulnerable due to its features of open medium,dynamic changing topology, cooperative routing algorithms.The article surveys the state of the art in security for wireless mesh networks.Firstly,we analyze various possible threats to security in wireless mesh networks.Secondly,we introduce some representative solutions to these threats,including solutions to the problems of key management,secure network routing,and intrusion detection.We also provide a comparison and discussion of their respective merits and drawbacks,and propose some improvements for these drawbacks.Finally,we also discuss the remaining challenges in the area. | Yi Ping Xing Hongkai Wu Yue Li Jianhua | 2009 | China Communications2009，6，3： | 3 |
| 5 | A simple fabricated thickness-based stiffness gradient for cell studies显示文摘In this work, we developed a simple method to fabricate a thickness-based continuous stiffness gradient for biological studies. It was made by glass slides, polydimethylsiloxane(PDMS) pre-polymer, spacer and clips only, without any sophisticated equipment. It is easy to fabricate in any general biological and pharmaceutical laboratories. The stiffness gradient was characterized in terms of apparent Young's modulus by atomic force microscopy(AFM) and the Young's modulus along the gradient was found to be 8.5–120 k Pa, which is within the physiological relevant range. He La-C3 cells were cultured on the gradient to study their morphological behavior according to the substrate stiffness. Furthermore, the drug efficiency of etoposide, an anti-cancer drug, was studied along the substrate stiffness gradient. It was found that He La-C3 cells cultured on the soft region of the gradient(8.5–11 k Pa) are more sensitive to etoposide. We believe the proposed device could promote cell investigations and drug screenings on a substrate with comparable stiffness to the native tissue. | Yiwei Shu HO Nam Chan Dongshi Guan Hongkai Wu Lan Ma | 2017 | Science Bulletin2017，62，3： | 2 |
| 6 | Ecology of testate amoebae and their potential use as palaeohydrologic indicators from peatland in Sanjiang Plain, Northeast China显示文摘留有遗嘱的阿米巴是在 peatlands 的底层潮湿的敏感指示物。在最后十年,他们被学习了重建自从 Holocene,水文学变化。然而,这些研究地理上被限制了为北美洲和欧洲。我们在最大的大陆人上进行了留有遗嘱的阿米巴的第一调查在 Sanjiang 平原的新鲜的水沼泽地,中国。这研究的目的是在东北中国的 peatlands 在留有遗嘱的阿米巴的生态学上提供基线数据并且估计在这个生态系统把他们用作环境指示物的潜力。我们在 5 浸泡了水的消沉以内在 46 microsites 检验了现代留有遗嘱的变形虫集合和种类环境的关系。测量的环境参数包括了:深度将在点火上浇表格, pH,和损失。结果证明主导的种类是 Trinema complanatum 类型, Euglypha 圆形大厅类型, Euglypha strigosa 类型,和 Centropyxis 产於欧洲的黑醋栗类型。冗余性分析证明水表格深度在留有遗嘱的变形虫集合上有最重要的效果,解释 16.7%(p = 0.002 ) 全部的变化。pH 不是为留有遗嘱的变形虫集合的一个统计上重要的因素。加权的平均和加权的平均部分最少的广场模型被用来造转移功能让深度浇表格。最好表现的转移功能被加权的平均部分最少的广场模型与 r 产生 < 啜 class= “ a-plus-plus ” > 2 < 潜水艇 class= “ a-plus-plus ” > 0.62 的 LOSO 和 RMSEP < 潜水艇 class= “ a-plus-plus ” > 6.96 厘米的 LOSO 。结果显示在浸泡了水的消沉 peatland 的留有遗嘱的阿米巴有潜力在 Sanjiang 平原为水文学变化并且为 palaeohydrologic 重建被用作指示物。 | Lihong SONG Hongkai LI Kehong WANG Donghui WU Haitao WU | 2014 | Frontiers of Earth Science2014，8，4： | 2 |
| 7 | Genetic architecture of maize yield traits dissected by QTL mapping and GWAS in maize显示文摘The study of yield traits can reveal the genetic architecture of grain yield for improving maize production.In this study, an association panel comprising 362 inbred lines and a recombinant inbred line population derived from X178 × 9782 were used to identify candidate genes for nine yield traits. High-priority overlap(HPO) genes, which are genes prioritized in a genome-wide association study(GWAS), were investigated using coexpression networks. The GWAS identified 51 environmentally stable SNPs in two environments and 36 pleiotropic SNPs, including three SNPs with both attributes. Seven hotspots containing 41 trait-associated SNPs were identified on six chromosomes by permutation. Pyramiding