|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Characterization of goat whey proteins and their bioactivity and toxicity assay显示文摘Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s physiology.Therefore,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute toxicity.Concentrated proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE methods.Antibacterial activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for L.monocytogenes growth.Antiproliferative activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of exposure.The highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical oxidation.The acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout exposure.Thus,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without toxicity.The present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry. | Maria Isabel Ferreira Campos Paula Perazzo de Souza Barbosa Laura Junqueira Camargo Luciano Da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos Jos´e Hon´orio Lopes Julia Mariano Caju de Oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha | 2022 | Food Bioscience2022，46，2： | 2 |
| 3 | Engineered resistance against fungal pathogens显示文摘 | | 1999 | Eur J Plant Pathol1999，105，： | 1 |
| 4 | Aggressive angiomyxoma in females:is radical resection the only option? 显示文摘 | Chan YM Hon E Ngai SW | 2000 | Acta Obstet Gynecol Scand2000，79，3： | 1 |
| 5 | WebLogo: a sequence logo generator显示文摘 | Crooks G E Hon G ChandoniaJ M | 2004 | Genome Res2004，14，6： | 1 |
| 6 | Solitarywave and doubly periodic wave solutions for the Kersten-Krasil' shchik coupled KdV-mKdV system显示文摘 | HON Y C FAN E G | 2004 | Chaos Solitons & Fractals2004，19，： | 1 |
| 7 | Tillage impacts on microbial biomass and soil carbon and nitrogen dynamics of corn and cotton rotations显示文摘 | Wright A L Hons F M Matocha J E Jr | 2005 | Appl Soil Ecol2005，29，1： | 1 |
| 8 | Electronic evaluation of the fetal heart rate pattern preceding fetal death, further observation显示文摘 | Hon E H Lee S T | 1963 | Am J Obste Gyneeol1963，87，： | 1 |
| 9 | A series of exact solutions for coupled Higgs field equation and coupled Schrtidinger - Boussinesq equation 显示文摘 | HON Y C FAN E G | 2009 | Nonlinear Analysis2009，71，： | 1 |
| 10 | Quasiperiodic waves and asymptotic behavior for Bogoyavlenskii’s breaking soliton equation in (2+1) dimensions显示文摘 | Fan E G Hon Y C | 2008 | Physical Review E2008，78，03： | 1 |
| 11 | Aggressive angiomyxomain females:is radical resection the only option? 显示文摘 | Chan Y M Hon E Ngai S W | 2000 | Acta Obstet Gynecol Scand2000，79，3： | 1 |
| 12 | Aggressive angiomyxoma in females: is radical resection the only option显示文摘 | Chan YM Hon E Ngai SW | 2000 | Acta Obstet Gynecol Scand2000，79，3： | 1 |
| 13 | WebLogo: a sequence logo generator 显示文摘 | CROOKS G E HON G CHANDONIA J M | 2004 | Genome Research2004，14，6： | 1 |
| 14 | Circumventing the ill-conditioningproblem with multiquadratic radial basis functions:applications to elliptic partial differential equations显示文摘 | KANSA E J HON Y C | 2000 | Comput Math Appl2000，39，78： | 1 |
| 15 | The splicing of yeast mitochondrial group I and group II introns requires a DEAD-box protein with RNA chaperone function显示文摘 | HON REN H CLAIRE E R SABINE M | 2005 | PNAS2005，102，1： | 1 |
| 16 | Aggressive angiomyxoma in females: is radical resection the only option 显示文摘 | Chan YM Hon E Ngai SW | 2000 | Acta Obstet Gynecol Scand2000，79，3： | 1 |
| 17 | A series of travelling wave solutions for two variant Boussineq equations in shallow water waves显示文摘 | Fan E G Hon Y C | 2003 | Chaos Solitons and fractals2003，15，： | 1 |
| 18 | Aggressive angiomyxoma in females: is radical resection the only option? 显示文摘 | Chan YM Hon E Ngai SW | 2000 | Acta Ob- stet Gynecol Scand2000，79，21： | 1 |
| 19 | Aggressive angiomyxoma in females:is radical resection the only option显示文摘 | Chan Y M Hon E Ngai S W | 2000 | Acta Obstet Gynecol Scand2000，79，3： | 1 |
| 20 | WebLogo: A sequence logo generator 显示文摘 | Crooks G E Hon G Chandonia J M Brenner S E | 2004 | Genome Research2004，14，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员