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| 1 | Management of gastroesophageal reflux disease: Patient and physician communication challenges and shared decision making显示文摘Gastroesophageal reflux disease(GERD) is a common upper esophageal condition and typical symptoms can include heartburn and sensation of regurgitation while atypical symptoms include chronic cough, asthma, hoarseness, dyspepsia and nausea. Typically, diag-nosis is presumptive given the presence of typical and atypical symptoms and is an indication for empiric therapy. Treatment management can include lifestyle modifications and/or medication therapy with proton pump inhibitor(PPI) class being the preferred and most effective. Complete symptom resolution is not always achieved and long-term PPI therapy can put patients at risk for serious side effects and needless expense. The brain-gut connection and hypervigilance plays an important role in symptom resolution and treatment success, especially in the case of non-PPI responders. Hypervigilance is a combination of increased esophageal sensory sensitivity in combination with exaggerated threat perception surrounding esophageal symptoms. Hypervigilance requires a different approach to GERD managements, where continued PPI therapy and surgery are usually not recommended. Rather, helping physicians and patients understand the brain-gut connection can guide and improve care.Education and reassurance should be the main pillars or treatment. However, it is important not to suggest the symptoms are due to anxiety alone, this often leads to patient dissatisfaction. Patient dissatisfaction with treatment reveals the need for a more patient-centered approach to GERD management and better communication between patients and providers. Shared decision making(SDM) with the incorporation of patient-reported outcomes(PRO) promotes patient adherence and satisfaction. SDM is a joint discussion between clinician and patient in which a mutually shared solution is explored for GERD symptoms. For SDM to work the physician needs to capture patients' perceptions which may not be obtained in the standard interview. This can be done through the use of PROs which promote a dialogue with patients about their symptoms and treatment priorities in the context of the SDM patient encounter. SDM could potentially help in the management of patient expectations for GERD treatment, ultimately positively impacting their health-related quality of life. | Scott Klenzak Igor Danelisen Grace D Brannan Melissa A Holland Miranda AL van Tilburg | 2018 | World Journal of Clinical Cases2018，6，15： | 10 |
| 2 | RNA virus populations as quasispecies显示文摘 | Holland J J de la Torre J C Steinhauer D A | 1992 | Curr Top Microbiol Immunol1992，176，： | 2 |
| 3 | Intestinal permeability:an overview 显示文摘 | Macpherson A Hollander D | 1995 | Gastroenterology1995，108，5： | 1 |
| 4 | The liquefaction of sands,a collapse surface approach显示文摘 | SLADEN J A D'HOLLANDER R D KRAHN J | 1985 | Can Geotech J1985，22，： | 1 |
| 5 | 'Healed' experimental gastric ulcers remain histologically and ultrastructurally abnormal显示文摘 | Tarnawski A Hollander D William JK | 1990 | J Clin gastroenterol1990，12，1： | 1 |
| 6 | Sub - pixel mapping of rural land cover objects from fine spatial resolution satellite sensor imagery using super-resolution pixel-swapping显示文摘 | Thornton M W Atkinson P M Holland D A | 2006 | ''International Journal of Remote Sensing2006，27，3： | 1 |
| 7 | Penetrating keratoplasty and transscler- al fixation of posterior chamber lens 显示文摘 | Holland E J Daya SM Evangelista A Ketcham JM Lubniewski A J Doughman D J | 1992 | Am J Ophthalmol1992，114，2： | 1 |
| 8 | Prostaglandin protection of the gastric mucosa against alcohol injury-a dynamic time-related process显示文摘 | Tarnawski A Hollander D Stachura J | 1985 | Gastroenterology1985，88，： | 1 |
| 9 | REE chemistry and Sm-Nd systematics of late Archean weathering profiles in the Fortescue Group, Western Australia显示文摘 | MacFarlane A W Danielson A Holland H D | 1994 | Geochimica et Cosmochimica Acta1994，58，7： | 1 |
| 10 | Net primary production in tropical forests: an evaluation and synthesis of existing field data显示文摘 | Clark D A Brown S Kichlighter W K Charmbers J Q Thomlinson J R Ni J Holland E A | 2001 | Ecological Applications2001，11，2： | 1 |
| 11 | Fluxes of nitrous oxide and methane from nitrogen-amended soils in a Colorado alpine ecosystem显示文摘 | Neff J C Bowman W D Holland E A | 1994 | Biogeochemistry1994，27，： | 1 |
| 12 | Establishment of long- term embryogenic cultures of seedless Vitis vinifera cuhivars - a synergistic effect of auxins and the role of abscisic acid显示文摘 | PERL A SAAD S SAHAR N HOLLAND D | 1995 | Plant Science1995，104，： | 1 |
| 13 | Single-and multiple-dose pharmacokinetics of caspofungin in healthy men显示文摘 | STONE J A HOLLAND S D WICKERSHAMPJ etal | 2002 | Antimicrob Agents Chemother2002，46，： | 1 |
| 14 | Cytoprotect-ion of the gastric mucosa byantacids and sucralfate but not by the H2 blockers显示文摘 | Tarnawski A Holland D Krause WJ | 1988 | Dig Dis Sci1988，33，7： | 1 |
| 15 | Directmethod for quantitation of extreme polymerase error frequencies at selected single base sites in viral RNA显示文摘 | Steinhauer D A Holland J J | 1986 | J Viro1986，157，： | 1 |
| 16 | A mass transfer model for copper and molybdenum in magmatic hydrothermal system: The origin of porphyry-type ore deposits显示文摘 | CANDELA P A HOLLAND H D | 1986 | Economic Geology1986，81，： | 1 |
| 17 | The evaporation path of seawater and the coprecipitation of Rr^- and K^+ with halite显示文摘 | McCaffrey M A Lazar B Holland H D | 1987 | Journal of Sedimentary Petrology1987，57，： | 1 |
| 18 | Climate,epahic,and biotic control over storage and turnover in carbon in soils显示文摘 | SCHOMEL D S BRASWELL B H HOLLAND E A | 1994 | Global Biogeochem Cycles1994，8，： | 1 |
| 19 | Specific cell targeting with nanobody conjugated branched gold nanop- articles for photothermal therapy显示文摘 | Van de Broek B Devoogdt N Hollander A D | 2011 | ACS Nano2011，5，6： | 1 |
| 20 | Specific Cell Targeting with Nanobody Conjugated Branched Gold Nanoparti cles for Photothermal Therapy显示文摘 | Van de Broek B Devoogdt N D' Hollander A | 2011 | ACS Nano2011，5，6： | 1 |
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