of superior alleles showed a highly positive effect on all traits, and the phenotypic values of ear diameter and ear weight consistently corresponded with the number of superior alleles in tropical and temperate germplasm. A total of 61 HPO genes were detected after trait-associated SNPs were combined with the coexpression networks. Linkage mapping identified 16 environmentally stable and 16 pleiotropic QTL.Seven SNPs that were located in QTL intervals were assigned as consensus SNPs for the yield traits.Among the candidate genes predicted by our study, some genes were confirmed to function in seed development. The gene Zm00001 d016656 encoding a serine/threonine protein kinase was associated with five different traits across multiple environments. Some genes were uniquely expressed in specific tissues and at certain stages of seed development. These findings will provide genetic information and resources for molecular breeding of maize grain yield. | Xiao Zhang Zhiyong Ren Bowen Luo Haixu Zhong Peng Ma Hongkai Zhang Hongmei Hu Yikai Wang Haiying Zhang Dan Liu Ling Wu Zhi Nie Yonghui Zhu Wenzhu He Suzhi Zhang Shunzong Su Yaou Shen Shibin Gao | 2022 | The Crop Journal2022，10，2： | 2 |
| 8 | Polymerization of styrene in anionic microemulsion with high monomer content显示文摘 | Xu Xiangling Zhang Zhicheng Wu Hongkai Ge Xuewu and Zhang Manwei | 1998 | Polymer1998，39，21： | 1 |
| 9 | Coating of poly(dim- ethylsiloxane) with n-dndeeyl-beta-D-maltoside to minimize nonspeeifie protein adsorption显示文摘 | Huang Bo Wu Hongkai Kim S | 2005 | Lab Chip2005，5，10： | 1 |
| 10 | Glucosamine, a naturally occurring amino monosaccharide, inhibits A549and H446 cell proliferation by blocking G1/S transition显示文摘 | Yinghua Ju Aiming Yu Xiuhua Sun Didi Wu Hongkai Zhang | 2013 | Molecular Medicine Reports2013，，3： | 1 |
| 11 | Polymerization of styrene in anionic microemulsion with high monomer ontent显示文摘 | Xiangling Xu Zhicheng Zhang Hongkai Wu | 1998 | Polymer1998，39，21： | 1 |
| 12 | Polymerization of styrene in anionic microemulsion with high monomer content显示文摘 | Xiangling Xu Zhicheng Zhang Hongkai Wu | 1998 | Polymer1998，39，21： | 1 |
| 13 | Generation of Alginate Microfibers with a Roller-Assited Microfluidic System显示文摘 | Jing Su Yizhe Zheng Hongkai Wu | | 0，，09： | 1 |
| 14 | A review on the transformation of birnessite in the environment:Implication for the stabilization of heavy metals显示文摘Birnessite is ubiquitous in the natural environment where heavy metals are retained and easily transformed.The surface properties and structure of birnessite change with the changes in external environmental conditions,which also affects the fate of heavy metals.Clarifying the effect and mechanism of the birnessite phase transition process on heavy metals is the key to taking effective measures to prevent and control heavy metal pollution.Therefore,the four transformation pathways of birnessite are summarized first in this review.Second,the relationship between transformation pathways and environmental conditions is proposed.These relevant environmental conditions include abiotic(e.g.,co-existing ions,pH,oxygen pressure,temperature,electric field,light,aging,pressure)and biotic factors(e.g.,microorganisms,biomolecules).The phase transformation is achieved by the key intermediate of Mn(Ⅲ)through interlayer-condensation,folding,neutralizationdisproportionation,and dissolution-recrystallization mechanisms.The AOS(average oxidation state)of Mn and interlayer spacing are closely correlated with the phase transformation of birnessite.Last but not least,the mechanisms of heavy metals immobilization in the transformation process of birnessite are summed up.They involve isomorphous substitution,redox,complexation,hydration/dehydration,etc.The transformation of birnessite and its implication on heavy metals will be helpful for understanding and predicting the behavior of heavy metals and the crucial phase of manganese oxides/hydroxides in natural and engineered environments. | Miao Shi Qingzhu Li Qingwei Wang Xuelei Yan Bensheng Li Linhai Feng Chao Wu Rongrong Qiu Hongkai Zhang Zhihui Yang Weichun Yang Qi Liao Liyuan Chai | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
| 15 | In Vivo Selection of Phage Sequences and Characterization of Peptide-specific Binding to Breast Cancer Cells显示文摘OBJECTIVE To screen specific polypeptide target binding to breast cancer xenogra s in vivo from a phage-displayed peptide library in order to provide peptide sequences for breast cancer tumor-targeting diagnosis and therapy. METHODS A mouse model for carrying breast cancer xenografts was established using Tientsin Albinao II mice(TA II).A 12-peptide library was biopanned through 4 rounds. Phages were recovered and titrated from tumor xenografts and control tissue(liver).The distribution of phages was detected by immunohistochemical staining. RESULTS Phage homing to breast cancer was enriched through 4 rounds of biopanning,being 14-fold of that recovered from liver tissue.A peptide sequence,ASANPFPTKALL was characterized by randomly picked-up clones which appeared most frequently. Immunohistochemical staining revealed phage localization in cancer xenografts 40 min after injection of the enriched phages. When a specific phage was tested individually,the phage reclaimed from breast cancer xenografts was 14 times as those from control tissues. CONCLUSION Tumor-specific homing peptides may provide an effective tool for breast cancer target therapy.The in vivo phage display selection technique employed in this study was feasible and applicable to screening peptides that home to breast cells. | Rui Wang Lin Zhang Hongkai Zhang Xiyin Wei Yi Yang Shiwu Zhang Jing Wu Min Wu Youjia Cao Ruifang Niu | 2008 | Chinese Journal of Clinical Oncology2008，5，2： | 0 |
| 16 | The divergence of brassinosteroid sensitivity between rice subspecies involves natural variation conferring altered internal auto-binding of OsBSK2显示文摘Japonica/geng and indica/xian are two major rice(Oryza sativa)subspecies with multiple divergent traits,but how these traits are related and interact within each subspecies remains elusive.Brassinosteroids(BRs)are a class of steroid phytohormones that modulate many important agronomic traits in rice.Here,using different physiological assays,we revealed that japonica rice exhibits an overall lower BR sensitivity than indica.Extensive screening of BR signaling genes led to the identification of a set of genes distributed throughout the primary BR signaling pathway with divergent polymorphisms.Among these,we demonstrate that the C38/T variant in BR Signaling Kinase2(OsBSK2),causing the amino acid change P13L,plays a central role in mediating differential BR signaling in japonica and indica rice.OsBSK2in indica plays a greater role in BR signaling than OsB SK2in japonica by affecting the auto-binding and protein accumulation of OsBSK2.Finally,we determined that OsBSK2 is involved in a number of divergent traits in japonica relative to indica rice,including grain shape,tiller number,cold adaptation,and nitrogen-use efficiency.Our study suggests that the natural variation in OsB SK2 plays a key role in the divergence of BR signaling,which underlies multiple divergent traits between japonica and indica. | Wenchao Yin Lulu Li Zhikun Yu Fan Zhang Dapu Liu Hongkai Wu Mei Niu Wenjing Meng Xiaoxing Zhang Nana Dong Yanzhao Yang Jihong Liu Yongqiang Liu Guoxia Zhang Jianlong Xu Shimei Wang Chengcai Chu Qian Qian Hongning Tong | 2022 | Journal of Integrative Plant Biology2022，64，8： | 0 |
| 17 | Venovenous extracorporeal membrane oxygenation for COVID-19 and influenza H1N1 associated acute respiratory distress syndrome:A comparative cohort study in China显示文摘Background Venovenous extracorporeal membrane oxygenation(VV-ECMO)has been demonstrated to be effective in treating patients with virus-induced acute respiratory distress syndrome(ARDS).However,whether the management of ECMO is different in treating H1N1 influenza and coronavirus disease 2019(COVID-19)-associated ARDS patients remains unknown.Methods This is a retrospective cohort study.We included 12 VV-ECMO-supported COVID-19 patients admitted to The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Eighth People's Hospital,and Wuhan Union Hospital West Campus between January 23 and March 31,2020.We retrospectively included VV-ECMO-supported patients with COVID-19 and H1N1 influenza-associated ARDS.Clinical characteristics,respiratory mechanics including plateau pressure,driving pressure,mechanical power,ventilatory ratio(VR)and lung compliance,and outcomes were compared.Results Data from 25 patients with COVID-19(n=12)and H1N1(n=13)associated ARDS who had received ECMO support were analyzed.COVID-19 patients were older than H1N1 influenza patients(P=0.004).The partial pressure of arterial carbon dioxide(PaCO_(2))and VR before ECMO initiation were significantly higher in COVID-19 patients than in H1N1 influenza patients(P<0.001 and P=0.004,respectively).COVID-19 patients showed increased plateau and driving pressure compared with H1N1 subjects(P=0.013 and P=0.018,respectively).Patients with COVID-19 remained longer on ECMO support than did H1N1 influenza patients(P=0.015).COVID-19 patients who required ECMO support also had fewer intensive care unit and ventilator-free days than H1N1.Conclusions Compared with H1N1 influenza patients,COVID-19 patients were older and presented with increased PaCO_(2) and VR values before ECMO initiation.The differences between ARDS patients with COVID-19 and influenza on VV-ECMO detailed herein could be helpful for obtaining a better understanding of COVID-19 and for better clinical management. | Yonghao Xu Yin Xi Shuijiang Cai Yuheng Yu Sibei Chen Weijie Guan Weibo Liang Hongkai Wu Weiqun He Xilong Deng Yuanda Xu Rong Zhang Manshu Li Jieyi Pan Zhenting Liang Ya Wang Shaofeng Kong Xiaoqing Liu Zheng Lv Yimin Li | 2023 | Journal of Intensive Medicine2023，3，4： | 0 |
| 18 | Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes显示文摘Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health,especially among immunocompromised populations.Given the intricate problem of dramatic increase in resistance to common biocides,the development of safe and efficient biocide formulated agents to alleviate drug resistance is highly demanding.In this study,Schiff-base ligands were successfully formed on natural biopolymer of epsilon-poly-L-lysine(ε-PL)decorated aldehyde functionalized mesoporous silica SBA-15(CHO-SBA-15)for the selective coordination of silver ions,which was affirmed by various physicochemical methods.Besides the identified broad-spectrum antibacterial activities,the as-prepared Schiff-base silver nanocomplex(CHO-SBA-15/ε-PL/Ag,CLA-1)exhibited an improved inhibitory effect on infectious pathogen growth typified by Escherichia coli and Staphylococcus aureus in comparison with two control silver complexes without Schiff-base conjugates,SBA-15/ε-PL/Ag and CHO-SBA-15/Ag,respectively.In addition,CLA-1 remarkably inhibited the growth of Mycobacterium tuberculosis due to the excellent antimicrobial activity of silver species.Significantly,CLA-1 kills Candida albicans cells,inhibits biofilm formation,and eliminates preformed biofilms,with no development of resistance during continuous serial passaging.The antifungal activity is connected to disruption of bacterial cell membranes and increased levels of intracellular reactive oxygen species.In mouse models of multidrug-resistant C.albicans infection,CLA-1 exhibited efficient in vivo fungicidal efficacy superior to two antifungal drugs,amphotericin B and fluconazole.Moreover,CLA-1 treatment induces negligible toxicity against normal tissues with safety.Therefore,this study reveals the pivotal role of the molecular design of Schiff-base silver nanocomplex formation on biopolymer surface-functionalized silica mesopores as a green and efficient nanoplatform to tackle infectious microbes. | Ling Cai Yanqiang Huang Yuanyuan Duan Qiao Liu Qilan Xu Jia Jia Jianming Wang Qian Tong Peipei Luo Yujie Wen Luming Peng Qian Wu Xudong Hang Huijun Jiang Ping Zhu Yanmei Yang Boshen Zhou Liping Zeng Hongkai Bi Jin Chen | 2021 | Nano Research2021，14，8： | 0 |
| 19 | APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation显示文摘Dear Editor,Cardiovascular diseases(CVDs)are the leading cause of death world-wide.Thus,diagnosing and treating CVD remains at the forefront for clinicians while identifying targetable disease mechanisms in preclinical models are focus areas for researchers and drug developers(Cai et al.,2022a).The polymorphic protein apolipoprotein E(APOE),central to lipid transport and metabolism,is well-recognized for the role of its isoforms as important predictors for human cardiovascular disorders and neurodegenerative diseases(Tudorache et al.,2017).Plasma APOE is generated primarily from liver hepatocytes,accounting for around 75%of the APOE production from the whole body(Getz and Reardon,2009),and plays important functional roles in monocytes/macrophages,adipocytes,and the central nervous system(Kockx et al.,2018).However,despite the fact that APOE is widely expressed in different mammalian cells,studies on the functional roles of APOE mostly focus on its extracellular secreted form,and the specific effects of APOE,particularly intracellular form in cell types closely related to human cardiovascular diseases are therefore still poorly understood. | Hongkai Zhao Kuan Yang Yiyuan Zhang Hongyu Li Qianzhao ji Zeming Wu Shuai Ma Si Wang Moshi Song Guang-Hui Liu Qiang Liu Weiqi Zhang Jing Qu | 2023 | Protein & Cell2023，14，12： | 0 |
| 20 | Printing ionic polymer metal composite actuators by fused deposition modeling technology显示文摘In this work,we printed a Nafion precursor membrane by fused deposition modeling(FDM)rapid prototyping technology and further fabricated IPMCs by electroless plating.The ion-exchange capacity of the Nafion membrane was tested,and the morphology of IPMCs was observed.The electro-mechanical properties of IPMCs under AC voltage inputs were studied,and grasping experiments were performed.The results show that the Nafion membrane after hydrolysis has a good ion-exchange ability and water-holding capacity.SEM observed that the thickness of the IPMC’s electrode layer was about 400 nm,and the platinum layer was tightly combined with the substrate membrane.When using a square wave input of 3.5 V and 0.1 Hz,the maximum current of IPMCs reached 0.30 A,and the displacement and blocking force were 7.57 mm and 10.5 mN,respectively.The new fabrication process ensures the good driving performance of the printed IPMC.And two pieces of IPMCs can capture the irregular objects successfully,indicating the feasibility of printing IPMCs by FDM technology.This paper provides a new and simple method for the fabrication of three-dimensional IPMCs,which can be further applied in flexible grippers and soft robotics. | Guoxiao Yin Qingsong He Xiangman Zhou Yuwei Wu Hongkai Li Min Yu | 2021 | International Journal of Smart and Nano Materials2021，12，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员